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Aldosterone-producing adrenal cortex adenoma

MedGen UID:
353374
Concept ID:
C1706762
Neoplastic Process
Synonyms: adrenocortical carcinoma with pure aldosterone hypersecretion; Adrenocortical carcinoma with pure aldosterone hypersecretion; Aldosterone Producing Adrenal Cortex Adenoma; aldosterone producing adrenal cortex adenoma; Aldosterone Producing Adrenal Cortical Adenoma; aldosterone producing adrenal cortical adenoma; Aldosterone-Producing Adrenal Cortex Adenoma; aldosterone-producing adrenal cortex adenoma; Aldosterone-Producing Adrenal Cortical Adenoma; Aldosterone-Producing Adrenal Gland Adenoma; APAC; Pure aldosterone-producing adrenocortical carcinoma; Pure aldosterone-secreting adrenocortical carcinoma; Pure APAC
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016505
Orphanet: ORPHA231625

Definition

An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone-producing gland located on top of each kidney. In most cases, individuals develop a single tumor in one of the adrenal glands. The adrenal tumor produces too much of the hormone aldosterone, which is a condition known as primary hyperaldosteronism. Aldosterone helps regulate the body's fluid levels and blood pressure by controlling the amount of salt retained by the kidneys. Excess aldosterone causes the kidneys to retain more salt than normal, which increases the body's fluid levels and blood pressure. People with an aldosterone-producing adenoma may develop severe high blood pressure (hypertension), and they have an increased risk of heart attack, stroke, or an irregular heart beat (atrial fibrillation). [from MedlinePlus Genetics]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAldosterone-producing adrenal cortex adenoma

Professional guidelines

PubMed

Mullen N, Curneen J, Donlon PT, Prakash P, Bancos I, Gurnell M, Dennedy MC
Endocr Rev 2024 Jan 4;45(1):125-170. doi: 10.1210/endrev/bnad026. PMID: 37556722Free PMC Article
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA
Lancet Diabetes Endocrinol 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068
Satoh F, Sasano H, Yamazaki Y, Ito S
Hypertension 2017 Jul;70(1):38-41. Epub 2017 Jun 5 doi: 10.1161/HYPERTENSIONAHA.117.09161. PMID: 28584015

Recent clinical studies

Etiology

Ekman N, Grossman AB, Dworakowska D
Int J Mol Sci 2024 Jan 11;25(2) doi: 10.3390/ijms25020900. PMID: 38255973Free PMC Article
Azizan EAB, Drake WM, Brown MJ
Nat Rev Nephrol 2023 Dec;19(12):788-806. Epub 2023 Aug 23 doi: 10.1038/s41581-023-00753-6. PMID: 37612380Free PMC Article
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Omata K, Tomlins SA, Rainey WE
Horm Metab Res 2017 Dec;49(12):951-956. Epub 2017 Dec 4 doi: 10.1055/s-0043-122394. PMID: 29202494Free PMC Article
Sacks BA, Sacks AC, Faintuch S
Curr Opin Endocrinol Diabetes Obes 2017 Jun;24(3):169-173. doi: 10.1097/MED.0000000000000329. PMID: 28248752

Diagnosis

Ekman N, Grossman AB, Dworakowska D
Int J Mol Sci 2024 Jan 11;25(2) doi: 10.3390/ijms25020900. PMID: 38255973Free PMC Article
Azizan EAB, Drake WM, Brown MJ
Nat Rev Nephrol 2023 Dec;19(12):788-806. Epub 2023 Aug 23 doi: 10.1038/s41581-023-00753-6. PMID: 37612380Free PMC Article
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA
Lancet Diabetes Endocrinol 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068
Hellman P, Björklund P, Åkerström T
Vitam Horm 2019;109:407-431. Epub 2019 Jan 8 doi: 10.1016/bs.vh.2018.10.007. PMID: 30678866

