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Mediastinum leiomyoma

MedGen UID:
277350
•Concept ID:
C1334659
•
Neoplastic Process
Synonyms: Leiomyoma of Mediastinum; leiomyoma of mediastinum; Leiomyoma of the Mediastinum; leiomyoma of the mediastinum; Mediastinal Leiomyoma; mediastinal leiomyoma; mediastinum leiomyoma
 
Monarch Initiative: MONDO:0003284

Definition

A benign smooth muscle neoplasm arising from the mediastium. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinum leiomyoma

Recent clinical studies

Etiology

A Giant Upper Esophageal Leiomyoma: A Rare Case.
Hasan W, Nabar U, Adnan J
Am J Case Rep 2021 Oct 15;22:e932430. doi: 10.12659/AJCR.932430. PMID: 34653118Free PMC Article
Endoscopic ultrasonography in pediatric patients--Experience from a tertiary care center in India.
Mahajan R, Simon EG, Chacko A, Reddy DV, Kalyan PR, Joseph AJ, Dutta AK, Chowdhury SD, Kurien RT
Indian J Gastroenterol 2016 Jan;35(1):14-9. Epub 2016 Mar 5 doi: 10.1007/s12664-016-0619-2. PMID: 26946134
Partial oesophagectomy for giant leiomyoma of the oesophagus: report of 7 cases.
De Giacomo T, Bruschini P, Arcieri S, Ruberto F, Venuta F, Diso D, Francioni F
Eur J Cardiothorac Surg 2015 Jan;47(1):143-5. Epub 2014 Apr 6 doi: 10.1093/ejcts/ezu146. PMID: 24711507
Operative techniques in robotic thoracic surgery for inferior or posterior mediastinal pathology.
Cerfolio RJ, Bryant AS, Minnich DJ
J Thorac Cardiovasc Surg 2012 May;143(5):1138-43. Epub 2012 Jan 12 doi: 10.1016/j.jtcvs.2011.12.021. PMID: 22244566
Leiomyomatous hamartoma of the posterior mediastinum.
Bibas BJ, Terra RM, Fernandez A, Shiang C, Pêgo-Fernandes PM, Jatene FB
Ann Thorac Surg 2010 Jan;89(1):304-5. doi: 10.1016/j.athoracsur.2009.06.046. PMID: 20103268

Diagnosis

Pulmonary and mediastinum metastasis of uterine leiomyoma: A case report.
Huang L, Shi G, Wang Q, Guo Y, Cong M
Medicine (Baltimore) 2019 Dec;98(49):e18276. doi: 10.1097/MD.0000000000018276. PMID: 31804368Free PMC Article
Rare mediastinal leiomyoma in a child.
Hakeem ZA, Rathore SS, Wahid A
Gen Thorac Cardiovasc Surg 2017 Jul;65(7):415-417. Epub 2016 Sep 17 doi: 10.1007/s11748-016-0705-5. PMID: 27640051
Endoscopic ultrasound: imaging techniques and applications in the mediastinum.
Bhatia V
Trop Gastroenterol 2010 Apr-Jun;30(2 Suppl):S4-19. PMID: 20715425
Unusual primary pleural leiomyoma.
Rodríguez PM, Freixinet JL, Plaza ML, Camacho R
Interact Cardiovasc Thorac Surg 2010 Mar;10(3):441-2. Epub 2009 Dec 29 doi: 10.1510/icvts.2009.219386. PMID: 20040476
Pulmonary lymphangiomyomatosis.
Shuman RL, Engelman R, Kittle CF
Ann Thorac Surg 1979 Jan;27(1):70-5. doi: 10.1016/s0003-4975(10)62975-x. PMID: 453961

Therapy

A 52-Year-Old Woman With an Abdominal Mass, Bilateral Pulmonary Nodules, and Mediastinal and Hilar Lymphadenopathy.
Van Treeck BJ, Gehlbach DA, Foster GH, Utz JP, Aubry MC, Colby TV, Yi ES
Chest 2019 Jun;155(6):e175-e178. doi: 10.1016/j.chest.2019.01.017. PMID: 31174663
Operative techniques in robotic thoracic surgery for inferior or posterior mediastinal pathology.
Cerfolio RJ, Bryant AS, Minnich DJ
J Thorac Cardiovasc Surg 2012 May;143(5):1138-43. Epub 2012 Jan 12 doi: 10.1016/j.jtcvs.2011.12.021. PMID: 22244566
The robotic approach for mediastinal lesions.
Augustin F, Schmid T, Bodner J
Int J Med Robot 2006 Sep;2(3):262-70. doi: 10.1002/rcs.84. PMID: 17520641

Prognosis

Giant Esophageal Leiomyoma: Diagnostic and Therapeutic Challenges.
Elbawab H, AlOtaibi AF, Binammar AA, Boumarah DN, AlHarbi TM, AlReshaid FT, AlGhamdi ZM
Am J Case Rep 2021 Nov 18;22:e934557. doi: 10.12659/AJCR.934557. PMID: 34789714Free PMC Article
Pulmonary and mediastinum metastasis of uterine leiomyoma: A case report.
Huang L, Shi G, Wang Q, Guo Y, Cong M
Medicine (Baltimore) 2019 Dec;98(49):e18276. doi: 10.1097/MD.0000000000018276. PMID: 31804368Free PMC Article
Esophageal schwannoma: a case report.
Kitada M, Matsuda Y, Hayashi S, Ishibashi K, Oikawa K, Miyokawa N
World J Surg Oncol 2013 Oct 2;11:253. doi: 10.1186/1477-7819-11-253. PMID: 24088647Free PMC Article
Leiomyomatous hamartoma of the posterior mediastinum.
Bibas BJ, Terra RM, Fernandez A, Shiang C, Pêgo-Fernandes PM, Jatene FB
Ann Thorac Surg 2010 Jan;89(1):304-5. doi: 10.1016/j.athoracsur.2009.06.046. PMID: 20103268
Endoscopic ultrasound guided biopsy of mediastinal lesions has a major impact on patient management.
Larsen SS, Krasnik M, Vilmann P, Jacobsen GK, Pedersen JH, Faurschou P, Folke K
Thorax 2002 Feb;57(2):98-103. doi: 10.1136/thorax.57.2.98. PMID: 11828036Free PMC Article

Clinical prediction guides

Complete laparoscopic-transhiatal removal of duplex benign oesophageal tumour: case report and review of literature.
Andrási L, Szepes Z, Tiszlavicz L, Lázár G, Paszt A
BMC Gastroenterol 2021 Feb 2;21(1):47. doi: 10.1186/s12876-021-01625-8. PMID: 33530938Free PMC Article
Pulmonary and mediastinum metastasis of uterine leiomyoma: A case report.
Huang L, Shi G, Wang Q, Guo Y, Cong M
Medicine (Baltimore) 2019 Dec;98(49):e18276. doi: 10.1097/MD.0000000000018276. PMID: 31804368Free PMC Article
Partial oesophagectomy for giant leiomyoma of the oesophagus: report of 7 cases.
De Giacomo T, Bruschini P, Arcieri S, Ruberto F, Venuta F, Diso D, Francioni F
Eur J Cardiothorac Surg 2015 Jan;47(1):143-5. Epub 2014 Apr 6 doi: 10.1093/ejcts/ezu146. PMID: 24711507
The robotic approach for mediastinal lesions.
Augustin F, Schmid T, Bodner J
Int J Med Robot 2006 Sep;2(3):262-70. doi: 10.1002/rcs.84. PMID: 17520641

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