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Androgen-Producing Adrenal Cortical Adenoma

MedGen UID:
312896
•Concept ID:
C1706810
•
Neoplastic Process
Synonyms: Androgen Producing Adrenal Cortex Adenoma; Androgen Producing Adrenal Cortical Adenoma; Androgen-Producing Adrenal Cortex Adenoma; Androgen-Producing Adrenal Gland Adenoma

Definition

A rare adenoma of the adrenal cortex that produces androgens. Female patients usually have symptoms related to virilism. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAndrogen-Producing Adrenal Cortical Adenoma

Recent clinical studies

Etiology

PURE ANDROGEN-PRODUCING ADRENAL TUMOR: CLINICAL FEATURES AND PATHOGENESIS.
Tong A, Jiang J, Wang F, Li C, Zhang Y, Wu X
Endocr Pract 2017 Apr 2;23(4):399-407. Epub 2017 Jan 17 doi: 10.4158/EP161580.OR. PMID: 28095038
Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens.
Kamenicky P, Houdoin L, Ferlicot S, Salenave S, Brailly S, Droupy S, Meduri G, Sasano H, Suzuki T, Young J, Chanson P
Clin Endocrinol (Oxf) 2007 Jun;66(6):778-88. Epub 2007 Apr 4 doi: 10.1111/j.1365-2265.2007.02810.x. PMID: 17408424
Androgen-secreting adrenal tumors.
Cordera F, Grant C, van Heerden J, Thompson G, Young W
Surgery 2003 Dec;134(6):874-80; discussion 880. doi: 10.1016/s0039-6060(03)00410-0. PMID: 14668717

Diagnosis

Immunoassay interferences: laboratory pitfall in the diagnosis of adrenocortical carcinoma.
Martins Ferreira M, Moreno C, Oliveira P, Paiva I
BMJ Case Rep 2024 Feb 10;17(2) doi: 10.1136/bcr-2023-257320. PMID: 38341198Free PMC Article
A rare case of pure testosterone-secreting adrenal adenoma in a postmenopausal elderly woman.
Zhou WB, Chen N, Li CJ
BMC Endocr Disord 2019 Jan 23;19(1):14. doi: 10.1186/s12902-019-0342-y. PMID: 30674304Free PMC Article
A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.
Sakaguchi C, Ashida K, Kohashi K, Ohe K, Fujii Y, Yano S, Matsuda Y, Sakamoto S, Sakamoto R, Oda Y, Nomura M, Ogawa Y
BMC Endocr Disord 2019 Jan 22;19(1):13. doi: 10.1186/s12902-019-0345-8. PMID: 30670014Free PMC Article
PURE ANDROGEN-PRODUCING ADRENAL TUMOR: CLINICAL FEATURES AND PATHOGENESIS.
Tong A, Jiang J, Wang F, Li C, Zhang Y, Wu X
Endocr Pract 2017 Apr 2;23(4):399-407. Epub 2017 Jan 17 doi: 10.4158/EP161580.OR. PMID: 28095038
Androgen-secreting adrenal tumors.
Cordera F, Grant C, van Heerden J, Thompson G, Young W
Surgery 2003 Dec;134(6):874-80; discussion 880. doi: 10.1016/s0039-6060(03)00410-0. PMID: 14668717

Therapy

A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.
Sakaguchi C, Ashida K, Kohashi K, Ohe K, Fujii Y, Yano S, Matsuda Y, Sakamoto S, Sakamoto R, Oda Y, Nomura M, Ogawa Y
BMC Endocr Disord 2019 Jan 22;19(1):13. doi: 10.1186/s12902-019-0345-8. PMID: 30670014Free PMC Article
Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens.
Kamenicky P, Houdoin L, Ferlicot S, Salenave S, Brailly S, Droupy S, Meduri G, Sasano H, Suzuki T, Young J, Chanson P
Clin Endocrinol (Oxf) 2007 Jun;66(6):778-88. Epub 2007 Apr 4 doi: 10.1111/j.1365-2265.2007.02810.x. PMID: 17408424

Prognosis

A rare case of pure testosterone-secreting adrenal adenoma in a postmenopausal elderly woman.
Zhou WB, Chen N, Li CJ
BMC Endocr Disord 2019 Jan 23;19(1):14. doi: 10.1186/s12902-019-0342-y. PMID: 30674304Free PMC Article
A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.
Sakaguchi C, Ashida K, Kohashi K, Ohe K, Fujii Y, Yano S, Matsuda Y, Sakamoto S, Sakamoto R, Oda Y, Nomura M, Ogawa Y
BMC Endocr Disord 2019 Jan 22;19(1):13. doi: 10.1186/s12902-019-0345-8. PMID: 30670014Free PMC Article
Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens.
Kamenicky P, Houdoin L, Ferlicot S, Salenave S, Brailly S, Droupy S, Meduri G, Sasano H, Suzuki T, Young J, Chanson P
Clin Endocrinol (Oxf) 2007 Jun;66(6):778-88. Epub 2007 Apr 4 doi: 10.1111/j.1365-2265.2007.02810.x. PMID: 17408424

Clinical prediction guides

Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Di Dalmazi G, Kisker C, Calebiro D, Mannelli M, Canu L, Arnaldi G, Quinkler M, Rayes N, Tabarin A, Laure Jullié M, Mantero F, Rubin B, Waldmann J, Bartsch DK, Pasquali R, Lohse M, Allolio B, Fassnacht M, Beuschlein F, Reincke M
J Clin Endocrinol Metab 2014 Oct;99(10):E2093-100. Epub 2014 Jul 24 doi: 10.1210/jc.2014-2152. PMID: 25057884
Androgen producing adrenocortical carcinoma.
Valente M, Pennelli N, Segato P, Bevilacqua L, Thiene G
Virchows Arch A Pathol Anat Histol 1978 Jun 2;378(2):91-103. doi: 10.1007/BF00432353. PMID: 208228

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