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Vaginal Mixed Epithelial and Mesenchymal Neoplasm

MedGen UID:
311446
•Concept ID:
C1519924
•
Neoplastic Process
Synonym: Vaginal Mixed Epithelial and Mesenchymal Tumor

Definition

A benign or malignant neoplasm that arises from the vagina and is characterized by the presence of epithelial and mesenchymal elements. This category includes benign mixed tumor, adenosarcoma, carcinosarcoma, and malignant mixed tumor resembling synovial sarcoma. [from NCI]

Professional guidelines

PubMed

Mixed tumors of the vagina: an immunohistochemical study of 13 cases with emphasis on the cell of origin and potential aid in differential diagnosis.
Oliva E, Gonzalez L, Dionigi A, Young RH
Mod Pathol 2004 Oct;17(10):1243-50. doi: 10.1038/modpathol.3800173. PMID: 15154010

Recent clinical studies

Etiology

Review literature on uterine carcinosarcoma.
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723
Synchronous uterine carcinosarcoma and contralateral breast cancer after tamoxifen therapy: a case report.
Shen L, Hong L, Zhang G, Mai R
Int J Clin Exp Pathol 2014;7(8):5295-301. Epub 2014 Jul 15 PMID: 25197413Free PMC Article
Mesonephric carcinosarcoma of the uterine cervix: a case report.
Lopez-Chardi L, González-Bosquet E, Rovira Zurriaga C, Laïlla Vicens JM
Eur J Gynaecol Oncol 2013;34(4):336-8. PMID: 24020142
Adenofibroma of the endometrium protruding into the vaginal cavity: findings on transvaginal ultrasonography, MRI and CT.
Konishi Y, Sato H, Fujimoto T, Tanaka H, Takahashi O, Tanaka T
J Obstet Gynaecol Res 2006 Dec;32(6):623-7. doi: 10.1111/j.1447-0756.2006.00467.x. PMID: 17100829
Benign mixed tumor of the vagina: case report with expanded immunohistochemical profile.
Murdoch F, Sharma R, Al-Nafussi A
Int J Gynecol Cancer 2003 Jul-Aug;13(4):543-7. doi: 10.1046/j.1525-1438.2003.13309.x. PMID: 12911736

Diagnosis

Two Components of Variant Profiles in Primary Vaginal Carcinosarcoma via Next-Generation Sequencing and a Literature Review.
Kotoku R, Yanazume S, Kuroda T, Kobayashi Y, Kitazono I, Akahane T, Tanimoto A, Kobayashi H
Int J Surg Pathol 2022 May;30(3):288-294. Epub 2021 Aug 31 doi: 10.1177/10668969211037915. PMID: 34463147
Benign mixed tumor of the vagina.
Song Y, Wu SG, Dong SN, Luo F, Liu KP
Eur J Gynaecol Oncol 2017;38(3):465-468. PMID: 29693894
Spindle Cell Epithelioma of the Vagina: Report of Two Cases, Literature Review, and New Immunohistochemical Markers.
Berdugo J, Gauthier P, Provencher D, Matte C, Piché J, Rahimi K
Int J Surg Pathol 2015 Dec;23(8):677-81. Epub 2015 May 20 doi: 10.1177/1066896915587920. PMID: 25998318
Review literature on uterine carcinosarcoma.
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723
Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature.
Tseng CE, Chen CH, Chen SJ, Chi CL
Int J Clin Exp Pathol 2014;7(3):1212-7. Epub 2014 Feb 15 PMID: 24696739Free PMC Article

Therapy

Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma.
Patnayak R, Rukmangadha N, Architha P, Reddy GS, Lakshmi AY, Kannan T, Jena A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):440-442. doi: 10.4103/IJPM.IJPM_1_18. PMID: 30004077
Synchronous uterine carcinosarcoma and contralateral breast cancer after tamoxifen therapy: a case report.
Shen L, Hong L, Zhang G, Mai R
Int J Clin Exp Pathol 2014;7(8):5295-301. Epub 2014 Jul 15 PMID: 25197413Free PMC Article

Prognosis

Review literature on uterine carcinosarcoma.
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723
Malignant mixed Müllerian tumor with an extensive squamous-cell carcinomatous component: a potential pitfall in liquid-based cervical cytology.
Bongiovanni M, Vitale VA, Grassi P, Mazzucchelli L
Acta Cytol 2014;58(4):413-8. Epub 2014 Jul 18 doi: 10.1159/000364851. PMID: 25059755
Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature.
Tseng CE, Chen CH, Chen SJ, Chi CL
Int J Clin Exp Pathol 2014;7(3):1212-7. Epub 2014 Feb 15 PMID: 24696739Free PMC Article
Mixed tumor of the vagina: sonographic and magnetic resonance imaging findings.
Laspas F, Roussakis A, Papadopoulos S, Fanariotis I, Kritikos N, Kehagias D
Ultrasound Obstet Gynecol 2010 May;35(5):617-9. doi: 10.1002/uog.7511. PMID: 20069660
Vaginal adenosarcoma arising from endometriosis.
Judson PL, Temple AM, Fowler WC Jr, Novotny DB, Funkhouser WK Jr
Gynecol Oncol 2000 Jan;76(1):123-5. doi: 10.1006/gyno.1999.5617. PMID: 10620454

Clinical prediction guides

Malignant mixed Müllerian tumor with an extensive squamous-cell carcinomatous component: a potential pitfall in liquid-based cervical cytology.
Bongiovanni M, Vitale VA, Grassi P, Mazzucchelli L
Acta Cytol 2014;58(4):413-8. Epub 2014 Jul 18 doi: 10.1159/000364851. PMID: 25059755

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