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Invasive Cutaneous Melanoma

MedGen UID:
310892
•Concept ID:
C1708565
•
Neoplastic Process
Synonyms: Infiltrating Melanoma; Invasive Melanoma; Invasive Skin Melanoma

Definition

A melanoma of the skin that is not confined to the dermal-epidermal junction, and has infiltrated the dermis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Cutaneous Melanoma

Professional guidelines

PubMed

Demographic Characteristics Influence Treatment Costs of Invasive Melanoma in Florida.
Avila FR, Spaulding AC, Rinker BD, Huayllani MT, Boczar D, Torres-Guzman RA, Maita KC, Ho OA, Forte AJ
Ann Plast Surg 2023 Mar 1;90(3):248-254. doi: 10.1097/SAP.0000000000003422. PMID: 36796047
Three-minute chemosurgical biopsy site treatment for invasive cutaneous melanoma.
Brooks NA
Dermatol Surg 2012 Jun;38(6):968-9. doi: 10.1111/j.1524-4725.2012.02411.x. PMID: 22642459
Selection criteria for genetic assessment of patients with familial melanoma.
Leachman SA, Carucci J, Kohlmann W, Banks KC, Asgari MM, Bergman W, Bianchi-Scarrà G, Brentnall T, Bressac-de Paillerets B, Bruno W, Curiel-Lewandrowski C, de Snoo FA, Debniak T, Demierre MF, Elder D, Goldstein AM, Grant-Kels J, Halpern AC, Ingvar C, Kefford RF, Lang J, MacKie RM, Mann GJ, Mueller K, Newton-Bishop J, Olsson H, Petersen GM, Puig S, Rigel D, Swetter SM, Tucker MA, Yakobson E, Zitelli JA, Tsao H
J Am Acad Dermatol 2009 Oct;61(4):677.e1-14. doi: 10.1016/j.jaad.2009.03.016. PMID: 19751883Free PMC Article

Recent clinical studies

Etiology

Invasive Cutaneous Melanoma: Evaluating the Prognostic Significance of Some Parameters Associated with Lymph Node Metastases.
Vița O, Jurescu A, Văduva A, Cornea R, Cornianu M, Tăban S, Szilagyi D, Micșescu C, Natarâș B, Dema A
Medicina (Kaunas) 2023 Jul 3;59(7) doi: 10.3390/medicina59071241. PMID: 37512052Free PMC Article
Association between surgical delay and outcomes among patients with invasive cutaneous melanoma.
Hewitt DB, Beane JD, Grignol VP, Contreras CM
Am J Surg 2023 Nov;226(5):631-639. Epub 2023 Apr 29 doi: 10.1016/j.amjsurg.2023.04.019. PMID: 37142517
Early inflammatory biomarkers and melanoma survival.
Fortes C, Mastroeni S, Zappalà AR, Passarelli F, Ricci F, Abeni D, Michelozzi P
Int J Dermatol 2023 Jun;62(6):752-758. Epub 2023 Mar 5 doi: 10.1111/ijd.16629. PMID: 36872079
Medical Immunosuppression and Outcomes in Cutaneous Melanoma: A Population-Based Cohort Study.
Bogach J, Wright FC, Austin J, Cheng SY, Diong C, Sutradhar R, Baxter NN, Look Hong NJ
Ann Surg Oncol 2021 Jun;28(6):3302-3311. Epub 2020 Oct 16 doi: 10.1245/s10434-020-09224-9. PMID: 33067747
Left-sided excess of invasive cutaneous melanoma in six countries.
Brewster DH, Horner MJ, Rowan S, Jelfs P, de Vries E, Pukkala E
Eur J Cancer 2007 Dec;43(18):2634-7. Epub 2007 Nov 7 doi: 10.1016/j.ejca.2007.09.021. PMID: 17988856

