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Thyroid Gland Paraganglioma

MedGen UID:
328114
•Concept ID:
C1710416
•
Neoplastic Process

Definition

A rare, circumscribed or encapsulated neuroendocrine tumor arising from the thyroid gland. Microscopically, it is characterized by the presence of tumor cells arranged in a nesting (Zellballen) growth pattern. The reported cases have followed a benign clinical course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Paraganglioma

Professional guidelines

PubMed

ASO Author Reflections: Informing Patients About New Genetic Testing.
Romero Arenas MA, Grubbs EG
Ann Surg Oncol 2019 Dec;26(Suppl 3):559-560. Epub 2019 Jan 7 doi: 10.1245/s10434-018-6954-z. PMID: 30617867
Genetics, diagnosis, and management of medullary thyroid carcinoma and pheochromocytoma/paraganglioma.
Moraitis AG, Martucci VL, Pacak K
Endocr Pract 2014 Feb;20(2):176-87. doi: 10.4158/EP13268.RA. PMID: 24449662
Multiple endocrine neoplasia type 2: clinical manifestations and management.
Traugott AL, Moley JF
Cancer Treat Res 2010;153:321-37. doi: 10.1007/978-1-4419-0857-5_18. PMID: 19957233

Recent clinical studies

Etiology

Updates on the genetics of multiple endocrine neoplasia.
Sahakian N, Castinetti F, Romanet P, Reznik Y, Brue T
Ann Endocrinol (Paris) 2024 Apr;85(2):127-135. Epub 2024 Feb 5 doi: 10.1016/j.ando.2023.11.005. PMID: 38325596
Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
(68)Ga-DOTATATE PET-CT imaging in carotid body paragangliomas.
Şimşek DH, Şanlı Y, Kuyumcu S, Başaran B, Mudun A
Ann Nucl Med 2018 May;32(4):297-301. Epub 2018 Feb 21 doi: 10.1007/s12149-018-1242-3. PMID: 29468487
Role of 18F-fluorodeoxyglucose PET in the study of neuroendocrine tumors.
Panagiotidis E, Bomanji J
PET Clin 2014 Jan;9(1):43-55. Epub 2013 Oct 4 doi: 10.1016/j.cpet.2013.08.008. PMID: 25029933
Multiple endocrine neoplasia type 2: achievements and current challenges.
Machens A, Dralle H
Clinics (Sao Paulo) 2012;67 Suppl 1(Suppl 1):113-8. doi: 10.6061/clinics/2012(sup01)19. PMID: 22584715Free PMC Article

Diagnosis

Anesthesia for Endocrine Emergencies.
Peramunage D, Nikravan S
Anesthesiol Clin 2020 Mar;38(1):149-163. Epub 2020 Jan 2 doi: 10.1016/j.anclin.2019.10.006. PMID: 32008649
Pheochromocytoma, thyroid disease, and hyperparathyroidism.
Bravo EL
J Clin Hypertens (Greenwich) 2005 Mar;7(3):173-7. doi: 10.1111/j.1524-6175.2005.04109.x. PMID: 15785159Free PMC Article
Neurofibromatosis update.
Riccardi VM
Neurofibromatosis 1989;2(5-6):284-91. PMID: 2518510
Pediatric endocrine surgery.
Telander RL, Zimmerman D, Kaufman BH, van Heerden JA
Surg Clin North Am 1985 Dec;65(6):1551-87. doi: 10.1016/s0039-6109(16)43786-2. PMID: 2866587
Endocrine emergencies.
Jordan RM
Med Clin North Am 1983 Nov;67(6):1193-213. doi: 10.1016/s0025-7125(16)31149-x. PMID: 6415353

Therapy

Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
Histone deacetylase inhibitors as a novel therapeutic approach for pheochromocytomas and paragangliomas.
Manta A, Kazanas S, Karamaroudis S, Gogas H, Ziogas DC
Oncol Res 2022;30(5):211-219. Epub 2023 Feb 3 doi: 10.32604/or.2022.026913. PMID: 37305348Free PMC Article
Medical disorders in pregnancy, including hypertensive diseases.
Sibai BM
Curr Opin Obstet Gynecol 1991 Feb;3(1):28-40. PMID: 1878494
Endocrine tumors.
Averbuch SD
Cancer Chemother Biol Response Modif 1991;12:491-508. PMID: 1681844
Endocrine surgery in children.
Schwartz DL, Gann DS, Haller JA Jr
Surg Clin North Am 1974 Apr;54(2):363-85. doi: 10.1016/s0039-6109(16)40285-9. PMID: 4361606

