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Undifferentiated Malignant Neoplasm

MedGen UID:
277840
•Concept ID:
C1336860
•
Neoplastic Process

Definition

A neoplasm that has minimal to no differentiating features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated Malignant Neoplasm

Professional guidelines

PubMed

The application of immunocytochemical techniques to routinely-fixed and stained cytologic specimens. An aid in the differential diagnosis of undifferentiated malignant neoplasms.
Weintraub J, Redard M, Wenger D, Vassilakos P
Pathol Res Pract 1990 Oct;186(5):658-65. doi: 10.1016/S0344-0338(11)80230-X. PMID: 1705023

Recent clinical studies

Etiology

Primary cutaneous SMARCA4-deficient undifferentiated malignant neoplasm: first two cases with clinicopathologic and molecular comparison to eight visceral counterparts.
Russell-Goldman E, MacConaill L, Hanna J
Mod Pathol 2022 Dec;35(12):1821-1828. Epub 2022 Sep 9 doi: 10.1038/s41379-022-01152-1. PMID: 36085356
Epidemiology of unknown primary tumours; incidence and population-based survival of 1285 patients in Southeast Netherlands, 1984-1992.
van de Wouw AJ, Janssen-Heijnen ML, Coebergh JW, Hillen HF
Eur J Cancer 2002 Feb;38(3):409-13. doi: 10.1016/s0959-8049(01)00378-1. PMID: 11818207
Large cell lymphoma of the orbit with microvillous projections ('porcupine lymphoma').
Font RL, Shields J
Arch Ophthalmol 1985 Nov;103(11):1715-9. doi: 10.1001/archopht.1985.01050110109038. PMID: 3904686
Bone-metastasizing primary renal tumors in children.
Lamego CM, Zerbini MC
Radiology 1983 May;147(2):449-54. doi: 10.1148/radiology.147.2.6300961. PMID: 6300961
Ultrastructural diagnosis of large cell 'undifferentiated' neoplasia.
Gillespie JJ
Diagn Histopathol 1982 Jan-Mar;5(1):33-51. PMID: 6978240

Diagnosis

Primary cutaneous SMARCA4-deficient undifferentiated malignant neoplasm: A rare case report and literature review.
Gumusgoz E, Graham BS, Hosler GA
J Cutan Pathol 2024 Apr;51(4):262-266. Epub 2023 Dec 20 doi: 10.1111/cup.14576. PMID: 38124373
Primary cutaneous SMARCA4-deficient undifferentiated malignant neoplasm: first two cases with clinicopathologic and molecular comparison to eight visceral counterparts.
Russell-Goldman E, MacConaill L, Hanna J
Mod Pathol 2022 Dec;35(12):1821-1828. Epub 2022 Sep 9 doi: 10.1038/s41379-022-01152-1. PMID: 36085356
Role of ancillary techniques in profiling unclassified laryngeal malignancies.
Hellquist H, Hunt JL, Cardesa A, Skalova A, Slootweg PJ, Rinaldo A, Ferlito A
Virchows Arch 2018 May;472(5):705-715. Epub 2018 Apr 6 doi: 10.1007/s00428-018-2348-7. PMID: 29623469
Undifferentiated malignant neoplasm involving the interdental gingiva: a case report.
Elkhoury J, Cacchillo DA, Tatakis DN, Kalmar JR, Allen CM, Sedghizadeh PP
J Periodontol 2004 Sep;75(9):1295-9. doi: 10.1902/jop.2004.75.9.1295. PMID: 15515348
Immunohistochemistry in surgical pathology. The case of the undifferentiated malignant neoplasm.
Linder J
Clin Lab Med 1990 Mar;10(1):59-76. PMID: 2184980

Therapy

Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response.
Kasago IS, Chatila WK, Lezcano CM, Febres-Aldana CA, Schultz N, Vanderbilt C, Dogan S, Bartlett EK, D'Angelo SP, Tap WD, Singer S, Ladanyi M, Shoushtari AN, Busam KJ, Hameed M
Mod Pathol 2023 Aug;36(8):100165. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100165. PMID: 36990277Free PMC Article

Prognosis

Primary cutaneous SMARCA4-deficient undifferentiated malignant neoplasm: first two cases with clinicopathologic and molecular comparison to eight visceral counterparts.
Russell-Goldman E, MacConaill L, Hanna J
Mod Pathol 2022 Dec;35(12):1821-1828. Epub 2022 Sep 9 doi: 10.1038/s41379-022-01152-1. PMID: 36085356
Utility of syndecan-1 (CD138) expression in the diagnosis of undifferentiated malignant neoplasms: a tissue microarray study of 1,754 cases.
Kambham N, Kong C, Longacre TA, Natkunam Y
Appl Immunohistochem Mol Morphol 2005 Dec;13(4):304-10. doi: 10.1097/01.pai.0000159773.50905.7b. PMID: 16280658
Epidemiology of unknown primary tumours; incidence and population-based survival of 1285 patients in Southeast Netherlands, 1984-1992.
van de Wouw AJ, Janssen-Heijnen ML, Coebergh JW, Hillen HF
Eur J Cancer 2002 Feb;38(3):409-13. doi: 10.1016/s0959-8049(01)00378-1. PMID: 11818207
Immunohistochemistry in surgical pathology. The case of the undifferentiated malignant neoplasm.
Linder J
Clin Lab Med 1990 Mar;10(1):59-76. PMID: 2184980
Sarcoma of the larynx in a newborn.
Abramowsky CR, Witt WJ
Cancer 1983 May 1;51(9):1726-30. doi: 10.1002/1097-0142(19830501)51:9<1726::aid-cncr2820510928>3.0.co;2-w. PMID: 6187433

Clinical prediction guides

Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response.
Kasago IS, Chatila WK, Lezcano CM, Febres-Aldana CA, Schultz N, Vanderbilt C, Dogan S, Bartlett EK, D'Angelo SP, Tap WD, Singer S, Ladanyi M, Shoushtari AN, Busam KJ, Hameed M
Mod Pathol 2023 Aug;36(8):100165. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100165. PMID: 36990277Free PMC Article
Utility of syndecan-1 (CD138) expression in the diagnosis of undifferentiated malignant neoplasms: a tissue microarray study of 1,754 cases.
Kambham N, Kong C, Longacre TA, Natkunam Y
Appl Immunohistochem Mol Morphol 2005 Dec;13(4):304-10. doi: 10.1097/01.pai.0000159773.50905.7b. PMID: 16280658

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