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Squamous cell carcinoma of the small intestine

MedGen UID:
313711
•Concept ID:
C1710111
•
Neoplastic Process
Synonyms: small intestinal squamous cell cancer; Small Intestinal Squamous Cell Carcinoma; small intestinal squamous cell carcinoma; small intestine squamous cell carcinoma; Squamous cell carcinoma of the small bowel; squamous cell carcinoma of the small bowel; squamous cell carcinoma of the small intestine
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018509
Orphanet: ORPHA423968

Definition

Squamous cell carcinoma of the small intestine is an extremely rare, malignant, epithelial tumor of the small intestine (most often localized in the duodenum). Presenting symptoms are often nonspecific, such as weight loss, epigastric pain, anorexia, weakness, fatigue, vomiting and abdominal distension, and vary depending on localization of the tumor. Gastrointestinal bleeding and perforation may occur in advanced cases. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous cell carcinoma of the small intestine

Professional guidelines

PubMed

Cervical cancer treated with reduced-volume intensity-modulated radiation therapy base on Sedlis criteria (NCCN VS RTOG).
Luo HC, Lin GS, Liao SG, Wang FM, Cheng HH, Feng J, Yin Q, Chen QH, Zhu JF, Xu JF, Wang D, Fu ZC
Br J Radiol 2018 Jan;91(1081):20170398. Epub 2017 Dec 5 doi: 10.1259/bjr.20170398. PMID: 29072851Free PMC Article
Surgical management of small bowel metastases from primary carcinoma of the lung.
Nishizawa Y, Kobayashi A, Saito N, Nagai K, Sugito M, Ito M, Nishizawa Y
Surg Today 2012 Feb;42(3):233-7. Epub 2011 Nov 3 doi: 10.1007/s00595-011-0005-8. PMID: 22045233
Surgical treatment and clinical course of patients with hypopharyngeal carcinoma.
Pesko P, Sabljak P, Bjelovic M, Stojakov D, Simic A, Nenadic B, Bumbasirevic M, Trajkovic G, Djukic V
Dis Esophagus 2006;19(4):248-53. doi: 10.1111/j.1442-2050.2006.00585.x. PMID: 16866855

Recent clinical studies

Etiology

Adeno-squamous and squamous cell carcinoma of the gallbladder: The importance of histology in surgical management.
Leigh N, Solomon D, Pletcher E, Sullivan B, Sarpel U, Labow DM, Magge DR, Golas BJ
Am J Surg 2020 Nov;220(5):1242-1248. Epub 2020 Jul 1 doi: 10.1016/j.amjsurg.2020.06.050. PMID: 32646581
Supraclavicular and celiac metastases in squamous cell carcinoma of the middle thoracic esophagus.
Okamura A, Watanabe M, Kozuki R, Toihata T, Yuda M, Imamura Y, Mine S
Langenbecks Arch Surg 2018 Dec;403(8):977-984. Epub 2018 Oct 25 doi: 10.1007/s00423-018-1722-x. PMID: 30361828
Surgical management of small bowel metastases from primary carcinoma of the lung.
Nishizawa Y, Kobayashi A, Saito N, Nagai K, Sugito M, Ito M, Nishizawa Y
Surg Today 2012 Feb;42(3):233-7. Epub 2011 Nov 3 doi: 10.1007/s00595-011-0005-8. PMID: 22045233
Field defects in progression to gastrointestinal tract cancers.
Bernstein C, Bernstein H, Payne CM, Dvorak K, Garewal H
Cancer Lett 2008 Feb 18;260(1-2):1-10. Epub 2007 Dec 31 doi: 10.1016/j.canlet.2007.11.027. PMID: 18164807Free PMC Article
Carcinoma of the pancreas.
Andersson A, Bergdahl L
Am Surg 1976 Mar;42(3):173-7. PMID: 1259248

