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Carotid artery thrombosis

MedGen UID:
40119
•Concept ID:
C0007274
•
Disease or Syndrome
Synonyms: Carotid Artery Thromboses; Carotid Artery Thrombosis; Carotid Thrombosis; Thrombosis, Carotid; Thrombosis, Carotid Artery
SNOMED CT: Carotid artery thrombosis (86003009)
 
Monarch Initiative: MONDO:0006690

Definition

Blood clot formation in any part of the carotid arteries. This may produce carotid stenosis or occlusion of the vessel, leading to transient ischemic attack; cerebral infarction; or amaurosis fugax. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarotid artery thrombosis

Professional guidelines

PubMed

Overview of evidence on risk factors and early management of acute carotid stent thrombosis during the last two decades.
Coelho AP, Lobo M, Nogueira C, Gouveia R, Campos J, Augusto R, Coelho N, Semião AC, Canedo A
J Vasc Surg 2019 Mar;69(3):952-964. doi: 10.1016/j.jvs.2018.09.053. PMID: 30798846
Current management of penetrating injuries of the soft palate.
Randall DA, Kang DR
Otolaryngol Head Neck Surg 2006 Sep;135(3):356-60. doi: 10.1016/j.otohns.2005.12.003. PMID: 16949964
Rhinocerebral mucormycosis: management and survival after carotid occlusion.
Galetta SL, Wulc AE, Goldberg HI, Nichols CW, Glaser JS
Ann Neurol 1990 Jul;28(1):103-7. doi: 10.1002/ana.410280121. PMID: 2375625

Recent clinical studies

Etiology

CTSS Modulates Stress-Related Carotid Artery Thrombosis in a Mouse FeCl(3) Model.
Xu S, Piao L, Wan Y, Huang Z, Meng X, Inoue A, Wang H, Yue X, Jin X, Shi GP, Kuzuya M, Cheng XW
Arterioscler Thromb Vasc Biol 2023 Jul;43(7):e238-e253. Epub 2023 Apr 27 doi: 10.1161/ATVBAHA.122.318455. PMID: 37128920
Intraluminal carotid thrombosis and acute ischemic stroke associated with COVID-19.
Hamouda D, Jillella DV, Bhatt N, Koneru S, Frankel MR, Nogueira RG
J Neurol 2021 Dec;268(12):4443-4447. Epub 2021 Apr 29 doi: 10.1007/s00415-021-10562-1. PMID: 33914141Free PMC Article
Internal carotid artery thrombosis in COVID 19.
Álvarez Moreno Y, Bú Figueroa J, Bú Figueroa E, Soto Fonseca M, Escober Torres J
Colomb Med (Cali) 2020 Sep 30;51(3):e504560. doi: 10.25100/cm.v51i3.4560. PMID: 33402757Free PMC Article
COVID-19-Associated Carotid Atherothrombosis and Stroke.
Esenwa C, Cheng NT, Lipsitz E, Hsu K, Zampolin R, Gersten A, Antoniello D, Soetanto A, Kirchoff K, Liberman A, Mabie P, Nisar T, Rahimian D, Brook A, Lee SK, Haranhalli N, Altschul D, Labovitz D
AJNR Am J Neuroradiol 2020 Nov;41(11):1993-1995. Epub 2020 Aug 20 doi: 10.3174/ajnr.A6752. PMID: 32819896Free PMC Article
Carotid stenting for atherothrombosis.
Mohler ER 3rd
Heart 2007 Sep;93(9):1147-51. doi: 10.1136/hrt.2005.085613. PMID: 17699181Free PMC Article

Diagnosis

Internal carotid artery thrombosis in COVID 19.
Álvarez Moreno Y, Bú Figueroa J, Bú Figueroa E, Soto Fonseca M, Escober Torres J
Colomb Med (Cali) 2020 Sep 30;51(3):e504560. doi: 10.25100/cm.v51i3.4560. PMID: 33402757Free PMC Article
The Involvement of Toll-like Receptor-2 in Arterial Thrombus Formation.
Reinhardt C
Hamostaseologie 2018 Nov;38(4):223-228. Epub 2018 Sep 27 doi: 10.1055/s-0038-1668164. PMID: 30261531
Measurement of carotid plaque burden.
Spence JD
JAMA Neurol 2015 Apr;72(4):383-4. doi: 10.1001/jamaneurol.2014.3002. PMID: 25686472
Cerebrovascular disease. Pathophysiology and diagnosis.
Gorelick PB
Nurs Clin North Am 1986 Jun;21(2):275-88. PMID: 3517818
Clinical neurology.
Boshes B, Brumlik J, Blonsky ER
Prog Neurol Psychiatry 1968;23:155-97. PMID: 4890078

