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Mediastinal Myeloid Sarcoma

MedGen UID:
313418
•Concept ID:
C1708956
•
Neoplastic Process

Definition

A mass-forming malignant neoplasm that arises from the mediastinum and is characterized by the proliferation of myeloblasts or immature myeloid cells. It may present in association with or precede acute myeloid leukemia, or it may be the first manifestation of relapse of acute myeloid leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal Myeloid Sarcoma

Recent clinical studies

Etiology

Successful nelarabine and venetoclax treatment of a relapsed/refractory mediastinal myeloid sarcoma with clonal TCR rearrangement.
Contejean A, Palmic P, Kosmider O, Belhadj M, Willems L, Lengliné E, Suarez F, Damotte D, Cottereau AS, Asnafi V, Bouscary D, Burroni B
Anticancer Drugs 2021 Nov 1;32(10):1118-1122. doi: 10.1097/CAD.0000000000001105. PMID: 34145177
Hematologic Malignancies Associated With Mediastinal Germ Cell Tumors: 10 Years' Experience at Thailand's National Pediatric Tertiary Referral Center.
Sowithayasakul P, Sinlapamongkolkul P, Treetipsatit J, Vathana N, Narkbunnam N, Sanpakit K, Buaboonnam J
J Pediatr Hematol Oncol 2018 Aug;40(6):450-455. doi: 10.1097/MPH.0000000000001233. PMID: 29864110
Acute myeloid leukaemia presenting with mediastinal myeloid sarcoma: report of three cases and review of literature.
Ramasamy K, Lim Z, Pagliuca A, Devereux S, Ho AY, Mufti GJ
Leuk Lymphoma 2007 Feb;48(2):290-4. doi: 10.1080/10428190601059803. PMID: 17325888

Diagnosis

Isolated Myeloid Sarcoma and Intracardiac Thrombus Resulting in Superior Mediastinal Syndrome.
Roy PS, Vohra V, Jain R, Singhal KK, Mahajan S, Chatterjee D, Saxena AK, Rohilla M, Bansal D
Indian J Pediatr 2022 Jun;89(6):591-593. Epub 2022 Jan 29 doi: 10.1007/s12098-021-04056-1. PMID: 35092581
Isolated Mediastinal Myeloid Sarcoma after NPM1-Positive Pediatric Acute Myeloid Leukemia.
Tüfekçi Ö, Yılmaz Ş, Erdem M, Baysal B, Ören H
Turk J Haematol 2019 Nov 18;36(4):285-286. Epub 2019 Mar 12 doi: 10.4274/tjh.galenos.2019.2018.0434. PMID: 30859798Free PMC Article
Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion Gene.
Naesens L, Devos H, Nollet F, Michaux L, Selleslag D
Acta Haematol 2018;140(2):97-104. Epub 2018 Sep 18 doi: 10.1159/000491596. PMID: 30227397
Isolated mediastinal myeloid sarcoma successfully treated with chemoradiotherapy followed by unrelated allogeneic stem cell transplantation.
Lee JM, Song HN, Kang Y, Kim H, Min JH, Suh YS, Ahn JH, Lee SH, Jo YW, Cheon YH, Kim MJ, Lee GW
Intern Med 2011;50(24):3003-7. Epub 2011 Dec 15 doi: 10.2169/internalmedicine.50.6125. PMID: 22185993
Acute myeloid leukaemia presenting with mediastinal myeloid sarcoma: report of three cases and review of literature.
Ramasamy K, Lim Z, Pagliuca A, Devereux S, Ho AY, Mufti GJ
Leuk Lymphoma 2007 Feb;48(2):290-4. doi: 10.1080/10428190601059803. PMID: 17325888

Therapy

Successful nelarabine and venetoclax treatment of a relapsed/refractory mediastinal myeloid sarcoma with clonal TCR rearrangement.
Contejean A, Palmic P, Kosmider O, Belhadj M, Willems L, Lengliné E, Suarez F, Damotte D, Cottereau AS, Asnafi V, Bouscary D, Burroni B
Anticancer Drugs 2021 Nov 1;32(10):1118-1122. doi: 10.1097/CAD.0000000000001105. PMID: 34145177
Acute myeloid leukemia with mediastinal myeloid sarcoma refractory to acute myeloid leukemia therapy but responsive to L-asparaginase.
Takahashi H, Koh K, Kato M, Kishimoto H, Oguma E, Hanada R
Int J Hematol 2012 Jul;96(1):136-40. Epub 2012 May 29 doi: 10.1007/s12185-012-1111-0. PMID: 22644614

Prognosis

Successful nelarabine and venetoclax treatment of a relapsed/refractory mediastinal myeloid sarcoma with clonal TCR rearrangement.
Contejean A, Palmic P, Kosmider O, Belhadj M, Willems L, Lengliné E, Suarez F, Damotte D, Cottereau AS, Asnafi V, Bouscary D, Burroni B
Anticancer Drugs 2021 Nov 1;32(10):1118-1122. doi: 10.1097/CAD.0000000000001105. PMID: 34145177
Acute myeloid leukemia with mediastinal myeloid sarcoma refractory to acute myeloid leukemia therapy but responsive to L-asparaginase.
Takahashi H, Koh K, Kato M, Kishimoto H, Oguma E, Hanada R
Int J Hematol 2012 Jul;96(1):136-40. Epub 2012 May 29 doi: 10.1007/s12185-012-1111-0. PMID: 22644614
Acute myeloid leukaemia presenting with mediastinal myeloid sarcoma: report of three cases and review of literature.
Ramasamy K, Lim Z, Pagliuca A, Devereux S, Ho AY, Mufti GJ
Leuk Lymphoma 2007 Feb;48(2):290-4. doi: 10.1080/10428190601059803. PMID: 17325888

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