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Skin Vascular Neoplasm

MedGen UID:
306135
•Concept ID:
C1456853
•
Neoplastic Process
Synonyms: Blood Vessel Tumor of Skin; Blood Vessel Tumor of the Skin; Cutaneous Vascular Neoplasm; Cutaneous vascular tumor; Cutaneous Vascular Tumor; Skin Vascular Tumor; Vascular neoplasm of skin; Vascular Neoplasm of Skin; Vascular Neoplasm of the Skin; Vascular Skin Neoplasm; Vascular Skin Tumor; Vascular tumor of skin; Vascular Tumor of Skin; Vascular Tumor of the Skin
SNOMED CT: Vascular neoplasm of skin (400132000); Vascular tumor of skin (400132000); Cutaneous vascular tumor (400132000)

Definition

A benign, intermediate, or malignant vascular neoplasm that arises from the skin. [from NCI]

Professional guidelines

PubMed

Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
The Diagnosis and Management of Neurofibromatosis Type 1.
Ly KI, Blakeley JO
Med Clin North Am 2019 Nov;103(6):1035-1054. doi: 10.1016/j.mcna.2019.07.004. PMID: 31582003
Clinical Practice Guideline for the Management of Infantile Hemangiomas.
Krowchuk DP, Frieden IJ, Mancini AJ, Darrow DH, Blei F, Greene AK, Annam A, Baker CN, Frommelt PC, Hodak A, Pate BM, Pelletier JL, Sandrock D, Weinberg ST, Whelan MA; SUBCOMMITTEE ON THE MANAGEMENT OF INFANTILE HEMANGIOMAS
Pediatrics 2019 Jan;143(1) doi: 10.1542/peds.2018-3475. PMID: 30584062

Recent clinical studies

Etiology

Radiation-induced angiosarcoma of the breast: A review.
Bonito FJP, de Almeida Cerejeira D, Dahlstedt-Ferreira C, Oliveira Coelho H, Rosas R
Breast J 2020 Mar;26(3):458-463. Epub 2019 Aug 25 doi: 10.1111/tbj.13504. PMID: 31448482
Nonepithelial Tumors and Tumor-like Lesions of the Skin and Subcutis in Children.
Dehner LP, Gru AA
Pediatr Dev Pathol 2018 Mar-Apr;21(2):150-207. doi: 10.1177/1093526617751529. PMID: 29607758
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174
Canine neoplasia--introductory paper.
Gamlem H, Nordstoga K, Glattre E
APMIS Suppl 2008;(125):5-18. doi: 10.1111/j.1600-0463.2008.125m2.x. PMID: 19385278
Verrucous hemangioma.
Wang G, Li C, Gao T
Int J Dermatol 2004 Oct;43(10):745-6. doi: 10.1111/j.1365-4632.2004.02261.x. PMID: 15485532

Diagnosis

Vascular Lesions.
Urban MJ, Williams EF 3rd
Facial Plast Surg Clin North Am 2024 Feb;32(1):13-25. Epub 2023 Oct 21 doi: 10.1016/j.fsc.2023.09.003. PMID: 37981409
Radiation-induced angiosarcoma of the breast: A review.
Bonito FJP, de Almeida Cerejeira D, Dahlstedt-Ferreira C, Oliveira Coelho H, Rosas R
Breast J 2020 Mar;26(3):458-463. Epub 2019 Aug 25 doi: 10.1111/tbj.13504. PMID: 31448482
Tumors of the hand.
Mavrogenis AF, Panagopoulos GN, Angelini A, Lesenský J, Vottis C, Megaloikonomos PD, Kokkalis ZT, Kontogeorgakos V, Ruggieri P, Papagelopoulos PJ
Eur J Orthop Surg Traumatol 2017 Aug;27(6):747-762. Epub 2017 Jun 5 doi: 10.1007/s00590-017-1984-y. PMID: 28585186
Vascular anomalies: differential diagnosis and mimickers.
Garzon MC, Weitz N, Powell J
Semin Cutan Med Surg 2016 Sep;35(3):170-6. doi: 10.12788/j.sder.2016.052. PMID: 27607326
Multifocal vascular lesions.
Levin LE, Lauren CT
Semin Cutan Med Surg 2016 Sep;35(3):153-60. doi: 10.12788/j.sder.2016.054. PMID: 27607324

