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Childhood embryonal testis carcinoma

MedGen UID:
272470
•Concept ID:
C1333007
•
Neoplastic Process
Synonyms: Childhood Embryonal Carcinoma of Testis; childhood embryonal carcinoma of testis; Childhood Embryonal Carcinoma of the Testis; childhood embryonal carcinoma of the testis; childhood embryonal testis carcinoma; Childhood Testicular Embryonal Carcinoma; childhood testicular embryonal carcinoma; paediatric embryonal carcinoma of testis; paediatric embryonal carcinoma of the testis; paediatric testicular embryonal carcinoma; Pediatric Embryonal Carcinoma of Testis; pediatric embryonal carcinoma of testis; Pediatric Embryonal Carcinoma of the Testis; pediatric embryonal carcinoma of the testis; Pediatric Testicular Embryonal Carcinoma; pediatric testicular embryonal carcinoma; testicular embryonal carcinoma of childhood
 
Monarch Initiative: MONDO:0003788

Definition

An embryonal carcinoma that arises from the testis during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood embryonal testis carcinoma

Professional guidelines

PubMed

Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan.
Suita S, Shono K, Tajiri T, Takamatsu T, Mizote H, Nagasaki A, Inomata Y, Hara T, Okamura J, Miyazaki S, Kawakami K, Eguchi H, Tsuneyoshi M; Committee for Pediatric Solid Malignant Tumors in the Kyushu Area
J Pediatr Surg 2002 Dec;37(12):1703-6. doi: 10.1053/jpsu.2002.36700. PMID: 12483635

Recent clinical studies

Etiology

Risk for testicular germ cell tumors and spermatogenesis failure in post-pubertal undescended testes.
Ergül RB, Bayramoğlu Z, Keçeli AM, Dönmez Mİ
Int Urol Nephrol 2024 Jul;56(7):2269-2274. Epub 2024 Feb 13 doi: 10.1007/s11255-024-03963-4. PMID: 38349599
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Dysregulation of the mitosis-meiosis switch in testicular carcinoma in situ.
Jørgensen A, Nielsen JE, Almstrup K, Toft BG, Petersen BL, Rajpert-De Meyts E
J Pathol 2013 Mar;229(4):588-98. Epub 2013 Feb 4 doi: 10.1002/path.4154. PMID: 23303528
Testicular tumors in children.
Ciftci AO, Bingöl-Koloğlu M, Senocak ME, Tanyel FC, Büyükpamukçu M, Büyükpamukçu N
J Pediatr Surg 2001 Dec;36(12):1796-801. doi: 10.1053/jpsu.2001.28841. PMID: 11733909
DNA content and expression of tumour markers in germ cells adjacent to germ cell tumours in childhood: probably a different origin for infantile and adolescent germ cell tumours.
Jørgensen N, Müller J, Giwercman A, Visfeldt J, Møller H, Skakkebaek NE
J Pathol 1995 Jul;176(3):269-78. doi: 10.1002/path.1711760309. PMID: 7674089

Diagnosis

The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells.
Camacho-Moll ME, Macdonald J, Looijenga LHJ, Rimmer MP, Donat R, Marwick JA, Shukla CJ, Carragher N, Jørgensen A, Mitchell RT
BMC Cancer 2019 Nov 19;19(1):1124. doi: 10.1186/s12885-019-6340-7. PMID: 31744479Free PMC Article
Frequency of gonadal tumours in complete androgen insensitivity syndrome (CAIS): A retrospective case-series analysis.
Chaudhry S, Tadokoro-Cuccaro R, Hannema SE, Acerini CL, Hughes IA
J Pediatr Urol 2017 Oct;13(5):498.e1-498.e6. Epub 2017 Mar 14 doi: 10.1016/j.jpurol.2017.02.013. PMID: 28351649
Testicular tumors in children.
Ciftci AO, Bingöl-Koloğlu M, Senocak ME, Tanyel FC, Büyükpamukçu M, Büyükpamukçu N
J Pediatr Surg 2001 Dec;36(12):1796-801. doi: 10.1053/jpsu.2001.28841. PMID: 11733909
Germ cell tumors in infancy and childhood: a 45-year experience.
Malogolowkin MH, Mahour GH, Krailo M, Ortega JA
Pediatr Pathol 1990;10(1-2):231-41. doi: 10.3109/15513819009067110. PMID: 2156245
Embryonal carcinoma of the testis in childhood.
Sabio H, Burgert EO Jr, Farrow GM, Kelalis PP
Cancer 1974 Dec;34(6):2118-21. doi: 10.1002/1097-0142(197412)34:6<2118::aid-cncr2820340636>3.0.co;2-t. PMID: 4434340

