U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

High Grade Paranasal Sinus Sarcoma

MedGen UID:
272719
•Concept ID:
C1334018
•
Neoplastic Process
Synonyms: High Grade Accessory Sinus Sarcoma; High Grade Sarcoma of Accessory Sinus; High Grade Sarcoma of Paranasal Sinus; High Grade Sarcoma of the Accessory Sinus; High Grade Sarcoma of the Paranasal Sinus

Definition

An aggressive malignant soft tissue neoplasm that arises from the paranasal sinus. It is characterized by the presence of high-grade histologic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Paranasal Sinus Sarcoma

Professional guidelines

PubMed

Challenging differential diagnoses in small biopsies from the sinonasal tract.
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435

Recent clinical studies

Etiology

Challenging differential diagnoses in small biopsies from the sinonasal tract.
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Top 10 Basaloid Neoplasms of the Sinonasal Tract.
Baněčková M, Cox D
Head Neck Pathol 2023 Mar;17(1):16-32. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01508-8. PMID: 36928732Free PMC Article
Sinonasal synovial sarcoma: evaluation of the role of radiological and clinicopathological features in diagnosis.
Lin N, Liu X, Zhang F, Pan Y, Qi M, Sha Y
Clin Radiol 2021 Jan;76(1):78.e1-78.e8. Epub 2020 Sep 28 doi: 10.1016/j.crad.2020.08.007. PMID: 32896427
Sarcomas of the head and neck.
Potter BO, Sturgis EM
Surg Oncol Clin N Am 2003 Apr;12(2):379-417. doi: 10.1016/s1055-3207(03)00005-x. PMID: 12916461
Head and neck sarcoma: report of the Head and Neck Sarcoma Registry. Society of Head and Neck Surgeons Committee on Research.
Wanebo HJ, Koness RJ, MacFarlane JK, Eilber FR, Byers RM, Elias EG, Spiro RH
Head Neck 1992 Jan-Feb;14(1):1-7. doi: 10.1002/hed.2880140102. PMID: 1624288

Diagnosis

Challenging differential diagnoses in small biopsies from the sinonasal tract.
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Top 10 Basaloid Neoplasms of the Sinonasal Tract.
Baněčková M, Cox D
Head Neck Pathol 2023 Mar;17(1):16-32. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01508-8. PMID: 36928732Free PMC Article
High-grade transformation of low-grade biphenotypic sinonasal sarcoma: Radiological, morphophenotypic variation and confirmatory molecular analysis.
Bell D, Phan J, DeMonte F, Hanna EY
Ann Diagn Pathol 2022 Apr;57:151889. Epub 2022 Jan 10 doi: 10.1016/j.anndiagpath.2021.151889. PMID: 35030392
Sinonasal synovial sarcoma: evaluation of the role of radiological and clinicopathological features in diagnosis.
Lin N, Liu X, Zhang F, Pan Y, Qi M, Sha Y
Clin Radiol 2021 Jan;76(1):78.e1-78.e8. Epub 2020 Sep 28 doi: 10.1016/j.crad.2020.08.007. PMID: 32896427
Low-grade myofibroblastic sarcoma of maxillary sinus and buccal mucosa: Two rare cases and review of the literature.
Ghosh A, Bandopadhyay A, Sarkar R
Indian J Pathol Microbiol 2019 Jan-Mar;62(1):119-121. doi: 10.4103/IJPM.IJPM_99_18. PMID: 30706874

Therapy

Excellent local control and survival after postoperative or definitive radiation therapy for sarcomas of the head and neck.
Andrä C, Rauch J, Li M, Ganswindt U, Belka C, Saleh-Ebrahimi L, Ballhausen H, Nachbichler SB, Roeder F
Radiat Oncol 2015 Jul 10;10:140. doi: 10.1186/s13014-015-0449-x. PMID: 26156022Free PMC Article
Treatment planning and verification of proton therapy using spot scanning: initial experiences.
Lomax AJ, Böhringer T, Bolsi A, Coray D, Emert F, Goitein G, Jermann M, Lin S, Pedroni E, Rutz H, Stadelmann O, Timmermann B, Verwey J, Weber DC
Med Phys 2004 Nov;31(11):3150-7. doi: 10.1118/1.1779371. PMID: 15587667
Sarcomas of the head and neck.
Potter BO, Sturgis EM
Surg Oncol Clin N Am 2003 Apr;12(2):379-417. doi: 10.1016/s1055-3207(03)00005-x. PMID: 12916461
Fast neutron radiotherapy for advanced malignant tumors of the paranasal sinuses.
Schwarz R, Hübener KH
Strahlenther Onkol 1990 Jan;166(1):99-101. PMID: 2154053

