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Lung Squamous Cell Carcinoma, Clear Cell Variant

MedGen UID:
318199
•Concept ID:
C1710174
•
Neoplastic Process

Definition

A morphologic variant of squamous cell lung carcinoma characterized by the presence of clear cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Squamous Cell Carcinoma, Clear Cell Variant

Professional guidelines

PubMed

Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects.
Belogubova EV, Ulibina YM, Suvorova IK, Kuligina ESh, Karpova MB, Shutkin VA, Koloskov AV, Kuchinskiy AP, Togo AV, Hanson KP, Hirvonen A, Imyanitov EN
J Cancer Res Clin Oncol 2006 May;132(5):327-31. Epub 2006 Jan 14 doi: 10.1007/s00432-005-0071-7. PMID: 16416283

Recent clinical studies

Etiology

Telomere length and cancer risk: finding Goldilocks.
Savage SA
Biogerontology 2024 Apr;25(2):265-278. Epub 2023 Dec 18 doi: 10.1007/s10522-023-10080-9. PMID: 38109000
Ancestry-specific predisposing germline variants in cancer.
Oak N, Cherniack AD, Mashl RJ; TCGA Analysis Network, Hirsch FR, Ding L, Beroukhim R, Gümüş ZH, Plon SE, Huang KL
Genome Med 2020 May 29;12(1):51. doi: 10.1186/s13073-020-00744-3. PMID: 32471518Free PMC Article
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
Large cell carcinoma of the lung.
Yesner R
Semin Diagn Pathol 1985 Nov;2(4):255-69. PMID: 3039629

Diagnosis

Transforming tumoroids derived from ALK-positive pulmonary adenocarcinoma to squamous cell carcinoma in vivo.
Yokota E, Iwai M, Ishida Y, Yukawa T, Matsubara M, Naomoto Y, Fujiwara H, Monobe Y, Haisa M, Takigawa N, Fukazawa T, Yamatsuji T
Hum Cell 2024 Jul;37(4):1132-1140. Epub 2024 Jun 3 doi: 10.1007/s13577-024-01085-8. PMID: 38829559Free PMC Article
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Clear cell basal cell carcinoma with pulmonary metastasis: case report and literature review.
Fernández-Aceñero MJ, Cenjor C, Córdova S
Am J Dermatopathol 2011 Jun;33(4):379-82. doi: 10.1097/DAD.0b013e3181e2ef6a. PMID: 21048492
Pathogenesis and pathology.
Yesner R
Clin Chest Med 1993 Mar;14(1):17-30. PMID: 8384961
Large cell carcinoma of the lung.
Yesner R
Semin Diagn Pathol 1985 Nov;2(4):255-69. PMID: 3039629

Therapy

Transforming tumoroids derived from ALK-positive pulmonary adenocarcinoma to squamous cell carcinoma in vivo.
Yokota E, Iwai M, Ishida Y, Yukawa T, Matsubara M, Naomoto Y, Fujiwara H, Monobe Y, Haisa M, Takigawa N, Fukazawa T, Yamatsuji T
Hum Cell 2024 Jul;37(4):1132-1140. Epub 2024 Jun 3 doi: 10.1007/s13577-024-01085-8. PMID: 38829559Free PMC Article
PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change.
Tsai KK, Khurana N, McCalmont T, Daud A, Bastian B, Yeh I
J Natl Compr Canc Netw 2019 Jul 1;17(7):778-783. doi: 10.6004/jnccn.2019.7313. PMID: 31319387
Secreted form of EphA7 in lung cancer.
Tsuboi M, Mori H, Bunai T, Kageyama S, Suzuki M, Okudela K, Takamochi K, Ogawa H, Niwa H, Shinmura K, Sugimura H
Int J Oncol 2010 Mar;36(3):635-40. PMID: 20126984
NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis.
Chao C, Zhang ZF, Berthiller J, Boffetta P, Hashibe M
Cancer Epidemiol Biomarkers Prev 2006 May;15(5):979-87. doi: 10.1158/1055-9965.EPI-05-0899. PMID: 16702380
Pathogenesis and pathology.
Yesner R
Clin Chest Med 1993 Mar;14(1):17-30. PMID: 8384961