Diagnosis

Primary Pure Duodenal Squamous Cell Carcinoma.
McCabe P, Rabkin J, Goyal B
Clin Gastroenterol Hepatol 2021 May;19(5):e48. Epub 2020 Mar 19 doi: 10.1016/j.cgh.2020.03.029. PMID: 32200081
Utilizing artificial intelligence in endoscopy: a clinician's guide.
Namikawa K, Hirasawa T, Yoshio T, Fujisaki J, Ozawa T, Ishihara S, Aoki T, Yamada A, Koike K, Suzuki H, Tada T
Expert Rev Gastroenterol Hepatol 2020 Aug;14(8):689-706. Epub 2020 Jun 17 doi: 10.1080/17474124.2020.1779058. PMID: 32500760
Lymphoepithelioma-like carcinoma of the duodenum: a very infrequent tumor.
Chaparro Mirete M, López-López V, Robles Campos R
Rev Esp Enferm Dig 2020 Mar;112(3):239. doi: 10.17235/reed.2020.6503/2019. PMID: 32022569
A case of lung squamous cell carcinoma with metastases to the duodenum and small intestine.
Yamada H, Akahane T, Horiuchi A, Shimada R, Shibuya H, Hayama T, Nozawa K, Ishihara S, Matsuda K, Watanabe T
Int Surg 2011 Apr-Jun;96(2):176-81. doi: 10.9738/1380.1. PMID: 22026313
Gastrointestinal cancer.
Thomas RM, Sobin LH
Cancer 1995 Jan 1;75(1 Suppl):154-70. doi: 10.1002/1097-0142(19950101)75:1+<154::aid-cncr2820751305>3.0.co;2-z. PMID: 8000994

Therapy

Risk of Cancer in Inflammatory Bowel Diseases: Umbrella Review and Reanalysis of Meta-analyses.
Piovani D, Hassan C, Repici A, Rimassa L, Carlo-Stella C, Nikolopoulos GK, Riboli E, Bonovas S
Gastroenterology 2022 Sep;163(3):671-684. Epub 2022 May 26 doi: 10.1053/j.gastro.2022.05.038. PMID: 35643170
Metachronous primary cancer of the tongue and malignant lymphoma of the small intestine: A case report.
Sugimoto K, Uejima S, Uchiyama Y, Yasue R, Nambu K, Ishikawa J, Koma Y, Akita T, Toh T, Fujimoto T
Medicine (Baltimore) 2021 Feb 19;100(7):e24806. doi: 10.1097/MD.0000000000024806. PMID: 33607843Free PMC Article
Small bowel obstruction after transoral robotic surgery.
McClellan J, Achim V, Clayburgh D
Head Neck 2018 Jan;40(1):E9-E12. Epub 2017 Nov 9 doi: 10.1002/hed.24989. PMID: 29120518
Surgical management of carcinoma of the cervical esophagus.
Daiko H, Hayashi R, Saikawa M, Sakuraba M, Yamazaki M, Miyazaki M, Ugumori T, Asai M, Oyama W, Ebihara S
J Surg Oncol 2007 Aug 1;96(2):166-72. doi: 10.1002/jso.20795. PMID: 17443746
The morbidity and utility of periaortic radiotherapy in cervical carcinoma.
Potish R, Adcock L, Jones T Jr, Levitt S, Prem K, Savage J, Twiggs L
Gynecol Oncol 1983 Feb;15(1):1-9. doi: 10.1016/0090-8258(83)90110-5. PMID: 6822360

