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Cramp in limb

MedGen UID:
41336
•Concept ID:
C0010263
•
Sign or Symptom
Synonyms: Cramp, Limb; Cramps, Limb; Limb Cramp; Limb Cramps
SNOMED CT: Cramp in limb (424647005); Cramp in extremity (424647005)

Definition

An involuntary contraction of a muscle in an extremity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCramp in limb

Professional guidelines

PubMed

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Muscle cramps and contractures: causes and treatment.
Dijkstra JN, Boon E, Kruijt N, Brusse E, Ramdas S, Jungbluth H, van Engelen BGM, Walters J, Voermans NC
Pract Neurol 2023 Feb;23(1):23-34. Epub 2022 Dec 15 doi: 10.1136/pn-2022-003574. PMID: 36522175
Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K
J Gastroenterol 2021 Jul;56(7):593-619. Epub 2021 Jul 7 doi: 10.1007/s00535-021-01788-x. PMID: 34231046Free PMC Article

Recent clinical studies

Etiology

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
An Evidence-Based Review of the Pathophysiology, Treatment, and Prevention of Exercise-Associated Muscle Cramps.
Miller KC, McDermott BP, Yeargin SW, Fiol A, Schwellnus MP
J Athl Train 2022 Jan 1;57(1):5-15. doi: 10.4085/1062-6050-0696.20. PMID: 34185846Free PMC Article
Magnesium for skeletal muscle cramps.
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, Sekhon RK, Dugré N
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD009402. doi: 10.1002/14651858.CD009402.pub3. PMID: 32956536Free PMC Article
Muscle Cramping During Exercise: Causes, Solutions, and Questions Remaining.
Maughan RJ, Shirreffs SM
Sports Med 2019 Dec;49(Suppl 2):115-124. doi: 10.1007/s40279-019-01162-1. PMID: 31696455Free PMC Article
Studies on the safety of creatine supplementation.
Kim HJ, Kim CK, Carpentier A, Poortmans JR
Amino Acids 2011 May;40(5):1409-18. Epub 2011 Mar 12 doi: 10.1007/s00726-011-0878-2. PMID: 21399917

Diagnosis

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Muscle cramps and contractures: causes and treatment.
Dijkstra JN, Boon E, Kruijt N, Brusse E, Ramdas S, Jungbluth H, van Engelen BGM, Walters J, Voermans NC
Pract Neurol 2023 Feb;23(1):23-34. Epub 2022 Dec 15 doi: 10.1136/pn-2022-003574. PMID: 36522175
Clinical practice guideline for the management of paediatric Charcot-Marie-Tooth disease.
Yiu EM, Bray P, Baets J, Baker SK, Barisic N, de Valle K, Estilow T, Farrar MA, Finkel RS, Haberlová J, Kennedy RA, Moroni I, Nicholson GA, Ramchandren S, Reilly MM, Rose K, Shy ME, Siskind CE, Yum SW, Menezes MP, Ryan MM, Burns J
J Neurol Neurosurg Psychiatry 2022 May;93(5):530-538. Epub 2022 Feb 9 doi: 10.1136/jnnp-2021-328483. PMID: 35140138
Neuromuscular hyperexcitability syndromes.
De Wel B, Claeys KG
Curr Opin Neurol 2021 Oct 1;34(5):714-720. doi: 10.1097/WCO.0000000000000963. PMID: 34914668
Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K
J Gastroenterol 2021 Jul;56(7):593-619. Epub 2021 Jul 7 doi: 10.1007/s00535-021-01788-x. PMID: 34231046Free PMC Article

