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Retroperitoneal leiomyosarcoma

MedGen UID:
412162
•Concept ID:
C2187547
•
Neoplastic Process
Synonyms: leiomyosarcoma of retroperitoneal space; Retroperitoneal Leiomyosarcoma; retroperitoneal leiomyosarcoma; retroperitoneal space leiomyosarcoma
 
Monarch Initiative: MONDO:0003370

Definition

An aggressive malignant smooth muscle neoplasm, arising from the retroperitoneum. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetroperitoneal leiomyosarcoma

Professional guidelines

PubMed

Serotonin Syndrome Complicating Treatment of Ifosfamide Neurotoxicity With Methylene Blue.
Snyder M, Gangadhara S, Brohl AS, Ludlow S, Nanjappa S
Cancer Control 2017 Oct-Dec;24(5):1073274817729070. doi: 10.1177/1073274817729070. PMID: 28975823Free PMC Article
Laboratory and clinical evidence of synergistic cytotoxicity of sequential treatment with gemcitabine followed by docetaxel in the treatment of sarcoma.
Leu KM, Ostruszka LJ, Shewach D, Zalupski M, Sondak V, Biermann JS, Lee JS, Couwlier C, Palazzolo K, Baker LH
J Clin Oncol 2004 May 1;22(9):1706-12. doi: 10.1200/JCO.2004.08.043. PMID: 15117993

Recent clinical studies

Etiology

A CT-based radiomics classification model for the prediction of histological type and tumour grade in retroperitoneal sarcoma (RADSARC-R): a retrospective multicohort analysis.
Arthur A, Orton MR, Emsley R, Vit S, Kelly-Morland C, Strauss D, Lunn J, Doran S, Lmalem H, Nzokirantevye A, Litiere S, Bonvalot S, Haas R, Gronchi A, Van Gestel D, Ducassou A, Raut CP, Meeus P, Spalek M, Hatton M, Le Pechoux C, Thway K, Fisher C, Jones R, Huang PH, Messiou C
Lancet Oncol 2023 Nov;24(11):1277-1286. doi: 10.1016/S1470-2045(23)00462-X. PMID: 37922931Free PMC Article
Recurrence patterns of retroperitoneal leiomyosarcoma and impact of salvage surgery.
Ikoma N, Torres KE, Lin HY, Ravi V, Roland CL, Mann GN, Hunt KK, Cormier JN, Feig BW
J Surg Oncol 2017 Sep;116(3):313-319. Epub 2017 May 29 doi: 10.1002/jso.24667. PMID: 28557016Free PMC Article
Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma.
Li Q, Zhuang R, Zhu J, Lu W, Hou Y, Liu J, Zhang Y, Wang Y, Liu T, Wang Z, Zhou Y
Future Oncol 2015;11(12):1759-66. doi: 10.2217/fon.15.54. PMID: 26075444
Radiation-induced sarcoma following curative radiotherapy for testicular seminoma: case report and brief review of the literature.
Stein ME, Leviov M, Drumea K, Goralnik L, Miselevich I, Kuten A
Tumori 1997 May-Jun;83(3):721-3. doi: 10.1177/030089169708300320. PMID: 9267497
Retroperitoneal leiomyosarcoma: a review of the literature.
Fisher NW, Nutinsky CL
J Am Osteopath Assoc 1989 Aug;89(8):1058-60, 1065. PMID: 2670858

