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Adult Erythroleukemia

MedGen UID:
389533
•Concept ID:
C2347748
•
Neoplastic Process

Definition

An erythroleukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Erythroleukemia

Professional guidelines

PubMed

Erythroleukemia: a review of 15 cases meeting 1985 FAB criteria and survey of the literature.
Atkinson J, Hrisinko MA, Weil SC
Blood Rev 1992 Dec;6(4):204-14. doi: 10.1016/0268-960x(92)90016-j. PMID: 1486289
Prognostic factors and treatment effects on survival in erythroleukemia: a retrospective study of 134 cases.
Roggli VL, Subach J, Saleem A
Cancer 1981 Sep 1;48(5):1101-5. doi: 10.1002/1097-0142(19810901)48:5<1101::aid-cncr2820480509>3.0.co;2-f. PMID: 6944145
Treatment of acute leukaemia in adults.
Wiernik PH
Clin Haematol 1978 Jun;7(2):259-73. doi: 10.1016/s0308-2261(78)80005-8. PMID: 354832

Recent clinical studies

Etiology

Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK, Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK, Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D'Andrea RJ, Lewis ID, Medeiros BC, Pollyea DA, King MC, Walsh T, Keel S, Shimamura A, Godley LA, Hahn CN, Churpek JE, Scott HS
Blood 2016 Feb 25;127(8):1017-23. Epub 2015 Dec 28 doi: 10.1182/blood-2015-10-676098. PMID: 26712909Free PMC Article
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
Schistocytes in erythroleukemia.
Atkins JN, Muss HB
Am J Med Sci 1985 Mar;289(3):110-3. doi: 10.1097/00000441-198503000-00004. PMID: 3856384
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Diagnosis

Germ line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition.
Zerella JR, Homan CC, Arts P, Lin X, Spinelli SJ, Venugopal P, Babic M, Brautigan PJ, Truong L, Arriola-Martinez L, Moore S, Hollins R, Parker WT, Nguyen H, Kassahn KS, Branford S, Feurstein S, Larcher L, Sicre de Fontbrune F, Demirdas S, de Munnik S, Antoine-Poirel H, Brichard B, Mansour S, Gordon K, Wlodarski MW, Koppayi A, Dobbins S, Mutsaers PGNJ, Nichols KE, Oak N, DeMille D, Mao R, Crawford A, McCarrier J, Basel D, Flores-Daboub J, Drazer MW, Phillips K, Poplawski NK, Birdsey GM, Pirri D, Ostergaard P, Simons A, Godley LA, Ross DM, Hiwase DK, Soulier J, Brown AL, Carmichael CL, Scott HS, Hahn CN
Blood 2024 Oct 24;144(17):1765-1780. doi: 10.1182/blood.2024024607. PMID: 38991192Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Schistocytes in erythroleukemia.
Atkins JN, Muss HB
Am J Med Sci 1985 Mar;289(3):110-3. doi: 10.1097/00000441-198503000-00004. PMID: 3856384
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440
The myeloproliferative disorders.
Gilbert HS, Dameshek W
Dis Mon 1970 Oct:1-52. doi: 10.1016/s0011-5029(70)80012-8. PMID: 4921953

Therapy

Di-O-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity.
Briot T, Roger E, Bou Haidar N, Bejaud J, Lautram N, Guillet C, Thépot S, Legeay S, Lagarce F
Int J Nanomedicine 2019;14:2091-2102. Epub 2019 Mar 26 doi: 10.2147/IJN.S190482. PMID: 30988610Free PMC Article
Subacute anthracycline cardiotoxicity.
Hengel CL, Russell PA, Gould PA, Kaye DM
Heart Lung Circ 2006 Feb;15(1):59-61. Epub 2005 Nov 11 doi: 10.1016/j.hlc.2005.06.003. PMID: 16473794
Acute erythroleukemia with t(3;5) accompanied by hepatocellular carcinoma.
Nakagawa H, Tanaka S, Takashima T, Shizumi Y, Nishigaki H, Horiike S, Taniwaki M, Misawa S, Kashima K, Hironaka T
Int J Hematol 1991 Jun;54(3):213-7. PMID: 1660736
Myeloproliferative diseases in childhood.
Nix WL, Fernbach DJ
Am J Pediatr Hematol Oncol 1981 Winter;3(4):397-407. PMID: 6174053
Erythroleukaemia.
Falkson G, Falkson HC
S Afr Med J 1968 Dec 14;42(47):1291-2. PMID: 5252320

Prognosis

Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK, Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK, Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D'Andrea RJ, Lewis ID, Medeiros BC, Pollyea DA, King MC, Walsh T, Keel S, Shimamura A, Godley LA, Hahn CN, Churpek JE, Scott HS
Blood 2016 Feb 25;127(8):1017-23. Epub 2015 Dec 28 doi: 10.1182/blood-2015-10-676098. PMID: 26712909Free PMC Article
Erythroleukemia: a need for a new definition.
Park S, Picard F, Dreyfus F
Leukemia 2002 Aug;16(8):1399-401. doi: 10.1038/sj.leu.2402549. PMID: 12145675
Erythroid cell differentiation.
Forget BG, Glass J, Housman D
Hamatol Bluttransfus 1976;19:109-24. doi: 10.1007/978-3-642-87524-3_12. PMID: 1070457
Cytogenetic analysis in leukemia.
Meisner LF
CRC Crit Rev Clin Lab Sci 1975 Oct;6(3):157-200. doi: 10.3109/10408367509151570. PMID: 1104261

Clinical prediction guides

Confirming the recessive inheritance of PERP-related erythrokeratoderma.
Patel N, Alkeraye S, Alobeid E, Alshidi T, Helaby R, Abdulwahab F, Shamseldin HE, Alkuraya FS
Clin Genet 2020 Apr;97(4):661-665. Epub 2020 Jan 12 doi: 10.1111/cge.13699. PMID: 31898316
Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK, Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK, Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D'Andrea RJ, Lewis ID, Medeiros BC, Pollyea DA, King MC, Walsh T, Keel S, Shimamura A, Godley LA, Hahn CN, Churpek JE, Scott HS
Blood 2016 Feb 25;127(8):1017-23. Epub 2015 Dec 28 doi: 10.1182/blood-2015-10-676098. PMID: 26712909Free PMC Article
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
Transcription factor GATA-1 and erythroid development.
Simon MC
Proc Soc Exp Biol Med 1993 Feb;202(2):115-21. doi: 10.3181/00379727-202-43519a. PMID: 8424101
Erythroid cell differentiation.
Forget BG, Glass J, Housman D
Hamatol Bluttransfus 1976;19:109-24. doi: 10.1007/978-3-642-87524-3_12. PMID: 1070457

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