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Lung Spindle Cell Carcinoma

MedGen UID:
310951
•Concept ID:
C1708784
•
Neoplastic Process
Synonym: Spindle cell carcinoma of lung
SNOMED CT: Spindle cell carcinoma of lung (1255395009)

Definition

A morphologic variant of sarcomatoid carcinoma characterized by the presence of malignant spindle cells and focal lymphoplasmacytic infiltrates. Adenocarcinoma cells, malignant squamous cells, and giant cells are not present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Spindle Cell Carcinoma

Professional guidelines

PubMed

Oncogene-addicted metastatic non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Hendriks LE, Kerr KM, Menis J, Mok TS, Nestle U, Passaro A, Peters S, Planchard D, Smit EF, Solomon BJ, Veronesi G, Reck M; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2023 Apr;34(4):339-357. Epub 2023 Jan 23 doi: 10.1016/j.annonc.2022.12.009. PMID: 36872130
SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection.
Wang Q, Gümüş ZH, Colarossi C, Memeo L, Wang X, Kong CY, Boffetta P
J Thorac Oncol 2023 Jan;18(1):31-46. Epub 2022 Oct 12 doi: 10.1016/j.jtho.2022.10.002. PMID: 36243387Free PMC Article
Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment.
Duma N, Santana-Davila R, Molina JR
Mayo Clin Proc 2019 Aug;94(8):1623-1640. doi: 10.1016/j.mayocp.2019.01.013. PMID: 31378236

Recent clinical studies

Etiology

Clinicopathological characteristics and prognosis of pulmonary spindle cell carcinoma (PSCC): a population-based retrospective study.
Zhang J, Yan Y, Hui B, Bai S, Ma W, Ren J
Ann Palliat Med 2021 Apr;10(4):3793-3803. Epub 2021 Mar 8 doi: 10.21037/apm-20-1841. PMID: 33691442

Diagnosis

Clinical case of lung spindle cell carcinoma markedly responsive to pembrolizumab.
Mizushina Y, Ohyanagi F, Shiihara J, Nomura M, Ohta H, Oshiro H, Tsubochi H, Kusaka G, Yamaguchi Y
Thorac Cancer 2021 Aug;12(16):2279-2282. Epub 2021 Jul 5 doi: 10.1111/1759-7714.14068. PMID: 34227241Free PMC Article

Therapy

TIM-3 expression induces resistance to PD-1 inhibitor in G-CSF-producing lung spindle cell carcinoma: A case report.
Hayashi F, Akagi K, Taniguchi H, Matsutake T, Kawahara H, Sekine I, Gyotoku H, Takemoto S, Soda H, Ashizawa K, Mukae H
Thorac Cancer 2023 Dec;14(36):3556-3560. Epub 2023 Nov 5 doi: 10.1111/1759-7714.15149. PMID: 37926435Free PMC Article
Clinical case of lung spindle cell carcinoma markedly responsive to pembrolizumab.
Mizushina Y, Ohyanagi F, Shiihara J, Nomura M, Ohta H, Oshiro H, Tsubochi H, Kusaka G, Yamaguchi Y
Thorac Cancer 2021 Aug;12(16):2279-2282. Epub 2021 Jul 5 doi: 10.1111/1759-7714.14068. PMID: 34227241Free PMC Article

Prognosis

Clinicopathological characteristics and prognosis of pulmonary spindle cell carcinoma (PSCC): a population-based retrospective study.
Zhang J, Yan Y, Hui B, Bai S, Ma W, Ren J
Ann Palliat Med 2021 Apr;10(4):3793-3803. Epub 2021 Mar 8 doi: 10.21037/apm-20-1841. PMID: 33691442

Clinical prediction guides

Clinical case of lung spindle cell carcinoma markedly responsive to pembrolizumab.
Mizushina Y, Ohyanagi F, Shiihara J, Nomura M, Ohta H, Oshiro H, Tsubochi H, Kusaka G, Yamaguchi Y
Thorac Cancer 2021 Aug;12(16):2279-2282. Epub 2021 Jul 5 doi: 10.1111/1759-7714.14068. PMID: 34227241Free PMC Article
Clinicopathological characteristics and prognosis of pulmonary spindle cell carcinoma (PSCC): a population-based retrospective study.
Zhang J, Yan Y, Hui B, Bai S, Ma W, Ren J
Ann Palliat Med 2021 Apr;10(4):3793-3803. Epub 2021 Mar 8 doi: 10.21037/apm-20-1841. PMID: 33691442

Supplemental Content

Table of contents

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