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Serum Soluble Fas Ligand Level Increased

MedGen UID:
275419
•Concept ID:
C1519268
•
Finding

Definition

An indication that the concentration of soluble Fas ligand in a sample has increased when compared to a normal baseline or a previous sample measurement. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSerum Soluble Fas Ligand Level Increased

Professional guidelines

PubMed

Serum DNase I, soluble Fas/FasL levels and cell surface Fas expression in patients with SLE: a possible explanation for the lack of efficacy of hrDNase I treatment.
Tinazzi E, Puccetti A, Gerli R, Rigo A, Migliorini P, Simeoni S, Beri R, Dolcino M, Martinelli N, Corrocher R, Lunardi C
Int Immunol 2009 Mar;21(3):237-43. Epub 2009 Jan 30 doi: 10.1093/intimm/dxn142. PMID: 19181929

Recent clinical studies

Etiology

Serum levels of soluble Fas and Fas ligand in pregnant women who smoke.
Hasan S, Alshaikh B, Yusuf K
Am J Reprod Immunol 2021 Jun;85(6):e13382. Epub 2020 Dec 16 doi: 10.1111/aji.13382. PMID: 33247994
Soluble Fas/FasLare elevated in the serum and cerebrospinal fluid of patients with neurocysticercosis.
Chen X, Yu X, Wang Y, Zhu J, Gu J
Parasitol Res 2017 Nov;116(11):3027-3036. Epub 2017 Sep 30 doi: 10.1007/s00436-017-5613-9. PMID: 28965226
Circulating levels of soluble Fas ligand reflect disease progression in multiple myeloma.
Alexandrakis MG, Pappa CA, Kolovou A, Kyriakaki S, Vyzoukaki R, Devetzoglou M, Tsirakis G
Med Oncol 2014 May;31(5):953. Epub 2014 Apr 13 doi: 10.1007/s12032-014-0953-0. PMID: 24729186
Soluble HLA class I molecules/CD8 ligation trigger apoptosis of CD8+ cells by Fas/Fas-ligand interaction.
Puppo F, Contini P, Ghio M, Indiveri F
ScientificWorldJournal 2002 Feb 12;2:421-3. doi: 10.1100/tsw.2002.122. PMID: 12806026Free PMC Article
Increased serum levels of soluble CD95 (APO-1/Fas) in relapsing-remitting multiple sclerosis.
Zipp F, Weller M, Calabresi PA, Frank JA, Bash CN, Dichgans J, McFarland HF, Martin R
Ann Neurol 1998 Jan;43(1):116-20. doi: 10.1002/ana.410430120. PMID: 9450777

Diagnosis

Matrix metalloproteinase 7, soluble Fas and Fas ligand serum levels for predicting docetaxel resistance and survival in castration-resistant prostate cancer.
Szarvas T, Sevcenco S, Módos O, Keresztes D, Nyirády P, Csizmarik A, Ristl R, Puhr M, Hoffmann MJ, Niedworok C, Hadaschik B, Maj-Hes A, Shariat SF, Kramer G
BJU Int 2018 Oct;122(4):695-704. Epub 2018 Jun 20 doi: 10.1111/bju.14415. PMID: 29802777
High soluble Fas and soluble Fas Ligand serum levels before stent implantation are protective against restenosis.
Katsaros KM, Wiesbauer F, Speidl WS, Kastl SP, Huber K, Zorn G, Niessner A, Glogar D, Maurer G, Wojta J
Thromb Haemost 2011 May;105(5):883-91. Epub 2011 Feb 28 doi: 10.1160/TH10-09-0566. PMID: 21359408
Alterations of Fas and Fas-related molecules in patients with silicosis.
Otsuki T, Miura Y, Nishimura Y, Hyodoh F, Takata A, Kusaka M, Katsuyama H, Tomita M, Ueki A, Kishimoto T
Exp Biol Med (Maywood) 2006 May;231(5):522-33. doi: 10.1177/153537020623100506. PMID: 16636300
Significance of Fas and Fas ligand in tuberculous lymphadenitis.
Mustafa T, Mogga SJ, Mfinanga SG, Mørkve O, Sviland L
Immunology 2005 Feb;114(2):255-62. doi: 10.1111/j.1365-2567.2004.02080.x. PMID: 15667570Free PMC Article
Interleukin-18 in hemophagocytic lymphohistiocytosis.
Takada H, Nomura A, Ohga S, Hara T
Leuk Lymphoma 2001 Jun;42(1-2):21-8. doi: 10.3109/10428190109097673. PMID: 11699209

