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Lung inflammatory myofibroblastic tumor

MedGen UID:
273512
•Concept ID:
C1518038
•
Neoplastic Process
Synonyms: inflammatory myofibroblastic lung tumor; inflammatory myofibroblastic lung tumour; Lung Inflammatory Myofibroblastic Tumor; lung inflammatory myofibroblastic tumor; Myofibroblastic Tumor, Peribronchial
 
Monarch Initiative: MONDO:0006276

Definition

An intermediate fibroblastic neoplasm arising from the lung. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung inflammatory myofibroblastic tumor

Professional guidelines

PubMed

Differential diagnosis of IgG4-positive plasma cells in the lung.
Mukhopadhyay S
Semin Diagn Pathol 2024 Mar;41(2):72-78. Epub 2023 Nov 15 doi: 10.1053/j.semdp.2023.11.006. PMID: 37993385
CT Signs and Differential Diagnosis of Peripheral Lung Cancer and Inflammatory Pseudotumor: A Meta-Analysis.
Zheng S, Shu J, Xue J, Ying C
J Healthc Eng 2022;2022:3547070. Epub 2022 Jan 3 doi: 10.1155/2022/3547070. PMID: 35028118Free PMC Article
Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma, and related lesions: an historical review with differential diagnostic considerations.
Coffin CM, Dehner LP, Meis-Kindblom JM
Semin Diagn Pathol 1998 May;15(2):102-10. PMID: 9606802

Recent clinical studies

Etiology

Distinct fibroblast subpopulations associated with bone, brain or intrapulmonary metastasis in advanced non-small-cell lung cancer.
Xu K, Wang H, Zou YX, Zhang HH, Wang YN, Ren XR, Wang HQ, Xu YH, Li JJ, Tang H, He C, Wei S, Tian T, Li LL, Zhou H, Xu LJ, Fang JW, Guo C, Yang JX, Zhou YY, Zhang ZH, Pan YY
Clin Transl Med 2024 Mar;14(3):e1605. doi: 10.1002/ctm2.1605. PMID: 38445456Free PMC Article
Inflammatory Myofibroblastic Tumor in Female Genital Tract.
Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784
Left main bronchus resection and reconstruction. A single institution experience.
Ragusa M, Vannucci J, Cagini L, Daddi N, Pecoriello R, Puma F
J Cardiothorac Surg 2012 Apr 10;7:29. doi: 10.1186/1749-8090-7-29. PMID: 22490234Free PMC Article
Post-operative imaging of soft tissue sarcomas.
James SL, Davies AM
Cancer Imaging 2008 Feb 27;8(1):8-18. doi: 10.1102/1470-7330.2008.0003. PMID: 18331968Free PMC Article
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468

Diagnosis

Inflammatory Myofibroblastic Tumors: Current Update.
Surabhi VR, Chua S, Patel RP, Takahashi N, Lalwani N, Prasad SR
Radiol Clin North Am 2016 May;54(3):553-63. Epub 2016 Mar 12 doi: 10.1016/j.rcl.2015.12.005. PMID: 27153788
Radiographic and Pathologic Manifestations of Uncommon and Rare Pulmonary Lesions.
Pfeifer K, Mian A, Adebowale A, Alomari A, Kalra V, Krejci E, Shin MS
Can Assoc Radiol J 2016 May;67(2):179-89. Epub 2015 Dec 11 doi: 10.1016/j.carj.2015.07.004. PMID: 26690551
ALK-immunoreactive neoplasms.
Minoo P, Wang HY
Int J Clin Exp Pathol 2012;5(5):397-410. Epub 2012 May 23 PMID: 22808292Free PMC Article
Pulmonary pseudoneoplasms.
Yi E, Aubry MC
Arch Pathol Lab Med 2010 Mar;134(3):417-26. doi: 10.5858/134.3.417. PMID: 20196669
Inflammatory pseudotumor.
Narla LD, Newman B, Spottswood SS, Narla S, Kolli R
Radiographics 2003 May-Jun;23(3):719-29. doi: 10.1148/rg.233025073. PMID: 12740472