Therapy

Infantile Hemangiomas.
Hasbani DJ, Hamie L
Dermatol Clin 2022 Oct;40(4):383-392. Epub 2022 Sep 16 doi: 10.1016/j.det.2022.06.004. PMID: 36243426
Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Efficacy and Safety of Topical Timolol for the Treatment of Infantile Hemangioma in the Early Proliferative Stage: A Randomized Clinical Trial.
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Vascular Lesions.
Slaughter KA, Chen T, Williams E 3rd
Facial Plast Surg Clin North Am 2016 Nov;24(4):559-571. doi: 10.1016/j.fsc.2016.06.009. PMID: 27712821

Prognosis

Radiation-induced angiosarcoma of the breast: A review.
Bonito FJP, de Almeida Cerejeira D, Dahlstedt-Ferreira C, Oliveira Coelho H, Rosas R
Breast J 2020 Mar;26(3):458-463. Epub 2019 Aug 25 doi: 10.1111/tbj.13504. PMID: 31448482
Cutaneous Malignant Vascular Neoplasms.
Shon W, Billings SD
Clin Lab Med 2017 Sep;37(3):633-646. Epub 2017 Jul 13 doi: 10.1016/j.cll.2017.06.004. PMID: 28802504
Treating vascular lesions.
Astner S, Anderson RR
Dermatol Ther 2005 May-Jun;18(3):267-81. doi: 10.1111/j.1529-8019.2005.05025.x. PMID: 16229727
Cutaneous vascular lesions.
Spring MA, Bentz ML
Clin Plast Surg 2005 Apr;32(2):171-86. doi: 10.1016/j.cps.2004.11.004. PMID: 15814115
Intravascular lymphomatosis.
Lui PC, Wong GK, Poon WS, Tse GM
J Clin Pathol 2003 Jun;56(6):468-70. doi: 10.1136/jcp.56.6.468. PMID: 12783976Free PMC Article

Clinical prediction guides

Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Cutaneous angiosarcoma: a current update.
Shustef E, Kazlouskaya V, Prieto VG, Ivan D, Aung PP
J Clin Pathol 2017 Nov;70(11):917-925. Epub 2017 Sep 15 doi: 10.1136/jclinpath-2017-204601. PMID: 28916596
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174
Infantile hemangioma.
Holland KE, Drolet BA
Pediatr Clin North Am 2010 Oct;57(5):1069-83. Epub 2010 Aug 21 doi: 10.1016/j.pcl.2010.07.008. PMID: 20888458
Cutaneous vascular lesions.
Spring MA, Bentz ML
Clin Plast Surg 2005 Apr;32(2):171-86. doi: 10.1016/j.cps.2004.11.004. PMID: 15814115