Diagnosis

A CT-based radiomics classification model for the prediction of histological type and tumour grade in retroperitoneal sarcoma (RADSARC-R): a retrospective multicohort analysis.
Arthur A, Orton MR, Emsley R, Vit S, Kelly-Morland C, Strauss D, Lunn J, Doran S, Lmalem H, Nzokirantevye A, Litiere S, Bonvalot S, Haas R, Gronchi A, Van Gestel D, Ducassou A, Raut CP, Meeus P, Spalek M, Hatton M, Le Pechoux C, Thway K, Fisher C, Jones R, Huang PH, Messiou C
Lancet Oncol 2023 Nov;24(11):1277-1286. doi: 10.1016/S1470-2045(23)00462-X. PMID: 37922931Free PMC Article
Retroperitoneal Leiomyosarcoma with Elevated CA 19-9.
Wechsler B, Anton B, Yim D
S D Med 2022 Apr;75(4):154-157. PMID: 35709345
Serotonin Syndrome Complicating Treatment of Ifosfamide Neurotoxicity With Methylene Blue.
Snyder M, Gangadhara S, Brohl AS, Ludlow S, Nanjappa S
Cancer Control 2017 Oct-Dec;24(5):1073274817729070. doi: 10.1177/1073274817729070. PMID: 28975823Free PMC Article
Metastatic Gastric Polyp Diagnosing Retroperitoneal Leiomyosarcoma.
Achdjian HS, Usta Y, StimsonRiahi SC, Aasen T, Shaughnessy R
Am J Gastroenterol 2016 Sep;111(9):1228. doi: 10.1038/ajg.2016.190. PMID: 27580773
Retroperitoneal leiomyosarcoma: a review of the literature.
Fisher NW, Nutinsky CL
J Am Osteopath Assoc 1989 Aug;89(8):1058-60, 1065. PMID: 2670858

Therapy

TRAbectedin in adVanced rEtroperitoneal well differentiated/dedifferentiated Liposarcoma and Leiomyosarcoma (TRAVELL): results of a phase II study from the Italian Sarcoma Group.
Fabbroni C, Grignani G, Vincenzi B, Fumagalli E, De Pas TM, Mazzocca A, Pantaleo MA, Brunello A, Baldi GG, Boglione A, Fatigoni S, Berruti A, Giordano M, Marrari A, Dei Tos AP, Alberton AS, Aliberti S, Carlucci L, Rulli E, Casali PG, Sanfilippo R
ESMO Open 2024 Aug;9(8):103667. Epub 2024 Aug 8 doi: 10.1016/j.esmoop.2024.103667. PMID: 39121815Free PMC Article
Web-based nomograms for predicting overall survival and cancer-specific survival in retroperitoneal leiomyosarcoma: a population-based analysis.
Feng Z, Li Y
J Cancer Res Clin Oncol 2023 Oct;149(13):11735-11748. Epub 2023 Jul 5 doi: 10.1007/s00432-023-05052-y. PMID: 37405479
Keeping up the 'race pace' in a patient with nonuterine leiomyosarcoma.
Szkandera J
Future Oncol 2022 Sep;18(29s):12-16. Epub 2022 Sep 26 doi: 10.2217/fon-2022-0636. PMID: 36154278
Serotonin Syndrome Complicating Treatment of Ifosfamide Neurotoxicity With Methylene Blue.
Snyder M, Gangadhara S, Brohl AS, Ludlow S, Nanjappa S
Cancer Control 2017 Oct-Dec;24(5):1073274817729070. doi: 10.1177/1073274817729070. PMID: 28975823Free PMC Article
Radiation-induced sarcoma following curative radiotherapy for testicular seminoma: case report and brief review of the literature.
Stein ME, Leviov M, Drumea K, Goralnik L, Miselevich I, Kuten A
Tumori 1997 May-Jun;83(3):721-3. doi: 10.1177/030089169708300320. PMID: 9267497

