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Basosquamous carcinoma

MedGen UID:
2841
Concept ID:
C0007118
Neoplastic Process
Synonyms: Basosquamous Carcinoma; Basosquamous Carcinomas; Carcinoma, Basosquamous; Carcinomas, Basosquamous
SNOMED CT: Metatypical carcinoma (6641007); Mixed basal - squamous cell carcinoma (37304002); Basisquamous cell carcinoma (37304002); BCC - Metatypical basal cell carcinoma of skin (254702000); Metatypical basal cell carcinoma of skin (254702000); Basosquamous carcinoma of skin (254702000); Basosquamous carcinoma (37304002); Mixed basal-squamous cell carcinoma (37304002)
 
Monarch Initiative: MONDO:0003264

Definition

A basal cell carcinoma which displays squamous differentiation. The neoplastic cells have more abundant cytoplasm with more marked keratinization than typical basal cell carcinomas. It usually has a more aggressive clinical course compared to typical basal cell carcinoma, and it may produce regional or widespread metastases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasosquamous carcinoma

Professional guidelines

PubMed

Zelin E, Mazzoletti V, Cavallo F, Nardello C, Corio A, Toffoli L, Tagliaferri L, Conforti C, Di Meo N, Zalaudek I
Australas J Dermatol 2024 Mar;65(2):103-113. Epub 2023 Nov 5 doi: 10.1111/ajd.14182. PMID: 37927116
Shukla S, Khachemoune A
Arch Dermatol Res 2020 Nov;312(9):605-609. Epub 2020 Mar 12 doi: 10.1007/s00403-020-02058-1. PMID: 32166375
VEIRS ER, ECKLEY R
Am Surg 1962 Sep;28:647-50. PMID: 13925195

Recent clinical studies

Etiology

Newsom E, Lee E, Rossi A, Dusza S, Nehal K
Dermatol Surg 2018 Jun;44(6):778-784. doi: 10.1097/DSS.0000000000001473. PMID: 29642110Free PMC Article
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):67-71. doi: 10.1053/j.semdp.2011.09.001. PMID: 22641955
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364
Bowman PH, Ratz JL, Knoepp TG, Barnes CJ, Finley EM
Dermatol Surg 2003 Aug;29(8):830-2; discussion 833. doi: 10.1046/j.1524-4725.2003.29217.x. PMID: 12859383
Müller E, Beleites E
Rhinology 2000 Dec;38(4):208-11. PMID: 11190760

Diagnosis

Murgia G, Denaro N, Boggio F, Nazzaro G, Benzecry V, Bortoluzzi P, Passoni E, Garrone O, Marzano A
Cells 2023 Nov 30;12(23) doi: 10.3390/cells12232737. PMID: 38067165Free PMC Article
Grisolia DS, Teles-Filho RV, Guilarde AO
Rev Soc Bras Med Trop 2021;54 Epub 2021 Mar 8 doi: 10.1590/0037-8682-0758-2020. PMID: 33681937Free PMC Article
Tavares LL, Costa JCMD, Delcourt NC, Rodrigues NCDS
An Bras Dermatol 2018 Jan-Feb;93(1):114-115. doi: 10.1590/abd1806-4841.20186515. PMID: 29641710Free PMC Article
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364
Maloney ML
Dermatol Surg 2000 May;26(5):505-6. doi: 10.1046/j.1524-4725.2000.00057.x. PMID: 10816246

Therapy

Zelin E, Mazzoletti V, Cavallo F, Nardello C, Corio A, Toffoli L, Tagliaferri L, Conforti C, Di Meo N, Zalaudek I
Australas J Dermatol 2024 Mar;65(2):103-113. Epub 2023 Nov 5 doi: 10.1111/ajd.14182. PMID: 37927116
Pirruccello J, Afzal MZ, Voudouri M, Shirai K
BMJ Case Rep 2023 Jul 14;16(7) doi: 10.1136/bcr-2022-251273. PMID: 37451798Free PMC Article
Tan CZ, Rieger KE, Sarin KY
Dermatol Surg 2017 Jan;43(1):23-31. doi: 10.1097/DSS.0000000000000815. PMID: 27340741
Wax MK, Quraishi H, Rodman S, Granke K
Laryngoscope 1997 Sep;107(9):1245-8. doi: 10.1097/00005537-199709000-00016. PMID: 9292611
Everall JD
Practitioner 1976 Feb;216(1292):167-73. PMID: 1264946

Prognosis

Khan SJA, Gawande M, Hande A, Patil S, Sonone A, Pakhale A
F1000Res 2023;12:1008. Epub 2024 Mar 26 doi: 10.12688/f1000research.134826.2. PMID: 38515860Free PMC Article
Murgia G, Denaro N, Boggio F, Nazzaro G, Benzecry V, Bortoluzzi P, Passoni E, Garrone O, Marzano A
Cells 2023 Nov 30;12(23) doi: 10.3390/cells12232737. PMID: 38067165Free PMC Article
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364
Ide F, Shimoyama T, Horie N, Kusama K
Oral Oncol 2002 Jan;38(1):120-4. doi: 10.1016/s1368-8375(01)00032-x. PMID: 11755833
Müller E, Beleites E
Rhinology 2000 Dec;38(4):208-11. PMID: 11190760

Clinical prediction guides

Venturi F, Erbacci V, Veronesi G, Scotti B, Baraldi C, Dika E
Skin Res Technol 2024 Aug;30(8):e70012. doi: 10.1111/srt.70012. PMID: 39137046Free PMC Article
Sgouros D, Apalla Z, Theofili M, Damaskou V, Kokkalis G, Kitsiou E, Lallas A, Kanelleas A, Stratigos A, Nikolaidou C, Bobos M, Panayiotides I, Rigopoulos D, Katoulis A
Eur J Dermatol 2021 Dec 1;31(6):779-784. doi: 10.1684/ejd.2021.4178. PMID: 34933836
Khatri ML
Int J Dermatol 2021 Mar;60(3):314-320. Epub 2021 Feb 4 doi: 10.1111/ijd.15395. PMID: 33538348
Akay BN, Saral S, Heper AO, Erdem C, Rosendahl C
J Dermatol 2017 Feb;44(2):127-134. Epub 2016 Aug 29 doi: 10.1111/1346-8138.13563. PMID: 27570202
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364

Recent systematic reviews

Pierce CM, Wang RJ, Howe R, Burgess BA, Owen JL
Arch Dermatol Res 2024 Oct 26;316(10):716. doi: 10.1007/s00403-024-03471-6. PMID: 39460789
Tan CZ, Rieger KE, Sarin KY
Dermatol Surg 2017 Jan;43(1):23-31. doi: 10.1097/DSS.0000000000000815. PMID: 27340741

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