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Tonsillar Undifferentiated Carcinoma

MedGen UID:
277822
•Concept ID:
C1336766
•
Neoplastic Process
Synonym: Tonsillar Lymphoepithelioma

Definition

A non-keratinizing carcinoma arising from the tonsil. It is characterized by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, syncytial growth pattern, and a lymphoplasmacytic infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTonsillar Undifferentiated Carcinoma

Professional guidelines

PubMed

Oropharyngeal squamous cell carcinoma and HPV. Systematic review on overall management.
De Santis S, Spinosi MC, Cambi J, Bengala C, Boccuzzi S
J Stomatol Oral Maxillofac Surg 2017 Apr;118(2):103-108. Epub 2017 Feb 24 doi: 10.1016/j.jormas.2017.02.004. PMID: 28345518
Brachytherapy in head and neck cancer: selection criteria and results at the University of Florida.
Mendenhall WM, Parsons JT, Mendenhall NP, Million RR
Oncology (Williston Park) 1991 Feb;5(2):44-54; discussion 59-60. PMID: 1826208
Tonsil carcinoma--treatment results.
Quenelle DJ, Crissman JD, Shumrick DA
Laryngoscope 1979 Nov;89(11):1842-6. doi: 10.1288/00005537-197911000-00019. PMID: 502706

Recent clinical studies

Etiology

Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma: Meta-analysis of published literature.
Tirelli G, Gardenal N, Zanelli E, Borsetto D, Phillips V, Marcuzzo AV, Fussey J, Polesel J, Boscolo-Rizzo P
Head Neck 2022 Oct;44(10):2265-2276. Epub 2022 Aug 1 doi: 10.1002/hed.27166. PMID: 35913029Free PMC Article
Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis.
Di Maio P, Iocca O, De Virgilio A, Ferreli F, Cristalli G, Pellini R, Golusinski P, Ricci G, Spriano G
Head Neck 2019 Apr;41(4):1112-1121. Epub 2018 Dec 21 doi: 10.1002/hed.25522. PMID: 30575162
HPV-associated oropharyngeal squamous cell carcinoma.
Smith TJ, Mendez A, Donald C, Nagel TH
JAAPA 2017 Jan;30(1):14-19. doi: 10.1097/01.JAA.0000510985.76167.ed. PMID: 27941569
ACR Appropriateness Criteria(®) Locoregional therapy for resectable oropharyngeal squamous cell carcinomas.
Beitler JJ, Quon H, Jones CU, Salama JK, Busse PM, Cooper JS, Koyfman SA, Ridge JA, Saba NF, Siddiqui F, Smith RV, Worden F, Yao M, Yom SS; Expert Panel on Radiation Oncology - Head and Neck
Head Neck 2016 Sep;38(9):1299-309. Epub 2016 Jun 22 doi: 10.1002/hed.24447. PMID: 27330003
Tonsil cancer.
Bopp FP, White JA
J La State Med Soc 1989 Apr;141(4):11-4. PMID: 2656893

Diagnosis

Radiation-Induced Laryngeal Mucous Membrane Pemphigoid.
Syal A, Lott DG, Karle WE
Ann Otol Rhinol Laryngol 2023 Oct;132(10):1261-1264. Epub 2022 Nov 26 doi: 10.1177/00034894221139121. PMID: 36433793
Tonsillar carcinoma.
Ulloa-Ortiz Ó, Martínez-Fernández P, Rivera-Silva G
Med Clin (Barc) 2020 Dec 11;155(11):517. Epub 2019 Nov 20 doi: 10.1016/j.medcli.2019.09.004. PMID: 31759692
HPV-associated oropharyngeal squamous cell carcinoma.
Smith TJ, Mendez A, Donald C, Nagel TH
JAAPA 2017 Jan;30(1):14-19. doi: 10.1097/01.JAA.0000510985.76167.ed. PMID: 27941569
ACR Appropriateness Criteria(®) Locoregional therapy for resectable oropharyngeal squamous cell carcinomas.
Beitler JJ, Quon H, Jones CU, Salama JK, Busse PM, Cooper JS, Koyfman SA, Ridge JA, Saba NF, Siddiqui F, Smith RV, Worden F, Yao M, Yom SS; Expert Panel on Radiation Oncology - Head and Neck
Head Neck 2016 Sep;38(9):1299-309. Epub 2016 Jun 22 doi: 10.1002/hed.24447. PMID: 27330003
Tonsil cancer.
Bopp FP, White JA
J La State Med Soc 1989 Apr;141(4):11-4. PMID: 2656893

Therapy

First Bite Syndrome: What Neurologists Need to Know.
Steel SJ, Robertson CE
Curr Pain Headache Rep 2021 Mar 24;25(5):31. doi: 10.1007/s11916-021-00950-7. PMID: 33761012
Accidental barium bronchography.
Zaheen A, Stanbrook MB
CMAJ 2017 May 8;189(18):E670. doi: 10.1503/cmaj.160969. PMID: 28483848Free PMC Article
HPV-associated oropharyngeal squamous cell carcinoma.
Smith TJ, Mendez A, Donald C, Nagel TH
JAAPA 2017 Jan;30(1):14-19. doi: 10.1097/01.JAA.0000510985.76167.ed. PMID: 27941569
Toxic epidermal necrolysis.
Smith LH
Clin J Oncol Nurs 2007 Jun;11(3):333-6. doi: 10.1188/07.CJON.333-336. PMID: 17623618
Cis-platinum vestibular toxicity.
Schaefer SD, Wright CG, Post JD, Frenkel EP
Cancer 1981 Mar 1;47(5):857-9. doi: 10.1002/1097-0142(19810301)47:5<857::aid-cncr2820470508>3.0.co;2-m. PMID: 6971699