Prognosis

Applications of Immunohistochemistry to Endocrine Pathology.
Higgins SE, Barletta JA
Adv Anat Pathol 2018 Nov;25(6):413-429. doi: 10.1097/PAP.0000000000000209. PMID: 30157042
PET/Computed Tomography in Neuroendocrine Tumor: Value to Patient Management and Survival Outcomes.
Shamim SA, Kumar A, Kumar R
PET Clin 2015 Jul;10(3):411-21. Epub 2015 Apr 14 doi: 10.1016/j.cpet.2015.03.005. PMID: 26099675
Role of 18F-fluorodeoxyglucose PET in the study of neuroendocrine tumors.
Panagiotidis E, Bomanji J
PET Clin 2014 Jan;9(1):43-55. Epub 2013 Oct 4 doi: 10.1016/j.cpet.2013.08.008. PMID: 25029933
RET and neuroendocrine tumors.
Murakumo Y, Jijiwa M, Asai N, Ichihara M, Takahashi M
Pituitary 2006;9(3):179-92. doi: 10.1007/s11102-006-0263-4. PMID: 17036197
Somatostatin receptor imaging for neuroendocrine tumors.
de Herder WW, Kwekkeboom DJ, Feelders RA, van Aken MO, Lamberts SW, van der Lely AJ, Krenning EP
Pituitary 2006;9(3):243-8. doi: 10.1007/s11102-006-0270-5. PMID: 17001462

Clinical prediction guides

Updates on the genetics of multiple endocrine neoplasia.
Sahakian N, Castinetti F, Romanet P, Reznik Y, Brue T
Ann Endocrinol (Paris) 2024 Apr;85(2):127-135. Epub 2024 Feb 5 doi: 10.1016/j.ando.2023.11.005. PMID: 38325596
Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
Perioperative hemodynamic instability in pheochromocytoma and sympathetic paraganglioma patients.
Kim JH, Lee HC, Kim SJ, Yoon SB, Kong SH, Yu HW, Chai YJ, Choi JY, Lee KE, Lee KW, Min SK, Shin CS, Park KJ
Sci Rep 2021 Sep 17;11(1):18574. doi: 10.1038/s41598-021-97964-3. PMID: 34535733Free PMC Article
Applications of Immunohistochemistry to Endocrine Pathology.
Higgins SE, Barletta JA
Adv Anat Pathol 2018 Nov;25(6):413-429. doi: 10.1097/PAP.0000000000000209. PMID: 30157042
Somatostatin receptor imaging for neuroendocrine tumors.
de Herder WW, Kwekkeboom DJ, Feelders RA, van Aken MO, Lamberts SW, van der Lely AJ, Krenning EP
Pituitary 2006;9(3):243-8. doi: 10.1007/s11102-006-0270-5. PMID: 17001462

Recent systematic reviews

Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis.
Ganni R, Torpy DJ, Falhammar H, Louise Rushworth R
J Clin Endocrinol Metab 2023 Aug 18;108(9):e885-e892. doi: 10.1210/clinem/dgad121. PMID: 36896586Free PMC Article
Thyroid paraganglioma: A case-based systematic review of literature.
Mishra P, Padhi S, Behera G
J Cancer Res Ther 2020 Dec;16(Supplement):S11-S21. doi: 10.4103/jcrt.JCRT_713_18. PMID: 33380646
Ki67 in endocrine neoplasms: to count or not to count, this is the question! A systematic review from the English language literature.
Guadagno E, D'Avella E, Cappabianca P, Colao A, Del Basso De Caro M
J Endocrinol Invest 2020 Oct;43(10):1429-1445. Epub 2020 May 15 doi: 10.1007/s40618-020-01275-9. PMID: 32415572
Thyroid Paraganglioma: Our Experience and Systematic Review of the Literature on a Rare Tumor.
Pelizzo MR, Conti C, Pennelli G, Bellan E, Cook GJ, Wong KK, Colletti PM, Merante Boschin I, Rubello D
Am J Clin Oncol 2018 Apr;41(4):416-423. doi: 10.1097/COC.0000000000000295. PMID: 27163832
Efficacy and Safety of Everolimus in Extrapancreatic Neuroendocrine Tumor: A Comprehensive Review of Literature.
Faggiano A, Malandrino P, Modica R, Agrimi D, Aversano M, Bassi V, Giordano EA, Guarnotta V, Logoluso FA, Messina E, Nicastro V, Nuzzo V, Sciaraffia M, Colao A
Oncologist 2016 Jul;21(7):875-86. Epub 2016 Apr 6 doi: 10.1634/theoncologist.2015-0420. PMID: 27053503Free PMC Article

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