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Colorectal leiomyoma

MedGen UID:
272497
•Concept ID:
C1333113
•
Neoplastic Process
Synonyms: Colorectal Leiomyoma; colorectal leiomyoma; colorectum leiomyoma; Large Bowel Leiomyoma; large bowel leiomyoma; Large Intestine Leiomyoma; large intestine leiomyoma; Leiomyoma of Large Bowel; leiomyoma of large bowel; Leiomyoma of large intestine; Leiomyoma of Large Intestine; leiomyoma of large intestine; Leiomyoma of the Large Bowel; leiomyoma of the large bowel; Leiomyoma of the Large Intestine; leiomyoma of the large intestine
SNOMED CT: Leiomyoma of large intestine (1196826007)
 
Monarch Initiative: MONDO:0003299

Definition

A well-circumscribed benign smooth muscle neoplasm arising from the colorectal area. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal leiomyoma

Professional guidelines

PubMed

Genetic testing by cancer site: uterus.
Daniels MS
Cancer J 2012 Jul-Aug;18(4):338-42. doi: 10.1097/PPO.0b013e3182610cc2. PMID: 22846735
DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases.
Miettinen M, Wang ZF, Lasota J
Am J Surg Pathol 2009 Sep;33(9):1401-8. doi: 10.1097/PAS.0b013e3181a90e1a. PMID: 19606013
Intestinal invagination in adults: preoperative diagnosis and management.
Martín-Lorenzo JG, Torralba-Martinez A, Lirón-Ruiz R, Flores-Pastor B, Miguel-Perelló J, Aguilar-Jimenez J, Aguayo-Albasini JL
Int J Colorectal Dis 2004 Jan;19(1):68-72. Epub 2003 Jun 28 doi: 10.1007/s00384-003-0514-z. PMID: 12838363

Recent clinical studies

Etiology

Gynecological lesions in hereditary cancer predisposition syndromes.
Dundr P, Cibula D, Foretová L, Macek M Jr, Kopečková K, Petruželka L, Němejcová K, Bártů M, Hojný J, Hájková N, Jakša R, Janega P, Stružinská I
Cesk Patol 2021 Summer;57(2):96-104. PMID: 34275319
Genetic testing by cancer site: uterus.
Daniels MS
Cancer J 2012 Jul-Aug;18(4):338-42. doi: 10.1097/PPO.0b013e3182610cc2. PMID: 22846735
Screening for uterine tumours.
Van den Bosch T, Coosemans A, Morina M, Timmerman D, Amant F
Best Pract Res Clin Obstet Gynaecol 2012 Apr;26(2):257-66. Epub 2011 Nov 9 doi: 10.1016/j.bpobgyn.2011.08.002. PMID: 22078749
Non-contraceptive benefits of oral contraceptives.
Huber JC, Bentz EK, Ott J, Tempfer CB
Expert Opin Pharmacother 2008 Sep;9(13):2317-25. doi: 10.1517/14656566.9.13.2317. PMID: 18710356
Oral contraceptives: current status.
Burkman RT
Clin Obstet Gynecol 2001 Mar;44(1):62-72. doi: 10.1097/00003081-200103000-00010. PMID: 11219247

Diagnosis

Giant multilocular prostatic cystadenoma.
Nakamura Y, Shida D, Shibayama T, Yoshida A, Matsui Y, Shinoda Y, Iwata S, Kanemitsu Y
World J Surg Oncol 2019 Feb 26;17(1):42. doi: 10.1186/s12957-019-1579-7. PMID: 30808350Free PMC Article
Imaging findings of hereditary renal tumors, a review of what the radiologist should know.
Czarniecki M, Gautam R, Choyke PL, Turkbey B
Eur J Radiol 2018 Apr;101:8-16. Epub 2018 Feb 2 doi: 10.1016/j.ejrad.2018.01.026. PMID: 29571805
Screening for uterine tumours.
Van den Bosch T, Coosemans A, Morina M, Timmerman D, Amant F
Best Pract Res Clin Obstet Gynaecol 2012 Apr;26(2):257-66. Epub 2011 Nov 9 doi: 10.1016/j.bpobgyn.2011.08.002. PMID: 22078749
Perianal leiomyoma.
Salvans Ruiz S, Gimeno Beltrán J, Parés D
Rev Esp Enferm Dig 2009 Mar;101(3):209-11. doi: 10.4321/s1130-01082009000300007. PMID: 19388801
Anorectal leiomyosarcomas.
Wang TK, Chung MT
J Gastroenterol 1998 Jun;33(3):402-7. doi: 10.1007/s005350050103. PMID: 9658321