Prognosis

Vitamin D and smell impairment, routine histology for unilateral tonsillar enlargement, and a machine learning model for predicting the three-year survival status of patients with hypopharyngeal squamous cell carcinoma.
Fishman J, Fisher E
J Laryngol Otol 2023 Sep;137(9):945. Epub 2023 Sep 6 doi: 10.1017/S0022215123001391. PMID: 37671443
Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma: Meta-analysis of published literature.
Tirelli G, Gardenal N, Zanelli E, Borsetto D, Phillips V, Marcuzzo AV, Fussey J, Polesel J, Boscolo-Rizzo P
Head Neck 2022 Oct;44(10):2265-2276. Epub 2022 Aug 1 doi: 10.1002/hed.27166. PMID: 35913029Free PMC Article
Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis.
Di Maio P, Iocca O, De Virgilio A, Ferreli F, Cristalli G, Pellini R, Golusinski P, Ricci G, Spriano G
Head Neck 2019 Apr;41(4):1112-1121. Epub 2018 Dec 21 doi: 10.1002/hed.25522. PMID: 30575162
ACR Appropriateness Criteria(®) Locoregional therapy for resectable oropharyngeal squamous cell carcinomas.
Beitler JJ, Quon H, Jones CU, Salama JK, Busse PM, Cooper JS, Koyfman SA, Ridge JA, Saba NF, Siddiqui F, Smith RV, Worden F, Yao M, Yom SS; Expert Panel on Radiation Oncology - Head and Neck
Head Neck 2016 Sep;38(9):1299-309. Epub 2016 Jun 22 doi: 10.1002/hed.24447. PMID: 27330003
Superficial ulnar artery perforator flap.
Schonauer F, Marlino S, Turrà F Jr, Graziano P, Dell'Aversana Orabona G
J Craniofac Surg 2014 Sep;25(5):1870-1. doi: 10.1097/SCS.0000000000001061. PMID: 25102397

Clinical prediction guides

Vitamin D and smell impairment, routine histology for unilateral tonsillar enlargement, and a machine learning model for predicting the three-year survival status of patients with hypopharyngeal squamous cell carcinoma.
Fishman J, Fisher E
J Laryngol Otol 2023 Sep;137(9):945. Epub 2023 Sep 6 doi: 10.1017/S0022215123001391. PMID: 37671443
Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma: Meta-analysis of published literature.
Tirelli G, Gardenal N, Zanelli E, Borsetto D, Phillips V, Marcuzzo AV, Fussey J, Polesel J, Boscolo-Rizzo P
Head Neck 2022 Oct;44(10):2265-2276. Epub 2022 Aug 1 doi: 10.1002/hed.27166. PMID: 35913029Free PMC Article
Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial.
Nichols AC, Theurer J, Prisman E, Read N, Berthelet E, Tran E, Fung K, de Almeida JR, Bayley A, Goldstein DP, Hier M, Sultanem K, Richardson K, Mlynarek A, Krishnan S, Le H, Yoo J, MacNeil SD, Winquist E, Hammond JA, Venkatesan V, Kuruvilla S, Warner A, Mitchell S, Chen J, Corsten M, Johnson-Obaseki S, Eapen L, Odell M, Parker C, Wehrli B, Kwan K, Palma DA
Lancet Oncol 2019 Oct;20(10):1349-1359. Epub 2019 Aug 12 doi: 10.1016/S1470-2045(19)30410-3. PMID: 31416685
Superficial ulnar artery perforator flap.
Schonauer F, Marlino S, Turrà F Jr, Graziano P, Dell'Aversana Orabona G
J Craniofac Surg 2014 Sep;25(5):1870-1. doi: 10.1097/SCS.0000000000001061. PMID: 25102397
HPV infections and tonsillar carcinoma.
Syrjänen S
J Clin Pathol 2004 May;57(5):449-55. doi: 10.1136/jcp.2003.008656. PMID: 15113849Free PMC Article

Recent systematic reviews

Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma: Meta-analysis of published literature.
Tirelli G, Gardenal N, Zanelli E, Borsetto D, Phillips V, Marcuzzo AV, Fussey J, Polesel J, Boscolo-Rizzo P
Head Neck 2022 Oct;44(10):2265-2276. Epub 2022 Aug 1 doi: 10.1002/hed.27166. PMID: 35913029Free PMC Article
A systematic review and meta-analysis of margins in transoral surgery for oropharyngeal carcinoma.
Gorphe P, Simon C
Oral Oncol 2019 Nov;98:69-77. Epub 2019 Sep 20 doi: 10.1016/j.oraloncology.2019.09.017. PMID: 31546183
Oropharyngeal squamous cell carcinoma and HPV. Systematic review on overall management.
De Santis S, Spinosi MC, Cambi J, Bengala C, Boccuzzi S
J Stomatol Oral Maxillofac Surg 2017 Apr;118(2):103-108. Epub 2017 Feb 24 doi: 10.1016/j.jormas.2017.02.004. PMID: 28345518
Tonsillar Helicobacter pylori colonization in chronic tonsillitis: systematic review and meta-analysis.
Hwang MS, Forman SN, Kanter JA, Friedman M
JAMA Otolaryngol Head Neck Surg 2015 Mar;141(3):245-9. doi: 10.1001/jamaoto.2014.3296. PMID: 25541915
Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis.
O'Rorke MA, Ellison MV, Murray LJ, Moran M, James J, Anderson LA
Oral Oncol 2012 Dec;48(12):1191-201. Epub 2012 Jul 28 doi: 10.1016/j.oraloncology.2012.06.019. PMID: 22841677

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