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Atrial fibrillation, familial, 2(ATFB2)

MedGen UID:
324886
Concept ID:
C1837812
Disease or Syndrome
Synonym: ATFB2
 
Monarch Initiative: MONDO:0012167
OMIM®: 608988

Definition

Atrial fibrillation is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke (Brugada et al., 1997). For a discussion of genetic heterogeneity of atrial fibrillation, see 608583. [from OMIM]

Clinical features

From HPO
Atrial fibrillation
MedGen UID:
445
Concept ID:
C0004238
Finding
An atrial arrhythmia characterized by disorganized atrial activity without discrete P waves on the surface EKG, but instead by an undulating baseline or more sharply circumscribed atrial deflections of varying amplitude an frequency ranging from 350 to 600 per minute.

Professional guidelines

PubMed

Douketis JD, Spyropoulos AC, Murad MH, Arcelus JI, Dager WE, Dunn AS, Fargo RA, Levy JH, Samama CM, Shah SH, Sherwood MW, Tafur AJ, Tang LV, Moores LK
Chest 2022 Nov;162(5):e207-e243. Epub 2022 Aug 11 doi: 10.1016/j.chest.2022.07.025. PMID: 35964704
Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW
Circulation 2022 May 3;145(18):e895-e1032. Epub 2022 Apr 1 doi: 10.1161/CIR.0000000000001063. PMID: 35363499
Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Muñoz D, Smith SC Jr, Virani SS, Williams KA Sr, Yeboah J, Ziaeian B
Circulation 2019 Sep 10;140(11):e596-e646. Epub 2019 Mar 17 doi: 10.1161/CIR.0000000000000678. PMID: 30879355Free PMC Article

Curated

UK NICE Guideline NG196, Atrial fibrillation: diagnosis and management, 2021

Recent clinical studies

Etiology

Polidori MC, Alves M, Bahat G, Boureau AS, Ozkok S, Pfister R, Pilotto A, Veronese N, Bo M; Special Interest Group “Cardiovascular Diseases” of the EuGMS
Eur Geriatr Med 2022 Feb;13(1):5-18. Epub 2021 Nov 2 doi: 10.1007/s41999-021-00537-w. PMID: 34727362Free PMC Article
Westerman S, Wenger N
Curr Cardiol Rev 2019;15(2):136-144. doi: 10.2174/1573403X15666181205110624. PMID: 30516110Free PMC Article
Reddy V, Taha W, Kundumadam S, Khan M
Indian Heart J 2017 Jul-Aug;69(4):545-550. Epub 2017 Jul 5 doi: 10.1016/j.ihj.2017.07.004. PMID: 28822529Free PMC Article
Bessissow A, Khan J, Devereaux PJ, Alvarez-Garcia J, Alonso-Coello P
J Thromb Haemost 2015 Jun;13 Suppl 1:S304-12. doi: 10.1111/jth.12974. PMID: 26149040
Andrade J, Khairy P, Dobrev D, Nattel S
Circ Res 2014 Apr 25;114(9):1453-68. doi: 10.1161/CIRCRESAHA.114.303211. PMID: 24763464

Diagnosis

Polidori MC, Alves M, Bahat G, Boureau AS, Ozkok S, Pfister R, Pilotto A, Veronese N, Bo M; Special Interest Group “Cardiovascular Diseases” of the EuGMS
Eur Geriatr Med 2022 Feb;13(1):5-18. Epub 2021 Nov 2 doi: 10.1007/s41999-021-00537-w. PMID: 34727362Free PMC Article
Lau DH, Linz D, Sanders P
Card Electrophysiol Clin 2019 Dec;11(4):563-571. doi: 10.1016/j.ccep.2019.08.007. PMID: 31706465
Reddy V, Taha W, Kundumadam S, Khan M
Indian Heart J 2017 Jul-Aug;69(4):545-550. Epub 2017 Jul 5 doi: 10.1016/j.ihj.2017.07.004. PMID: 28822529Free PMC Article
Andrade J, Khairy P, Dobrev D, Nattel S
Circ Res 2014 Apr 25;114(9):1453-68. doi: 10.1161/CIRCRESAHA.114.303211. PMID: 24763464
Bradley A, Sheridan P
BMJ 2013 Jun 17;346:f3719. doi: 10.1136/bmj.f3719. PMID: 23775800

Therapy

Gawałko M, Linz D
Hypertension 2023 Mar;80(3):523-533. Epub 2022 Dec 15 doi: 10.1161/HYPERTENSIONAHA.122.19459. PMID: 36519436
Packer DL, Piccini JP, Monahan KH, Al-Khalidi HR, Silverstein AP, Noseworthy PA, Poole JE, Bahnson TD, Lee KL, Mark DB; CABANA Investigators
Circulation 2021 Apr 6;143(14):1377-1390. Epub 2021 Feb 8 doi: 10.1161/CIRCULATIONAHA.120.050991. PMID: 33554614Free PMC Article
Poole JE, Bahnson TD, Monahan KH, Johnson G, Rostami H, Silverstein AP, Al-Khalidi HR, Rosenberg Y, Mark DB, Lee KL, Packer DL; CABANA Investigators and ECG Rhythm Core Lab
J Am Coll Cardiol 2020 Jun 30;75(25):3105-3118. doi: 10.1016/j.jacc.2020.04.065. PMID: 32586583Free PMC Article
Packer DL, Mark DB, Robb RA, Monahan KH, Bahnson TD, Poole JE, Noseworthy PA, Rosenberg YD, Jeffries N, Mitchell LB, Flaker GC, Pokushalov E, Romanov A, Bunch TJ, Noelker G, Ardashev A, Revishvili A, Wilber DJ, Cappato R, Kuck KH, Hindricks G, Davies DW, Kowey PR, Naccarelli GV, Reiffel JA, Piccini JP, Silverstein AP, Al-Khalidi HR, Lee KL; CABANA Investigators
JAMA 2019 Apr 2;321(13):1261-1274. doi: 10.1001/jama.2019.0693. PMID: 30874766Free PMC Article
Kühlkamp V, Bosch R, Mewis C, Seipel L
Am J Cardiovasc Drugs 2002;2(1):37-42. doi: 10.2165/00129784-200202010-00005. PMID: 14727997

