U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade 4 Encephalopathy, CTCAE

MedGen UID:
295740
•Concept ID:
C1561318
•
Finding

Definition

Life-threatening consequences; urgent intervention indicated [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Encephalopathy, CTCAE

Professional guidelines

PubMed

Response to trametinib treatment in progressive pediatric low-grade glioma patients.
Selt F, van Tilburg CM, Bison B, Sievers P, Harting I, Ecker J, Pajtler KW, Sahm F, Bahr A, Simon M, Jones DTW, Well L, Mautner VF, Capper D, Hernáiz Driever P, Gnekow A, Pfister SM, Witt O, Milde T
J Neurooncol 2020 Sep;149(3):499-510. Epub 2020 Oct 7 doi: 10.1007/s11060-020-03640-3. PMID: 33026636Free PMC Article
Safety and efficacy of mTOR inhibitor treatment in patients with tuberous sclerosis complex under 2 years of age - a multicenter retrospective study.
Saffari A, Brösse I, Wiemer-Kruel A, Wilken B, Kreuzaler P, Hahn A, Bernhard MK, van Tilburg CM, Hoffmann GF, Gorenflo M, Hethey S, Kaiser O, Kölker S, Wagner R, Witt O, Merkenschlager A, Möckel A, Roser T, Schlump JU, Serfling A, Spiegler J, Milde T, Ziegler A, Syrbe S
Orphanet J Rare Dis 2019 May 3;14(1):96. doi: 10.1186/s13023-019-1077-6. PMID: 31053163Free PMC Article
Impact of 2-staged stereotactic radiosurgery for treatment of brain metastases ≥ 2 cm.
Angelov L, Mohammadi AM, Bennett EE, Abbassy M, Elson P, Chao ST, Montgomery JS, Habboub G, Vogelbaum MA, Suh JH, Murphy ES, Ahluwalia MS, Nagel SJ, Barnett GH
J Neurosurg 2018 Aug;129(2):366-382. Epub 2017 Sep 22 doi: 10.3171/2017.3.JNS162532. PMID: 28937324

Recent clinical studies

Etiology

Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.
Roth P, Gorlia T, Reijneveld JC, de Vos F, Idbaih A, Frenel JS, Le Rhun E, Sepulveda JM, Perry J, Masucci GL, Freres P, Hirte H, Seidel C, Walenkamp A, Lukacova S, Meijnders P, Blais A, Ducray F, Verschaeve V, Nicholas G, Balana C, Bota DA, Preusser M, Nuyens S, Dhermain F, van den Bent M, O'Callaghan CJ, Vanlancker M, Mason W, Weller M
Neuro Oncol 2024 Sep 5;26(9):1670-1682. doi: 10.1093/neuonc/noae053. PMID: 38502052Free PMC Article
Feasibility of preirradiation temozolomide in cases of high-grade gliomas: Our experience and review of literature.
Arora S, Rathi AK, Singh K, Ansari FA
J Cancer Res Ther 2023 Jan-Mar;19(2):221-227. doi: 10.4103/jcrt.jcrt_942_21. PMID: 37006062
Review of Safety Data for Adenovirus 5 as a Delivery Vector for Intratumoral Cancer Gene Therapy.
Sheldon Y, Yoo BC, Kmiec E, Petrelli N, Tiesi G, Warner S
Hum Gene Ther 2023 Apr;34(7-8):314-324. doi: 10.1089/hum.2022.228. PMID: 36851898
Analysis of safety and efficacy of proton radiotherapy for IDH-mutated glioma WHO grade 2 and 3.
Eichkorn T, Lischalk JW, Hörner-Rieber J, Deng M, Meixner E, Krämer A, Hoegen P, Sandrini E, Regnery S, Held T, Harrabi S, Jungk C, Herfarth K, Debus J, König L
J Neurooncol 2023 May;162(3):489-501. Epub 2023 Jan 4 doi: 10.1007/s11060-022-04217-y. PMID: 36598613Free PMC Article
Optimizing bevacizumab dosing in glioblastoma: less is more.
Ajlan A, Thomas P, Albakr A, Nagpal S, Recht L
J Neurooncol 2017 Oct;135(1):99-105. Epub 2017 Jun 30 doi: 10.1007/s11060-017-2553-2. PMID: 28667595

