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Mild Anemia

MedGen UID:
388097
•Concept ID:
C1858586
•
Finding
Synonyms: Anemia (mild); Anemia, mild; Mild anemia

Definition

Anemia not associated with symptoms of fatigue, headaches, palpitations, or shortness of breath. In asymptomatic anemia the hematocrit levels usually range from 32 to 35%. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMild Anemia

Professional guidelines

PubMed

Consensus guidelines for diagnosis and management of anemia in epidermolysis bullosa.
Liy-Wong C, Tarango C, Pope E, Coates T, Bruckner AL, Feinstein JA, Schwieger-Briel A, Hubbard LD, Jane C, Torres-Pradilla M, Zmazek M, Lara-Corrales I
Orphanet J Rare Dis 2023 Feb 23;18(1):38. doi: 10.1186/s13023-022-02448-w. PMID: 36823529Free PMC Article
Anemia at older age: etiologies, clinical implications, and management.
Stauder R, Valent P, Theurl I
Blood 2018 Feb 1;131(5):505-514. Epub 2017 Nov 15 doi: 10.1182/blood-2017-07-746446. PMID: 29141943
Treatment of mild anemia.
Waltzman RJ
J Natl Compr Canc Netw 2004 Sep;2 Suppl 3:S-38-41. PMID: 23570098

Recent clinical studies

Etiology

Black esophagus.
González Díaz I, Moreno-Sánchez M, Zarauza Soto Y, Burgos Garcia A
Rev Esp Enferm Dig 2023 Nov;115(11):646-647. doi: 10.17235/reed.2022.9217/2022. PMID: 36205331
Global Prevalence of Anemia in Pregnant Women: A Comprehensive Systematic Review and Meta-Analysis.
Karami M, Chaleshgar M, Salari N, Akbari H, Mohammadi M
Matern Child Health J 2022 Jul;26(7):1473-1487. Epub 2022 May 24 doi: 10.1007/s10995-022-03450-1. PMID: 35608810
Severity of Anemia During Pregnancy and Adverse Maternal and Fetal Outcomes.
Shi H, Chen L, Wang Y, Sun M, Guo Y, Ma S, Wang X, Jiang H, Wang X, Lu J, Ge L, Dong S, Zhuang Y, Zhao Y, Wei Y, Ma X, Qiao J
JAMA Netw Open 2022 Feb 1;5(2):e2147046. doi: 10.1001/jamanetworkopen.2021.47046. PMID: 35113162Free PMC Article
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Clinical manifestations of α-thalassemia.
Vichinsky EP
Cold Spring Harb Perspect Med 2013 May 1;3(5):a011742. doi: 10.1101/cshperspect.a011742. PMID: 23543077Free PMC Article

Diagnosis

Severity of Anemia During Pregnancy and Adverse Maternal and Fetal Outcomes.
Shi H, Chen L, Wang Y, Sun M, Guo Y, Ma S, Wang X, Jiang H, Wang X, Lu J, Ge L, Dong S, Zhuang Y, Zhao Y, Wei Y, Ma X, Qiao J
JAMA Netw Open 2022 Feb 1;5(2):e2147046. doi: 10.1001/jamanetworkopen.2021.47046. PMID: 35113162Free PMC Article
Iron Deficiency Anemia in Pregnancy.
James AH
Obstet Gynecol 2021 Oct 1;138(4):663-674. doi: 10.1097/AOG.0000000000004559. PMID: 34623079
Diagnosis and therapeutic strategies for small bowel vascular lesions.
Sakai E, Ohata K, Nakajima A, Matsuhashi N
World J Gastroenterol 2019 Jun 14;25(22):2720-2733. doi: 10.3748/wjg.v25.i22.2720. PMID: 31235995Free PMC Article
Anemia at older age: etiologies, clinical implications, and management.
Stauder R, Valent P, Theurl I
Blood 2018 Feb 1;131(5):505-514. Epub 2017 Nov 15 doi: 10.1182/blood-2017-07-746446. PMID: 29141943
Laboratory diagnosis of thalassemia.
Brancaleoni V, Di Pierro E, Motta I, Cappellini MD
Int J Lab Hematol 2016 May;38 Suppl 1:32-40. Epub 2016 May 16 doi: 10.1111/ijlh.12527. PMID: 27183541

