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Testicular yolk sac tumor, endodermal sinus pattern

MedGen UID:
273636
•Concept ID:
C1515303
•
Neoplastic Process
Synonyms: endodermal sinus pattern testicular yolk sac tumor; endodermal sinus pattern testicular yolk sac tumour; Testicular Yolk Sac Tumor, Endodermal Sinus Pattern; testicular yolk sac tumor, endodermal sinus pattern; Testicular Yolk Sac Tumor, Endodermal Sinus/Perivascular Pattern
 
Monarch Initiative: MONDO:0004178

Definition

A yolk sac tumor that arises from the testis and is characterized by the presence of connective tissue stalks that contain a blood vessel and are lined by cells with clear cytoplasm and prominent nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular yolk sac tumor, endodermal sinus pattern

Professional guidelines

PubMed

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
Immunohistochemical expression of SALL4 in hepatocellular carcinoma, a potential pitfall in the differential diagnosis of yolk sac tumors.
Gonzalez-Roibon N, Katz B, Chaux A, Sharma R, Munari E, Faraj SF, Illei PB, Torbenson M, Netto GJ
Hum Pathol 2013 Jul;44(7):1293-9. Epub 2013 Jan 21 doi: 10.1016/j.humpath.2012.10.017. PMID: 23347651
Clinical behavior and a contemporary management algorithm for prepubertal testis tumors: a summary of the Prepubertal Testis Tumor Registry.
Ross JH, Rybicki L, Kay R
J Urol 2002 Oct;168(4 Pt 2):1675-8; discussion 1678-9. doi: 10.1097/01.ju.0000030749.27823.f5. PMID: 12352332

Recent clinical studies

Etiology

Malignant testicular tumors in children: overview on 10 years of Saudi Cancer Registry.
Alkhayal AM, Aljarallah MF, Alqirnas MQ, Aldusari RS, Alyami F, Jamalalail Y, Hadhoud H, Alrabeeah K, Alsaikhan BH, Ghazwani Y, Noureldin YA
Int Urol Nephrol 2023 Nov;55(11):2677-2683. Epub 2023 Jul 21 doi: 10.1007/s11255-023-03701-2. PMID: 37477777
Yolk sac tumor of postpubertal-type does not exhibit immunohistochemical loss of SMARCB1/INI1 and SMARCA4/BRG1…but choriocarcinoma?
Ricci C, Ambrosi F, Franceschini T, Giunchi F, Franchini E, Massari F, Mollica V, Bianchi FM, Colecchia M, Acosta AM, Fiorentino M
Pathol Res Pract 2023 Jan;241:154269. Epub 2022 Dec 7 doi: 10.1016/j.prp.2022.154269. PMID: 36502737
High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors.
Shojaei H, Hong H, Redline RW
Mod Pathol 2016 Oct;29(10):1278-88. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.131. PMID: 27443515
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253

Diagnosis

FoxA2 is a reliable marker for the diagnosis of yolk sac tumour postpubertal-type.
Ricci C, Ambrosi F, Franceschini T, Giunchi F, Di Filippo G, Franchini E, Massari F, Mollica V, Tateo V, Bianchi FM, Colecchia M, Acosta AM, Fiorentino M
Histopathology 2023 Sep;83(3):465-476. Epub 2023 Jun 14 doi: 10.1111/his.14968. PMID: 37317674
Pure post-pubertal yolk sac tumor of the testis: An extremely rare and aggressive entity.
Patel S, Satturwar S, Khan W, Ashman D, Quiroga-Garza GM
Ann Diagn Pathol 2023 Apr;63:152086. Epub 2022 Dec 23 doi: 10.1016/j.anndiagpath.2022.152086. PMID: 36580878
Recent advances in the regulation of testicular germ cell tumors by microRNAs.
Batool A, Liu XM, Zhang CL, Hao CF, Chen SR, Liu YX
Front Biosci (Landmark Ed) 2019 Mar 1;24(4):765-776. doi: 10.2741/4749. PMID: 30844711
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
The yolk sac tumor: reflections on a remarkable neoplasm and two of the many intrigued by it-Gunnar Teilum and Aleksander Talerman-and the bond it formed between them.
Young RH
Int J Surg Pathol 2014 Dec;22(8):677-87. Epub 2014 Nov 12 doi: 10.1177/1066896914558265. PMID: 25395492

Therapy

Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor.
Ulbright TM, Young RH
Am J Surg Pathol 2005 Apr;29(4):500-5. doi: 10.1097/01.pas.0000155146.60670.3f. PMID: 15767805
Testicular cancer metastatic exclusively to the brain and spleen.
Nguyen MM, Corr AS, Evans CP
Urology 2004 Jan;63(1):176-8. doi: 10.1016/j.urology.2003.08.021. PMID: 14751386
Accidental iatrogenic intoxications by cytotoxic drugs: error analysis and practical preventive strategies.
Zernikow B, Michel E, Fleischhack G, Bode U
Drug Saf 1999 Jul;21(1):57-74. doi: 10.2165/00002018-199921010-00005. PMID: 10433353
Microcystic Leydig cell tumors mimicking yolk sac tumor: a report of four cases.
Billings SD, Roth LM, Ulbright TM
Am J Surg Pathol 1999 May;23(5):546-51. doi: 10.1097/00000478-199905000-00008. PMID: 10328086

Prognosis

Recent advances in the regulation of testicular germ cell tumors by microRNAs.
Batool A, Liu XM, Zhang CL, Hao CF, Chen SR, Liu YX
Front Biosci (Landmark Ed) 2019 Mar 1;24(4):765-776. doi: 10.2741/4749. PMID: 30844711
Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases.
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2012 Mar;36(3):360-7. doi: 10.1097/PAS.0b013e31823c510b. PMID: 22261704

Clinical prediction guides

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors.
Shojaei H, Hong H, Redline RW
Mod Pathol 2016 Oct;29(10):1278-88. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.131. PMID: 27443515
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases.
Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH
Am J Surg Pathol 2015 Aug;39(8):1121-31. doi: 10.1097/PAS.0000000000000432. PMID: 25828390
Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases.
Kao CS, Idrees MT, Young RH, Ulbright TM
Am J Surg Pathol 2012 Mar;36(3):360-7. doi: 10.1097/PAS.0b013e31823c510b. PMID: 22261704

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