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Neoplasm of Uncertain Histogenesis

MedGen UID:
277410
•Concept ID:
C1334936
•
Neoplastic Process
Synonyms: Neoplasm of Uncertain Origin; Tumor of Uncertain Histogenesis; Tumor of Uncertain Origin

Definition

A benign or malignant, primary or metastatic neoplasm with uncertain histogenesis. [from NCI]

Professional guidelines

PubMed

Advances in treatment of alveolar soft part sarcoma: an updated review.
Fujiwara T, Kunisada T, Nakata E, Nishida K, Yanai H, Nakamura T, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102. PMID: 37626447Free PMC Article
Ossifying Fibromyxoid Tumor: A Review With Emphasis on Recent Molecular Advances and Differential Diagnosis.
Carter CS, Patel RM
Arch Pathol Lab Med 2019 Dec;143(12):1504-1512. doi: 10.5858/arpa.2019-0371-RA. PMID: 31765250

Recent clinical studies

Etiology

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Pleomorphic angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement.
Weinreb I, Rubin BP, Goldblum JR
J Cutan Pathol 2008 Sep;35(9):855-60. Epub 2008 Apr 17 doi: 10.1111/j.1600-0560.2007.00908.x. PMID: 18422688
A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium.
Devouassoux-Shisheboran M, Hayashi T, Linnoila RI, Koss MN, Travis WD
Am J Surg Pathol 2000 Jul;24(7):906-16. doi: 10.1097/00000478-200007000-00002. PMID: 10895813
Pigmented neuroectodermal tumour of infancy: an immunohistochemical study.
Stirling RW, Powell G, Fletcher CD
Histopathology 1988 Apr;12(4):425-35. doi: 10.1111/j.1365-2559.1988.tb01957.x. PMID: 2453438

Diagnosis

Advances in treatment of alveolar soft part sarcoma: an updated review.
Fujiwara T, Kunisada T, Nakata E, Nishida K, Yanai H, Nakamura T, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102. PMID: 37626447Free PMC Article
The many faces of Atypical fibroxanthoma.
Agaimy A
Semin Diagn Pathol 2023 Jul;40(4):306-312. Epub 2023 Jun 23 doi: 10.1053/j.semdp.2023.06.001. PMID: 37438163
The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Ossifying Fibromyxoid Tumor: A Review With Emphasis on Recent Molecular Advances and Differential Diagnosis.
Carter CS, Patel RM
Arch Pathol Lab Med 2019 Dec;143(12):1504-1512. doi: 10.5858/arpa.2019-0371-RA. PMID: 31765250
Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of Therapy.
Koch M, Freundl AJ, Agaimy A, Kiesewetter F, Künzel J, Cicha I, Alexiou C
Anticancer Res 2015 Nov;35(11):5717-35. PMID: 26503993

Therapy

Intraabdominal desmoplastic small-cell tumors with divergent differentiation. Observations on three cases of childhood.
Gonzalez-Crussi F, Crawford SE, Sun CC
Am J Surg Pathol 1990 Jul;14(7):633-42. doi: 10.1097/00000478-199007000-00004. PMID: 2356923

Prognosis

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Uterine tumour resembling ovarian sex cord tumour: first report of a large series with follow-up.
Moore M, McCluggage WG
Histopathology 2017 Nov;71(5):751-759. Epub 2017 Sep 8 doi: 10.1111/his.13296. PMID: 28656712
The diagnostic utility of reduced immunohistochemical expression of SMARCB1 in synovial sarcomas: a validation study.
Ito J, Asano N, Kawai A, Yoshida A
Hum Pathol 2016 Jan;47(1):32-7. Epub 2015 Sep 25 doi: 10.1016/j.humpath.2015.09.010. PMID: 26520417
Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of Therapy.
Koch M, Freundl AJ, Agaimy A, Kiesewetter F, Künzel J, Cicha I, Alexiou C
Anticancer Res 2015 Nov;35(11):5717-35. PMID: 26503993
Pleuro-pulmonary solitary fibrous tumors: a clinicopathologic, immunohistochemical, and molecular study of 88 cases confirming the prognostic value of de Perrot staging system and p53 expression, and evaluating the role of c-kit, BRAF, PDGFRs (alpha/beta), c-met, and EGFR.
Schirosi L, Lantuejoul S, Cavazza A, Murer B, Yves Brichon P, Migaldi M, Sartori G, Sgambato A, Rossi G
Am J Surg Pathol 2008 Nov;32(11):1627-42. doi: 10.1097/PAS.0b013e31817a8a89. PMID: 18753943

Clinical prediction guides

Uterine tumour resembling ovarian sex cord tumour: first report of a large series with follow-up.
Moore M, McCluggage WG
Histopathology 2017 Nov;71(5):751-759. Epub 2017 Sep 8 doi: 10.1111/his.13296. PMID: 28656712
Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of Therapy.
Koch M, Freundl AJ, Agaimy A, Kiesewetter F, Künzel J, Cicha I, Alexiou C
Anticancer Res 2015 Nov;35(11):5717-35. PMID: 26503993
Borderline ovarian mucinous neoplasm recurring as small cell carcinoma of hypercalcemic type: evidence for an epithelial histogenesis and relationship with ovarian mucinous tumors for this enigmatic neoplasm.
Mansor S, Nagarajan S, Sumathi VP, McCluggage WG
Int J Gynecol Pathol 2011 Jul;30(4):380-5. doi: 10.1097/PGP.0b013e318209aebc. PMID: 21623206
Chordoid glioma of the third ventricle: a report of two new cases, with further evidence supporting an ependymal differentiation, and review of the literature.
Pasquier B, Péoc'h M, Morrison AL, Gay E, Pasquier D, Grand S, Sindou M, Kopp N
Am J Surg Pathol 2002 Oct;26(10):1330-42. doi: 10.1097/00000478-200210000-00010. PMID: 12360048
Alveolar soft part sarcoma of the uterine cervix.
Flint A, Gikas PW, Roberts JA
Gynecol Oncol 1985 Oct;22(2):263-7. doi: 10.1016/0090-8258(85)90037-x. PMID: 4054722

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