Prognosis

Roberts JD, Vittinghoff E, Lu AT, Alonso A, Wang B, Sitlani CM, Mohammadi-Shemirani P, Fornage M, Kornej J, Brody JA, Arking DE, Lin H, Heckbert SR, Prokic I, Ghanbari M, Skanes AC, Bartz TM, Perez MV, Taylor KD, Lubitz SA, Ellinor PT, Lunetta KL, Pankow JS, Paré G, Sotoodehnia N, Benjamin EJ, Horvath S, Marcus GM
Circulation 2021 Dec 14;144(24):1899-1911. Epub 2021 Sep 30 doi: 10.1161/CIRCULATIONAHA.121.056456. PMID: 34587750Free PMC Article
Schnabel RB, Yin X, Gona P, Larson MG, Beiser AS, McManus DD, Newton-Cheh C, Lubitz SA, Magnani JW, Ellinor PT, Seshadri S, Wolf PA, Vasan RS, Benjamin EJ, Levy D
Lancet 2015 Jul 11;386(9989):154-62. Epub 2015 May 7 doi: 10.1016/S0140-6736(14)61774-8. PMID: 25960110Free PMC Article
Mahida S
Cardiovasc Res 2014 Feb 1;101(2):194-202. Epub 2013 Nov 21 doi: 10.1093/cvr/cvt261. PMID: 24265295
Kozlowski D, Budrejko S, Lip GY, Rysz J, Mikhailidis DP, Raczak G, Banach M
Heart 2010 Apr;96(7):498-503. Epub 2009 Aug 26 doi: 10.1136/hrt.2009.176321. PMID: 19713203
Reardon M, Camm AJ
Clin Cardiol 1996 Oct;19(10):765-75. doi: 10.1002/clc.4960191003. PMID: 8896908

Clinical prediction guides

Kikuchi Y, Saijo Y, Narita M, Shibagaki K, Okubo R, Kunioka S, Shirasaka T, Kamiya H
Int J Cardiovasc Imaging 2022 Aug;38(8):1873-1879. Epub 2022 Mar 30 doi: 10.1007/s10554-022-02560-9. PMID: 37726512
Spannella F, Giulietti F, Pimpini L, Lombardi FE, Re S, Schiavi P, Dragano G, Antonicelli R, Sarzani R
Aging (Albany NY) 2021 Jul 1;13(13):17024-17037. doi: 10.18632/aging.203270. PMID: 34198265Free PMC Article
Karantoumanis I, Doundoulakis I, Zafeiropoulos S, Oikonomou K, Makridis P, Pliakos C, Karvounis H, Giannakoulas G
Int J Cardiovasc Imaging 2021 Apr;37(4):1267-1277. Epub 2021 Jan 3 doi: 10.1007/s10554-020-02113-y. PMID: 33389363
Yamashita K, Ranjan R
Cardiol Clin 2019 May;37(2):147-156. Epub 2019 Feb 22 doi: 10.1016/j.ccl.2019.01.007. PMID: 30926016Free PMC Article
Prabhu S, McLellan AJ, Walters TE, Sharma M, Voskoboinik A, Kistler PM
Prog Cardiovasc Dis 2015 Sep-Oct;58(2):152-67. Epub 2015 Aug 4 doi: 10.1016/j.pcad.2015.08.004. PMID: 26247494

Recent systematic reviews

Serban T, Mannhart D, Abid QU, Höchli A, Lazar S, Krisai P, Bettelini AS, Knecht S, Kühne M, Sticherling C, du Fay de Lavallaz J, Badertscher P
Europace 2023 Nov 2;25(11) doi: 10.1093/europace/euad335. PMID: 37944133Free PMC Article
Cardoso R, Justino GB, Graffunder FP, Benevides L, Knijnik L, Sanchez LMF, d'Avila A
Arq Bras Cardiol 2022 Jul;119(1):87-94. doi: 10.36660/abc.20210477. PMID: 35830118Free PMC Article
Proietti M, Romiti GF, Raparelli V, Diemberger I, Boriani G, Dalla Vecchia LA, Bellelli G, Marzetti E, Lip GY, Cesari M
Ageing Res Rev 2022 Aug;79:101652. Epub 2022 May 31 doi: 10.1016/j.arr.2022.101652. PMID: 35659945
Ramesh T, Lee PYK, Mitta M, Allencherril J
J Cardiol 2021 Nov;78(5):375-381. Epub 2021 Jun 20 doi: 10.1016/j.jjcc.2021.06.001. PMID: 34162502
Ruddox V, Sandven I, Munkhaugen J, Skattebu J, Edvardsen T, Otterstad JE
Eur J Prev Cardiol 2017 Sep;24(14):1555-1566. Epub 2017 Jun 15 doi: 10.1177/2047487317715769. PMID: 28617620Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG196, Atrial fibrillation: diagnosis and management, 2021

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