Diagnosis

The impact of the COVID-19 pandemic in 2020 on the diagnosis, treatment, and outcomes of invasive cutaneous melanoma: A retrospective national cohort study.
Xiong DD, Bordeaux J
J Am Acad Dermatol 2023 Dec;89(6):1167-1176. Epub 2023 Aug 23 doi: 10.1016/j.jaad.2023.08.040. PMID: 37625699
Association between surgical delay and outcomes among patients with invasive cutaneous melanoma.
Hewitt DB, Beane JD, Grignol VP, Contreras CM
Am J Surg 2023 Nov;226(5):631-639. Epub 2023 Apr 29 doi: 10.1016/j.amjsurg.2023.04.019. PMID: 37142517
Early inflammatory biomarkers and melanoma survival.
Fortes C, Mastroeni S, Zappalà AR, Passarelli F, Ricci F, Abeni D, Michelozzi P
Int J Dermatol 2023 Jun;62(6):752-758. Epub 2023 Mar 5 doi: 10.1111/ijd.16629. PMID: 36872079
Medical Immunosuppression and Outcomes in Cutaneous Melanoma: A Population-Based Cohort Study.
Bogach J, Wright FC, Austin J, Cheng SY, Diong C, Sutradhar R, Baxter NN, Look Hong NJ
Ann Surg Oncol 2021 Jun;28(6):3302-3311. Epub 2020 Oct 16 doi: 10.1245/s10434-020-09224-9. PMID: 33067747
Epidemiology of invasive cutaneous melanoma.
MacKie RM, Hauschild A, Eggermont AM
Ann Oncol 2009 Aug;20 Suppl 6(Suppl 6):vi1-7. doi: 10.1093/annonc/mdp252. PMID: 19617292Free PMC Article

Therapy

Intraoperative Immunohistochemistry During Mohs Micrographic Surgery and Staged Excision Decreases Local Recurrence Rates for Invasive Cutaneous Melanoma: A Systematic Review and Meta-Analysis.
O'Hern K, Crum OM, Demer AM, Brewer JD
Dermatol Surg 2024 Jul 1;50(7):601-610. Epub 2024 Mar 26 doi: 10.1097/DSS.0000000000004164. PMID: 38530980
Prognostic Significance of Sentinel Lymph Node Status in Thick Primary Melanomas (> 4 mm).
Holmberg CJ, Mikiver R, Isaksson K, Ingvar C, Moncrieff M, Nielsen K, Ny L, Lyth J, Olofsson Bagge R
Ann Surg Oncol 2023 Dec;30(13):8026-8033. Epub 2023 Aug 14 doi: 10.1245/s10434-023-14050-w. PMID: 37574516Free PMC Article
Use of Nonsteroidal Anti-Inflammatory Drugs and Incidence of Melanoma in the United States Radiologic Technologists Study.
Mai JZ, Kitahara CM, Sargen MR, Little MP, Alexander BH, Linet MS, Tucker MA, Cahoon EK
Cancer Prev Res (Phila) 2022 Nov 1;15(11):727-732. doi: 10.1158/1940-6207.CAPR-22-0229. PMID: 35902885Free PMC Article
Survival after cutaneous melanoma in kidney transplant recipients: a population-based matched cohort study.
Vajdic CM, Chong AH, Kelly PJ, Meagher NS, Van Leeuwen MT, Grulich AE, Webster AC
Am J Transplant 2014 Jun;14(6):1368-75. Epub 2014 Apr 14 doi: 10.1111/ajt.12716. PMID: 24730453
Association of cutaneous melanoma incidence with area-based socioeconomic indicators-United States, 2004-2006.
Singh SD, Ajani UA, Johnson CJ, Roland KB, Eide M, Jemal A, Negoita S, Bayakly RA, Ekwueme DU
J Am Acad Dermatol 2011 Nov;65(5 Suppl 1):S58-68. doi: 10.1016/j.jaad.2011.05.035. PMID: 22018068

