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Nonarteritic anterior ischemic optic neuropathy

MedGen UID:
338887
•Concept ID:
C1852242
•
Disease or Syndrome
Synonyms: NAION; Nonarteritic Anterior Ischemic Optic Neuropathy
 
HPO: HP:0007634
Monarch Initiative: MONDO:0000499
Orphanet: ORPHA415300

Definition

An acute condition characterized by sudden visual loss (usually discovered in the morning), optic disc edema at onset, optic disc-related visual field defects. Nonarteritic anterior ischemic optic neuropathy can be associated with flame hemorrhages on the swollen disk or nearby neuroretinal layer, and sometimes with nearby cotton-wool exudates. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNonarteritic anterior ischemic optic neuropathy

Conditions with this feature

Nonarteritic anterior ischemic optic neuropathy, susceptibility to
MedGen UID:
338294
•Concept ID:
C1847711
•
Finding
See: Condition Record
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
MedGen UID:
1634330
•Concept ID:
C4551768
•
Disease or Syndrome
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is characterized by mid-adult onset of recurrent ischemic stroke, cognitive decline progressing to dementia, a history of migraine with aura, mood disturbance, apathy, and diffuse white matter lesions and subcortical infarcts on neuroimaging.
See: Condition Record
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
Nonarteritic anterior ischemic optic neuropathy, susceptibility to

Professional guidelines

PubMed

Steroid Treatment of Optic Neuropathies.
Stunkel L, Van Stavern GP
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):218-228. Epub 2018 Jul 2 doi: 10.22608/APO.2018127. PMID: 29962119
Is there treatment for nonarteritic anterior ischemic optic neuropathy.
Katz DM, Trobe JD
Curr Opin Ophthalmol 2015 Nov;26(6):458-63. doi: 10.1097/ICU.0000000000000199. PMID: 26367094
Treatment of nonarteritic anterior ischemic optic neuropathy.
Atkins EJ, Bruce BB, Newman NJ, Biousse V
Surv Ophthalmol 2010 Jan-Feb;55(1):47-63. doi: 10.1016/j.survophthal.2009.06.008. PMID: 20006051Free PMC Article

Recent clinical studies

Etiology

Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy.
Pomeranz HD
Neurol Clin 2017 Feb;35(1):17-27. doi: 10.1016/j.ncl.2016.08.007. PMID: 27886893
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy.
Foroozan R
Neurol Clin 2017 Feb;35(1):1-15. doi: 10.1016/j.ncl.2016.08.003. PMID: 27886887
The enigma of nonarteritic anterior ischemic optic neuropathy: an update for the comprehensive ophthalmologist.
Gaier ED, Torun N
Curr Opin Ophthalmol 2016 Nov;27(6):498-504. doi: 10.1097/ICU.0000000000000318. PMID: 27585212
Is there treatment for nonarteritic anterior ischemic optic neuropathy.
Katz DM, Trobe JD
Curr Opin Ophthalmol 2015 Nov;26(6):458-63. doi: 10.1097/ICU.0000000000000199. PMID: 26367094
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Diagnosis

Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy.
Mollan SP
JAMA Ophthalmol 2024 Aug 1;142(8):740-741. doi: 10.1001/jamaophthalmol.2024.2514. PMID: 38958953
A sticky situation.
Weng CY, Khimani KS, Foroozan R, Gospe SM 3rd, Bhatti MT
Surv Ophthalmol 2018 Sep-Oct;63(5):736-744. Epub 2018 Apr 27 doi: 10.1016/j.survophthal.2018.04.004. PMID: 29705174
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy.
Pomeranz HD
Neurol Clin 2017 Feb;35(1):17-27. doi: 10.1016/j.ncl.2016.08.007. PMID: 27886893
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy.
Foroozan R
Neurol Clin 2017 Feb;35(1):1-15. doi: 10.1016/j.ncl.2016.08.003. PMID: 27886887
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Therapy

Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy.
Mollan SP
JAMA Ophthalmol 2024 Aug 1;142(8):740-741. doi: 10.1001/jamaophthalmol.2024.2514. PMID: 38958953
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy.
Pomeranz HD
Neurol Clin 2017 Feb;35(1):17-27. doi: 10.1016/j.ncl.2016.08.007. PMID: 27886893
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy.
Foroozan R
Neurol Clin 2017 Feb;35(1):1-15. doi: 10.1016/j.ncl.2016.08.003. PMID: 27886887
A Nonarteritic Anterior Ischemic Optic Neuropathy Clinical Trial: An Industry and NORDIC Collaboration.
Kupersmith MJ, Miller NR
J Neuroophthalmol 2016 Sep;36(3):235-7. doi: 10.1097/WNO.0000000000000409. PMID: 27389625
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Prognosis

