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Aneuploid Dysplastic Oral Leukoplakia

MedGen UID:
273020
•Concept ID:
C1515988
•
Neoplastic Process

Definition

Oral leukoplakia associated with advanced dysplasia in which genetic studies show aneuploidy. The vast majority of patients develop aggressive invasive squamous cell carcinomas. Complete resection of the lesion does not reduce the risk of developing invasive squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAneuploid Dysplastic Oral Leukoplakia

Professional guidelines

PubMed

Application of 5-aminolevulinic acid-mediated Waterlase-assisted photodynamic therapy in the treatment of oral leukoplakia.
Ou J, Gao Y, Li H, Ling T, Xie X
Sci Rep 2022 Jun 7;12(1):9391. doi: 10.1038/s41598-022-13497-3. PMID: 35672359Free PMC Article

Recent clinical studies

Etiology

Clinical evaluation of photodynamic therapy for oral leukoplakia: a retrospective study of 50 patients.
Wang Y, Tang H, Wang K, Zhao Y, Xu J, Fan Y
BMC Oral Health 2024 Jan 3;24(1):9. doi: 10.1186/s12903-023-03791-5. PMID: 38172857Free PMC Article
Correlation between dysplasia and ploidy status in oral leukoplakia.
van Zyl AW, van Heerden MB, Langenegger E, van Heerden WF
Head Neck Pathol 2012 Sep;6(3):322-7. Epub 2012 Mar 20 doi: 10.1007/s12105-012-0352-9. PMID: 22430773Free PMC Article
Oral cancer genesis and progression: DNA near-diploid aneuploidization and endoreduplication by high resolution flow cytometry.
Donadini A, Maffei M, Cavallero A, Pentenero M, Malacarne D, Di Nallo E, Truini M, Navone R, Mereu P, Scala M, Santelli A, Gandolfo S, Giaretti W
Cell Oncol 2010;32(5-6):373-83. doi: 10.3233/CLO-2010-0525. PMID: 20448331Free PMC Article
The influence of resection and aneuploidy on mortality in oral leukoplakia.
Sudbø J, Lippman SM, Lee JJ, Mao L, Kildal W, Sudbø A, Sagen S, Bryne M, El-Naggar A, Risberg B, Evensen JF, Reith A
N Engl J Med 2004 Apr 1;350(14):1405-13. doi: 10.1056/NEJMoa033374. PMID: 15070790
Flow cytometric analysis of nuclear DNA content in oral leukoplakia.
Seoane J, Bascones A, Asenjo JA, García-Pola M, Varela-Centelles PI
Clin Otolaryngol Allied Sci 1998 Apr;23(2):136-40. doi: 10.1046/j.1365-2273.1998.00116.x. PMID: 9597283

Diagnosis

Clinical evaluation of photodynamic therapy for oral leukoplakia: a retrospective study of 50 patients.
Wang Y, Tang H, Wang K, Zhao Y, Xu J, Fan Y
BMC Oral Health 2024 Jan 3;24(1):9. doi: 10.1186/s12903-023-03791-5. PMID: 38172857Free PMC Article
Oral cancer genesis and progression: DNA near-diploid aneuploidization and endoreduplication by high resolution flow cytometry.
Donadini A, Maffei M, Cavallero A, Pentenero M, Malacarne D, Di Nallo E, Truini M, Navone R, Mereu P, Scala M, Santelli A, Gandolfo S, Giaretti W
Cell Oncol 2010;32(5-6):373-83. doi: 10.3233/CLO-2010-0525. PMID: 20448331Free PMC Article
The evolution of predictive oncology and molecular-based therapy for oral cancer prevention.
Sudbø J, Reith A
Int J Cancer 2005 Jun 20;115(3):339-45. doi: 10.1002/ijc.20896. PMID: 15688375
The influence of resection and aneuploidy on mortality in oral leukoplakia.
Sudbø J, Lippman SM, Lee JJ, Mao L, Kildal W, Sudbø A, Sagen S, Bryne M, El-Naggar A, Risberg B, Evensen JF, Reith A
N Engl J Med 2004 Apr 1;350(14):1405-13. doi: 10.1056/NEJMoa033374. PMID: 15070790
Flow cytometric analysis of nuclear DNA content in oral leukoplakia.
Seoane J, Bascones A, Asenjo JA, García-Pola M, Varela-Centelles PI
Clin Otolaryngol Allied Sci 1998 Apr;23(2):136-40. doi: 10.1046/j.1365-2273.1998.00116.x. PMID: 9597283

