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Monoclonal B-Cell Lymphocytosis

MedGen UID:
395902
Concept ID:
C2698259
Neoplastic Process
Synonyms: MBL - monoclonal B-cell lymphocytosis; Monoclonal B-cell lymphocytosis
SNOMED CT: MBL - monoclonal B-cell lymphocytosis (717780007); Monoclonal B-cell lymphocytosis (717780007); Monoclonal B-cell lymphocytosis (789740004)

Definition

A monoclonal expansion of B-lymphocytes with or without the characteristic immunophenotype of chronic lymphocytic leukemia. It precedes virtually all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Monoclonal B-Cell Lymphocytosis

Professional guidelines

PubMed

Nguyen-Khac F, Balogh Z, Chauzeix J, Veronese L, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103410. Epub 2023 Sep 17 doi: 10.1016/j.retram.2023.103410. PMID: 38039634
Tang C, Shen Y, Soosapilla A, Mulligan SP
Leuk Lymphoma 2022 Dec;63(12):2795-2806. Epub 2022 Jun 29 doi: 10.1080/10428194.2022.2092857. PMID: 35767361
Shanafelt TD, Ghia P, Lanasa MC, Landgren O, Rawstron AC
Leukemia 2010 Mar;24(3):512-20. Epub 2010 Jan 21 doi: 10.1038/leu.2009.287. PMID: 20090778Free PMC Article

Recent clinical studies

Etiology

Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article
Criado I, Blanco E, Rodríguez-Caballero A, Alcoceba M, Contreras T, Gutiérrez ML, Romero A, Fernández-Navarro P, González M, Solano F, Gómez C, Pérez-Andrés M, van Dongen JJM, Almeida J, Orfao A; EuroFlow PID Group and The Primary Health Care Group of Salamanca for the Study of MBL
Leukemia 2018 Dec;32(12):2701-2705. Epub 2018 Jun 21 doi: 10.1038/s41375-018-0164-3. PMID: 29930299Free PMC Article
Tees MT, Flinn IW
Expert Rev Hematol 2017 Feb;10(2):137-146. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270203. PMID: 27936980
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article

Diagnosis

Lim DZJ, Tee SI, Cao L, Wang DY
Acta Derm Venereol 2023 Nov 28;103:adv18371. doi: 10.2340/actadv.v103.18371. PMID: 38014831Free PMC Article
Lanza L, Koroveshi B, Barducchi F, Lorenzo A, Venturino E, Cappelli E, Lillo F, Bain BJ
Am J Hematol 2022 Oct;97(10):1372-1373. Epub 2022 May 10 doi: 10.1002/ajh.26582. PMID: 35472004Free PMC Article
Tees MT, Flinn IW
Expert Rev Hematol 2017 Feb;10(2):137-146. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270203. PMID: 27936980
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article

Therapy

Alfano G, Fontana F, Colaci E, Franceschini E, Ligabue G, Messerotti A, Bettelli F, Grottola A, Gennari W, Potenza L, Guaraldi G, Mussini C, Luppi M, Cappelli G
Clin Transplant 2018 Aug;32(8):e13338. Epub 2018 Aug 26 doi: 10.1111/ctr.13338. PMID: 30074641
Svenningsen M, Herborg LL, Hokland P, Ludvigsen M
Dan Med J 2017 Dec;64(12) PMID: 29206098
Wiernik PH
Curr Treat Options Oncol 2015 Feb;16(2):8. doi: 10.1007/s11864-014-0323-3. PMID: 25762123
Rawstron AC
Hematology Am Soc Hematol Educ Program 2009:430-9. doi: 10.1182/asheducation-2009.1.430. PMID: 20008229
Blair A, Purdue MP, Weisenburger DD, Baris D
Br J Haematol 2007 Dec;139(5):753-61. Epub 2007 Oct 24 doi: 10.1111/j.1365-2141.2007.06874.x. PMID: 17961189

Prognosis

Geyer JT, Kluk MJ
Surg Pathol Clin 2023 Jun;16(2):411-421. Epub 2023 Mar 8 doi: 10.1016/j.path.2023.01.012. PMID: 37149366
Perincheri S
Surg Pathol Clin 2019 Sep;12(3):719-731. Epub 2019 May 15 doi: 10.1016/j.path.2019.03.004. PMID: 31352984
Tees MT, Flinn IW
Expert Rev Hematol 2017 Feb;10(2):137-146. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270203. PMID: 27936980
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Wiernik PH
Curr Treat Options Oncol 2015 Feb;16(2):8. doi: 10.1007/s11864-014-0323-3. PMID: 25762123

Clinical prediction guides

Agathangelidis A, Roussos A, Kardamiliotis K, Psomopoulos F, Stamatopoulos K
Methods Mol Biol 2025;2865:125-143. doi: 10.1007/978-1-0716-4188-0_6. PMID: 39424723
Abdelbaky SB, Giacopelli B, Rabe KG, Yamaguchi K, Wu YZ, Yan H, Shanafelt TD, Parikh SA, Ding W, Hampel PJ, Brown S, Cerhan JR, Vachon CM, Kay NE, Hanson CA, Parker AS, Braggio E, Slager SL, Oakes CC
Blood 2024 Apr 25;143(17):1752-1757. doi: 10.1182/blood.2023022180. PMID: 38194687Free PMC Article
Celis M, Navarro Y, Serrano N, Martínez D, Nieto W
Biomedica 2023 Dec 29;43(Sp. 3):66-78. doi: 10.7705/biomedica.7099. PMID: 38207149Free PMC Article
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article

Recent systematic reviews

Hodgson K, Ferrer G, Montserrat E, Moreno C
Haematologica 2011 May;96(5):752-61. Epub 2011 Jan 17 doi: 10.3324/haematol.2010.036152. PMID: 21242190Free PMC Article
Shim YK, Middleton DC, Caporaso NE, Rachel JM, Landgren O, Abbasi F, Raveche ES, Rawstron AC, Orfao A, Marti GE, Vogt RF
Cytometry B Clin Cytom 2010;78 Suppl 1(Suppl 1):S10-8. doi: 10.1002/cyto.b.20538. PMID: 20839330Free PMC Article

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