Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Low Grade Appendix Mucinous Neoplasm

MedGen UID:: 317841
•Concept ID:: C1708747
•: Neoplastic Process

Synonyms:	Appendix Well Differentiated Mucinous Adenocarcinoma; Low Grade Appendiceal Mucinous Neoplasm; Low grade appendiceal mucinous neoplasm; Low-Grade Appendiceal Mucinous Neoplasm; Low-Grade Appendix Mucinous Neoplasm
SNOMED CT:	Low grade appendiceal mucinous neoplasm (450896006)

Definition

A well differentiated mucinous neoplasm that arises from the appendix. It is characterized by slow growth and it is associated with the development of pseudomyxoma peritonei. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLow Grade Appendix Mucinous Neoplasm

Disorder of gastrointestinal tract
- Intestinal disorder
  - Cecal disorder
    - Cecal neoplasm
      - Appendiceal neoplasm
        Appendix Mucinous Neoplasm
        Low Grade Appendix Mucinous Neoplasm
        Stage 0 Low Grade Appendix Mucinous Neoplasm (LAMN) AJCC v8

Professional guidelines

PubMed

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.

Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986

Appendiceal Mucinous Neoplasms: Diagnosis and Management.

Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356 Free PMC Article

Management of pseudomyxoma peritonei.

Fallis SA, Moran BJ
J BUON 2015 May;20 Suppl 1:S47-55. PMID: 26051332

See all (15)

Recent clinical studies

Etiology

Necessity of posttreatment surveillance for low-grade appendiceal mucinous neoplasms.

Gupta AR, Brajcich BC, Yang AD, Bentrem DJ, Merkow RP
J Surg Oncol 2021 Dec;124(7):1115-1120. Epub 2021 Aug 1 doi: 10.1002/jso.26621. PMID: 34333785

Grading and staging mucinous neoplasms of the appendix: a case series and review of the literature.

Umetsu SE, Shafizadeh N, Kakar S
Hum Pathol 2017 Nov;69:81-89. Epub 2017 Sep 29 doi: 10.1016/j.humpath.2017.09.005. PMID: 28970138

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.

Appendiceal Mucinous Neoplasms: Diagnosis and Management.

Mucinous neoplasms of the appendix: a current comprehensive clinicopathologic and imaging review.

Tirumani SH, Fraser-Hill M, Auer R, Shabana W, Walsh C, Lee F, Ryan JG
Cancer Imaging 2013 Feb 22;13(1):14-25. doi: 10.1102/1470-7330.2013.0003. PMID: 23439060 Free PMC Article

See all (103)

Diagnosis

Low-grade appendiceal mucinous neoplasm.

Dong J, Tian Y
Clin Res Hepatol Gastroenterol 2021 May;45(3):101647. Epub 2021 Feb 12 doi: 10.1016/j.clinre.2021.101647. PMID: 33588100

Updates in Appendix Pathology: The Precarious Cutting Edge.

Carr NJ
Surg Pathol Clin 2020 Sep;13(3):469-484. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.006. PMID: 32773195

Low-grade appendiceal mucinous neoplasms confined to the appendix: clinical manifestations and CT findings.

Yu XR, Mao J, Tang W, Meng XY, Tian Y, Du ZL
J Investig Med 2020 Jan;68(1):75-81. Epub 2019 Jul 11 doi: 10.1136/jim-2018-000975. PMID: 31300469 Free PMC Article

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.

Appendiceal Mucinous Neoplasms: Diagnosis and Management.

See all (123)

Therapy

Pathogenesis of histologic variations of appendiceal mucinous neoplasms.

Sugarbaker PH, Chang D, Liang J
Eur J Surg Oncol 2023 May;49(5):895-901. Epub 2023 Feb 27 doi: 10.1016/j.ejso.2023.02.014. PMID: 36863914

Acute lower gastrointestinal bleeding due to low-grade mucinous neoplasm of appendix.

Karatas M, Simsek C, Gunay S, Zengel B, Okut G, Yıldırım AM, Vardar E, Uslu A
Acta Chir Belg 2022 Oct;122(5):357-360. Epub 2020 Dec 16 doi: 10.1080/00015458.2020.1860397. PMID: 33274692

Mucinous Adenocarcinoma of the Appendix With Histologic Response to Neoadjuvant Chemotherapy: Review of Histologic and Clinical Spectrum of Epithelial Neoplastic Mucinous Lesions of the Appendix.

Copur M, Cushman-Vokoun A, Padussis J, Whitney W, Schroeder C, Herold D, Lintel N, Horn A
Oncology (Williston Park) 2021 Jun 23;35(6):335-340. doi: 10.46883/ONC.2021.3506.0335. PMID: 34161053

Low-Grade Appendiceal Mucinous Neoplasms: A Single Institution Experience of 64 Cases With Clinical Follow-up and Correlation With the Current (Eighth Edition) AJCC Staging.