Prognosis

Top 10 Basaloid Neoplasms of the Sinonasal Tract.
Baněčková M, Cox D
Head Neck Pathol 2023 Mar;17(1):16-32. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01508-8. PMID: 36928732Free PMC Article
Clinical Implication of Diagnostic and Histopathologic Discrepancies in Sinonasal Malignancies.
Choi KY, Amit M, Tam S, Bell D, Phan J, Garden AS, Williams MD, Ferrarotto R, El-Naggar AK, Raza SM, DeMonte F, Kupferman ME, Hanna EY, Su SY
Laryngoscope 2021 May;131(5):E1468-E1475. Epub 2020 Sep 18 doi: 10.1002/lary.29102. PMID: 32946597
Outcomes of Sinonasal Cancer Treated With Proton Therapy.
Dagan R, Bryant C, Li Z, Yeung D, Justice J, Dzieglewiski P, Werning J, Fernandes R, Pirgousis P, Lanza DC, Morris CG, Mendenhall WM
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):377-385. Epub 2016 Feb 12 doi: 10.1016/j.ijrobp.2016.02.019. PMID: 27084655
Sarcomas of the head and neck.
Potter BO, Sturgis EM
Surg Oncol Clin N Am 2003 Apr;12(2):379-417. doi: 10.1016/s1055-3207(03)00005-x. PMID: 12916461
Head and neck sarcoma: report of the Head and Neck Sarcoma Registry. Society of Head and Neck Surgeons Committee on Research.
Wanebo HJ, Koness RJ, MacFarlane JK, Eilber FR, Byers RM, Elias EG, Spiro RH
Head Neck 1992 Jan-Feb;14(1):1-7. doi: 10.1002/hed.2880140102. PMID: 1624288

Clinical prediction guides

Sinonasal synovial sarcoma: evaluation of the role of radiological and clinicopathological features in diagnosis.
Lin N, Liu X, Zhang F, Pan Y, Qi M, Sha Y
Clin Radiol 2021 Jan;76(1):78.e1-78.e8. Epub 2020 Sep 28 doi: 10.1016/j.crad.2020.08.007. PMID: 32896427
Outcomes following proton therapy for Ewing sarcoma of the cranium and skull base.
Kharod SM, Indelicato DJ, Rotondo RL, Mailhot Vega RB, Uezono H, Morris CG, Bradfield S, Sandler ES, Bradley JA
Pediatr Blood Cancer 2020 Feb;67(2):e28080. Epub 2019 Nov 17 doi: 10.1002/pbc.28080. PMID: 31736243
Sinonasal Leiomyosarcoma: Clinicopathological Analysis of Nine Cases with Emphasis on Common Association with Other Malignancies and Late Distant Metastasis.
Agaimy A, Semrau S, Koch M, Thompson LDR
Head Neck Pathol 2018 Dec;12(4):463-470. Epub 2017 Dec 21 doi: 10.1007/s12105-017-0876-0. PMID: 29270859Free PMC Article
Excellent local control and survival after postoperative or definitive radiation therapy for sarcomas of the head and neck.
Andrä C, Rauch J, Li M, Ganswindt U, Belka C, Saleh-Ebrahimi L, Ballhausen H, Nachbichler SB, Roeder F
Radiat Oncol 2015 Jul 10;10:140. doi: 10.1186/s13014-015-0449-x. PMID: 26156022Free PMC Article
Sarcomas of the head and neck.
Potter BO, Sturgis EM
Surg Oncol Clin N Am 2003 Apr;12(2):379-417. doi: 10.1016/s1055-3207(03)00005-x. PMID: 12916461

Recent systematic reviews

Risk Factors for Recurrence and the Role of Radiotherapy in Low-grade Myofibroblastic Sarcoma: A Systematic Review.
Mamikunian G, Ziegler A, Block A, Thorpe E
Am J Clin Oncol 2023 Sep 1;46(9):420-425. Epub 2023 Jun 26 doi: 10.1097/COC.0000000000001025. PMID: 37358303

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...