Therapy

Efficacy of Testosterone Replacement Therapy in Correcting Anemia in Men With Hypogonadism: A Randomized Clinical Trial.
Pencina KM, Travison TG, Artz AS, Lincoff AM, Nissen SE, Flevaris P, Chan A, Li X, Diegel SA, Wannemuehler K, Bhasin S
JAMA Netw Open 2023 Oct 2;6(10):e2340030. doi: 10.1001/jamanetworkopen.2023.40030. PMID: 37889486Free PMC Article
Iron Deficiency Anemia in Pregnancy.
James AH
Obstet Gynecol 2021 Oct 1;138(4):663-674. doi: 10.1097/AOG.0000000000004559. PMID: 34623079
Diagnosis and therapeutic strategies for small bowel vascular lesions.
Sakai E, Ohata K, Nakajima A, Matsuhashi N
World J Gastroenterol 2019 Jun 14;25(22):2720-2733. doi: 10.3748/wjg.v25.i22.2720. PMID: 31235995Free PMC Article
Micronutrient supplementation during pregnancy and the risk of pregnancy-induced hypertension: A randomized clinical trial.
Chen S, Li N, Mei Z, Ye R, Li Z, Liu J, Serdula MK
Clin Nutr 2019 Feb;38(1):146-151. Epub 2018 Feb 15 doi: 10.1016/j.clnu.2018.01.029. PMID: 29428785Free PMC Article
Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses.
Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise KJ Jr, Dorman KF, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel JA, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell SC
N Engl J Med 2000 Jan 6;342(1):9-14. doi: 10.1056/NEJM200001063420102. PMID: 10620643

Prognosis

Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Laboratory diagnosis of thalassemia.
Brancaleoni V, Di Pierro E, Motta I, Cappellini MD
Int J Lab Hematol 2016 May;38 Suppl 1:32-40. Epub 2016 May 16 doi: 10.1111/ijlh.12527. PMID: 27183541
Pseudomelanosis of stomach, duodenum, and jejunum.
Rustagi T, Mansoor MS, Gibson JA, Kapadia CR
J Clin Gastroenterol 2015 Feb;49(2):124-6. doi: 10.1097/MCG.0000000000000081. PMID: 24492404
Clinical manifestations of α-thalassemia.
Vichinsky EP
Cold Spring Harb Perspect Med 2013 May 1;3(5):a011742. doi: 10.1101/cshperspect.a011742. PMID: 23543077Free PMC Article
Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses.
Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise KJ Jr, Dorman KF, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel JA, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell SC
N Engl J Med 2000 Jan 6;342(1):9-14. doi: 10.1056/NEJM200001063420102. PMID: 10620643

Clinical prediction guides

Association between anemia severity and migraine in iron deficiency anemia.
Sari US, Kama Başci Ö
Eur Rev Med Pharmacol Sci 2024 Feb;28(3):995-1001. doi: 10.26355/eurrev_202402_35335. PMID: 38375703
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Laboratory diagnosis of thalassemia.
Brancaleoni V, Di Pierro E, Motta I, Cappellini MD
Int J Lab Hematol 2016 May;38 Suppl 1:32-40. Epub 2016 May 16 doi: 10.1111/ijlh.12527. PMID: 27183541
Pseudomelanosis of stomach, duodenum, and jejunum.
Rustagi T, Mansoor MS, Gibson JA, Kapadia CR
J Clin Gastroenterol 2015 Feb;49(2):124-6. doi: 10.1097/MCG.0000000000000081. PMID: 24492404
Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses.
Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise KJ Jr, Dorman KF, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel JA, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell SC
N Engl J Med 2000 Jan 6;342(1):9-14. doi: 10.1056/NEJM200001063420102. PMID: 10620643

Recent systematic reviews

Red blood cell transfusion in neurocritical patients: a systematic review and meta-analysis.
Yu Y, Fu Y, Li W, Sun T, Cheng C, Chong Y, Han R, Cui W
BMC Anesthesiol 2024 Mar 19;24(1):106. doi: 10.1186/s12871-024-02487-9. PMID: 38504153Free PMC Article
Prevalence and types of anemia among people with tuberculosis in Africa: a systematic review and meta-analysis.
Abaynew Y, Ali A, Taye G, Shenkut M
Sci Rep 2023 Apr 3;13(1):5385. doi: 10.1038/s41598-023-32609-1. PMID: 37012387Free PMC Article
Global Prevalence of Anemia in Pregnant Women: A Comprehensive Systematic Review and Meta-Analysis.
Karami M, Chaleshgar M, Salari N, Akbari H, Mohammadi M
Matern Child Health J 2022 Jul;26(7):1473-1487. Epub 2022 May 24 doi: 10.1007/s10995-022-03450-1. PMID: 35608810
Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials.
Abu Hashim H, Foda O, Ghayaty E
Eur J Obstet Gynecol Reprod Biol 2017 Dec;219:45-52. Epub 2017 Oct 4 doi: 10.1016/j.ejogrb.2017.10.003. PMID: 29059584
Prevalence and outcomes of anemia in rheumatoid arthritis: a systematic review of the literature.
Wilson A, Yu HT, Goodnough LT, Nissenson AR
Am J Med 2004 Apr 5;116 Suppl 7A:50S-57S. doi: 10.1016/j.amjmed.2003.12.012. PMID: 15050886

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