Therapy

Serum Bcl-2, caspase-9 and soluble FasL levels as perinatal markers in late preterm pregnancies with intrauterine growth restriction.
Genç ŞÖ, Karakuş S, Çetin A, Çetin M, Doğan HO, Korgalı EÜ
Turk J Pediatr 2019;61(5):686-696. doi: 10.24953/turkjped.2019.05.007. PMID: 32105000
Matrix metalloproteinase 7, soluble Fas and Fas ligand serum levels for predicting docetaxel resistance and survival in castration-resistant prostate cancer.
Szarvas T, Sevcenco S, Módos O, Keresztes D, Nyirády P, Csizmarik A, Ristl R, Puhr M, Hoffmann MJ, Niedworok C, Hadaschik B, Maj-Hes A, Shariat SF, Kramer G
BJU Int 2018 Oct;122(4):695-704. Epub 2018 Jun 20 doi: 10.1111/bju.14415. PMID: 29802777
Soluble Fas and Fas ligand in HIV/HCV coinfected patients and impact of HCV therapy.
Guzmán-Fulgencio M, Berenguer J, García-Álvarez M, Micheloud D, C López J, Cosín J, Fernández de Castro I, Catalán P, Miralles P, Resino S
Eur J Clin Microbiol Infect Dis 2011 Oct;30(10):1213-21. Epub 2011 Mar 26 doi: 10.1007/s10096-011-1215-0. PMID: 21442358
High soluble Fas and soluble Fas Ligand serum levels before stent implantation are protective against restenosis.
Katsaros KM, Wiesbauer F, Speidl WS, Kastl SP, Huber K, Zorn G, Niessner A, Glogar D, Maurer G, Wojta J
Thromb Haemost 2011 May;105(5):883-91. Epub 2011 Feb 28 doi: 10.1160/TH10-09-0566. PMID: 21359408
Increased serum levels of soluble CD95 (APO-1/Fas) in relapsing-remitting multiple sclerosis.
Zipp F, Weller M, Calabresi PA, Frank JA, Bash CN, Dichgans J, McFarland HF, Martin R
Ann Neurol 1998 Jan;43(1):116-20. doi: 10.1002/ana.410430120. PMID: 9450777

Prognosis

FAS-antisense 1 lncRNA and production of soluble versus membrane Fas in B-cell lymphoma.
Sehgal L, Mathur R, Braun FK, Wise JF, Berkova Z, Neelapu S, Kwak LW, Samaniego F
Leukemia 2014 Dec;28(12):2376-87. Epub 2014 Apr 3 doi: 10.1038/leu.2014.126. PMID: 24811343Free PMC Article
Circulating levels of soluble Fas ligand reflect disease progression in multiple myeloma.
Alexandrakis MG, Pappa CA, Kolovou A, Kyriakaki S, Vyzoukaki R, Devetzoglou M, Tsirakis G
Med Oncol 2014 May;31(5):953. Epub 2014 Apr 13 doi: 10.1007/s12032-014-0953-0. PMID: 24729186
High soluble Fas and soluble Fas Ligand serum levels before stent implantation are protective against restenosis.
Katsaros KM, Wiesbauer F, Speidl WS, Kastl SP, Huber K, Zorn G, Niessner A, Glogar D, Maurer G, Wojta J
Thromb Haemost 2011 May;105(5):883-91. Epub 2011 Feb 28 doi: 10.1160/TH10-09-0566. PMID: 21359408
Soluble HLA class I molecules/CD8 ligation trigger apoptosis of CD8+ cells by Fas/Fas-ligand interaction.
Puppo F, Contini P, Ghio M, Indiveri F
ScientificWorldJournal 2002 Feb 12;2:421-3. doi: 10.1100/tsw.2002.122. PMID: 12806026Free PMC Article
Increased serum levels of soluble Fas in progressive B-CLL.
Osorio LM, Aguilar-Santelises M, De Santiago A, Hachiya T, Mellstedt H, Jondal M
Eur J Haematol 2001 May;66(5):342-6. doi: 10.1034/j.1600-0609.2001.066005342.x. PMID: 11422415

Clinical prediction guides

Increased serum sFas, sTRAIL, and reduced sFasL in juvenile-onset systemic lupus erythematosus.
Liphaus BL, Kiss MHB, Carrasco S, Palmeira P, Goldenstein-Schainberg C, Carneiro-Sampaio M
Clin Rheumatol 2017 Dec;36(12):2847-2852. Epub 2017 Apr 4 doi: 10.1007/s10067-017-3615-8. PMID: 28378099
Expression of Fas and Fas ligand in human testicular germ cell tumours.
Baldini E, Ulisse S, Marchioni E, Di Benedetto A, Giovannetti G, Petrangeli E, Sentinelli S, Donnorso RP, Reale MG, Mottolese M, Gandini L, Lenzi A, D'Armiento M
Int J Androl 2009 Apr;32(2):123-30. Epub 2007 Oct 3 doi: 10.1111/j.1365-2605.2007.00823.x. PMID: 17916181
Soluble HLA class I molecules/CD8 ligation trigger apoptosis of CD8+ cells by Fas/Fas-ligand interaction.
Puppo F, Contini P, Ghio M, Indiveri F
ScientificWorldJournal 2002 Feb 12;2:421-3. doi: 10.1100/tsw.2002.122. PMID: 12806026Free PMC Article
Interleukin-18 in hemophagocytic lymphohistiocytosis.
Takada H, Nomura A, Ohga S, Hara T
Leuk Lymphoma 2001 Jun;42(1-2):21-8. doi: 10.3109/10428190109097673. PMID: 11699209
Increased serum levels of soluble Fas in progressive B-CLL.
Osorio LM, Aguilar-Santelises M, De Santiago A, Hachiya T, Mellstedt H, Jondal M
Eur J Haematol 2001 May;66(5):342-6. doi: 10.1034/j.1600-0609.2001.066005342.x. PMID: 11422415

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