Therapy

Clinical stage I nonseminomatous germ cell tumors of the testis in childhood and adolescence: an analysis of 31 cases.
Terenziani M, Piva L, Spreafico F, Salvioni R, Massimino M, Luksch R, Cefalo G, Casanova M, Ferrari A, Polastri D, Mazza E, Bellani FF, Nicolai N
J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):454-8. doi: 10.1097/00043426-200208000-00009. PMID: 12218592
Successful chemotherapy for childhood metastatic embryonal cell carcinoma of the testicle: a preliminary report.
Holbrook CT, Crist WM, Cain W, Bueschen A
Med Pediatr Oncol 1980;8(1):75-81. doi: 10.1002/mpo.2950080111. PMID: 6160380
Childhood embryonal carcinoma of testes.
Drago JR, Nelson RP, Palmer JM
Urology 1978 Nov;12(5):499-503. doi: 10.1016/0090-4295(78)90460-0. PMID: 726167
Childhood embryonal carcinoma of testis, report of two unusual cases, and the implication on clinical management.
Chu JY, O'Connor DM, DeMello D, Razek AA, McElfresh AE
Med Pediatr Oncol 1978;4(2):175-80. doi: 10.1002/mpo.2950040214. PMID: 661753
Embryonal carcinoma of the testis in childhood.
Sabio H, Burgert EO Jr, Farrow GM, Kelalis PP
Cancer 1974 Dec;34(6):2118-21. doi: 10.1002/1097-0142(197412)34:6<2118::aid-cncr2820340636>3.0.co;2-t. PMID: 4434340

Prognosis

About an unique case of embryocarcinoma with nasal onset.
Bozzo C, Stomeo F, Meloni F, Lubelli A, Profili S
Rhinology 2005 Jun;43(2):146-51. PMID: 16008073
Germ cell tumors in infancy and childhood: a 45-year experience.
Malogolowkin MH, Mahour GH, Krailo M, Ortega JA
Pediatr Pathol 1990;10(1-2):231-41. doi: 10.3109/15513819009067110. PMID: 2156245
Teratomas in infancy and childhood. A 54-year experience at the Children's Hospital Medical Center.
Tapper D, Lack EE
Ann Surg 1983 Sep;198(3):398-410. doi: 10.1097/00000658-198309000-00016. PMID: 6684416Free PMC Article
Successful chemotherapy for childhood metastatic embryonal cell carcinoma of the testicle: a preliminary report.
Holbrook CT, Crist WM, Cain W, Bueschen A
Med Pediatr Oncol 1980;8(1):75-81. doi: 10.1002/mpo.2950080111. PMID: 6160380
Childhood embryonal carcinoma of testis, report of two unusual cases, and the implication on clinical management.
Chu JY, O'Connor DM, DeMello D, Razek AA, McElfresh AE
Med Pediatr Oncol 1978;4(2):175-80. doi: 10.1002/mpo.2950040214. PMID: 661753

Clinical prediction guides

Risk for testicular germ cell tumors and spermatogenesis failure in post-pubertal undescended testes.
Ergül RB, Bayramoğlu Z, Keçeli AM, Dönmez Mİ
Int Urol Nephrol 2024 Jul;56(7):2269-2274. Epub 2024 Feb 13 doi: 10.1007/s11255-024-03963-4. PMID: 38349599
The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells.
Camacho-Moll ME, Macdonald J, Looijenga LHJ, Rimmer MP, Donat R, Marwick JA, Shukla CJ, Carragher N, Jørgensen A, Mitchell RT
BMC Cancer 2019 Nov 19;19(1):1124. doi: 10.1186/s12885-019-6340-7. PMID: 31744479Free PMC Article
Less advanced testicular dysgenesis is associated by a higher prevalence of germ cell neoplasia.
Guminska A, Oszukowska E, Kuzanski W, Sosnowski M, Wolski JK, Walczak-Jedrzejowska R, Marchlewska K, Niedzielski J, Kula K, Slowikowska-Hilczer J
Int J Androl 2010 Feb;33(1):e153-62. Epub 2009 Aug 31 doi: 10.1111/j.1365-2605.2009.00981.x. PMID: 19719533
About an unique case of embryocarcinoma with nasal onset.
Bozzo C, Stomeo F, Meloni F, Lubelli A, Profili S
Rhinology 2005 Jun;43(2):146-51. PMID: 16008073
Clinical stage I nonseminomatous germ cell tumors of the testis in childhood and adolescence: an analysis of 31 cases.
Terenziani M, Piva L, Spreafico F, Salvioni R, Massimino M, Luksch R, Cefalo G, Casanova M, Ferrari A, Polastri D, Mazza E, Bellani FF, Nicolai N
J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):454-8. doi: 10.1097/00043426-200208000-00009. PMID: 12218592

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