Wong M, Barrows B, Gangi A, Kim S, Mertens RB, Dhall D
Int J Surg Pathol 2020 May;28(3):252-258. Epub 2019 Oct 24 doi: 10.1177/1066896919883679. PMID: 31645160

Management of pseudomyxoma peritonei.

Fallis SA, Moran BJ
J BUON 2015 May;20 Suppl 1:S47-55. PMID: 26051332

See all (24)

Prognosis

Updates in Appendix Pathology: The Precarious Cutting Edge.

Carr NJ
Surg Pathol Clin 2020 Sep;13(3):469-484. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.006. PMID: 32773195

Low-grade appendiceal mucinous neoplasms confined to the appendix: clinical manifestations and CT findings.

Yu XR, Mao J, Tang W, Meng XY, Tian Y, Du ZL
J Investig Med 2020 Jan;68(1):75-81. Epub 2019 Jul 11 doi: 10.1136/jim-2018-000975. PMID: 31300469 Free PMC Article

Management of pseudomyxoma peritonei.

Fallis SA, Moran BJ
J BUON 2015 May;20 Suppl 1:S47-55. PMID: 26051332

Mucinous epithelial neoplasms of the appendix and pseudomyxoma peritonei.

Misdraji J
Mod Pathol 2015 Jan;28 Suppl 1:S67-79. doi: 10.1038/modpathol.2014.129. PMID: 25560600

Mucinous neoplasms of the appendix: a current comprehensive clinicopathologic and imaging review.

Tirumani SH, Fraser-Hill M, Auer R, Shabana W, Walsh C, Lee F, Ryan JG
Cancer Imaging 2013 Feb 22;13(1):14-25. doi: 10.1102/1470-7330.2013.0003. PMID: 23439060 Free PMC Article

See all (91)

Clinical prediction guides

Controversies in appendiceal pathology: mucinous and goblet cell neoplasms.

Orr CE, Yantiss RK
Pathology 2022 Mar;54(2):167-176. Epub 2021 Nov 23 doi: 10.1016/j.pathol.2021.09.003. PMID: 34836648

Long-term Results of Low Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Analysis of 24 Patients.

Gok M, Topal U, Akyüz M, Öz AB, Sozuer E, Deniz K
Arch Iran Med 2021 Aug 1;24(8):615-621. doi: 10.34172/aim.2021.87. PMID: 34488329

A retrospective analysis and literature review of neoplastic appendiceal mucinous lesions.

Matias-García B, Mendoza-Moreno F, Blasco-Martínez A, Busteros-Moraza JI, Diez-Alonso M, Garcia-Moreno Nisa F
BMC Surg 2021 Feb 11;21(1):79. doi: 10.1186/s12893-021-01091-9. PMID: 33573654 Free PMC Article

Low-Grade Appendiceal Mucinous Neoplasms: A Single Institution Experience of 64 Cases With Clinical Follow-up and Correlation With the Current (Eighth Edition) AJCC Staging.

Wong M, Barrows B, Gangi A, Kim S, Mertens RB, Dhall D
Int J Surg Pathol 2020 May;28(3):252-258. Epub 2019 Oct 24 doi: 10.1177/1066896919883679. PMID: 31645160

Low-grade appendiceal mucinous neoplasms confined to the appendix: clinical manifestations and CT findings.

Yu XR, Mao J, Tang W, Meng XY, Tian Y, Du ZL
J Investig Med 2020 Jan;68(1):75-81. Epub 2019 Jul 11 doi: 10.1136/jim-2018-000975. PMID: 31300469 Free PMC Article

See all (58)

Recent systematic reviews

Efficacy and safety in the use of intraperitoneal hyperthermia chemotherapy and peritoneal cytoreductive surgery for pseudomyxoma peritonei from appendiceal neoplasm: A systematic review.

Floriano I, Silvinato A, Reis JC, Cafalli C, Bernardo WM
Clinics (Sao Paulo) 2022;77:100039. Epub 2022 May 13 doi: 10.1016/j.clinsp.2022.100039. PMID: 35576869 Free PMC Article

Defining stage in mucinous tumours of the appendix with peritoneal dissemination: the importance of grading terminology: systematic review.

Martín-Román L, Lozano P, Vásquez W, Palencia N, Gómez Y, Fernández-Aceñero MJ, González-Bayón L
BJS Open 2021 Jul 6;5(4) doi: 10.1093/bjsopen/zrab059. PMID: 34355239 Free PMC Article

Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.

Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358

See all (3)

MedGen

National Center for Biotechnology Information

Send to:

Low Grade Appendix Mucinous Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity