U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mixed epithelial/mesenchymal metaplastic breast carcinoma

MedGen UID:
307769
•Concept ID:
C1513365
•
Neoplastic Process
Synonyms: Breast Carcinosarcoma; breast carcinosarcoma; Breast Mixed Epithelial/Mesenchymal Metaplastic Carcinoma; Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma; mixed epithelial/mesenchymal metaplastic breast carcinoma; mixed type metaplastic breast cancer
 
Monarch Initiative: MONDO:0004274

Definition

An invasive breast carcinoma characterized by the presence of a mesenchymal cellular component. The mesenchymal cellular component ranges from cartilaginous and osseous, to purely sarcomatous. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed epithelial/mesenchymal metaplastic breast carcinoma

Recent clinical studies

Etiology

Understanding the histogenesis of a HRAS-PIK3R1 co-driven metastatic metaplastic breast carcinoma associated with squamous metaplasia of lactiferous ducts.
Febres-Aldana CA, Alvarez Moreno JC, Rivera M, Kaplan S, Paramo J, Poppiti R
Pathol Int 2020 Feb;70(2):101-107. Epub 2019 Dec 23 doi: 10.1111/pin.12887. PMID: 31867792
Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications.
McCart Reed AE, Kalaw E, Nones K, Bettington M, Lim M, Bennett J, Johnstone K, Kutasovic JR, Saunus JM, Kazakoff S, Xu Q, Wood S, Holmes O, Leonard C, Reid LE, Black D, Niland C, Ferguson K, Gresshoff I, Raghavendra A, Harvey K, Cooper C, Liu C, Kalinowski L, Reid AS, Davidson M, Pearson JV, Pathmanathan N, Tse G, Papadimos D, Pathmanathan R, Harris G, Yamaguchi R, Tan PH, Fox SB, O'Toole SA, Simpson PT, Waddell N, Lakhani SR
J Pathol 2019 Feb;247(2):214-227. Epub 2018 Dec 20 doi: 10.1002/path.5184. PMID: 30350370
Analysis of metaplastic breast carcinoma: FNAC; histopathology and immunohistochemistry are complementary for diagnosis.
Abd El Hafez A, Shawky Ael-A
Breast Dis 2013 Jan 1;34(2):67-75. doi: 10.3233/BD-130353. PMID: 24077354
Metaplastic breast carcinoma. A diagnostic problem in fine needle aspiration biopsy.
Jebsen PW, Hagmar BM, Nesland JM
Acta Cytol 1991 Jul-Aug;35(4):396-402. PMID: 1718111

Diagnosis

Clinicopathologic characteristics of mixed epithelial/mesenchymal metaplastic breast carcinoma (carcinosarcoma): a meta-analysis of Chinese patients.
Xu D, Hou L
Pol J Pathol 2019;70(3):174-182. doi: 10.5114/pjp.2019.90393. PMID: 31820860
Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications.
McCart Reed AE, Kalaw E, Nones K, Bettington M, Lim M, Bennett J, Johnstone K, Kutasovic JR, Saunus JM, Kazakoff S, Xu Q, Wood S, Holmes O, Leonard C, Reid LE, Black D, Niland C, Ferguson K, Gresshoff I, Raghavendra A, Harvey K, Cooper C, Liu C, Kalinowski L, Reid AS, Davidson M, Pearson JV, Pathmanathan N, Tse G, Papadimos D, Pathmanathan R, Harris G, Yamaguchi R, Tan PH, Fox SB, O'Toole SA, Simpson PT, Waddell N, Lakhani SR
J Pathol 2019 Feb;247(2):214-227. Epub 2018 Dec 20 doi: 10.1002/path.5184. PMID: 30350370
Carcinosarcoma of the Pancreas: Case Report With Comprehensive Literature Review.
Ruess DA, Kayser C, Neubauer J, Fichtner-Feigl S, Hopt UT, Wittel UA
Pancreas 2017 Oct;46(9):1225-1233. doi: 10.1097/MPA.0000000000000904. PMID: 28902796
Analysis of metaplastic breast carcinoma: FNAC; histopathology and immunohistochemistry are complementary for diagnosis.
Abd El Hafez A, Shawky Ael-A
Breast Dis 2013 Jan 1;34(2):67-75. doi: 10.3233/BD-130353. PMID: 24077354
Mixed epithelial/mesenchymal metaplastic carcinoma (carcinosarcoma) of the breast in BRCA1 carrier.
Suspitsin EN, Sokolenko AP, Voskresenskiy DA, Ivantsov AO, Shelehova KV, Klimashevskiy VF, Matsko DE, Semiglazov VF, Imyanitov EN
Breast Cancer 2011 Apr;18(2):137-40. Epub 2009 Apr 7 doi: 10.1007/s12282-009-0105-0. PMID: 19350356

Prognosis

Clinicopathologic characteristics of mixed epithelial/mesenchymal metaplastic breast carcinoma (carcinosarcoma): a meta-analysis of Chinese patients.
Xu D, Hou L
Pol J Pathol 2019;70(3):174-182. doi: 10.5114/pjp.2019.90393. PMID: 31820860
Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications.
McCart Reed AE, Kalaw E, Nones K, Bettington M, Lim M, Bennett J, Johnstone K, Kutasovic JR, Saunus JM, Kazakoff S, Xu Q, Wood S, Holmes O, Leonard C, Reid LE, Black D, Niland C, Ferguson K, Gresshoff I, Raghavendra A, Harvey K, Cooper C, Liu C, Kalinowski L, Reid AS, Davidson M, Pearson JV, Pathmanathan N, Tse G, Papadimos D, Pathmanathan R, Harris G, Yamaguchi R, Tan PH, Fox SB, O'Toole SA, Simpson PT, Waddell N, Lakhani SR
J Pathol 2019 Feb;247(2):214-227. Epub 2018 Dec 20 doi: 10.1002/path.5184. PMID: 30350370
Carcinosarcoma of the Pancreas: Case Report With Comprehensive Literature Review.
Ruess DA, Kayser C, Neubauer J, Fichtner-Feigl S, Hopt UT, Wittel UA
Pancreas 2017 Oct;46(9):1225-1233. doi: 10.1097/MPA.0000000000000904. PMID: 28902796
Metaplastic carcinoma show different expression pattern of YAP compared to triple-negative breast cancer.
Min Kim H, Kim SK, Jung WH, Koo JS
Tumour Biol 2015 Feb;36(2):1207-12. Epub 2014 Oct 25 doi: 10.1007/s13277-014-2735-x. PMID: 25344213
Clinicopathologic features of the mixed epithelial and mesenchymal type metaplastic breast carcinoma with myoepithelial differentiation in a subset of six cases.
Yigit S, Pehlivan FS, Evcim G, Etit D
Pathol Res Pract 2012 Mar 15;208(3):147-50. Epub 2012 Feb 21 doi: 10.1016/j.prp.2011.12.014. PMID: 22361036

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...