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Appendix Mixed Adenoneuroendocrine Carcinoma

MedGen UID:
317381
•Concept ID:
C1706831
•
Neoplastic Process
Synonyms: Appendix MANEC; Appendix Mixed Endocrine-Exocrine Neoplasm

Definition

A carcinoma that arises from the appendix. It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix Mixed Adenoneuroendocrine Carcinoma

Professional guidelines

PubMed

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article

Recent clinical studies

Etiology

Mixed adenoneuroendocrine carcinoma originating from the appendix and colorectum: a comparative analysis of a large population-based database.
Zhao B, Wang J, Ye H, Cheng X, Meng K, Yang T
Tech Coloproctol 2023 Nov;27(11):1017-1024. Epub 2023 Mar 30 doi: 10.1007/s10151-023-02786-2. PMID: 36995458
The other colon cancer: a population-based cohort study of appendix tumour trends and prognosis.
Halfter K, Schubert-Fritschle G, Klauschen F, Werner J, Mayerle J, Weichert W, Friess H, Schmid R, Kremer M, Ruppert R, Hoelzl J, Krenz D, Nerlich A, Agha A, Fuchs M, Becker I, Nowak K, Engel J, Schlesinger-Raab A
Colorectal Dis 2023 May;25(5):943-953. Epub 2023 Feb 20 doi: 10.1111/codi.16510. PMID: 36748436
Goblet cell tumors of the appendix: A review.
Sinno SAJ, Jurdi NMH
Ann Diagn Pathol 2019 Dec;43:151401. Epub 2019 Aug 21 doi: 10.1016/j.anndiagpath.2019.151401. PMID: 31675676
Mixed Adeno-neuroendocrine Carcinoma: An Aggressive Clinical Entity.
Brathwaite S, Rock J, Yearsley MM, Bekaii-Saab T, Wei L, Frankel WL, Hays J, Wu C, Abdel-Misih S
Ann Surg Oncol 2016 Jul;23(7):2281-6. Epub 2016 Mar 10 doi: 10.1245/s10434-016-5179-2. PMID: 26965701Free PMC Article
Gastroenteropancreatic neuroendocrine neoplasms: a 10-year experience of a single center.
Lewkowicz E, Trofimiuk-Müldner M, Wysocka K, Pach D, Kiełtyka A, Stefańska A, Sowa-Staszczak A, Tomaszewska R, Hubalewska-Dydejczyk A
Pol Arch Med Wewn 2015;125(5):337-46. Epub 2015 Apr 29 doi: 10.20452/pamw.2832. PMID: 25924181

Diagnosis

Mixed adenoneuroendocrine carcinoma originating from the appendix and colorectum: a comparative analysis of a large population-based database.
Zhao B, Wang J, Ye H, Cheng X, Meng K, Yang T
Tech Coloproctol 2023 Nov;27(11):1017-1024. Epub 2023 Mar 30 doi: 10.1007/s10151-023-02786-2. PMID: 36995458
Mixed adenoneuroendocrine carcinoma (MANEC) of the lower gastrointestinal tract: A systematic review with Bayesian hierarchical survival analysis.
Grossi U, Bonis A, Carrington EV, Mazzobel E, Santoro GA, Cattaneo L, Centonze G, Gallo G, Kazemi Nava A, Romano M, Di Tanna GL, Zanus G
Eur J Surg Oncol 2021 Nov;47(11):2893-2899. Epub 2021 May 14 doi: 10.1016/j.ejso.2021.05.021. PMID: 34052038
Goblet cell tumors of the appendix: A review.
Sinno SAJ, Jurdi NMH
Ann Diagn Pathol 2019 Dec;43:151401. Epub 2019 Aug 21 doi: 10.1016/j.anndiagpath.2019.151401. PMID: 31675676
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature.
Romeo M, Quer A, Tarrats A, Molina C, Radua J, Manzano JL
World J Surg Oncol 2015 Nov 26;13:325. doi: 10.1186/s12957-015-0740-1. PMID: 26612593Free PMC Article