Prognosis

Primary Squamous Cell Carcinoma of the Small Intestine: Pathogenesis and Clinical Features.
Wang FD, Wang ZW, Xue HD, Wu HW, Zhang Y, Yu JC, Jin ZY
Chin Med J (Engl) 2016 Sep 5;129(17):2131-3. doi: 10.4103/0366-6999.189067. PMID: 27569244Free PMC Article
Surgical management of small bowel metastases from primary carcinoma of the lung.
Nishizawa Y, Kobayashi A, Saito N, Nagai K, Sugito M, Ito M, Nishizawa Y
Surg Today 2012 Feb;42(3):233-7. Epub 2011 Nov 3 doi: 10.1007/s00595-011-0005-8. PMID: 22045233
Comprehensive review of small bowel metastasis from head and neck squamous cell carcinoma.
Dwivedi RC, Kazi R, Agrawal N, Chisholm E, St Rose S, Elmiyeh B, Rennie C, Pepper C, Clarke PM, Kerawala CJ, Rhys-Evans PH, Harrington KJ, Nutting CM
Oral Oncol 2010 May;46(5):330-5. Epub 2010 Feb 26 doi: 10.1016/j.oraloncology.2010.01.013. PMID: 20189444
Gastrointestinal cancer.
Thomas RM, Sobin LH
Cancer 1995 Jan 1;75(1 Suppl):154-70. doi: 10.1002/1097-0142(19950101)75:1+<154::aid-cncr2820751305>3.0.co;2-z. PMID: 8000994
Leiomyosarcoma of the gastro-intestinal tract: general pattern of metastasis and recurrence.
Lee YT
Cancer Treat Rev 1983 Jun;10(2):91-101. doi: 10.1016/0305-7372(83)90007-5. PMID: 6347377

Clinical prediction guides

Supraclavicular and celiac metastases in squamous cell carcinoma of the middle thoracic esophagus.
Okamura A, Watanabe M, Kozuki R, Toihata T, Yuda M, Imamura Y, Mine S
Langenbecks Arch Surg 2018 Dec;403(8):977-984. Epub 2018 Oct 25 doi: 10.1007/s00423-018-1722-x. PMID: 30361828
Adenosquamous carcinoma of the ampulla of Vater: a case report and literature review.
Hoshimoto S, Aiura K, Shito M, Kakefuda T, Sugiura H
World J Surg Oncol 2015 Sep 29;13:287. doi: 10.1186/s12957-015-0709-0. PMID: 26420726Free PMC Article
Lymphadenopathy in the mesenteric pedicle of the free jejunal flap: reactive lymphadenopathy, not metastatic.
Makimoto Y, Yamamoto S, Takano H, Motoori K, Ueda T, Kaneoya K, Shimofusa R, Uno T, Ito H, Okamoto Y
J Comput Assist Tomogr 2006 Jan-Feb;30(1):65-7. doi: 10.1097/01.rct.0000177606.90817.cb. PMID: 16365575
Cancer risk in patients with inflammatory bowel disease.
Lewis JD, Deren JJ, Lichtenstein GR
Gastroenterol Clin North Am 1999 Jun;28(2):459-77, x. doi: 10.1016/s0889-8553(05)70065-0. PMID: 10372277
Postoperative function of "free" jejunal transplants for replacement of the cervical esophagus.
Meyers WC, Seigler HF, Hanks JB, Thompson WM, Postlethwait R, Jones RS, Akwari OK, Cole TB
Ann Surg 1980;192(4):439-50. doi: 10.1097/00000658-198010000-00002. PMID: 6158920Free PMC Article

Recent systematic reviews

Risk of Cancer in Inflammatory Bowel Diseases: Umbrella Review and Reanalysis of Meta-analyses.
Piovani D, Hassan C, Repici A, Rimassa L, Carlo-Stella C, Nikolopoulos GK, Riboli E, Bonovas S
Gastroenterology 2022 Sep;163(3):671-684. Epub 2022 May 26 doi: 10.1053/j.gastro.2022.05.038. PMID: 35643170
Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: A systematic review of case reports. Casualty or causality?
Parra-Medina R, Moreno-Lucero P, Jimenez-Moreno J, Parra-Morales AM, Romero-Rojas A
PLoS One 2019;14(5):e0216647. Epub 2019 May 14 doi: 10.1371/journal.pone.0216647. PMID: 31086397Free PMC Article

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