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Anterior Pituitary Gland Neoplasm

MedGen UID:
310471
•Concept ID:
C1706819
•
Neoplastic Process
Synonym: Neoplasm of the Anterior Lobe of the Pituitary Gland

Definition

A neoplasm arising from the anterior lobe of the pituitary gland. The vast majority are pituitary neuroendocrine tumors (formerly pituitary adenomas). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnterior Pituitary Gland Neoplasm

Professional guidelines

PubMed

Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 1, general recommendations.
Korbonits M, Blair JC, Boguslawska A, Ayuk J, Davies JH, Druce MR, Evanson J, Flanagan D, Glynn N, Higham CE, Jacques TS, Sinha S, Simmons I, Thorp N, Swords FM, Storr HL, Spoudeas HA
Nat Rev Endocrinol 2024 May;20(5):278-289. Epub 2024 Feb 9 doi: 10.1038/s41574-023-00948-8. PMID: 38336897
Diagnosis and Treatment of Parasellar Lesions.
Gatto F, Perez-Rivas LG, Olarescu NC, Khandeva P, Chachlaki K, Trivellin G, Gahete MD, Cuny T; on behalf of the ENEA Young Researchers Committee (EYRC)
Neuroendocrinology 2020;110(9-10):728-739. Epub 2020 Mar 4 doi: 10.1159/000506905. PMID: 32126547
Primary amenorrhea: diagnosis and management.
Marsh CA, Grimstad FW
Obstet Gynecol Surv 2014 Oct;69(10):603-12. doi: 10.1097/OGX.0000000000000111. PMID: 25336070

Recent clinical studies

Etiology

Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 1, general recommendations.
Korbonits M, Blair JC, Boguslawska A, Ayuk J, Davies JH, Druce MR, Evanson J, Flanagan D, Glynn N, Higham CE, Jacques TS, Sinha S, Simmons I, Thorp N, Swords FM, Storr HL, Spoudeas HA
Nat Rev Endocrinol 2024 May;20(5):278-289. Epub 2024 Feb 9 doi: 10.1038/s41574-023-00948-8. PMID: 38336897
Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067

Diagnosis

Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 1, general recommendations.
Korbonits M, Blair JC, Boguslawska A, Ayuk J, Davies JH, Druce MR, Evanson J, Flanagan D, Glynn N, Higham CE, Jacques TS, Sinha S, Simmons I, Thorp N, Swords FM, Storr HL, Spoudeas HA
Nat Rev Endocrinol 2024 May;20(5):278-289. Epub 2024 Feb 9 doi: 10.1038/s41574-023-00948-8. PMID: 38336897
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Pituicytoma.
Kowalski RJ, Prayson RA, Mayberg MR
Ann Diagn Pathol 2004 Oct;8(5):290-4. doi: 10.1016/j.anndiagpath.2004.07.006. PMID: 15494936

Therapy

Aggressive corticotroph tumors and carcinomas.
Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G
J Neuroendocrinol 2022 Aug;34(8):e13169. Epub 2022 Aug 18 doi: 10.1111/jne.13169. PMID: 35979732Free PMC Article
Insights into non-classic and emerging causes of hypopituitarism.
Prodam F, Caputo M, Mele C, Marzullo P, Aimaretti G
Nat Rev Endocrinol 2021 Feb;17(2):114-129. Epub 2020 Nov 27 doi: 10.1038/s41574-020-00437-2. PMID: 33247226
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Resistant prolactinomas.
Vasilev V, Daly AF, Vroonen L, Zacharieva S, Beckers A
J Endocrinol Invest 2011 Apr;34(4):312-6. Epub 2011 Mar 15 doi: 10.1007/BF03347092. PMID: 21406957
GnRH-antagonists in reproductive medicine.
Griesinger G, Felberbaum R, Diedrich K
Arch Gynecol Obstet 2005 Dec;273(2):71-8. Epub 2005 Jul 1 doi: 10.1007/s00404-005-0021-2. PMID: 15991015

Prognosis

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Pituitary metastasis: a clinical overview.
Henry A, Nugent A, Wallace IR, Oladipo B, Sheehy O, Johnston PC
Ulster Med J 2021 Sep;90(3):146-150. Epub 2021 Nov 11 PMID: 34815592Free PMC Article
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Gonadotrope Tumors.
Asa SL, Ezzat S
Prog Mol Biol Transl Sci 2016;143:187-210. Epub 2016 Sep 7 doi: 10.1016/bs.pmbts.2016.08.005. PMID: 27697203
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067

Clinical prediction guides

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
MicroRNAs in pituitary tumors.
Wierinckx A, Roche M, Legras-Lachuer C, Trouillas J, Raverot G, Lachuer J
Mol Cell Endocrinol 2017 Nov 15;456:51-61. Epub 2017 Jan 13 doi: 10.1016/j.mce.2017.01.021. PMID: 28089822
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Pituicytoma.
Kowalski RJ, Prayson RA, Mayberg MR
Ann Diagn Pathol 2004 Oct;8(5):290-4. doi: 10.1016/j.anndiagpath.2004.07.006. PMID: 15494936
Leptin and the pituitary.
Popovic V, Damjanovic S, Dieguez C, Casanueva FF
Pituitary 2001 Jan-Apr;4(1-2):7-14. doi: 10.1023/a:1012938308654. PMID: 11824510

Recent systematic reviews

The clinicopathological features and prognosis of silent corticotroph tumors: an updated systematic review and meta-analysis.
Vuong HG, Dunn IF
Endocrine 2023 Dec;82(3):527-535. Epub 2023 Jul 18 doi: 10.1007/s12020-023-03449-w. PMID: 37462809
Post-operative surveillance for somatotroph, lactotroph and non-functional pituitary adenomas after curative resection: a systematic review.
Caulley L, Whelan J, Khoury M, Mavedatnia D, Sahlollbey N, Amrani L, Eid A, Doyle MA, Malcolm J, Alkherayf F, Ramsay T, Moher D, Johnson-Obaseki S, Schramm D, Hunink MGM, Kilty SJ
Pituitary 2023 Feb;26(1):73-93. Epub 2022 Nov 23 doi: 10.1007/s11102-022-01289-x. PMID: 36422846
Isolated Pituitary Metastasis of Renal Cell Carcinoma: A Case Report and Systematic Review of the Literature.
Öven BB, Demir MK, Çelik S, Moujawaz R, Somay A, Kılıc T
Curr Med Imaging 2022;18(13):1426-1432. doi: 10.2174/0929866529666220426121245. PMID: 35490330
Primary pituitary lymphoma: an update of the literature.
Tarabay A, Cossu G, Berhouma M, Levivier M, Daniel RT, Messerer M
J Neurooncol 2016 Dec;130(3):383-395. Epub 2016 Aug 31 doi: 10.1007/s11060-016-2249-z. PMID: 27581598
Metastatic involvement of the pituitary gland: a systematic review with pooled individual patient data analysis.
He W, Chen F, Dalm B, Kirby PA, Greenlee JD
Pituitary 2015 Feb;18(1):159-68. doi: 10.1007/s11102-014-0552-2. PMID: 24445565

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