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Inflammatory bowel disease 3(IBD3)

MedGen UID:
346785
Concept ID:
C1858303
Disease or Syndrome
Synonym: IBD3
 
Monarch Initiative: MONDO:0011471
OMIM®: 604519

Definition

An inflammatory bowel disease that has material basis in variation in the chromosome region 6p21.3. [from MONDO]

Clinical features

From HPO
Ulcerative colitis
MedGen UID:
3532
Concept ID:
C0009324
Disease or Syndrome
A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset and intermittent periods of exacerbated symptoms contrasting with periods that are relatively symptom-free. In contrast to Crohn's disease this special form of colitis begins in the distal parts of the rectum, spreads continually upwards and affects only mucose and submucose tissue of the colon.

Professional guidelines

PubMed

Nuij V, Fuhler GM, Edel AJ, Ouwendijk RJ, Rijk MC, Beukers R, Quispel R, van Tilburg AJ, Tang TJ, Smalbraak H, Bruin KF, Lindenburg F, Peyrin-Biroulet L, van der Woude CJ; Dutch Delta IBD Group
J Crohns Colitis 2015 Nov;9(11):997-1003. Epub 2015 Jul 29 doi: 10.1093/ecco-jcc/jjv130. PMID: 26223842

Recent clinical studies

Etiology

Classen JM, Muzalyova A, Nagl S, Fleischmann C, Ebigbo A, Römmele C, Messmann H, Schnoy E
Dig Dis 2022;40(6):719-727. Epub 2021 Dec 10 doi: 10.1159/000521343. PMID: 34915480Free PMC Article
Yelencich E, Truong E, Widaman AM, Pignotti G, Yang L, Jeon Y, Weber AT, Shah R, Smith J, Sauk JS, Limketkai BN
Clin Gastroenterol Hepatol 2022 Jun;20(6):1282-1289.e1. Epub 2021 Aug 11 doi: 10.1016/j.cgh.2021.08.009. PMID: 34389486
Luis AS, Jin C, Pereira GV, Glowacki RWP, Gugel SR, Singh S, Byrne DP, Pudlo NA, London JA, Baslé A, Reihill M, Oscarson S, Eyers PA, Czjzek M, Michel G, Barbeyron T, Yates EA, Hansson GC, Karlsson NG, Cartmell A, Martens EC
Nature 2021 Oct;598(7880):332-337. Epub 2021 Oct 6 doi: 10.1038/s41586-021-03967-5. PMID: 34616040Free PMC Article
Chaudhary P, Nabi I, Arora MP
Int J Surg 2014;12(9):1010-3. Epub 2014 Jul 30 doi: 10.1016/j.ijsu.2014.07.265. PMID: 25084099
Ludwig J
Mayo Clin Proc 1998 Mar;73(3):285-91. doi: 10.4065/73.3.285. PMID: 9511789

Diagnosis

Li XV, Leonardi I, Putzel GG, Semon A, Fiers WD, Kusakabe T, Lin WY, Gao IH, Doron I, Gutierrez-Guerrero A, DeCelie MB, Carriche GM, Mesko M, Yang C, Naglik JR, Hube B, Scherl EJ, Iliev ID
Nature 2022 Mar;603(7902):672-678. Epub 2022 Mar 16 doi: 10.1038/s41586-022-04502-w. PMID: 35296857Free PMC Article
Brown LJ, Weppler A, Bhave P, Allayous C, Patrinely JR Jr, Ott P, Sandhu S, Haydon A, Lebbe C, Johnson DB, Long GV, Menzies AA, Carlino MS
J Immunother Cancer 2021 May;9(5) doi: 10.1136/jitc-2020-002121. PMID: 33963010Free PMC Article
Shinnick JE, Schadt K, Strawser C, Wilcox N, Perlman SL, Wilmot GR, Gomez CM, Mathews KD, Yoon G, Zesiewicz T, Hoyle C, Subramony SH, Yiu EM, Delatycki MB, Brocht AF, Farmer JM, Lynch DR
J Child Neurol 2016 Aug;31(9):1161-5. Epub 2016 Apr 12 doi: 10.1177/0883073816643408. PMID: 27071470
Bodur H, Ataman S, Buğdaycı DS, Rezvani A, Nas K, Uzunca K, Emlakçıoğlu E, Karatepe AG, Durmuş B, Sezgin M, Ayhan F, Yazgan P, Duruöz T, Yener M, Gürgan A, Kırnap M, Cakar E, Altan L, Soydemir R, Capkın E, Tekeoğlu I, Aydın G, Günendi Z, Nacır B, Sallı A, Oztürk C, Memiş A, Turan Y, Kozanoğlu E, Sivrioğlu K; Türkiye Romatizma Araştırma ve Savaş Derneği [TRASD] (Turkish League Against Rheumatism) Ankylosing Spondylitis [AS] Study Group
Rheumatol Int 2012 Jan;32(1):169-76. Epub 2010 Aug 14 doi: 10.1007/s00296-010-1599-7. PMID: 20711591
Ludwig J
Mayo Clin Proc 1998 Mar;73(3):285-91. doi: 10.4065/73.3.285. PMID: 9511789