Recent systematic reviews

Cardiovascular and Venous Thromboembolic Risk With JAK Inhibitors in Immune-Mediated Inflammatory Skin Diseases: A Systematic Review and Meta-Analysis.
Ingrassia JP, Maqsood MH, Gelfand JM, Weber BN, Bangalore S, Lo Sicco KI, Garshick MS
JAMA Dermatol 2024 Jan 1;160(1):28-36. doi: 10.1001/jamadermatol.2023.4090. PMID: 37910098Free PMC Article
The use of specific antihypertensive medication and skin cancer risk: A systematic review of the literature and meta-analysis.
Heisel AGU, Vuurboom MD, Daams JG, de Rie MA, Vogt L, van den Born BH, Olde Engberink RHG
Vascul Pharmacol 2023 Jun;150:107173. Epub 2023 Apr 20 doi: 10.1016/j.vph.2023.107173. PMID: 37084802
Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.
Global Burden of Disease 2019 Cancer Collaboration, Kocarnik JM, Compton K, Dean FE, Fu W, Gaw BL, Harvey JD, Henrikson HJ, Lu D, Pennini A, Xu R, Ababneh E, Abbasi-Kangevari M, Abbastabar H, Abd-Elsalam SM, Abdoli A, Abedi A, Abidi H, Abolhassani H, Adedeji IA, Adnani QES, Advani SM, Afzal MS, Aghaali M, Ahinkorah BO, Ahmad S, Ahmad T, Ahmadi A, Ahmadi S, Ahmed Rashid T, Ahmed Salih Y, Akalu GT, Aklilu A, Akram T, Akunna CJ, Al Hamad H, Alahdab F, Al-Aly Z, Ali S, Alimohamadi Y, Alipour V, Aljunid SM, Alkhayyat M, Almasi-Hashiani A, Almasri NA, Al-Maweri SAA, Almustanyir S, Alonso N, Alvis-Guzman N, Amu H, Anbesu EW, Ancuceanu R, Ansari F, Ansari-Moghaddam A, Antwi MH, Anvari D, Anyasodor AE, Aqeel M, Arabloo J, Arab-Zozani M, Aremu O, Ariffin H, Aripov T, Arshad M, Artaman A, Arulappan J, Asemi Z, Asghari Jafarabadi M, Ashraf T, Atorkey P, Aujayeb A, Ausloos M, Awedew AF, Ayala Quintanilla BP, Ayenew T, Azab MA, Azadnajafabad S, Azari Jafari A, Azarian G, Azzam AY, Badiye AD, Bahadory S, Baig AA, Baker JL, Balakrishnan S, Banach M, Bärnighausen TW, Barone-Adesi F, Barra F, Barrow A, Behzadifar M, Belgaumi UI, Bezabhe WMM, Bezabih YM, Bhagat DS, Bhagavathula AS, Bhardwaj N, Bhardwaj P, Bhaskar S, Bhattacharyya K, Bhojaraja VS, Bibi S, Bijani A, Biondi A, Bisignano C, Bjørge T, Bleyer A, Blyuss O, Bolarinwa OA, Bolla SR, Braithwaite D, Brar A, Brenner H, Bustamante-Teixeira MT, Butt NS, Butt ZA, Caetano Dos Santos FL, Cao Y, Carreras G, Catalá-López F, Cembranel F, Cerin E, Cernigliaro A, Chakinala RC, Chattu SK, Chattu VK, Chaturvedi P, Chimed-Ochir O, Cho DY, Christopher DJ, Chu DT, Chung MT, Conde J, Cortés S, Cortesi PA, Costa VM, Cunha AR, Dadras O, Dagnew AB, Dahlawi SMA, Dai X, Dandona L, Dandona R, Darwesh AM, das Neves J, De la Hoz FP, Demis AB, Denova-Gutiérrez E, Dhamnetiya D, Dhimal ML, Dhimal M, Dianatinasab M, Diaz D, Djalalinia S, Do HP, Doaei S, Dorostkar F, Dos Santos Figueiredo FW, Driscoll TR, Ebrahimi H, Eftekharzadeh S, El Tantawi M, El-Abid H, Elbarazi I, Elhabashy