Therapy

Clinical evaluation of photodynamic therapy for oral leukoplakia: a retrospective study of 50 patients.
Wang Y, Tang H, Wang K, Zhao Y, Xu J, Fan Y
BMC Oral Health 2024 Jan 3;24(1):9. doi: 10.1186/s12903-023-03791-5. PMID: 38172857Free PMC Article
Continuous artificial intelligence-assisted DNA aneuploidy cytology for surveilling dysplastic oral leukoplakia treated by photodynamic therapy.
He MJ, Wang F, Zhang J, Tan YQ, Chen XJ, Zhou G, Lu R
Photodiagnosis Photodyn Ther 2023 Jun;42:103588. Epub 2023 Apr 29 doi: 10.1016/j.pdpdt.2023.103588. PMID: 37127242
Application of 5-aminolevulinic acid-mediated Waterlase-assisted photodynamic therapy in the treatment of oral leukoplakia.
Ou J, Gao Y, Li H, Ling T, Xie X
Sci Rep 2022 Jun 7;12(1):9391. doi: 10.1038/s41598-022-13497-3. PMID: 35672359Free PMC Article
The evolution of predictive oncology and molecular-based therapy for oral cancer prevention.
Sudbø J, Reith A
Int J Cancer 2005 Jun 20;115(3):339-45. doi: 10.1002/ijc.20896. PMID: 15688375

Prognosis

Continuous artificial intelligence-assisted DNA aneuploidy cytology for surveilling dysplastic oral leukoplakia treated by photodynamic therapy.
He MJ, Wang F, Zhang J, Tan YQ, Chen XJ, Zhou G, Lu R
Photodiagnosis Photodyn Ther 2023 Jun;42:103588. Epub 2023 Apr 29 doi: 10.1016/j.pdpdt.2023.103588. PMID: 37127242
Correlation between dysplasia and ploidy status in oral leukoplakia.
van Zyl AW, van Heerden MB, Langenegger E, van Heerden WF
Head Neck Pathol 2012 Sep;6(3):322-7. Epub 2012 Mar 20 doi: 10.1007/s12105-012-0352-9. PMID: 22430773Free PMC Article
The evolution of predictive oncology and molecular-based therapy for oral cancer prevention.
Sudbø J, Reith A
Int J Cancer 2005 Jun 20;115(3):339-45. doi: 10.1002/ijc.20896. PMID: 15688375
The influence of resection and aneuploidy on mortality in oral leukoplakia.
Sudbø J, Lippman SM, Lee JJ, Mao L, Kildal W, Sudbø A, Sagen S, Bryne M, El-Naggar A, Risberg B, Evensen JF, Reith A
N Engl J Med 2004 Apr 1;350(14):1405-13. doi: 10.1056/NEJMoa033374. PMID: 15070790
Flow cytometric analysis of nuclear DNA content in oral leukoplakia.
Seoane J, Bascones A, Asenjo JA, García-Pola M, Varela-Centelles PI
Clin Otolaryngol Allied Sci 1998 Apr;23(2):136-40. doi: 10.1046/j.1365-2273.1998.00116.x. PMID: 9597283

Clinical prediction guides

DNA aneuploidy and tissue architecture in oral potentially malignant disorders with epithelial dysplasia assessed by a 10 locus FISH panel.
Zaini ZM, Neat M, Stokes A, Tavassoli M, Odell EW
Oncol Rep 2020 Mar;43(3):877-885. Epub 2020 Jan 13 doi: 10.3892/or.2020.7461. PMID: 32020221Free PMC Article
Correlation between dysplasia and ploidy status in oral leukoplakia.
van Zyl AW, van Heerden MB, Langenegger E, van Heerden WF
Head Neck Pathol 2012 Sep;6(3):322-7. Epub 2012 Mar 20 doi: 10.1007/s12105-012-0352-9. PMID: 22430773Free PMC Article
Field effect in oral precancer as assessed by DNA flow cytometry and array-CGH.
Pentenero M, Donadini A, Di Nallo E, Maffei M, Marino R, Familiari U, Castagnola P, Gandolfo S, Giaretti W
J Oral Pathol Med 2012 Feb;41(2):119-23. Epub 2011 Sep 23 doi: 10.1111/j.1600-0714.2011.01085.x. PMID: 21950471
The evolution of predictive oncology and molecular-based therapy for oral cancer prevention.
Sudbø J, Reith A
Int J Cancer 2005 Jun 20;115(3):339-45. doi: 10.1002/ijc.20896. PMID: 15688375
Flow cytometric analysis of nuclear DNA content in oral leukoplakia.
Seoane J, Bascones A, Asenjo JA, García-Pola M, Varela-Centelles PI
Clin Otolaryngol Allied Sci 1998 Apr;23(2):136-40. doi: 10.1046/j.1365-2273.1998.00116.x. PMID: 9597283

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