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Acute Myelomonocytic Leukemia without Abnormal Eosinophils

MedGen UID:
310448
•Concept ID:
C1706708
•
Neoplastic Process

Definition

Acute myelomonocytic leukemia without an abnormal eosinophilic component in the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Myelomonocytic Leukemia without Abnormal Eosinophils

Recent clinical studies

Etiology

Systemic mastocytosis in the elderly.
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Acute myeloid leukemia with t(6;9) (p23;q34): association with myelodysplasia, basophilia, and initial CD34 negative immunophenotype.
Alsabeh R, Brynes RK, Slovak ML, Arber DA
Am J Clin Pathol 1997 Apr;107(4):430-7. doi: 10.1093/ajcp/107.4.430. PMID: 9124211
AML M1 and M2 with eosinophilia and AML M4Eo: diagnostic and clinical aspects.
Löffler H, Gassmann W, Haferlach T
Leuk Lymphoma 1995;18 Suppl 1:61-3. doi: 10.3109/10428199509075305. PMID: 7496357
Abnormalities of chromosome 16 in association with acute myelomonocytic leukemia and dysplastic bone marrow eosinophils.
Hogge DE, Misawa S, Parsa NZ, Pollak A, Testa JR
J Clin Oncol 1984 Jun;2(6):550-7. doi: 10.1200/JCO.1984.2.6.550. PMID: 6587018
A morphologic and cytochemical study of acute myelomonocytic leukemia with abnormal marrow eosinophils associated with inv(16)(p13q22).
Bitter MA, Le Beau MM, Larson RA, Rosner MC, Golomb HM, Rowley JD, Vardiman JW
Am J Clin Pathol 1984 Jun;81(6):733-41. doi: 10.1093/ajcp/81.6.733. PMID: 6203400

Diagnosis

Systemic mastocytosis in the elderly.
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up.
Chang ST, Hsieh YC, Lee LP, Tzeng CC, Chuang SS
Chang Gung Med J 2006 Sep-Oct;29(5):532-7. PMID: 17214400
Acute myelomonocytic leukemia with abnormal eosinophils presenting as an ovarian mass: a report of two cases and a review of the literature.
Drinkard LC, Waggoner S, Stein RN, Byrne RA, Larson RA
Gynecol Oncol 1995 Feb;56(2):307-11. doi: 10.1006/gyno.1995.1052. PMID: 7896204
Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD
Blood 1986 Dec;68(6):1242-9. PMID: 3465376
Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association.
Le Beau MM, Larson RA, Bitter MA, Vardiman JW, Golomb HM, Rowley JD
N Engl J Med 1983 Sep 15;309(11):630-6. doi: 10.1056/NEJM198309153091103. PMID: 6577285

Therapy

Core-binding factor abnormalities involving chromosome 16 in acute myeloid leukaemia: prognostic and therapeutic implications.
Panigrahi C, Tikare N, Das PK, Padhi S
BMJ Case Rep 2023 Aug 17;16(8) doi: 10.1136/bcr-2022-252915. PMID: 37591621Free PMC Article
The biological significance of the multidrug resistance gene MRP in inversion 16 leukemias.
Kuss BJ, Deeley RG, Cole SP, Willman CL, Kopecky KJ, Wolman SR, Eyre HJ, Callen DF
Leuk Lymphoma 1996 Feb;20(5-6):357-64. doi: 10.3109/10428199609052416. PMID: 8833390
Clinical aspects of acute myeloid leukemias of the FAB types M3 and M4Eo. The AML Cooperative Group.
Haferlach T, Gassmann W, Löffler H, Jürgensen C, Noak J, Ludwig WD, Thiel E, Haase D, Fonatsch C, Becher R
Ann Hematol 1993 Apr;66(4):165-70. doi: 10.1007/BF01703230. PMID: 8485203
Syndromes of acute nonlymphocytic leukemia.
Koeffler HP
Ann Intern Med 1987 Nov;107(5):748-58. doi: 10.7326/0003-4819-107-5-748. PMID: 3310797
Acute myelomonocytic leukemia (M-4 subtype) with abnormal marrow eosinophilia and a normal chromosome 16.
Stark EW, Garvin DF, Surana RB, Dale NL, Hummer W, Clark M, Schumacher HR
Am J Clin Pathol 1985 Oct;84(4):551-4. doi: 10.1093/ajcp/84.4.551. PMID: 3862338

Prognosis

Systemic mastocytosis in the elderly.
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up.
Chang ST, Hsieh YC, Lee LP, Tzeng CC, Chuang SS
Chang Gung Med J 2006 Sep-Oct;29(5):532-7. PMID: 17214400
Acute myelomonocytic leukemia with abnormal eosinophils presenting as an ovarian mass: a report of two cases and a review of the literature.
Drinkard LC, Waggoner S, Stein RN, Byrne RA, Larson RA
Gynecol Oncol 1995 Feb;56(2):307-11. doi: 10.1006/gyno.1995.1052. PMID: 7896204
Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD
Blood 1986 Dec;68(6):1242-9. PMID: 3465376
Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association.
Le Beau MM, Larson RA, Bitter MA, Vardiman JW, Golomb HM, Rowley JD
N Engl J Med 1983 Sep 15;309(11):630-6. doi: 10.1056/NEJM198309153091103. PMID: 6577285

Clinical prediction guides

Systemic mastocytosis in the elderly.
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Detection of CBFbeta/MYH11 fusion transcripts in acute myeloid leukemia: heterogeneity of cytological and molecular characteristics.
Costello R, Sainty D, Lecine P, Cusenier A, Mozziconacci MJ, Arnoulet C, Maraninchi D, Gastaut JA, Imbert J, Lafage-Pochitaloff M, Gabert J
Leukemia 1997 May;11(5):644-50. doi: 10.1038/sj.leu.2400629. PMID: 9180286
The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: a combination of May-Grünwald-Giemsa staining and fluorescence in situ hybridization.
Haferlach T, Winkemann M, Löffler H, Schoch R, Gassmann W, Fonatsch C, Schoch C, Poetsch M, Weber-Matthiesen K, Schlegelberger B
Blood 1996 Mar 15;87(6):2459-63. PMID: 8630411
Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD
Blood 1986 Dec;68(6):1242-9. PMID: 3465376
A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv(16)(p13q22).
Holmes R, Keating MJ, Cork A, Broach Y, Trujillo J, Dalton WT Jr, McCredie KB, Freireich EJ
Blood 1985 May;65(5):1071-8. PMID: 3857943

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