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Childhood Acute Monoblastic and Monocytic Leukemia

MedGen UID:
272456
•Concept ID:
C1332941
•
Neoplastic Process
Synonyms: Childhood Acute Monoblastic and Monocytic Leukemia (M5); Childhood Acute Monoblastic Leukemia and Acute Monocytic Leukemia

Definition

An acute monoblastic and monocytic leukemia occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Acute Monoblastic and Monocytic Leukemia

Professional guidelines

PubMed

Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009

Recent clinical studies

Etiology

Abnormalities of chromosome band 11q23 and the MLL gene in pediatric myelomonocytic and monoblastic leukemias. Identification of the t(9;11) as an indicator of long survival.
Martinez-Climent JA, Espinosa R 3rd, Thirman MJ, Le Beau MM, Rowley JD
J Pediatr Hematol Oncol 1995 Nov;17(4):277-83. doi: 10.1097/00043426-199511000-00001. PMID: 7583381
Childhood acute megakaryoblastic leukemia with internalization of hemic cells.
Shimizu H, Ui T, Sasaki K, Kawai S, Kaneko Y, Fujimoto T
Am J Pediatr Hematol Oncol 1990 Winter;12(4):477-9. doi: 10.1097/00043426-199024000-00013. PMID: 2285130

Diagnosis

Granulocytic sarcomas in body cavities in childhood acute myeloid leukemias with 11q23/MLL rearrangements.
Johansson B, Fioretos T, Kullendorff CM, Wiebe T, Békássy AN, Garwicz S, Forestier E, Roos G, Akerman M, Mitelman F, Billström R
Genes Chromosomes Cancer 2000 Feb;27(2):136-42. PMID: 10612801
Abnormalities of chromosome band 11q23 and the MLL gene in pediatric myelomonocytic and monoblastic leukemias. Identification of the t(9;11) as an indicator of long survival.
Martinez-Climent JA, Espinosa R 3rd, Thirman MJ, Le Beau MM, Rowley JD
J Pediatr Hematol Oncol 1995 Nov;17(4):277-83. doi: 10.1097/00043426-199511000-00001. PMID: 7583381
Autologous bone marrow transplantation in secondary acute monoblastic leukemia following Hodgkin's disease.
Rossetti F, Messina C, Colleselli P, De Silvestro G, Sotti G, Destro R, Zanesco L
Bone Marrow Transplant 1991;7 Suppl 3:131-2. PMID: 1855076
Childhood acute megakaryoblastic leukemia with internalization of hemic cells.
Shimizu H, Ui T, Sasaki K, Kawai S, Kaneko Y, Fujimoto T
Am J Pediatr Hematol Oncol 1990 Winter;12(4):477-9. doi: 10.1097/00043426-199024000-00013. PMID: 2285130
Antemortem diagnosis of gross cardiac metastasis in childhood leukemia: echocardiographic demonstration.
Hunkeler N, Canter CE
Pediatr Cardiol 1990 Oct;11(4):225-6. doi: 10.1007/BF02238374. PMID: 2148821

Therapy

Acute monoblastic leukemia in a child following chemotherapy for neuroblastoma.
Jaing TH, Yang CP, Hung IJ
J Formos Med Assoc 1999 Oct;98(10):688-91. PMID: 10575839
Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009

Prognosis

Acute monoblastic leukemia in a child following chemotherapy for neuroblastoma.
Jaing TH, Yang CP, Hung IJ
J Formos Med Assoc 1999 Oct;98(10):688-91. PMID: 10575839
Abnormalities of chromosome band 11q23 and the MLL gene in pediatric myelomonocytic and monoblastic leukemias. Identification of the t(9;11) as an indicator of long survival.
Martinez-Climent JA, Espinosa R 3rd, Thirman MJ, Le Beau MM, Rowley JD
J Pediatr Hematol Oncol 1995 Nov;17(4):277-83. doi: 10.1097/00043426-199511000-00001. PMID: 7583381
Autologous bone marrow transplantation in secondary acute monoblastic leukemia following Hodgkin's disease.
Rossetti F, Messina C, Colleselli P, De Silvestro G, Sotti G, Destro R, Zanesco L
Bone Marrow Transplant 1991;7 Suppl 3:131-2. PMID: 1855076

Clinical prediction guides

Childhood acute megakaryoblastic leukemia with internalization of hemic cells.
Shimizu H, Ui T, Sasaki K, Kawai S, Kaneko Y, Fujimoto T
Am J Pediatr Hematol Oncol 1990 Winter;12(4):477-9. doi: 10.1097/00043426-199024000-00013. PMID: 2285130
In vitro characteristics of childhood leukemic monoblasts.
Weetman RM, Chilcote RR, Rierden WJ, Baehner RL
Exp Hematol 1978 Jan;6(1):9-17. PMID: 304810

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