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Adult Gliosarcoma

MedGen UID:
323796
•Concept ID:
C1541317
•
Neoplastic Process

Definition

A gliosarcoma occurring in adults. [from NCI]

Professional guidelines

PubMed

Primary gliosarcoma: epidemiology, clinical presentation, management, and survival.
Ma R, Alexe DM, Pereira EA
J Neurosurg Sci 2020 Aug;64(4):341-346. Epub 2017 Nov 20 doi: 10.23736/S0390-5616.17.04077-2. PMID: 29154508
Prognosis and management of gliosarcoma patients: A review of literature.
Saadeh F, El Iskandarani S, Najjar M, Assi HI
Clin Neurol Neurosurg 2019 Jul;182:98-103. Epub 2019 May 14 doi: 10.1016/j.clineuro.2019.05.008. PMID: 31112812
Therapeutic management of gliosarcoma in the temozolomide era.
McAleer MF, Brown PD
CNS Oncol 2015;4(3):171-8. Epub 2015 Apr 23 doi: 10.2217/cns.14.61. PMID: 25905568Free PMC Article

Recent clinical studies

Etiology

Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
Umemura Y, Orringer D, Junck L, Varela ML, West MEJ, Faisal SM, Comba A, Heth J, Sagher O, Leung D, Mammoser A, Hervey-Jumper S, Zamler D, Yadav VN, Dunn P, Al-Holou W, Hollon T, Kim MM, Wahl DR, Camelo-Piragua S, Lieberman AP, Venneti S, McKeever P, Lawrence T, Kurokawa R, Sagher K, Altshuler D, Zhao L, Muraszko K, Castro MG, Lowenstein PR
Lancet Oncol 2023 Sep;24(9):1042-1052. doi: 10.1016/S1470-2045(23)00347-9. PMID: 37657463
Estimated Prevalence, Tumor Spectrum, and Neurofibromatosis Type 1-Like Phenotype of CDKN2A-Related Melanoma-Astrocytoma Syndrome.
Sargen MR, Kim J, Potjer TP, Velthuizen ME, Martir-Negron AE, Odia Y, Helgadottir H, Hatton JN, Haley JS, Thone G, Widemann BC, Gross AM, Yohe ME, Kaplan RN, Shern JF, Sundby RT, Astiazaran-Symonds E, Yang XR, Carey DJ, Tucker MA, Stewart DR, Goldstein AM
JAMA Dermatol 2023 Oct 1;159(10):1112-1118. doi: 10.1001/jamadermatol.2023.2621. PMID: 37585199Free PMC Article
Clinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1.
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO
Neuro Oncol 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. PMID: 36840626Free PMC Article
Prognosis and management of gliosarcoma patients: A review of literature.
Saadeh F, El Iskandarani S, Najjar M, Assi HI
Clin Neurol Neurosurg 2019 Jul;182:98-103. Epub 2019 May 14 doi: 10.1016/j.clineuro.2019.05.008. PMID: 31112812
Gliosarcoma: MR features.
Dwyer KW, Naul LG, Hise JH
J Comput Assist Tomogr 1996 Sep-Oct;20(5):719-23. doi: 10.1097/00004728-199609000-00006. PMID: 8797900

Diagnosis

Clinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1.
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO
Neuro Oncol 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. PMID: 36840626Free PMC Article
Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Prognosis and management of gliosarcoma patients: A review of literature.
Saadeh F, El Iskandarani S, Najjar M, Assi HI
Clin Neurol Neurosurg 2019 Jul;182:98-103. Epub 2019 May 14 doi: 10.1016/j.clineuro.2019.05.008. PMID: 31112812
Dural lesions mimicking meningiomas.
Johnson MD, Powell SZ, Boyer PJ, Weil RJ, Moots PL
Hum Pathol 2002 Dec;33(12):1211-26. doi: 10.1053/hupa.2002.129200. PMID: 12514791
Gliosarcoma: MR features.
Dwyer KW, Naul LG, Hise JH
J Comput Assist Tomogr 1996 Sep-Oct;20(5):719-23. doi: 10.1097/00004728-199609000-00006. PMID: 8797900

Therapy

Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
Umemura Y, Orringer D, Junck L, Varela ML, West MEJ, Faisal SM, Comba A, Heth J, Sagher O, Leung D, Mammoser A, Hervey-Jumper S, Zamler D, Yadav VN, Dunn P, Al-Holou W, Hollon T, Kim MM, Wahl DR, Camelo-Piragua S, Lieberman AP, Venneti S, McKeever P, Lawrence T, Kurokawa R, Sagher K, Altshuler D, Zhao L, Muraszko K, Castro MG, Lowenstein PR
Lancet Oncol 2023 Sep;24(9):1042-1052. doi: 10.1016/S1470-2045(23)00347-9. PMID: 37657463
Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors.
Kim H, Lim KY, Park JW, Kang J, Won JK, Lee K, Shim Y, Park CK, Kim SK, Choi SH, Kim TM, Yun H, Park SH
Lab Invest 2022 Feb;102(2):160-171. Epub 2021 Nov 30 doi: 10.1038/s41374-021-00694-3. PMID: 34848827Free PMC Article
Genomic landscape of gliosarcoma: distinguishing features and targetable alterations.
Zaki MM, Mashouf LA, Woodward E, Langat P, Gupta S, Dunn IF, Wen PY, Nahed BV, Bi WL
Sci Rep 2021 Sep 9;11(1):18009. doi: 10.1038/s41598-021-97454-6. PMID: 34504233Free PMC Article
The clinical, radiological, and immunohistochemical characteristics and outcomes of primary intracranial gliosarcoma: a retrospective single-centre study.
Zhang Y, Ma JP, Weng JC, Wang L, Wu Z, Li D, Zhang JT
Neurosurg Rev 2021 Apr;44(2):1003-1015. Epub 2020 Mar 18 doi: 10.1007/s10143-020-01285-4. PMID: 32189095
Therapeutic management of gliosarcoma in the temozolomide era.
McAleer MF, Brown PD
CNS Oncol 2015;4(3):171-8. Epub 2015 Apr 23 doi: 10.2217/cns.14.61. PMID: 25905568Free PMC Article

Prognosis

Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
Umemura Y, Orringer D, Junck L, Varela ML, West MEJ, Faisal SM, Comba A, Heth J, Sagher O, Leung D, Mammoser A, Hervey-Jumper S, Zamler D, Yadav VN, Dunn P, Al-Holou W, Hollon T, Kim MM, Wahl DR, Camelo-Piragua S, Lieberman AP, Venneti S, McKeever P, Lawrence T, Kurokawa R, Sagher K, Altshuler D, Zhao L, Muraszko K, Castro MG, Lowenstein PR
Lancet Oncol 2023 Sep;24(9):1042-1052. doi: 10.1016/S1470-2045(23)00347-9. PMID: 37657463
Clinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1.
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO
Neuro Oncol 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. PMID: 36840626Free PMC Article
Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Prognosis and management of gliosarcoma patients: A review of literature.
Saadeh F, El Iskandarani S, Najjar M, Assi HI
Clin Neurol Neurosurg 2019 Jul;182:98-103. Epub 2019 May 14 doi: 10.1016/j.clineuro.2019.05.008. PMID: 31112812
Clinical and molecular characteristics of gliosarcoma and modern prognostic significance relative to conventional glioblastoma.
Smith DR, Wu CC, Saadatmand HJ, Isaacson SR, Cheng SK, Sisti MB, Bruce JN, Sheth SA, Lassman AB, Iwamoto FM, Wang SH, Canoll P, McKhann GM 2nd, Wang TJC
J Neurooncol 2018 Apr;137(2):303-311. Epub 2017 Dec 20 doi: 10.1007/s11060-017-2718-z. PMID: 29264835Free PMC Article

Clinical prediction guides

Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
Umemura Y, Orringer D, Junck L, Varela ML, West MEJ, Faisal SM, Comba A, Heth J, Sagher O, Leung D, Mammoser A, Hervey-Jumper S, Zamler D, Yadav VN, Dunn P, Al-Holou W, Hollon T, Kim MM, Wahl DR, Camelo-Piragua S, Lieberman AP, Venneti S, McKeever P, Lawrence T, Kurokawa R, Sagher K, Altshuler D, Zhao L, Muraszko K, Castro MG, Lowenstein PR
Lancet Oncol 2023 Sep;24(9):1042-1052. doi: 10.1016/S1470-2045(23)00347-9. PMID: 37657463
Demographic, radiographic, molecular and clinical characteristics of primary gliosarcoma and differences to glioblastoma.
Pierscianek D, Ahmadipour Y, Michel A, Rauschenbach L, Darkwah Oppong M, Deuschl C, Kebir S, Wrede KH, Glas M, Stuschke M, Sure U, Jabbarli R
Clin Neurol Neurosurg 2021 Jan;200:106348. Epub 2020 Nov 1 doi: 10.1016/j.clineuro.2020.106348. PMID: 33158630
The clinical, radiological, and immunohistochemical characteristics and outcomes of primary intracranial gliosarcoma: a retrospective single-centre study.
Zhang Y, Ma JP, Weng JC, Wang L, Wu Z, Li D, Zhang JT
Neurosurg Rev 2021 Apr;44(2):1003-1015. Epub 2020 Mar 18 doi: 10.1007/s10143-020-01285-4. PMID: 32189095
Gliosarcoma: a clinical and radiological analysis of 48 cases.
Yi X, Cao H, Tang H, Gong G, Hu Z, Liao W, Sun L, Chen BT, Li X
Eur Radiol 2019 Jan;29(1):429-438. Epub 2018 Jun 12 doi: 10.1007/s00330-018-5398-y. PMID: 29948068
Clinical and molecular characteristics of gliosarcoma and modern prognostic significance relative to conventional glioblastoma.
Smith DR, Wu CC, Saadatmand HJ, Isaacson SR, Cheng SK, Sisti MB, Bruce JN, Sheth SA, Lassman AB, Iwamoto FM, Wang SH, Canoll P, McKhann GM 2nd, Wang TJC
J Neurooncol 2018 Apr;137(2):303-311. Epub 2017 Dec 20 doi: 10.1007/s11060-017-2718-z. PMID: 29264835Free PMC Article

Recent systematic reviews

Radiation-induced malignancies after stereotactic radiosurgery for brain arteriovenous malformations: a large single-center retrospective study and systematic review.
Hirata T, Umekawa M, Shinya Y, Hasegawa H, Katano A, Shinozaki-Ushiku A, Saito N
Neurosurg Rev 2024 Nov 26;47(1):870. doi: 10.1007/s10143-024-03093-6. PMID: 39586842Free PMC Article
A Systematic Review on the Characteristics, Treatments and Outcomes of the Patients with Primary Spinal Glioblastomas or Gliosarcomas Reported in Literature until March 2015.
Beyer S, von Bueren AO, Klautke G, Guckenberger M, Kortmann RD, Pietschmann S, Müller K
PLoS One 2016;11(2):e0148312. Epub 2016 Feb 9 doi: 10.1371/journal.pone.0148312. PMID: 26859136Free PMC Article

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