Therapy

Mullen N, Curneen J, Donlon PT, Prakash P, Bancos I, Gurnell M, Dennedy MC
Endocr Rev 2024 Jan 4;45(1):125-170. doi: 10.1210/endrev/bnad026. PMID: 37556722Free PMC Article
Deinum J, Groenewoud H, van der Wilt GJ, Lenzini L, Rossi GP
Eur J Endocrinol 2019 Sep;181(3):D15-D26. doi: 10.1530/EJE-18-0844. PMID: 31176302
Amar L, Lorthioir A, Azizi M, Plouin PF
Eur J Endocrinol 2015 Mar;172(3):R125-9. Epub 2014 Oct 14 doi: 10.1530/EJE-14-0585. PMID: 25315875
Hegstad R, Brown RD, Jiang NS, Kao P, Weinshilboum RM, Strong C, Wisgerhof M
Am J Med 1983 Mar;74(3):442-8. doi: 10.1016/0002-9343(83)90971-3. PMID: 6338717
Mackett MC, Crane MG, Smith LL
Am J Surg 1981 Jul;142(1):89-95. doi: 10.1016/s0002-9610(81)80033-5. PMID: 7020461

Prognosis

Mullen N, Curneen J, Donlon PT, Prakash P, Bancos I, Gurnell M, Dennedy MC
Endocr Rev 2024 Jan 4;45(1):125-170. doi: 10.1210/endrev/bnad026. PMID: 37556722Free PMC Article
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Yang Y, Reincke M, Williams TA
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101365. Epub 2019 Dec 5 doi: 10.1016/j.beem.2019.101365. PMID: 31837980
Åkerström T, Carling T, Beuschlein F, Hellman P
J Intern Med 2016 Dec;280(6):540-550. doi: 10.1111/joim.12452. PMID: 27864864
Crudo V, Monticone S, Burrello J, Buffolo F, Tetti M, Veglio F, Mulatero P
High Blood Press Cardiovasc Prev 2016 Sep;23(3):203-8. Epub 2016 May 2 doi: 10.1007/s40292-016-0151-6. PMID: 27136934

Clinical prediction guides

Mullen N, Curneen J, Donlon PT, Prakash P, Bancos I, Gurnell M, Dennedy MC
Endocr Rev 2024 Jan 4;45(1):125-170. doi: 10.1210/endrev/bnad026. PMID: 37556722Free PMC Article
Bruedgam D, Adolf C, Schneider H, Schwarzlmueller P, Mueller L, Handgriff L, Bidlingmaier M, Kunz S, Zimmermann P, Deniz S, Williams TA, Beuschlein F, Reincke M, Heinrich DA
Eur J Endocrinol 2023 Dec 6;189(6):611-618. doi: 10.1093/ejendo/lvad159. PMID: 38048424
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Lim JS, Plaska SW, Rege J, Rainey WE, Turcu AF
Front Endocrinol (Lausanne) 2021;12:644382. Epub 2021 Mar 16 doi: 10.3389/fendo.2021.644382. PMID: 33796077Free PMC Article
Crudo V, Monticone S, Burrello J, Buffolo F, Tetti M, Veglio F, Mulatero P
High Blood Press Cardiovasc Prev 2016 Sep;23(3):203-8. Epub 2016 May 2 doi: 10.1007/s40292-016-0151-6. PMID: 27136934

Recent systematic reviews

Kato H, Kitamoto T, Kimura S, Sunouchi T, Hoshino Y, Hidaka N, Tsurutani Y, Ito N, Makita N, Nishikawa T, Nangaku M, Inoue K
Endocr Pract 2024 Jul;30(7):670-678. Epub 2024 Apr 22 doi: 10.1016/j.eprac.2024.04.007. PMID: 38657793
Marzano L, Kazory A, Husain-Syed F, Ronco C
Clin Endocrinol (Oxf) 2023 Jul;99(1):17-34. Epub 2023 Apr 20 doi: 10.1111/cen.14918. PMID: 37032125
Velema MS, de Nooijer AH, Burgers VWG, Hermus ARMM, Timmers HJLM, Lenders JWM, Husson O, Deinum J
Horm Metab Res 2017 Dec;49(12):943-950. Epub 2017 Dec 4 doi: 10.1055/s-0043-121706. PMID: 29202493

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