Prognosis

Invasive Cutaneous Melanoma: Evaluating the Prognostic Significance of Some Parameters Associated with Lymph Node Metastases.
Vița O, Jurescu A, Văduva A, Cornea R, Cornianu M, Tăban S, Szilagyi D, Micșescu C, Natarâș B, Dema A
Medicina (Kaunas) 2023 Jul 3;59(7) doi: 10.3390/medicina59071241. PMID: 37512052Free PMC Article
Early inflammatory biomarkers and melanoma survival.
Fortes C, Mastroeni S, Zappalà AR, Passarelli F, Ricci F, Abeni D, Michelozzi P
Int J Dermatol 2023 Jun;62(6):752-758. Epub 2023 Mar 5 doi: 10.1111/ijd.16629. PMID: 36872079
Differences in Thickness-Specific Incidence and Factors Associated With Cutaneous Melanoma in the US From 2010 to 2018.
Chen ML, de Vere Hunt IJ, John EM, Weinstock MA, Swetter SM, Linos E
JAMA Oncol 2022 May 1;8(5):755-759. doi: 10.1001/jamaoncol.2022.0134. PMID: 35323844Free PMC Article
Melanoma survival with Classification and Regression Trees Analysis: a complement for the communication of prognosis to patients.
Mancini S, Crocetti E, Bucchi L, Pimpinelli N, Vattiato R, Giuliani O, Ravaioli A, Baldacchini F, Balducci C, Stanganelli I, Falcini F
Ital J Dermatol Venerol 2021 Aug;156(4):460-466. Epub 2019 Jun 17 doi: 10.23736/S2784-8671.19.06402-2. PMID: 31210469
Epidemiology of invasive cutaneous melanoma.
MacKie RM, Hauschild A, Eggermont AM
Ann Oncol 2009 Aug;20 Suppl 6(Suppl 6):vi1-7. doi: 10.1093/annonc/mdp252. PMID: 19617292Free PMC Article

Clinical prediction guides

Invasive Cutaneous Melanoma: Evaluating the Prognostic Significance of Some Parameters Associated with Lymph Node Metastases.
Vița O, Jurescu A, Văduva A, Cornea R, Cornianu M, Tăban S, Szilagyi D, Micșescu C, Natarâș B, Dema A
Medicina (Kaunas) 2023 Jul 3;59(7) doi: 10.3390/medicina59071241. PMID: 37512052Free PMC Article
Validation of a microRNA liquid biopsy assay for diagnosis and risk stratification of invasive cutaneous melanoma.
Van Laar R, Latif B, King S, Love C, Taubenheim N, Kalansooriya E, Wang W, Saad M, Winship I, Azzi A, Lilleyman A, Landgren T
Br J Dermatol 2023 Aug 24;189(3):292-301. doi: 10.1093/bjd/ljad137. PMID: 37144735
Early inflammatory biomarkers and melanoma survival.
Fortes C, Mastroeni S, Zappalà AR, Passarelli F, Ricci F, Abeni D, Michelozzi P
Int J Dermatol 2023 Jun;62(6):752-758. Epub 2023 Mar 5 doi: 10.1111/ijd.16629. PMID: 36872079
Incidence trends and clinical-pathological characteristics of invasive cutaneous melanoma from 1980 to 2010 in the Canton of Zurich, Switzerland.
Minini R, Rohrmann S, Braun R, Korol D, Dehler S
Melanoma Res 2017 Apr;27(2):145-151. doi: 10.1097/CMR.0000000000000312. PMID: 27926588
Epidemiology of invasive cutaneous melanoma.
MacKie RM, Hauschild A, Eggermont AM
Ann Oncol 2009 Aug;20 Suppl 6(Suppl 6):vi1-7. doi: 10.1093/annonc/mdp252. PMID: 19617292Free PMC Article

Recent systematic reviews

Intraoperative Immunohistochemistry During Mohs Micrographic Surgery and Staged Excision Decreases Local Recurrence Rates for Invasive Cutaneous Melanoma: A Systematic Review and Meta-Analysis.
O'Hern K, Crum OM, Demer AM, Brewer JD
Dermatol Surg 2024 Jul 1;50(7):601-610. Epub 2024 Mar 26 doi: 10.1097/DSS.0000000000004164. PMID: 38530980
Laser and light-based therapy for cutaneous and soft-tissue metastases of malignant melanoma: a systematic review.
Austin E, Mamalis A, Ho D, Jagdeo J
Arch Dermatol Res 2017 May;309(4):229-242. Epub 2017 Mar 17 doi: 10.1007/s00403-017-1720-9. PMID: 28314913

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