HR, Elhadi M, El-Jaafary SI, Eshrati B, Eskandarieh S, Esmaeilzadeh F, Etemadi A, Ezzikouri S, Faisaluddin M, Faraon EJA, Fares J, Farzadfar F, Feroze AH, Ferrero S, Ferro Desideri L, Filip I, Fischer F, Fisher JL, Foroutan M, Fukumoto T, Gaal PA, Gad MM, Gadanya MA, Gallus S, Gaspar Fonseca M, Getachew Obsa A, Ghafourifard M, Ghashghaee A, Ghith N, Gholamalizadeh M, Gilani SA, Ginindza TG, Gizaw ATT, Glasbey JC, Golechha M, Goleij P, Gomez RS, Gopalani SV, Gorini G, Goudarzi H, Grosso G, Gubari MIM, Guerra MR, Guha A, Gunasekera DS, Gupta B, Gupta VB, Gupta VK, Gutiérrez RA, Hafezi-Nejad N, Haider MR, Haj-Mirzaian A, Halwani R, Hamadeh RR, Hameed S, Hamidi S, Hanif A, Haque S, Harlianto NI, Haro JM, Hasaballah AI, Hassanipour S, Hay RJ, Hay SI, Hayat K, Heidari G, Heidari M, Herrera-Serna BY, Herteliu C, Hezam K, Holla R, Hossain MM, Hossain MBH, Hosseini MS, Hosseini M, Hosseinzadeh M, Hostiuc M, Hostiuc S, Househ M, Hsairi M, Huang J, Hugo FN, Hussain R, Hussein NR, Hwang BF, Iavicoli I, Ibitoye SE, Ida F, Ikuta KS, Ilesanmi OS, Ilic IM, Ilic MD, Irham LM, Islam JY, Islam RM, Islam SMS, Ismail NE, Isola G, Iwagami M, Jacob L, Jain V, Jakovljevic MB, Javaheri T, Jayaram S, Jazayeri SB, Jha RP, Jonas JB, Joo T, Joseph N, Joukar F, Jürisson M, Kabir A, Kahrizi D, Kalankesh LR, Kalhor R, Kaliyadan F, Kalkonde Y, Kamath A, Kameran Al-Salihi N, Kandel H, Kapoor N, Karch A, Kasa AS, Katikireddi SV, Kauppila JH, Kavetskyy T, Kebede SA, Keshavarz P, Keykhaei M, Khader YS, Khalilov R, Khan G, Khan M, Khan MN, Khan MAB, Khang YH, Khater AM, Khayamzadeh M, Kim GR, Kim YJ, Kisa A, Kisa S, Kissimova-Skarbek K, Kopec JA, Koteeswaran R, Koul PA, Koulmane Laxminarayana SL, Koyanagi A, Kucuk Bicer B, Kugbey N, Kumar GA, Kumar N, Kumar N, Kurmi OP, Kutluk T, La Vecchia C, Lami FH, Landires I, Lauriola P, Lee SW, Lee SWH, Lee WC, Lee YH, Leigh J, Leong E, Li J, Li MC, Liu X, Loureiro JA, Lunevicius R, Magdy Abd El Razek M, Majeed A, Makki A, Male S, Malik AA, Mansournia MA, Martini S, Masoumi SZ, Mathur P, McKee M, Mehrotra R, Mendoza W, Menezes RG, Mengesha EW, Mesregah MK, Mestrovic T, Miao Jonasson J, Miazgowski B, Miazgowski T, Michalek IM, Miller TR, Mirzaei H, Mirzaei HR, Misra S, Mithra P, Moghadaszadeh M, Mohammad KA, Mohammad Y, Mohammadi M, Mohammadi SM, Mohammadian-Hafshejani A, Mohammed S, Moka N, Mokdad AH, Molokhia M, Monasta L, Moni MA, Moosavi MA, Moradi Y, Moraga P, Morgado-da-Costa J, Morrison SD, Mosapour A, Mubarik S, Mwanri L, Nagarajan AJ, Nagaraju SP, Nagata C, Naimzada MD, Nangia V, Naqvi AA, Narasimha Swamy S, Ndejjo R, Nduaguba SO, Negoi I, Negru SM, Neupane Kandel S, Nguyen CT, Nguyen HLT, Niazi RK, Nnaji CA, Noor NM, Nuñez-Samudio V, Nzoputam CI, Oancea B, Ochir C, Odukoya OO, Ogbo FA, Olagunju AT, Olakunde BO, Omar