Diagnosis

Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.
Roth P, Gorlia T, Reijneveld JC, de Vos F, Idbaih A, Frenel JS, Le Rhun E, Sepulveda JM, Perry J, Masucci GL, Freres P, Hirte H, Seidel C, Walenkamp A, Lukacova S, Meijnders P, Blais A, Ducray F, Verschaeve V, Nicholas G, Balana C, Bota DA, Preusser M, Nuyens S, Dhermain F, van den Bent M, O'Callaghan CJ, Vanlancker M, Mason W, Weller M
Neuro Oncol 2024 Sep 5;26(9):1670-1682. doi: 10.1093/neuonc/noae053. PMID: 38502052Free PMC Article
REGOMA-OSS: a large, Italian, multicenter, prospective, observational study evaluating the efficacy and safety of regorafenib in patients with recurrent glioblastoma.
Caccese M, Desideri I, Villani V, Simonelli M, Buglione M, Chiesa S, Franceschi E, Gaviani P, Stasi I, Caserta C, Brugnara S, Lolli I, Bennicelli E, Bini P, Cuccu AS, Scoccianti S, Padovan M, Gori S, Bonetti A, Giordano P, Pellerino A, Gregucci F, Riva N, Cinieri S, Internò V, Santoni M, Pernice G, Dealis C, Stievano L, Paiar F, Magni G, De Salvo GL, Zagonel V, Lombardi G
ESMO Open 2024 Apr;9(4):102943. Epub 2024 Mar 15 doi: 10.1016/j.esmoop.2024.102943. PMID: 38492275Free PMC Article
Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes.
Li T, Timmins HC, Trinh T, Mizrahi D, Harrison M, Horvath LG, Grimison P, Friedlander M, Kiernan MC, King MT, Rutherford C, Goldstein D, Park SB
J Natl Compr Canc Netw 2023 Feb;21(2):125-132.e3. doi: 10.6004/jnccn.2022.7074. PMID: 36791763
Analysis of safety and efficacy of proton radiotherapy for IDH-mutated glioma WHO grade 2 and 3.
Eichkorn T, Lischalk JW, Hörner-Rieber J, Deng M, Meixner E, Krämer A, Hoegen P, Sandrini E, Regnery S, Held T, Harrabi S, Jungk C, Herfarth K, Debus J, König L
J Neurooncol 2023 May;162(3):489-501. Epub 2023 Jan 4 doi: 10.1007/s11060-022-04217-y. PMID: 36598613Free PMC Article
Chemotherapy-induced peripheral neuropathy-patient-reported outcomes compared with NCI-CTCAE grade.
Tan AC, McCrary JM, Park SB, Trinh T, Goldstein D
Support Care Cancer 2019 Dec;27(12):4771-4777. Epub 2019 Apr 10 doi: 10.1007/s00520-019-04781-6. PMID: 30972648

Therapy

Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.
Roth P, Gorlia T, Reijneveld JC, de Vos F, Idbaih A, Frenel JS, Le Rhun E, Sepulveda JM, Perry J, Masucci GL, Freres P, Hirte H, Seidel C, Walenkamp A, Lukacova S, Meijnders P, Blais A, Ducray F, Verschaeve V, Nicholas G, Balana C, Bota DA, Preusser M, Nuyens S, Dhermain F, van den Bent M, O'Callaghan CJ, Vanlancker M, Mason W, Weller M
Neuro Oncol 2024 Sep 5;26(9):1670-1682. doi: 10.1093/neuonc/noae053. PMID: 38502052Free PMC Article
Surgically targeted radiation therapy (STaRT) for recurrent brain metastases: Initial clinical experience.
Kutuk T, Tolakanahalli R, Chaswal V, Yarlagadda S, Herrera R, Appel H, La Rosa A, Mishra V, Wieczorek DJJ, McDermott MW, Siomin V, Mehta MP, Odia Y, Gutierrez AN, Kotecha R
Brachytherapy 2023 Nov-Dec;22(6):872-881. Epub 2023 Sep 16 doi: 10.1016/j.brachy.2023.08.002. PMID: 37722990
Feasibility of preirradiation temozolomide in cases of high-grade gliomas: Our experience and review of literature.
Arora S, Rathi AK, Singh K, Ansari FA
J Cancer Res Ther 2023 Jan-Mar;19(2):221-227. doi: 10.4103/jcrt.jcrt_942_21. PMID: 37006062
Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes.
Li T, Timmins HC, Trinh T, Mizrahi D, Harrison M, Horvath LG, Grimison P, Friedlander M, Kiernan MC, King MT, Rutherford C, Goldstein D, Park SB
J Natl Compr Canc Netw 2023 Feb;21(2):125-132.e3. doi: 10.6004/jnccn.2022.7074. PMID: 36791763
Optimizing bevacizumab dosing in glioblastoma: less is more.
Ajlan A, Thomas P, Albakr A, Nagpal S, Recht L
J Neurooncol 2017 Oct;135(1):99-105. Epub 2017 Jun 30 doi: 10.1007/s11060-017-2553-2. PMID: 28667595