Therapy

Jak2 V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk.
Liu W, Pircher J, Schuermans A, Ul Ain Q, Zhang Z, Honigberg MC, Yalcinkaya M, Nakao T, Pournamadri A, Xiao T, Hajebrahimi MA, Wasner L, Stegner D, Petzold T, Natarajan P, Massberg S, Tall AR, Schulz C, Wang N
Blood 2024 Apr 11;143(15):1539-1550. doi: 10.1182/blood.2023022260. PMID: 38142422Free PMC Article
Non-Vitamin K Oral Anticoagulants (NOACs) and Their Reversal.
Reddy ST, Cossey TC, Savitz SI, Grotta JC
Curr Neurol Neurosci Rep 2017 Sep;17(9):67. doi: 10.1007/s11910-017-0774-6. PMID: 28735353
Is Acute Carotid Artery Stent Thrombosis an Avoidable Complication?
Köklü E, Yüksel İÖ, Bayar N, Arslan Ş
J Stroke Cerebrovasc Dis 2015 Oct;24(10):2219-22. Epub 2015 Aug 21 doi: 10.1016/j.jstrokecerebrovasdis.2015.05.029. PMID: 26303788
Cisplatin-associated thrombosis.
Jafri M, Protheroe A
Anticancer Drugs 2008 Oct;19(9):927-9. doi: 10.1097/CAD.0b013e3283100e9c. PMID: 18766008
Carotid stenting for atherothrombosis.
Mohler ER 3rd
Heart 2007 Sep;93(9):1147-51. doi: 10.1136/hrt.2005.085613. PMID: 17699181Free PMC Article

Prognosis

Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis.
Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin SR
Proc Natl Acad Sci U S A 2010 Oct 26;107(43):18605-10. Epub 2010 Oct 7 doi: 10.1073/pnas.1013309107. PMID: 20930120Free PMC Article
Free-floating thrombus of the carotid artery: literature review and case reports.
Bhatti AF, Leon LR Jr, Labropoulos N, Rubinas TL, Rodriguez H, Kalman PG, Schneck M, Psalms SB, Biller J
J Vasc Surg 2007 Jan;45(1):199-205. doi: 10.1016/j.jvs.2006.09.057. PMID: 17210411
Current management of penetrating injuries of the soft palate.
Randall DA, Kang DR
Otolaryngol Head Neck Surg 2006 Sep;135(3):356-60. doi: 10.1016/j.otohns.2005.12.003. PMID: 16949964
Pharmacological actions of sulodexide.
Ofosu FA
Semin Thromb Hemost 1998;24(2):127-38. doi: 10.1055/s-2007-995831. PMID: 9579633
Bilateral internal carotid artery thrombosis. Prognosis and risk factors.
Waltimo O, Fogelholm R
Acta Neurol Scand 1975 Mar;51(3):240-4. doi: 10.1111/j.1600-0404.1975.tb07605.x. PMID: 1146502

Clinical prediction guides

Red and White Thrombus Characteristics in Patients Undergoing Carotid Endarterectomy.
Tosun H, Kamışlı S, Tecellioğlu M, Alan S, Tecellioğlu FS, Öztanır MN, Kablan Y
J Stroke Cerebrovasc Dis 2021 Feb;30(2):105451. Epub 2020 Dec 2 doi: 10.1016/j.jstrokecerebrovasdis.2020.105451. PMID: 33278805
Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis.
Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin SR
Proc Natl Acad Sci U S A 2010 Oct 26;107(43):18605-10. Epub 2010 Oct 7 doi: 10.1073/pnas.1013309107. PMID: 20930120Free PMC Article
Current management of penetrating injuries of the soft palate.
Randall DA, Kang DR
Otolaryngol Head Neck Surg 2006 Sep;135(3):356-60. doi: 10.1016/j.otohns.2005.12.003. PMID: 16949964
Pharmacological actions of sulodexide.
Ofosu FA
Semin Thromb Hemost 1998;24(2):127-38. doi: 10.1055/s-2007-995831. PMID: 9579633
Some neuro-ophthalmological observations.
Fisher CM
J Neurol Neurosurg Psychiatry 1967 Oct;30(5):383-92. doi: 10.1136/jnnp.30.5.383. PMID: 6062990Free PMC Article

Recent systematic reviews

Concurrent Cardio-Cerebral Infarctions in COVID-19: A Systematic Review of Published Case Reports/Series.
Desai R, Mondal A, Prasad A, Vyas A, Jain A, Rupareliya C, Shah M, Paul T, Kumar G, Sachdeva R
Curr Probl Cardiol 2023 Oct;48(10):101814. Epub 2023 May 18 doi: 10.1016/j.cpcardiol.2023.101814. PMID: 37209804Free PMC Article
Mechanical recanalization for acute bilateral cerebral artery occlusion - literature overview with a case.
Jeromel M, Milosevic ZV, Oblak JP
Radiol Oncol 2020 Mar 26;54(2):144-148. doi: 10.2478/raon-2020-0017. PMID: 32229680Free PMC Article
Overview of evidence on risk factors and early management of acute carotid stent thrombosis during the last two decades.
Coelho AP, Lobo M, Nogueira C, Gouveia R, Campos J, Augusto R, Coelho N, Semião AC, Canedo A
J Vasc Surg 2019 Mar;69(3):952-964. doi: 10.1016/j.jvs.2018.09.053. PMID: 30798846
Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke.
Lindekleiv H, Berge E, Bruins Slot KM, Wardlaw JM
Cochrane Database Syst Rev 2018 Oct 26;10(10):CD009292. doi: 10.1002/14651858.CD009292.pub2. PMID: 30365156Free PMC Article
Association between apolipoprotein E genotype and carotid intima-media thickness may suggest a specific effect on large artery atherothrombotic stroke.
Paternoster L, Martínez González NA, Lewis S, Sudlow C
Stroke 2008 Jan;39(1):48-54. Epub 2007 Dec 6 doi: 10.1161/STROKEAHA.107.488866. PMID: 18063831Free PMC Article

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