The enigma of nonarteritic anterior ischemic optic neuropathy: an update for the comprehensive ophthalmologist.
Gaier ED, Torun N
Curr Opin Ophthalmol 2016 Nov;27(6):498-504. doi: 10.1097/ICU.0000000000000318. PMID: 27585212
Is there treatment for nonarteritic anterior ischemic optic neuropathy.
Katz DM, Trobe JD
Curr Opin Ophthalmol 2015 Nov;26(6):458-63. doi: 10.1097/ICU.0000000000000199. PMID: 26367094
Surgery for nonarteritic anterior ischemic optic neuropathy.
Dickersin K, Li T
Cochrane Database Syst Rev 2015 Mar 12;2015(3):CD001538. doi: 10.1002/14651858.CD001538.pub4. PMID: 25763979Free PMC Article
Nonarteritic anterior ischemic optic neuropathy.
Mathews MK
Curr Opin Ophthalmol 2005 Dec;16(6):341-5. doi: 10.1097/01.icu.0000188361.52166.93. PMID: 16264343
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Clinical prediction guides

Follow-up of Nonarteritic Anterior Ischemic Optic Neuropathy With Optical Coherence Tomography Angiography.
Aghsaei Fard M, Ghahvechian H, Subramanian PS
J Neuroophthalmol 2021 Dec 1;41(4):e433-e439. doi: 10.1097/WNO.0000000000000997. PMID: 34788242
Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease.
Kim MS, Jeong HY, Cho KH, Oh SW, Byun SJ, Woo SJ, Yang HK, Hwang JM, Park KH, Kim CK, Park SJ
PLoS One 2019;14(11):e0225322. Epub 2019 Nov 14 doi: 10.1371/journal.pone.0225322. PMID: 31725805Free PMC Article
Risk of Nonarteritic Anterior Ischemic Optic Neuropathy After Cataract Surgery.
Yang HK, Park SJ, Byun SJ, Park KH, Hwang JM
Am J Ophthalmol 2019 Nov;207:343-350. Epub 2019 Aug 12 doi: 10.1016/j.ajo.2019.08.001. PMID: 31415735
Optic disk drusen in children.
Chang MY, Pineles SL
Surv Ophthalmol 2016 Nov-Dec;61(6):745-758. Epub 2016 Mar 29 doi: 10.1016/j.survophthal.2016.03.007. PMID: 27033945Free PMC Article
Nonarteritic anterior ischemic optic neuropathy (NAION) and its experimental models.
Bernstein SL, Johnson MA, Miller NR
Prog Retin Eye Res 2011 May;30(3):167-87. Epub 2011 Mar 2 doi: 10.1016/j.preteyeres.2011.02.003. PMID: 21376134Free PMC Article

Recent systematic reviews

Nonarteritic Anterior Ischemic Optic Neuropathy After Cataract Surgery: A Systematic Review and Meta-Analysis.
Shew W, Wang MTM, Danesh-Meyer HV
J Neuroophthalmol 2023 Mar 1;43(1):17-28. Epub 2022 Jun 23 doi: 10.1097/WNO.0000000000001625. PMID: 36166807
The association between ophthalmologic diseases and obstructive sleep apnea: a systematic review and meta-analysis.
Huon LK, Liu SY, Camacho M, Guilleminault C
Sleep Breath 2016 Dec;20(4):1145-1154. Epub 2016 May 26 doi: 10.1007/s11325-016-1358-4. PMID: 27230013
The Association Between Obstructive Sleep Apnea and Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.
Wu Y, Zhou LM, Lou H, Cheng JW, Wei RL
Curr Eye Res 2016 Jul;41(7):987-92. Epub 2015 Oct 7 doi: 10.3109/02713683.2015.1075221. PMID: 26443989
Surgery for nonarteritic anterior ischemic optic neuropathy.
Dickersin K, Li T
Cochrane Database Syst Rev 2015 Mar 12;2015(3):CD001538. doi: 10.1002/14651858.CD001538.pub4. PMID: 25763979Free PMC Article
The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis.
Chen T, Song D, Shan G, Wang K, Wang Y, Ma J, Zhong Y
PLoS One 2013;8(9):e76653. Epub 2013 Sep 30 doi: 10.1371/journal.pone.0076653. PMID: 24098798Free PMC Article

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