E, Omar Bali A, Omonisi AEE, Ong S, Onwujekwe OE, Orru H, Ortega-Altamirano DV, Otstavnov N, Otstavnov SS, Owolabi MO, P A M, Padubidri JR, Pakshir K, Pana A, Panagiotakos D, Panda-Jonas S, Pardhan S, Park EC, Park EK, Pashazadeh Kan F, Patel HK, Patel JR, Pati S, Pattanshetty SM, Paudel U, Pereira DM, Pereira RB, Perianayagam A, Pillay JD, Pirouzpanah S, Pishgar F, Podder I, Postma MJ, Pourjafar H, Prashant A, Preotescu L, Rabiee M, Rabiee N, Radfar A, Radhakrishnan RA, Radhakrishnan V, Rafiee A, Rahim F, Rahimzadeh S, Rahman M, Rahman MA, Rahmani AM, Rajai N, Rajesh A, Rakovac I, Ram P, Ramezanzadeh K, Ranabhat K, Ranasinghe P, Rao CR, Rao SJ, Rawassizadeh R, Razeghinia MS, Renzaho AMN, Rezaei N, Rezaei N, Rezapour A, Roberts TJ, Rodriguez JAB, Rohloff P, Romoli M, Ronfani L, Roshandel G, Rwegerera GM, S M, Sabour S, Saddik B, Saeed U, Sahebkar A, Sahoo H, Salehi S, Salem MR, Salimzadeh H, Samaei M, Samy AM, Sanabria J, Sankararaman S, Santric-Milicevic MM, Sardiwalla Y, Sarveazad A, Sathian B, Sawhney M, Saylan M, Schneider IJC, Sekerija M, Seylani A, Shafaat O, Shaghaghi Z, Shaikh MA, Shamsoddin E, Shannawaz M, Sharma R, Sheikh A, Sheikhbahaei S, Shetty A, Shetty JK, Shetty PH, Shibuya K, Shirkoohi R, Shivakumar KM, Shivarov V, Siabani S, Siddappa Malleshappa SK, Silva DAS, Singh JA, Sintayehu Y, Skryabin VY, Skryabina AA, Soeberg MJ, Sofi-Mahmudi A, Sotoudeh H, Steiropoulos P, Straif K, Subedi R, Sufiyan MB, Sultan I, Sultana S, Sur D, Szerencsés V, Szócska M, Tabarés-Seisdedos R, Tabuchi T, Tadbiri H, Taherkhani A, Takahashi K, Talaat IM, Tan KK, Tat VY, Tedla BAA, Tefera YG, Tehrani-Banihashemi A, Temsah MH, Tesfay FH, Tessema GA, Thapar R, Thavamani A, Thoguluva Chandrasekar V, Thomas N, Tohidinik HR, Touvier M, Tovani-Palone MR, Traini E, Tran BX, Tran KB, Tran MTN, Tripathy JP, Tusa BS, Ullah I, Ullah S, Umapathi KK, Unnikrishnan B, Upadhyay E, Vacante M, Vaezi M, Valadan Tahbaz S, Velazquez DZ, Veroux M, Violante FS, Vlassov V, Vo B, Volovici V, Vu GT, Waheed Y, Wamai RG, Ward P, Wen YF, Westerman R, Winkler AS, Yadav L, Yahyazadeh Jabbari SH, Yang L, Yaya S, Yazie TSY, Yeshaw Y, Yonemoto N, Younis MZ, Yousefi Z, Yu C, Yuce D, Yunusa I, Zadnik V, Zare F, Zastrozhin MS, Zastrozhina A, Zhang J, Zhong C, Zhou L, Zhu C, Ziapour A, Zimmermann IR, Fitzmaurice C, Murray CJL, Force LM
JAMA Oncol 2022 Mar 1;8(3):420-444. doi: 10.1001/jamaoncol.2021.6987. PMID: 34967848Free PMC Article
Propranolol versus corticosteroids: what should be the treatment of choice in infantile hemangiomas?
Theunissen CI, Smitt JH, van der Horst CM
Ann Plast Surg 2015 Feb;74(2):237-41. doi: 10.1097/SAP.0b013e318299cd4e. PMID: 24051459
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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