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Anus disorder

MedGen UID:
359
Concept ID:
C0003462
Disease or Syndrome
Synonym: Anus disease
SNOMED CT: Disorder of anus (32110003); Anal disorder (32110003)
 
Monarch Initiative: MONDO:0002519

Definition

A non-neoplastic or neoplastic disorder that affects the anal canal or anal margin. Representative examples of non-neoplastic disorders include hemorrhoids and anal ulcer. Representative examples of neoplastic disorders include carcinoma, lymphoma, and melanoma. [from NCI]

Professional guidelines

PubMed

Stier EA, Clarke MA, Deshmukh AA, Wentzensen N, Liu Y, Poynten IM, Cavallari EN, Fink V, Barroso LF, Clifford GM, Cuming T, Goldstone SE, Hillman RJ, Rosa-Cunha I, La Rosa L, Palefsky JM, Plotzker R, Roberts JM, Jay N
Int J Cancer 2024 May 15;154(10):1694-1702. Epub 2024 Jan 31 doi: 10.1002/ijc.34850. PMID: 38297406
Knowles CH, Cohen RC
Cleve Clin J Med 2022 Jun 1;89(6):336-343. doi: 10.3949/ccjm.89a.21102. PMID: 35649568
Wendt S, Trawinski H, Schubert S, Rodloff AC, Mössner J, Lübbert C
Dtsch Arztebl Int 2019 Mar 29;116(13):213-219. doi: 10.3238/arztebl.2019.0213. PMID: 31064642Free PMC Article

Recent clinical studies

Etiology

Scott SM, Carrington EV
Curr Gastroenterol Rep 2020 Sep 15;22(11):55. doi: 10.1007/s11894-020-00793-z. PMID: 32935278Free PMC Article
Amato A, Bottini C, De Nardi P, Giamundo P, Lauretta A, Realis Luc A, Piloni V
Tech Coloproctol 2020 Feb;24(2):127-143. Epub 2020 Jan 23 doi: 10.1007/s10151-019-02144-1. PMID: 31974827
Sahnan K, Adegbola SO, Tozer PJ, Watfah J, Phillips RK
BMJ 2017 Feb 21;356:j475. doi: 10.1136/bmj.j475. PMID: 28223268
Singh B, McC Mortensen NJ, Jewell DP, George B
Br J Surg 2004 Jul;91(7):801-14. doi: 10.1002/bjs.4613. PMID: 15227686
Alexander-Williams J, Buchmann P
World J Surg 1980;4(2):203-8. doi: 10.1007/BF02393577. PMID: 7405258

Diagnosis

Dickstein DR, Edwards CR, Rowan CR, Avanessian B, Chubak BM, Wheldon CW, Simoes PK, Buckstein MH, Keefer LA, Safer JD, Sigel K, Goodman KA, Rosser BRS, Goldstone SE, Wong SY, Marshall DC
Nat Rev Gastroenterol Hepatol 2024 Jun;21(6):377-405. Epub 2024 May 19 doi: 10.1038/s41575-024-00932-1. PMID: 38763974
Drezdzon MK, Peterson CY
Surg Clin North Am 2023 Dec;103(6):1153-1170. Epub 2023 Jul 21 doi: 10.1016/j.suc.2023.05.014. PMID: 37838461
Knowles CH, Cohen RC
Cleve Clin J Med 2022 Jun 1;89(6):336-343. doi: 10.3949/ccjm.89a.21102. PMID: 35649568
Rao SSC, Tetangco EP
J Clin Gastroenterol 2020 Aug;54(7):606-613. doi: 10.1097/MCG.0000000000001348. PMID: 32692116
Cohee MW, Hurff A, Gazewood JD
Am Fam Physician 2020 Jan 1;101(1):24-33. PMID: 31894930

Therapy

Newton K, Dumville J, Briggs M, Law J, Martin J, Pearce L, Kirwan C, Pinkney T, Needham A, Jackson R, Winn S, McCulloch H, Hill J; PPAC2 Collaborators
Br J Surg 2022 Sep 9;109(10):951-957. doi: 10.1093/bjs/znac225. PMID: 35929816Free PMC Article
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Carrington EV, Popa SL, Chiarioni G
Curr Gastroenterol Rep 2020 Jun 9;22(7):35. doi: 10.1007/s11894-020-00768-0. PMID: 32519087
Zalieckas JM
Semin Pediatr Surg 2017 Dec;26(6):391-397. Epub 2017 Oct 10 doi: 10.1053/j.sempedsurg.2017.10.009. PMID: 29126509
Singh B, McC Mortensen NJ, Jewell DP, George B
Br J Surg 2004 Jul;91(7):801-14. doi: 10.1002/bjs.4613. PMID: 15227686

Prognosis

Narayanan SP, Bharucha AE
Curr Gastroenterol Rep 2019 Apr 23;21(5):21. doi: 10.1007/s11894-019-0688-3. PMID: 31016468
Sahnan K, Adegbola SO, Tozer PJ, Watfah J, Phillips RK
BMJ 2017 Feb 21;356:j475. doi: 10.1136/bmj.j475. PMID: 28223268
Singh B, McC Mortensen NJ, Jewell DP, George B
Br J Surg 2004 Jul;91(7):801-14. doi: 10.1002/bjs.4613. PMID: 15227686
Parè AA, Gottesman L
Gastroenterol Clin North Am 1997 Jun;26(2):367-76. doi: 10.1016/s0889-8553(05)70299-5. PMID: 9187929
Berth-Jones J, Graham-Brown RA, Burns DA
Arch Dis Child 1989 Aug;64(8):1204-6. doi: 10.1136/adc.64.8.1204. PMID: 2675775Free PMC Article

Clinical prediction guides

Newton K, Dumville J, Briggs M, Law J, Martin J, Pearce L, Kirwan C, Pinkney T, Needham A, Jackson R, Winn S, McCulloch H, Hill J; PPAC2 Collaborators
Br J Surg 2022 Sep 9;109(10):951-957. doi: 10.1093/bjs/znac225. PMID: 35929816Free PMC Article
Narayanan SP, Bharucha AE
Curr Gastroenterol Rep 2019 Apr 23;21(5):21. doi: 10.1007/s11894-019-0688-3. PMID: 31016468
Carrington EV, Scott SM, Bharucha A, Mion F, Remes-Troche JM, Malcolm A, Heinrich H, Fox M, Rao SS; International Anorectal Physiology Working Group and the International Working Group for Disorders of Gastrointestinal Motility and Function
Nat Rev Gastroenterol Hepatol 2018 May;15(5):309-323. Epub 2018 Apr 11 doi: 10.1038/nrgastro.2018.27. PMID: 29636555Free PMC Article
Assi R, Reddy V, Einarsdottir H, Longo WE
Yale J Biol Med 2014 Dec;87(4):537-47. Epub 2014 Dec 12 PMID: 25506286Free PMC Article
Singh B, McC Mortensen NJ, Jewell DP, George B
Br J Surg 2004 Jul;91(7):801-14. doi: 10.1002/bjs.4613. PMID: 15227686

Recent systematic reviews

Clarke MA, Deshmukh AA, Suk R, Roberts J, Gilson R, Jay N, Stier EA, Wentzensen N
Int J Cancer 2022 Dec 1;151(11):1889-1901. Epub 2022 Aug 6 doi: 10.1002/ijc.34199. PMID: 35793241Free PMC Article
Costa-Silva M, Fernandes I, Rodrigues AG, Lisboa C
An Bras Dermatol 2017 Sep-Oct;92(5):675-681. doi: 10.1590/abd1806-4841.201756411. PMID: 29166505Free PMC Article
Nelson RL
BMJ Clin Evid 2014 Nov 12;2014 PMID: 25391392Free PMC Article
Nelson RL, Thomas K, Morgan J, Jones A
Cochrane Database Syst Rev 2012 Feb 15;2012(2):CD003431. doi: 10.1002/14651858.CD003431.pub3. PMID: 22336789Free PMC Article
Nelson R
BMJ Clin Evid 2010 Mar 24;2010 PMID: 21718564Free PMC Article

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