Therapy

Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Prognosis

Mixed adenoneuroendocrine carcinoma originating from the appendix and colorectum: a comparative analysis of a large population-based database.
Zhao B, Wang J, Ye H, Cheng X, Meng K, Yang T
Tech Coloproctol 2023 Nov;27(11):1017-1024. Epub 2023 Mar 30 doi: 10.1007/s10151-023-02786-2. PMID: 36995458
Goblet cell tumors of the appendix: A review.
Sinno SAJ, Jurdi NMH
Ann Diagn Pathol 2019 Dec;43:151401. Epub 2019 Aug 21 doi: 10.1016/j.anndiagpath.2019.151401. PMID: 31675676
Neuroendocrine, goblet cell and mixed adeno-neuroendocrine tumours of the appendix: updates, clinical applications and the future.
Clift AK, Frilling A
Expert Rev Gastroenterol Hepatol 2017 Mar;11(3):237-247. Epub 2017 Jan 20 doi: 10.1080/17474124.2017.1282314. PMID: 28081662
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature.
Romeo M, Quer A, Tarrats A, Molina C, Radua J, Manzano JL
World J Surg Oncol 2015 Nov 26;13:325. doi: 10.1186/s12957-015-0740-1. PMID: 26612593Free PMC Article

Clinical prediction guides

Mixed adenoneuroendocrine carcinoma originating from the appendix and colorectum: a comparative analysis of a large population-based database.
Zhao B, Wang J, Ye H, Cheng X, Meng K, Yang T
Tech Coloproctol 2023 Nov;27(11):1017-1024. Epub 2023 Mar 30 doi: 10.1007/s10151-023-02786-2. PMID: 36995458
The other colon cancer: a population-based cohort study of appendix tumour trends and prognosis.
Halfter K, Schubert-Fritschle G, Klauschen F, Werner J, Mayerle J, Weichert W, Friess H, Schmid R, Kremer M, Ruppert R, Hoelzl J, Krenz D, Nerlich A, Agha A, Fuchs M, Becker I, Nowak K, Engel J, Schlesinger-Raab A
Colorectal Dis 2023 May;25(5):943-953. Epub 2023 Feb 20 doi: 10.1111/codi.16510. PMID: 36748436
Appendiceal goblet cell carcinoid: common errors in staging and clinical interpretation with a proposal for an improved terminology.
Wen KW, Hale G, Shafizadeh N, Hosseini M, Huang A, Kakar S
Hum Pathol 2017 Jul;65:187-193. Epub 2017 May 24 doi: 10.1016/j.humpath.2017.05.012. PMID: 28551326
Neuroendocrine, goblet cell and mixed adeno-neuroendocrine tumours of the appendix: updates, clinical applications and the future.
Clift AK, Frilling A
Expert Rev Gastroenterol Hepatol 2017 Mar;11(3):237-247. Epub 2017 Jan 20 doi: 10.1080/17474124.2017.1282314. PMID: 28081662
Simplified 2-tier histologic grading system accurately predicts outcomes in goblet cell carcinoid of the appendix.
Lee LH, McConnell YJ, Tsang E, Zerhouni S, Speers C, Kennecke H, Schaeffer DF
Hum Pathol 2015 Dec;46(12):1881-9. Epub 2015 Aug 22 doi: 10.1016/j.humpath.2015.08.005. PMID: 26433702

Recent systematic reviews

Mixed adenoneuroendocrine carcinoma (MANEC) of the lower gastrointestinal tract: A systematic review with Bayesian hierarchical survival analysis.
Grossi U, Bonis A, Carrington EV, Mazzobel E, Santoro GA, Cattaneo L, Centonze G, Gallo G, Kazemi Nava A, Romano M, Di Tanna GL, Zanus G
Eur J Surg Oncol 2021 Nov;47(11):2893-2899. Epub 2021 May 14 doi: 10.1016/j.ejso.2021.05.021. PMID: 34052038
Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article

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