Prognosis

BRD3-NUTM1-expressing NUT carcinoma of lung on endobronchial ultrasound-guided transbronchial needle aspiration cytology, a diagnostic pitfall.
Aryal SC, Zia S, Rodgers S, Shen Y, Perry K, Yuan L
Diagn Cytopathol 2022 Feb;50(2):E47-E53. Epub 2021 Oct 21 doi: 10.1002/dc.24885. PMID: 34672128
Ancestry-specific predisposing germline variants in cancer.
Oak N, Cherniack AD, Mashl RJ; TCGA Analysis Network, Hirsch FR, Ding L, Beroukhim R, Gümüş ZH, Plon SE, Huang KL
Genome Med 2020 May 29;12(1):51. doi: 10.1186/s13073-020-00744-3. PMID: 32471518Free PMC Article
PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change.
Tsai KK, Khurana N, McCalmont T, Daud A, Bastian B, Yeh I
J Natl Compr Canc Netw 2019 Jul 1;17(7):778-783. doi: 10.6004/jnccn.2019.7313. PMID: 31319387
Clinical Presentation and Treatment Options for Clear Cell Lung Cancer: University of Cincinnati A Case Series and Literature Review of Clear Cell Lung Cancer.
Eldessouki I, Gaber O, Riaz MK, Wang J, Abdel Karim N
Asian Pac J Cancer Prev 2018 Sep 26;19(9):2373-2376. doi: 10.22034/APJCP.2018.19.9.2373. PMID: 30255689Free PMC Article
Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.
Boukakis G, Patrinou-Georgoula M, Lekarakou M, Valavanis C, Guialis A
BMC Cancer 2010 Aug 17;10:434. doi: 10.1186/1471-2407-10-434. PMID: 20716340Free PMC Article

Clinical prediction guides

Transforming tumoroids derived from ALK-positive pulmonary adenocarcinoma to squamous cell carcinoma in vivo.
Yokota E, Iwai M, Ishida Y, Yukawa T, Matsubara M, Naomoto Y, Fujiwara H, Monobe Y, Haisa M, Takigawa N, Fukazawa T, Yamatsuji T
Hum Cell 2024 Jul;37(4):1132-1140. Epub 2024 Jun 3 doi: 10.1007/s13577-024-01085-8. PMID: 38829559Free PMC Article
Telomere length and cancer risk: finding Goldilocks.
Savage SA
Biogerontology 2024 Apr;25(2):265-278. Epub 2023 Dec 18 doi: 10.1007/s10522-023-10080-9. PMID: 38109000
The Clinical Significance of the Insulin-Like Growth Factor-1 Receptor Polymorphism in Non-Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation.
Liu TC, Hsieh MJ, Liu MC, Chiang WL, Tsao TC, Yang SF
Int J Mol Sci 2016 May 18;17(5) doi: 10.3390/ijms17050763. PMID: 27213344Free PMC Article
SMARCB1(INI1)-deficient sinonasal basaloid carcinoma: a novel member of the expanding family of SMARCB1-deficient neoplasms.
Agaimy A, Koch M, Lell M, Semrau S, Dudek W, Wachter DL, Knöll A, Iro H, Haller F, Hartmann A
Am J Surg Pathol 2014 Sep;38(9):1274-81. doi: 10.1097/PAS.0000000000000236. PMID: 24832165Free PMC Article
Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.
Girard N, Deshpande C, Lau C, Finley D, Rusch V, Pao W, Travis WD
Am J Surg Pathol 2009 Dec;33(12):1752-64. doi: 10.1097/PAS.0b013e3181b8cf03. PMID: 19773638Free PMC Article

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