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Oxyphilic adenoma

MedGen UID:
307150
Concept ID:
C1510502
Neoplastic Process
Synonyms: Oncocytic adenoma; Oncocytoma
SNOMED CT: Oxyphilic adenoma (89439007); Oncocytic adenoma (89439007); Oncocytoma (89439007); Follicular adenoma, oxyphilic cell (89439007)
 
Monarch Initiative: MONDO:0003424
OMIM®: 553000

Definition

Oncocytomas are usually benign tumors that occur in various organs but particularly in the kidneys. Histologic evaluation of renal oncocytomas shows that they are composed entirely of peculiar epithelial cells with granular eosinophilic cytoplasm. Ultrastructural characterization exhibits densely packed cells with mitochondria, which show morphologic differences from those in normal cells. On the average they are larger than those in renal carcinoma cells and their shape is abnormal (summary by Welter et al., 1989). [from OMIM]

Clinical features

From HPO
Oncocytoma of kidney
MedGen UID:
91094
Concept ID:
C0346255
Neoplastic Process
A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm.

Professional guidelines

PubMed

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Recent clinical studies

Etiology

Oszwald A, Wasinger G, Zisser L, Compérat E
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Diagnosis

McCarthy M, Whaley RD, Erickson LA
Mayo Clin Proc 2022 Nov;97(11):2168-2169. doi: 10.1016/j.mayocp.2022.09.015. PMID: 36333022
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Abdessater M, Kanbar A, Comperat E, Dupont-Athenor A, Alechinsky L, Mouton M, Sebe P
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Schatz SM, Lieber MM
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Therapy

San Román Gil M, Pozas J, Molina-Cerrillo J, Gómez J, Pian H, Pozas M, Carrato A, Grande E, Alonso-Gordoa T
Int J Mol Sci 2020 Jul 13;21(14) doi: 10.3390/ijms21144951. PMID: 32668761Free PMC Article
Sherman SI
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Yutan E, Clark OH
Curr Treat Options Oncol 2001 Aug;2(4):331-5. doi: 10.1007/s11864-001-0026-4. PMID: 12057113

Prognosis

Gruszczynski NR, Hasan SS, Brennan AG, De La Chapa J, Reddy AS, Martin DN, Batchala PP, Stelow EB, Dowling EM, Fedder KL, Garneau JC, Shonka DC Jr
Head Neck 2024 Aug;46(8):2042-2047. Epub 2024 Feb 23 doi: 10.1002/hed.27700. PMID: 38390640
Tortosa F, Webb SM
Endocrinol Diabetes Nutr 2017 Mar;64(3):152-161. Epub 2017 Feb 23 doi: 10.1016/j.endinu.2016.10.004. PMID: 28440754
Schatz SM, Lieber MM
Curr Urol Rep 2003 Feb;4(1):30-5. doi: 10.1007/s11934-003-0054-7. PMID: 12537936
Yutan E, Clark OH
Curr Treat Options Oncol 2001 Aug;2(4):331-5. doi: 10.1007/s11864-001-0026-4. PMID: 12057113
Beckner ME, Heffess CS, Oertel JE
Am J Clin Pathol 1995 Mar;103(3):280-7. doi: 10.1093/ajcp/103.3.280. PMID: 7872249

Clinical prediction guides

Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
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Green O, Keisling M, Kambalapalli M, McDaniel J, Boulanger S, Fornwalt BE, Jeyakumar A
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Recent systematic reviews

Alberto PL, Ashim S, Megan K, Wei Z, Nestor G, Matthew Z, Dayana M, Marcelo V, John W
Head Neck Pathol 2024 Nov 30;18(1):126. doi: 10.1007/s12105-024-01730-6. PMID: 39614964Free PMC Article
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