Therapy

Disseminated peritoneal leiomyomatosis: a devastating sequelae of unconfined laparoscopic morcellation.
Tan HL, Koh YX, Chew MH, Wang J, Lim JSK, Leow WQ, Lee SY
Singapore Med J 2019 Dec;60(12):652-654. doi: 10.11622/smedj.2019159. PMID: 31889207Free PMC Article
Non-contraceptive benefits of hormonal and intrauterine reversible contraceptive methods.
Bahamondes L, Valeria Bahamondes M, Shulman LP
Hum Reprod Update 2015 Sep-Oct;21(5):640-51. Epub 2015 Jun 1 doi: 10.1093/humupd/dmv023. PMID: 26037216
Screening for uterine tumours.
Van den Bosch T, Coosemans A, Morina M, Timmerman D, Amant F
Best Pract Res Clin Obstet Gynaecol 2012 Apr;26(2):257-66. Epub 2011 Nov 9 doi: 10.1016/j.bpobgyn.2011.08.002. PMID: 22078749
Non-contraceptive benefits of oral contraceptives.
Huber JC, Bentz EK, Ott J, Tempfer CB
Expert Opin Pharmacother 2008 Sep;9(13):2317-25. doi: 10.1517/14656566.9.13.2317. PMID: 18710356
Oral contraceptives: current status.
Burkman RT
Clin Obstet Gynecol 2001 Mar;44(1):62-72. doi: 10.1097/00003081-200103000-00010. PMID: 11219247

Prognosis

Cystic Ovarian Leiomyoma in a Patient with Progressive Abdominal Pain.
Alshwairikh K, AlOtaibi W, Alshammari S, Alshammari T, Hakami R, Alswayyed M, Bin Traiki T
Am J Case Rep 2021 Jun 30;22:e930299. doi: 10.12659/AJCR.930299. PMID: 34191791Free PMC Article
Schwannoma of the colon and rectum: a systematic literature review.
Bohlok A, El Khoury M, Bormans A, Galdon MG, Vouche M, El Nakadi I, Donckier V, Liberale G
World J Surg Oncol 2018 Jul 3;16(1):125. doi: 10.1186/s12957-018-1427-1. PMID: 29970075Free PMC Article
The genetics of uterine leiomyomata: what clinicians need to know.
Stewart EA, Morton CC
Obstet Gynecol 2006 Apr;107(4):917-21. doi: 10.1097/01.AOG.0000206161.84965.0b. PMID: 16582132
Anorectal leiomyosarcomas.
Wang TK, Chung MT
J Gastroenterol 1998 Jun;33(3):402-7. doi: 10.1007/s005350050103. PMID: 9658321
Hepatic incidentaloma: a modern problem.
Little JM, Kenny J, Hollands MJ
World J Surg 1990 Jul-Aug;14(4):448-51. doi: 10.1007/BF01658665. PMID: 2166378

Clinical prediction guides

Cutaneous lesions and other non-endocrine manifestations of Multiple Endocrine Neoplasia type 1 syndrome.
Pierotti L, Pardi E, Dinoi E, Piaggi P, Borsari S, Della Valentina S, Sardella C, Michelucci A, Caligo MA, Bogazzi F, Marcocci C, Cetani F
Front Endocrinol (Lausanne) 2023;14:1191040. Epub 2023 Jul 7 doi: 10.3389/fendo.2023.1191040. PMID: 37484956Free PMC Article
Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.
Kämpjärvi K, Park MJ, Mehine M, Kim NH, Clark AD, Bützow R, Böhling T, Böhm J, Mecklin JP, Järvinen H, Tomlinson IP, van der Spuy ZM, Sjöberg J, Boyer TG, Vahteristo P
Hum Mutat 2014 Sep;35(9):1136-41. Epub 2014 Jul 21 doi: 10.1002/humu.22612. PMID: 24980722
Frequent POLE1 p.S297F mutation in Chinese patients with ovarian endometrioid carcinoma.
Zou Y, Liu FY, Liu H, Wang F, Li W, Huang MZ, Huang Y, Yuan XQ, Xu XY, Huang OP, He M
Mutat Res 2014 Mar;761:49-52. Epub 2014 Jan 25 doi: 10.1016/j.mrfmmm.2014.01.003. PMID: 24472300
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.
Kämpjärvi K, Mäkinen N, Kilpivaara O, Arola J, Heinonen HR, Böhm J, Abdel-Wahab O, Lehtonen HJ, Pelttari LM, Mehine M, Schrewe H, Nevanlinna H, Levine RL, Hokland P, Böhling T, Mecklin JP, Bützow R, Aaltonen LA, Vahteristo P
Br J Cancer 2012 Nov 6;107(10):1761-5. Epub 2012 Sep 20 doi: 10.1038/bjc.2012.428. PMID: 23132392Free PMC Article
Colorectal mesenchymal tumor: a clinicopathologic study of 25 cases.
Lee CH, Jan YJ, Chen JT, Ho WL, Tseng CH, Wang J
J Chin Med Assoc 2005 Jul;68(7):291-8. doi: 10.1016/S1726-4901(09)70164-9. PMID: 16038368

Recent systematic reviews

Uterine artery embolization vs myomectomy for the management of women with uterine leiomyomas: a systematic review and meta-analysis.
Tzanis AA, Antoniou SA, Gkegkes ID, Iavazzo C
Am J Obstet Gynecol 2024 Aug;231(2):187-195.e1. Epub 2024 Jan 26 doi: 10.1016/j.ajog.2024.01.014. PMID: 38280434

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