Prognosis

Defining the role of surgery for patients with multiple brain metastases.
Ersoy TF, Brainman D, Coras R, Berger B, Weissinger F, Grote A, Simon M
J Neurooncol 2024 Sep;169(2):317-328. Epub 2024 Jun 25 doi: 10.1007/s11060-024-04739-7. PMID: 38916848Free PMC Article
Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.
Roth P, Gorlia T, Reijneveld JC, de Vos F, Idbaih A, Frenel JS, Le Rhun E, Sepulveda JM, Perry J, Masucci GL, Freres P, Hirte H, Seidel C, Walenkamp A, Lukacova S, Meijnders P, Blais A, Ducray F, Verschaeve V, Nicholas G, Balana C, Bota DA, Preusser M, Nuyens S, Dhermain F, van den Bent M, O'Callaghan CJ, Vanlancker M, Mason W, Weller M
Neuro Oncol 2024 Sep 5;26(9):1670-1682. doi: 10.1093/neuonc/noae053. PMID: 38502052Free PMC Article
Surgically targeted radiation therapy (STaRT) for recurrent brain metastases: Initial clinical experience.
Kutuk T, Tolakanahalli R, Chaswal V, Yarlagadda S, Herrera R, Appel H, La Rosa A, Mishra V, Wieczorek DJJ, McDermott MW, Siomin V, Mehta MP, Odia Y, Gutierrez AN, Kotecha R
Brachytherapy 2023 Nov-Dec;22(6):872-881. Epub 2023 Sep 16 doi: 10.1016/j.brachy.2023.08.002. PMID: 37722990
Teratoma Removal, Steroid, IVIG, Rituximab and Tocilizumab (T-SIRT) in Anti-NMDAR Encephalitis.
Lee WJ, Lee ST, Shin YW, Lee HS, Shin HR, Kim DY, Kim S, Lim JA, Moon J, Park KI, Kim HS, Chu K, Lee SK
Neurotherapeutics 2021 Jan;18(1):474-487. doi: 10.1007/s13311-020-00921-7. PMID: 32880854Free PMC Article
Optimizing bevacizumab dosing in glioblastoma: less is more.
Ajlan A, Thomas P, Albakr A, Nagpal S, Recht L
J Neurooncol 2017 Oct;135(1):99-105. Epub 2017 Jun 30 doi: 10.1007/s11060-017-2553-2. PMID: 28667595

Clinical prediction guides

Defining the role of surgery for patients with multiple brain metastases.
Ersoy TF, Brainman D, Coras R, Berger B, Weissinger F, Grote A, Simon M
J Neurooncol 2024 Sep;169(2):317-328. Epub 2024 Jun 25 doi: 10.1007/s11060-024-04739-7. PMID: 38916848Free PMC Article
Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial.
Roth P, Gorlia T, Reijneveld JC, de Vos F, Idbaih A, Frenel JS, Le Rhun E, Sepulveda JM, Perry J, Masucci GL, Freres P, Hirte H, Seidel C, Walenkamp A, Lukacova S, Meijnders P, Blais A, Ducray F, Verschaeve V, Nicholas G, Balana C, Bota DA, Preusser M, Nuyens S, Dhermain F, van den Bent M, O'Callaghan CJ, Vanlancker M, Mason W, Weller M
Neuro Oncol 2024 Sep 5;26(9):1670-1682. doi: 10.1093/neuonc/noae053. PMID: 38502052Free PMC Article
REGOMA-OSS: a large, Italian, multicenter, prospective, observational study evaluating the efficacy and safety of regorafenib in patients with recurrent glioblastoma.
Caccese M, Desideri I, Villani V, Simonelli M, Buglione M, Chiesa S, Franceschi E, Gaviani P, Stasi I, Caserta C, Brugnara S, Lolli I, Bennicelli E, Bini P, Cuccu AS, Scoccianti S, Padovan M, Gori S, Bonetti A, Giordano P, Pellerino A, Gregucci F, Riva N, Cinieri S, Internò V, Santoni M, Pernice G, Dealis C, Stievano L, Paiar F, Magni G, De Salvo GL, Zagonel V, Lombardi G
ESMO Open 2024 Apr;9(4):102943. Epub 2024 Mar 15 doi: 10.1016/j.esmoop.2024.102943. PMID: 38492275Free PMC Article
Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes.
Li T, Timmins HC, Trinh T, Mizrahi D, Harrison M, Horvath LG, Grimison P, Friedlander M, Kiernan MC, King MT, Rutherford C, Goldstein D, Park SB
J Natl Compr Canc Netw 2023 Feb;21(2):125-132.e3. doi: 10.6004/jnccn.2022.7074. PMID: 36791763
Teratoma Removal, Steroid, IVIG, Rituximab and Tocilizumab (T-SIRT) in Anti-NMDAR Encephalitis.
Lee WJ, Lee ST, Shin YW, Lee HS, Shin HR, Kim DY, Kim S, Lim JA, Moon J, Park KI, Kim HS, Chu K, Lee SK
Neurotherapeutics 2021 Jan;18(1):474-487. doi: 10.1007/s13311-020-00921-7. PMID: 32880854Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...