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Myxoid Leiomyoma

MedGen UID:
416948
•Concept ID:
C2347314
•
Neoplastic Process
Synonym: Myxoid leiomyoma
SNOMED CT: Myxoid leiomyoma (703635008)

Definition

A leiomyoma characterized by the presence of abundant myxoid matrix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyxoid Leiomyoma

Professional guidelines

PubMed

Smooth muscle tumors of the ovary: a clinicopathologic study of 54 cases emphasizing prognostic criteria, histologic variants, and differential diagnosis.
Lerwill MF, Sung R, Oliva E, Prat J, Young RH
Am J Surg Pathol 2004 Nov;28(11):1436-51. doi: 10.1097/01.pas.0000141393.99300.d0. PMID: 15489647
Uterine leiomyomas: histopathologic features, MR imaging findings, differential diagnosis, and treatment.
Murase E, Siegelman ES, Outwater EK, Perez-Jaffe LA, Tureck RW
Radiographics 1999 Sep-Oct;19(5):1179-97. doi: 10.1148/radiographics.19.5.g99se131179. PMID: 10489175
Diffuse, perinodular, and other patterns of hydropic degeneration within and adjacent to uterine leiomyomas. Problems in differential diagnosis.
Clement PB, Young RH, Scully RE
Am J Surg Pathol 1992 Jan;16(1):26-32. doi: 10.1097/00000478-199201000-00004. PMID: 1309411

Recent clinical studies

Etiology

Myxoid change of the myometrium and cervical stroma: description of a hitherto unreported non-neoplastic phenomenon with discussion of myxoid uterine lesions.
McCluggage WG, Young RH
Int J Gynecol Pathol 2010 Jul;29(4):351-7. doi: 10.1097/PGP.0b013e3181c6a79a. PMID: 20567149
Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy.
Ip PP, Tse KY, Tam KF
Adv Anat Pathol 2010 Mar;17(2):91-112. doi: 10.1097/PAP.0b013e3181cfb901. PMID: 20179432
The diagnostic problem of endometrial stromal sarcoma: report on six cases.
Amant F, Moerman P, Cadron I, Neven P, Berteloot P, Vergote I
Gynecol Oncol 2003 Jul;90(1):37-43. doi: 10.1016/s0090-8258(03)00207-5. PMID: 12821339

Diagnosis

Ovarian leiomyoma with myxoid stroma.
Moulla A, Magdy N, El-Bahrawy M
Pathologica 2017 Dec;109(4):389-391. PMID: 29449730
Myxoid Leiomyosarcoma of the Uterus: A Clinicopathologic Analysis of 30 Cases and Review of the Literature With Reappraisal of Its Distinction From Other Uterine Myxoid Mesenchymal Neoplasms.
Parra-Herran C, Schoolmeester JK, Yuan L, Dal Cin P, Fletcher CD, Quade BJ, Nucci MR
Am J Surg Pathol 2016 Mar;40(3):285-301. doi: 10.1097/PAS.0000000000000593. PMID: 26866354
Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy.
Ip PP, Tse KY, Tam KF
Adv Anat Pathol 2010 Mar;17(2):91-112. doi: 10.1097/PAP.0b013e3181cfb901. PMID: 20179432
Vaginal para-urethral myxoid leiomyoma: case report and review of the literature.
Costantini E, Cochetti G, Porena M
Int Urogynecol J Pelvic Floor Dysfunct 2008 Aug;19(8):1183-5. Epub 2008 Mar 20 doi: 10.1007/s00192-008-0588-9. PMID: 18351279
Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds.
Ueda H, Togashi K, Konishi I, Kataoka ML, Koyama T, Fujiwara T, Kobayashi H, Fujii S, Konishi J
Radiographics 1999 Oct;19 Spec No:S131-45. doi: 10.1148/radiographics.19.suppl_1.g99oc04s131. PMID: 10517450

Prognosis

Myxoid Leiomyosarcoma of the Uterus: A Clinicopathologic Analysis of 30 Cases and Review of the Literature With Reappraisal of Its Distinction From Other Uterine Myxoid Mesenchymal Neoplasms.
Parra-Herran C, Schoolmeester JK, Yuan L, Dal Cin P, Fletcher CD, Quade BJ, Nucci MR
Am J Surg Pathol 2016 Mar;40(3):285-301. doi: 10.1097/PAS.0000000000000593. PMID: 26866354

Clinical prediction guides

Myxoid Leiomyosarcoma of the Uterus: A Clinicopathologic Analysis of 30 Cases and Review of the Literature With Reappraisal of Its Distinction From Other Uterine Myxoid Mesenchymal Neoplasms.
Parra-Herran C, Schoolmeester JK, Yuan L, Dal Cin P, Fletcher CD, Quade BJ, Nucci MR
Am J Surg Pathol 2016 Mar;40(3):285-301. doi: 10.1097/PAS.0000000000000593. PMID: 26866354
Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds.
Ueda H, Togashi K, Konishi I, Kataoka ML, Koyama T, Fujiwara T, Kobayashi H, Fujii S, Konishi J
Radiographics 1999 Oct;19 Spec No:S131-45. doi: 10.1148/radiographics.19.suppl_1.g99oc04s131. PMID: 10517450

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