Therapy

Classen JM, Muzalyova A, Nagl S, Fleischmann C, Ebigbo A, Römmele C, Messmann H, Schnoy E
Dig Dis 2022;40(6):719-727. Epub 2021 Dec 10 doi: 10.1159/000521343. PMID: 34915480Free PMC Article
Brown LJ, Weppler A, Bhave P, Allayous C, Patrinely JR Jr, Ott P, Sandhu S, Haydon A, Lebbe C, Johnson DB, Long GV, Menzies AA, Carlino MS
J Immunother Cancer 2021 May;9(5) doi: 10.1136/jitc-2020-002121. PMID: 33963010Free PMC Article
Chaudhary P, Nabi I, Arora MP
Int J Surg 2014;12(9):1010-3. Epub 2014 Jul 30 doi: 10.1016/j.ijsu.2014.07.265. PMID: 25084099
Bodur H, Ataman S, Buğdaycı DS, Rezvani A, Nas K, Uzunca K, Emlakçıoğlu E, Karatepe AG, Durmuş B, Sezgin M, Ayhan F, Yazgan P, Duruöz T, Yener M, Gürgan A, Kırnap M, Cakar E, Altan L, Soydemir R, Capkın E, Tekeoğlu I, Aydın G, Günendi Z, Nacır B, Sallı A, Oztürk C, Memiş A, Turan Y, Kozanoğlu E, Sivrioğlu K; Türkiye Romatizma Araştırma ve Savaş Derneği [TRASD] (Turkish League Against Rheumatism) Ankylosing Spondylitis [AS] Study Group
Rheumatol Int 2012 Jan;32(1):169-76. Epub 2010 Aug 14 doi: 10.1007/s00296-010-1599-7. PMID: 20711591
Cataldo PA
Dis Colon Rectum 1996 Mar;39(3):257-61. doi: 10.1007/BF02049463. PMID: 8603544

Prognosis

de Carvalho HM, Bortoluzzo AB, Gonçalves CR, da Silva JA, Ximenes AC, Bértolo MB, Ribeiro SL, Keiserman M, Menin R, Skare TL, Carneiro S, Azevedo VF, Vieira WP, Albuquerque EN, Bianchi WA, Bonfiglioli R, Campanholo C, Costa IP, Duarte AP, Gavi MB, Kohem CL, Leite NH, Lima SA, Meirelles ES, Pereira IA, Pinheiro MM, Polito E, Resende GG, Rocha FA, Santiago MB, Sauma Mde F, Sampaio-Barros PD; Brazilian Registry on Spondyloarthritis
Clin Rheumatol 2012 Apr;31(4):687-95. Epub 2011 Dec 28 doi: 10.1007/s10067-011-1890-3. PMID: 22203094
Bodur H, Ataman S, Buğdaycı DS, Rezvani A, Nas K, Uzunca K, Emlakçıoğlu E, Karatepe AG, Durmuş B, Sezgin M, Ayhan F, Yazgan P, Duruöz T, Yener M, Gürgan A, Kırnap M, Cakar E, Altan L, Soydemir R, Capkın E, Tekeoğlu I, Aydın G, Günendi Z, Nacır B, Sallı A, Oztürk C, Memiş A, Turan Y, Kozanoğlu E, Sivrioğlu K; Türkiye Romatizma Araştırma ve Savaş Derneği [TRASD] (Turkish League Against Rheumatism) Ankylosing Spondylitis [AS] Study Group
Rheumatol Int 2012 Jan;32(1):169-76. Epub 2010 Aug 14 doi: 10.1007/s00296-010-1599-7. PMID: 20711591
Ludwig J
Mayo Clin Proc 1998 Mar;73(3):285-91. doi: 10.4065/73.3.285. PMID: 9511789
Miller LC, Sisson BA, Tucker LB, Schaller JG
J Pediatr 1996 Sep;129(3):419-23. doi: 10.1016/s0022-3476(96)70075-6. PMID: 8804332
Gibson P, Lichtenstein M, Salehi N, Hebbard G, Andrews J
Gut 1991 Dec;32(12):1502-7. doi: 10.1136/gut.32.12.1502. PMID: 1773957Free PMC Article

Clinical prediction guides

Classen JM, Muzalyova A, Nagl S, Fleischmann C, Ebigbo A, Römmele C, Messmann H, Schnoy E
Dig Dis 2022;40(6):719-727. Epub 2021 Dec 10 doi: 10.1159/000521343. PMID: 34915480Free PMC Article
Yelencich E, Truong E, Widaman AM, Pignotti G, Yang L, Jeon Y, Weber AT, Shah R, Smith J, Sauk JS, Limketkai BN
Clin Gastroenterol Hepatol 2022 Jun;20(6):1282-1289.e1. Epub 2021 Aug 11 doi: 10.1016/j.cgh.2021.08.009. PMID: 34389486
Tong Y, Trilling B, Sage PY, Girard E, Faucheron JL
Tech Coloproctol 2019 Mar;23(3):245-249. Epub 2019 Apr 1 doi: 10.1007/s10151-019-01948-5. PMID: 30937645
de Carvalho HM, Bortoluzzo AB, Gonçalves CR, da Silva JA, Ximenes AC, Bértolo MB, Ribeiro SL, Keiserman M, Menin R, Skare TL, Carneiro S, Azevedo VF, Vieira WP, Albuquerque EN, Bianchi WA, Bonfiglioli R, Campanholo C, Costa IP, Duarte AP, Gavi MB, Kohem CL, Leite NH, Lima SA, Meirelles ES, Pereira IA, Pinheiro MM, Polito E, Resende GG, Rocha FA, Santiago MB, Sauma Mde F, Sampaio-Barros PD; Brazilian Registry on Spondyloarthritis
Clin Rheumatol 2012 Apr;31(4):687-95. Epub 2011 Dec 28 doi: 10.1007/s10067-011-1890-3. PMID: 22203094
Gibson P, Lichtenstein M, Salehi N, Hebbard G, Andrews J
Gut 1991 Dec;32(12):1502-7. doi: 10.1136/gut.32.12.1502. PMID: 1773957Free PMC Article

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