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Cardiac Inflammatory Myofibroblastic Tumor

MedGen UID:
317490
•Concept ID:
C1707299
•
Neoplastic Process
Synonym: Heart Inflammatory Myofibroblastic Tumor

Definition

An intermediate fibroblastic neoplasm arising from the heart. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiac Inflammatory Myofibroblastic Tumor

Recent clinical studies

Etiology

Cardiac inflammatory myofibroblastic tumor: a "benign" neoplasm that may result in syncope, myocardial infarction, and sudden death.
Burke A, Li L, Kling E, Kutys R, Virmani R, Miettinen M
Am J Surg Pathol 2007 Jul;31(7):1115-22. doi: 10.1097/PAS.0b013e31802d68ff. PMID: 17592279

Diagnosis

A forensic autopsy case: Sudden unexpected death due to cardiac inflammatory myofibroblastic tumor.
Suzuki S, Ohtani M, Matsuo Y, Yoshida M, Goto A, Fukuda M, Mimasaka S
Leg Med (Tokyo) 2021 Nov;53:101931. Epub 2021 Jun 12 doi: 10.1016/j.legalmed.2021.101931. PMID: 34147823
Cardiac Inflammatory Myofibroblastic Tumor Causing Pulmonary Artery Obstruction: A Rare Case Report.
Yildiz K, Genc HZ, Kir M, Unal N, Oto O, Paytoncu S, Yuzuguldu RI, Ozer E
J Pediatr Hematol Oncol 2021 Oct 1;43(7):e903-e906. doi: 10.1097/MPH.0000000000002000. PMID: 33273411
Cardiac Inflammatory Myofibroblastic Tumor.
D'Angelo T, Mazziotti S, Inserra MC, De Luca F, Agati S, Magliolo E, Pathan F, Blandino A, Romeo P
Circ Cardiovasc Imaging 2019 Sep;12(9):e009443. Epub 2019 Sep 10 doi: 10.1161/CIRCIMAGING.119.009443. PMID: 31500449Free PMC Article
A rare cardiac inflammatory myofibroblastic tumor involving aortic valve.
Luo W, Teng P, Ni Y
J Cardiothorac Surg 2017 Mar 2;12(1):13. doi: 10.1186/s13019-017-0577-5. PMID: 28253894Free PMC Article
Cardiac inflammatory myofibroblastic tumor: a comprehensive review of the literature.
Eilers AL, Nazarullah AN, Shipper ES, Jagirdar JS, Calhoon JH, Husain SA
World J Pediatr Congenit Heart Surg 2014 Oct;5(4):556-64. doi: 10.1177/2150135114546203. PMID: 25324254

Therapy

Neonatal tuberculosis and cardiac inflammatory myofibroblastic tumor.
Banque MN, Ribu RO, Policarpio MT
Asian Cardiovasc Thorac Ann 2013 Apr;21(2):218-21. doi: 10.1177/0218492312451982. PMID: 24532627

Prognosis

Gastric and cardiac inflammatory myofibroblastic tumor: an extremely rare case.
Huang Y, Zhang M, Li Q, Huang Q
J Cardiothorac Surg 2024 Jan 29;19(1):31. doi: 10.1186/s13019-024-02481-9. PMID: 38287440Free PMC Article
Cardiac Inflammatory Myofibroblastic Tumor Causing Pulmonary Artery Obstruction: A Rare Case Report.
Yildiz K, Genc HZ, Kir M, Unal N, Oto O, Paytoncu S, Yuzuguldu RI, Ozer E
J Pediatr Hematol Oncol 2021 Oct 1;43(7):e903-e906. doi: 10.1097/MPH.0000000000002000. PMID: 33273411
A rare cardiac inflammatory myofibroblastic tumor involving aortic valve.
Luo W, Teng P, Ni Y
J Cardiothorac Surg 2017 Mar 2;12(1):13. doi: 10.1186/s13019-017-0577-5. PMID: 28253894Free PMC Article
Cardiac inflammatory myofibroblastic tumor: a comprehensive review of the literature.
Eilers AL, Nazarullah AN, Shipper ES, Jagirdar JS, Calhoon JH, Husain SA
World J Pediatr Congenit Heart Surg 2014 Oct;5(4):556-64. doi: 10.1177/2150135114546203. PMID: 25324254
Inflammatory myofibroblastic tumor of the aortic valves causing sudden cardiac death: a case report and review of the literature.
Xu B, Fraser RS, Renaud C, Youssef S, Gottesman RD, Bernard C
Pediatr Dev Pathol 2014 May-Jun;17(3):231-9. Epub 2014 Mar 20 doi: 10.2350/13-12-1414-CR.1. PMID: 24649800

Clinical prediction guides

Gastric and cardiac inflammatory myofibroblastic tumor: an extremely rare case.
Huang Y, Zhang M, Li Q, Huang Q
J Cardiothorac Surg 2024 Jan 29;19(1):31. doi: 10.1186/s13019-024-02481-9. PMID: 38287440Free PMC Article
A forensic autopsy case: Sudden unexpected death due to cardiac inflammatory myofibroblastic tumor.
Suzuki S, Ohtani M, Matsuo Y, Yoshida M, Goto A, Fukuda M, Mimasaka S
Leg Med (Tokyo) 2021 Nov;53:101931. Epub 2021 Jun 12 doi: 10.1016/j.legalmed.2021.101931. PMID: 34147823

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