U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Multilocular Thymic Cyst

MedGen UID:
353946
•Concept ID:
C1709089
•
Finding

Definition

A multicystic lesion that arises from the epithelial component of the thymus gland. It is usually associated with the presence of lymphoid follicles and degenerative changes. Although its etiology is unknown, it has been described in patients with HIV infection and in patients with nodular sclerosis Hodgkin lymphoma affecting the thymus gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultilocular Thymic Cyst

Recent clinical studies

Etiology

Multilocular thymic cyst (MTC) and other tumors with MTC features: Pitfalls in diagnosis.
Oramas DM, Moran CA
Semin Diagn Pathol 2022 Mar;39(2):105-112. Epub 2021 Jun 11 doi: 10.1053/j.semdp.2021.06.004. PMID: 34147305
Micronodular Thymomas With Prominent Cystic Changes: A Clinicopathological and Immunohistochemical Study of 25 Cases.
Oramas DM, Moran CA
Int J Surg Pathol 2021 Jun;29(4):352-357. Epub 2020 Oct 7 doi: 10.1177/1066896920963803. PMID: 33026263
Multilocular mediastinal cyst with rim calcification: report of a case.
Osaki T, Nakagawa M
Surg Today 2008;38(1):52-5. Epub 2007 Dec 24 doi: 10.1007/s00595-007-3566-9. PMID: 18085364
Multilocular thymic cysts: imaging features in children with human immunodeficiency virus infection.
Avila NA, Mueller BU, Carrasquillo JA, Kontny HU, Jaffe ES, Pizzo PA
Radiology 1996 Oct;201(1):130-4. doi: 10.1148/radiology.201.1.8816533. PMID: 8816533

Diagnosis

Multilocular thymic cyst (MTC) and other tumors with MTC features: Pitfalls in diagnosis.
Oramas DM, Moran CA
Semin Diagn Pathol 2022 Mar;39(2):105-112. Epub 2021 Jun 11 doi: 10.1053/j.semdp.2021.06.004. PMID: 34147305
Multilocular Thymic Cyst With Mucinous Differentiation: A Mimicker of Thymic Mucoepidermoid Carcinoma.
Prieto-Granada CN, Stevens T
Int J Surg Pathol 2018 Feb;26(1):35-36. Epub 2017 May 16 doi: 10.1177/1066896917709947. PMID: 28508687
Regression of thymoma associated with a multilocular thymic cyst: report of a case.
Toyokawa G, Taguchi K, Ohba T, Hirai F, Yamaguchi M, Hamatake M, Seto T, Nishiyama K, Shida Y, Sugio K, Ichinose Y
Surg Today 2014 Mar;44(3):577-80. Epub 2012 Nov 25 doi: 10.1007/s00595-012-0436-x. PMID: 23184327
Multilocular thymic cyst associated with Sjögren's syndrome.
Kondo K, Miyoshi T, Sakiyama S, Shimosato Y, Monden Y
Ann Thorac Surg 2001 Oct;72(4):1367-9. doi: 10.1016/s0003-4975(00)02706-5. PMID: 11603465
Multilocular thymic cyst in a child with acquired immunodeficiency syndrome.
Shalaby-Rana E, Selby D, Ivy P, Schutzbank T, Chan M, Chandra R, Majd M
Pediatr Infect Dis J 1996 Jan;15(1):83-6. doi: 10.1097/00006454-199601000-00018. PMID: 8684883

Therapy

Thoracic diseases associated with HIV infection in the era of antiretroviral therapy: clinical and imaging findings.
Chou SH, Prabhu SJ, Crothers K, Stern EJ, Godwin JD, Pipavath SN
Radiographics 2014 Jul-Aug;34(4):895-911. doi: 10.1148/rg.344130115. PMID: 25019430Free PMC Article
Regression of thymoma associated with a multilocular thymic cyst: report of a case.
Toyokawa G, Taguchi K, Ohba T, Hirai F, Yamaguchi M, Hamatake M, Seto T, Nishiyama K, Shida Y, Sugio K, Ichinose Y
Surg Today 2014 Mar;44(3):577-80. Epub 2012 Nov 25 doi: 10.1007/s00595-012-0436-x. PMID: 23184327
Multilocular thymic cysts: imaging features in children with human immunodeficiency virus infection.
Avila NA, Mueller BU, Carrasquillo JA, Kontny HU, Jaffe ES, Pizzo PA
Radiology 1996 Oct;201(1):130-4. doi: 10.1148/radiology.201.1.8816533. PMID: 8816533

Prognosis

Micronodular Thymomas With Prominent Cystic Changes: A Clinicopathological and Immunohistochemical Study of 25 Cases.
Oramas DM, Moran CA
Int J Surg Pathol 2021 Jun;29(4):352-357. Epub 2020 Oct 7 doi: 10.1177/1066896920963803. PMID: 33026263
Thymoma and thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic analysis of 18 cases.
Shen X, Jin Y, Shen L, Sun Y, Chen H, Li Y
Diagn Pathol 2018 Jun 26;13(1):41. doi: 10.1186/s13000-018-0719-7. PMID: 29945642Free PMC Article
Micronodular thymoma with lymphoid stroma: Two cases, one in a multilocular thymic cyst, and literature review.
Qu L, Xiong Y, Yao Q, Zhang B, Li T
Thorac Cancer 2017 Nov;8(6):734-740. Epub 2017 Sep 20 doi: 10.1111/1759-7714.12517. PMID: 28941195Free PMC Article
Multilocular thymic cyst associated with thymoma: a clinicopathologic study of 20 cases with an emphasis on the pathogenesis of cyst formation.
Nakamura S, Tateyama H, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Mizuno T, Ishiguro F, Yokoi K
Am J Surg Pathol 2012 Dec;36(12):1857-64. doi: 10.1097/PAS.0b013e31826320c4. PMID: 23026930
Multilocular thymic cyst associated with follicular hyperplasia: clinicopathologic study of 4 resected cases.
Izumi H, Nobukawa B, Takahashi K, Kumasaka T, Miyamoto H, Yamazaki A, Sonobe S, Uekusa T, Suda K
Hum Pathol 2005 Jul;36(7):841-4. doi: 10.1016/j.humpath.2005.05.004. PMID: 16084956

Clinical prediction guides

Thymoma and thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic analysis of 18 cases.
Shen X, Jin Y, Shen L, Sun Y, Chen H, Li Y
Diagn Pathol 2018 Jun 26;13(1):41. doi: 10.1186/s13000-018-0719-7. PMID: 29945642Free PMC Article
Regression of thymoma associated with a multilocular thymic cyst: report of a case.
Toyokawa G, Taguchi K, Ohba T, Hirai F, Yamaguchi M, Hamatake M, Seto T, Nishiyama K, Shida Y, Sugio K, Ichinose Y
Surg Today 2014 Mar;44(3):577-80. Epub 2012 Nov 25 doi: 10.1007/s00595-012-0436-x. PMID: 23184327
Multilocular thymic cyst associated with thymoma: a clinicopathologic study of 20 cases with an emphasis on the pathogenesis of cyst formation.
Nakamura S, Tateyama H, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Mizuno T, Ishiguro F, Yokoi K
Am J Surg Pathol 2012 Dec;36(12):1857-64. doi: 10.1097/PAS.0b013e31826320c4. PMID: 23026930
Thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic study of 7 cases.
Weissferdt A, Moran CA
Am J Surg Pathol 2011 Jul;35(7):1074-9. doi: 10.1097/PAS.0b013e31821c7402. PMID: 21677542
Multilocular thymic cyst associated with follicular hyperplasia: clinicopathologic study of 4 resected cases.
Izumi H, Nobukawa B, Takahashi K, Kumasaka T, Miyamoto H, Yamazaki A, Sonobe S, Uekusa T, Suda K
Hum Pathol 2005 Jul;36(7):841-4. doi: 10.1016/j.humpath.2005.05.004. PMID: 16084956

Supplemental Content

Table of contents

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...