Therapy

Does Magnesium Supplementation Treat Nocturnal Leg Cramps?
Kaufman N, White D, Bull J, Radi R, DeSanto K
Am Fam Physician 2023 Dec;108(6):619-620. PMID: 38215424
Magnesium for skeletal muscle cramps.
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, Sekhon RK, Dugré N
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD009402. doi: 10.1002/14651858.CD009402.pub3. PMID: 32956536Free PMC Article
Leg cramps.
Young G
BMJ Clin Evid 2015 May 13;2015 PMID: 25970567Free PMC Article
Muscle cramps.
McGee SR
Arch Intern Med 1990 Mar;150(3):511-8. PMID: 2178579
Cramps.
Layzer RB, Rowland LP
N Engl J Med 1971 Jul 1;285(1):31-40. doi: 10.1056/NEJM197107012850109. PMID: 4327027

Prognosis

Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K
J Gastroenterol 2021 Jul;56(7):593-619. Epub 2021 Jul 7 doi: 10.1007/s00535-021-01788-x. PMID: 34231046Free PMC Article
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group
Lancet 2021 May 1;397(10285):1637-1645. doi: 10.1016/S0140-6736(21)00676-0. PMID: 33933206Free PMC Article
Pain in amyotrophic lateral sclerosis.
Chiò A, Mora G, Lauria G
Lancet Neurol 2017 Feb;16(2):144-157. Epub 2016 Dec 8 doi: 10.1016/S1474-4422(16)30358-1. PMID: 27964824
Muscle pain, fatigue, and fasiculations.
Kincaid JC
Neurol Clin 1997 Aug;15(3):697-709. doi: 10.1016/s0733-8619(05)70340-6. PMID: 9227959
Leg cramps in children.
Leung AK, Wong BE, Cho HY, Chan PY
Clin Pediatr (Phila) 1997 Feb;36(2):69-73. doi: 10.1177/000992289703600202. PMID: 9118592

Clinical prediction guides

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Pickle Juice Intervention for Cirrhotic Cramps Reduction: The PICCLES Randomized Controlled Trial.
Tapper EB, Salim N, Baki J, Zhao Z, Sundaram V, Patwardhan V, Nikirk SJ
Am J Gastroenterol 2022 Jun 1;117(6):895-901. Epub 2022 Apr 13 doi: 10.14309/ajg.0000000000001781. PMID: 35416793Free PMC Article
Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K
J Gastroenterol 2021 Jul;56(7):593-619. Epub 2021 Jul 7 doi: 10.1007/s00535-021-01788-x. PMID: 34231046Free PMC Article
Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
Qu H, Guo M, Chai H, Wang WT, Gao ZY, Shi DZ
J Am Heart Assoc 2018 Oct 2;7(19):e009835. doi: 10.1161/JAHA.118.009835. PMID: 30371340Free PMC Article
Pain in amyotrophic lateral sclerosis.
Chiò A, Mora G, Lauria G
Lancet Neurol 2017 Feb;16(2):144-157. Epub 2016 Dec 8 doi: 10.1016/S1474-4422(16)30358-1. PMID: 27964824

Recent systematic reviews

Combined oral contraceptive pill for primary dysmenorrhoea.
Schroll JB, Black AY, Farquhar C, Chen I
Cochrane Database Syst Rev 2023 Jul 31;7(7):CD002120. doi: 10.1002/14651858.CD002120.pub4. PMID: 37523477Free PMC Article
Exertional Rhabdomyolysis in Athletes: Systematic Review and Current Perspectives.
Bäcker HC, Richards JT, Kienzle A, Cunningham J, Braun KF
Clin J Sport Med 2023 Mar 1;33(2):187-194. Epub 2022 Oct 20 doi: 10.1097/JSM.0000000000001082. PMID: 36877581
Magnesium for skeletal muscle cramps.
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, Sekhon RK, Dugré N
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD009402. doi: 10.1002/14651858.CD009402.pub3. PMID: 32956536Free PMC Article
Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease.
Ng L, Khan F, Young CA, Galea M
Cochrane Database Syst Rev 2017 Jan 10;1(1):CD011776. doi: 10.1002/14651858.CD011776.pub2. PMID: 28072907Free PMC Article
Leg cramps.
Young G
BMJ Clin Evid 2015 May 13;2015 PMID: 25970567Free PMC Article

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