Therapy

Update of Diagnosis and Targeted Therapy for ALK(+) Inflammation Myofibroblastic Tumor.
Wang QA, Chen HW, Wu RC, Wu CE
Curr Treat Options Oncol 2023 Dec;24(12):1683-1702. Epub 2023 Nov 8 doi: 10.1007/s11864-023-01144-6. PMID: 37938503Free PMC Article
ROS1 [corrected].
Pal P, Khan Z
J Clin Pathol 2017 Dec;70(12):1001-1009. Epub 2017 Sep 13 doi: 10.1136/jclinpath-2016-204244. PMID: 28903995
Pneumonectomy-Sparing NSAID Therapy for Pulmonary Inflammatory Myofibroblastic Tumor.
Ghani S, Desai A, Pokharel S, Demmy T, Dy GK
J Thorac Oncol 2015 Sep;10(9):e89-e90. doi: 10.1097/JTO.0000000000000574. PMID: 26291018
ALK-immunoreactive neoplasms.
Minoo P, Wang HY
Int J Clin Exp Pathol 2012;5(5):397-410. Epub 2012 May 23 PMID: 22808292Free PMC Article
IgG4-related sclerosing disease.
Kamisawa T, Okamoto A
World J Gastroenterol 2008 Jul 7;14(25):3948-55. doi: 10.3748/wjg.14.3948. PMID: 18609677Free PMC Article

Prognosis

The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional atlas.
Chen B, Chan WN, Xie F, Mui CW, Liu X, Cheung AHK, Lung RWM, Chow C, Zhang Z, Fang C, Yu P, Shi S, Zhou S, Chen G, Wang Z, Wang S, Ding X, Huang B, Liang L, Dong Y, Wong CC, Wu WKK, Cheng ASL, Wong N, Yu J, Lo KW, Tse GMK, Kang W, To KF
Clin Transl Med 2023 Dec;13(12):e1516. doi: 10.1002/ctm2.1516. PMID: 38148640Free PMC Article
Inflammatory myofibroblastic tumor of the lung.
Khatri A, Agrawal A, Sikachi RR, Mehta D, Sahni S, Meena N
Adv Respir Med 2018;86(1):27-35. doi: 10.5603/ARM.2018.0007. PMID: 29490419
Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK.
Mariño-Enríquez A, Wang WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, Coffin CM, Hornick JL
Am J Surg Pathol 2011 Jan;35(1):135-44. doi: 10.1097/PAS.0b013e318200cfd5. PMID: 21164297
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468
Inflammatory pseudotumour (plasma cell granuloma) of lung, liver and other organs.
Anthony PP
Histopathology 1993 Nov;23(5):501-3. doi: 10.1111/j.1365-2559.1993.tb00508.x. PMID: 8314233

Clinical prediction guides

Distinct fibroblast subpopulations associated with bone, brain or intrapulmonary metastasis in advanced non-small-cell lung cancer.
Xu K, Wang H, Zou YX, Zhang HH, Wang YN, Ren XR, Wang HQ, Xu YH, Li JJ, Tang H, He C, Wei S, Tian T, Li LL, Zhou H, Xu LJ, Fang JW, Guo C, Yang JX, Zhou YY, Zhang ZH, Pan YY
Clin Transl Med 2024 Mar;14(3):e1605. doi: 10.1002/ctm2.1605. PMID: 38445456Free PMC Article
Adaptation to the intracellular environment of primary human macrophages influences drug susceptibility of Mycobacterium tuberculosis.
Lanni F, Wijnant GJ, Xie M, Osiecki P, Dartois V, Sarathy JP
Tuberculosis (Edinb) 2023 Mar;139:102318. Epub 2023 Jan 23 doi: 10.1016/j.tube.2023.102318. PMID: 36889104
The role of anaplastic lymphoma kinase in pediatric cancers.
Takita J
Cancer Sci 2017 Oct;108(10):1913-1920. Epub 2017 Aug 24 doi: 10.1111/cas.13333. PMID: 28756644Free PMC Article
Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK.
Mariño-Enríquez A, Wang WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, Coffin CM, Hornick JL
Am J Surg Pathol 2011 Jan;35(1):135-44. doi: 10.1097/PAS.0b013e318200cfd5. PMID: 21164297
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468

Recent systematic reviews

Treatment modalities of ALK-positive relapsed/refractory inflammatory myofibroblastic tumor of the brain and lungs in 7-year-old girl: case-based reviews.
Chanthong S, Sathitsamitphong L, Natesirinilkul R, Charoenkwan P, Suwansirikul S, Choed-Amphai C
Childs Nerv Syst 2023 Feb;39(2):331-342. Epub 2022 Dec 14 doi: 10.1007/s00381-022-05789-w. PMID: 36515740

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