Prognosis

A CT-based radiomics classification model for the prediction of histological type and tumour grade in retroperitoneal sarcoma (RADSARC-R): a retrospective multicohort analysis.
Arthur A, Orton MR, Emsley R, Vit S, Kelly-Morland C, Strauss D, Lunn J, Doran S, Lmalem H, Nzokirantevye A, Litiere S, Bonvalot S, Haas R, Gronchi A, Van Gestel D, Ducassou A, Raut CP, Meeus P, Spalek M, Hatton M, Le Pechoux C, Thway K, Fisher C, Jones R, Huang PH, Messiou C
Lancet Oncol 2023 Nov;24(11):1277-1286. doi: 10.1016/S1470-2045(23)00462-X. PMID: 37922931Free PMC Article
Recurrence patterns of retroperitoneal leiomyosarcoma and impact of salvage surgery.
Ikoma N, Torres KE, Lin HY, Ravi V, Roland CL, Mann GN, Hunt KK, Cormier JN, Feig BW
J Surg Oncol 2017 Sep;116(3):313-319. Epub 2017 May 29 doi: 10.1002/jso.24667. PMID: 28557016Free PMC Article
Right atrial extension of a giant retroperitoneal leiomyosarcoma.
Saran S, Khera PS, Gautam P, Elhence P
Ann Afr Med 2017 Apr-Jun;16(2):90-93. doi: 10.4103/aam.aam_42_16. PMID: 28469124Free PMC Article
Abdominal aortic invasion by leiomyosarcoma.
Cantwell CP, Stack J
Abdom Imaging 2006 Jan-Feb;31(1):120-2. doi: 10.1007/s00261-005-0163-5. PMID: 16314992
Retroperitoneal leiomyosarcoma: a review of the literature.
Fisher NW, Nutinsky CL
J Am Osteopath Assoc 1989 Aug;89(8):1058-60, 1065. PMID: 2670858

Clinical prediction guides

TRAbectedin in adVanced rEtroperitoneal well differentiated/dedifferentiated Liposarcoma and Leiomyosarcoma (TRAVELL): results of a phase II study from the Italian Sarcoma Group.
Fabbroni C, Grignani G, Vincenzi B, Fumagalli E, De Pas TM, Mazzocca A, Pantaleo MA, Brunello A, Baldi GG, Boglione A, Fatigoni S, Berruti A, Giordano M, Marrari A, Dei Tos AP, Alberton AS, Aliberti S, Carlucci L, Rulli E, Casali PG, Sanfilippo R
ESMO Open 2024 Aug;9(8):103667. Epub 2024 Aug 8 doi: 10.1016/j.esmoop.2024.103667. PMID: 39121815Free PMC Article
A CT-based radiomics classification model for the prediction of histological type and tumour grade in retroperitoneal sarcoma (RADSARC-R): a retrospective multicohort analysis.
Arthur A, Orton MR, Emsley R, Vit S, Kelly-Morland C, Strauss D, Lunn J, Doran S, Lmalem H, Nzokirantevye A, Litiere S, Bonvalot S, Haas R, Gronchi A, Van Gestel D, Ducassou A, Raut CP, Meeus P, Spalek M, Hatton M, Le Pechoux C, Thway K, Fisher C, Jones R, Huang PH, Messiou C
Lancet Oncol 2023 Nov;24(11):1277-1286. doi: 10.1016/S1470-2045(23)00462-X. PMID: 37922931Free PMC Article
Nomogram predicting overall survival after surgical resection for retroperitoneal leiomyosarcoma patients.
Zhuang A, Yue X, Tong H, Zhang Y, He F, Lu W
Front Endocrinol (Lausanne) 2023;14:1160817. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1160817. PMID: 37534215Free PMC Article
Web-based nomograms for predicting overall survival and cancer-specific survival in retroperitoneal leiomyosarcoma: a population-based analysis.
Feng Z, Li Y
J Cancer Res Clin Oncol 2023 Oct;149(13):11735-11748. Epub 2023 Jul 5 doi: 10.1007/s00432-023-05052-y. PMID: 37405479
CT imaging improves histopathological grading of retroperitoneal leiomyosarcomas.
Mcaddy NC, Hallin M, Strauss D, Smith M, Hayes A, Yusuf S, Moskovic E, Fotiadis N, van Houdt W, Jones RL, Gronchi A, Thway K, Messiou C
Eur J Surg Oncol 2020 Feb;46(2):288-292. Epub 2019 Oct 10 doi: 10.1016/j.ejso.2019.10.007. PMID: 31653457

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