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Esophageal Schwannoma

MedGen UID:
272355
•Concept ID:
C1332495
•
Neoplastic Process
Synonyms: Benign Esophageal Neurilemmoma; Benign Esophageal Schwannoma; Benign Esophagus Neurilemmoma; Benign Esophagus Schwannoma; Benign Neurilemmoma of Esophagus; Benign Neurilemmoma of the Esophagus; Benign Schwannoma of Esophagus; Benign Schwannoma of the Esophagus

Definition

A slowly growing, benign, usually encapsulated neoplasm arising from the esophagus. Morphologically, it is composed of neoplastic differentiated Schwann cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Schwannoma

Professional guidelines

PubMed

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797

Recent clinical studies

Etiology

Efficacy of endoscopic ultrasound and endoscopic resection for esophageal schwannoma.
Jiao J, Fan X, Luo L, Zhao W, Zheng Z, Chen X, Wang T, Wang B, Liu W
Scand J Gastroenterol 2023 Jul-Dec;58(8):963-969. Epub 2023 Mar 7 doi: 10.1080/00365521.2023.2185867. PMID: 36880341
Clinicopathologic characteristics and surgical management of schwannomas of the upper digestive tract.
Parsak CK, Teke Z, Topal U, Unal AG, Bal N
Ann Ital Chir 2022;92:307-312. PMID: 34711705
Thoracoscopic enucleation of esophageal schwannoma exhibiting (18) F-fluorodeoxyglucose uptake on positron emission tomography.
Makino T, Yamasaki M, Takeno A, Kurokawa Y, Miyata H, Takiguchi S, Nakajima K, Fujiwara Y, Mori M, Doki Y
Dis Esophagus 2013 Apr;26(3):331-2. Epub 2011 May 3 doi: 10.1111/j.1442-2050.2011.01196.x. PMID: 21539674
Plexiform schwannoma of the esophagus in a child with neurofibromatosis type 2.
Retrosi G, Nanni L, Ricci R, Manzoni C, Pintus C
J Pediatr Surg 2009 Jul;44(7):1458-61. doi: 10.1016/j.jpedsurg.2009.03.029. PMID: 19573680
Benign esophageal schwannoma compressing the trachea in pregnancy.
Mizuguchi S, Inoue K, Imagawa A, Kitano Y, Kameyama M, Ueda H, Inoue Y
Ann Thorac Surg 2008 Feb;85(2):660-2. doi: 10.1016/j.athoracsur.2007.07.088. PMID: 18222295

Diagnosis

Efficacy of endoscopic ultrasound and endoscopic resection for esophageal schwannoma.
Jiao J, Fan X, Luo L, Zhao W, Zheng Z, Chen X, Wang T, Wang B, Liu W
Scand J Gastroenterol 2023 Jul-Dec;58(8):963-969. Epub 2023 Mar 7 doi: 10.1080/00365521.2023.2185867. PMID: 36880341
Endoscopic resection of an esophageal schwannoma.
Trindade AJ, Fan C, Cheung M, Greenberg RE
Dig Liver Dis 2018 Mar;50(3):309. Epub 2017 Nov 2 doi: 10.1016/j.dld.2017.10.018. PMID: 29153489
Esophageal schwannoma.
Basoglu A, Celik B, Sengul TA, Yildiz L
J Thorac Cardiovasc Surg 2006 Feb;131(2):492-3. doi: 10.1016/j.jtcvs.2005.09.020. PMID: 16434293
Benign schwannoma of the esophagus removed by enucleation: report of a case.
Ohno M, Sugihara J, Miyamura K, Tabata T, Matsuura T, Matsui S, Fukuda H, Ohbayashi C
Surg Today 2000;30(1):59-62. doi: 10.1007/PL00010048. PMID: 10648085
Esophageal schwannoma.
Iwata H, Kataoka M, Yamakawa Y, Kuwabara Y, Kureyama Y, Masaoka A
Ann Thorac Surg 1993 Aug;56(2):376-7. doi: 10.1016/0003-4975(93)91184-o. PMID: 8347029

Therapy

Robot-assisted enucleation of large dumbbell-shaped esophageal schwannoma: a case report.
Zhang Y, Han Y, Xiang J, Li H
BMC Surg 2018 Jun 5;18(1):36. doi: 10.1186/s12893-018-0370-y. PMID: 29871678Free PMC Article

Prognosis

Clinicopathological features of esophageal schwannomas in mainland China: systematic review of the literature.
Gao ZY, Liu XB, Pandey S, Gao B, Liu P, Zhang QH, Gao YJ, Li SB
Int J Clin Oncol 2021 Feb;26(2):284-295. Epub 2020 Nov 20 doi: 10.1007/s10147-020-01809-4. PMID: 33216242
Benign esophageal schwannoma: A case report and review of literature.
Zhu L, Li W, Zhu Z, Chai Y
Niger J Clin Pract 2019 May;22(5):731-733. doi: 10.4103/njcp.njcp_142_18. PMID: 31089031
Thoracoscopic enucleation of esophageal schwannoma exhibiting (18) F-fluorodeoxyglucose uptake on positron emission tomography.
Makino T, Yamasaki M, Takeno A, Kurokawa Y, Miyata H, Takiguchi S, Nakajima K, Fujiwara Y, Mori M, Doki Y
Dis Esophagus 2013 Apr;26(3):331-2. Epub 2011 May 3 doi: 10.1111/j.1442-2050.2011.01196.x. PMID: 21539674
Plexiform schwannoma of the esophagus in a child with neurofibromatosis type 2.
Retrosi G, Nanni L, Ricci R, Manzoni C, Pintus C
J Pediatr Surg 2009 Jul;44(7):1458-61. doi: 10.1016/j.jpedsurg.2009.03.029. PMID: 19573680
Benign esophageal schwannoma compressing the trachea in pregnancy.
Mizuguchi S, Inoue K, Imagawa A, Kitano Y, Kameyama M, Ueda H, Inoue Y
Ann Thorac Surg 2008 Feb;85(2):660-2. doi: 10.1016/j.athoracsur.2007.07.088. PMID: 18222295

Clinical prediction guides

Combined thoracoscopic and endoscopic surgery for a large esophageal schwannoma.
Onodera Y, Nakano T, Takeyama D, Maruyama S, Taniyama Y, Sakurai T, Heishi T, Sato C, Kumagai T, Kamei T
World J Gastroenterol 2017 Dec 14;23(46):8256-8260. doi: 10.3748/wjg.v23.i46.8256. PMID: 29290662Free PMC Article
Thoracoscopic enucleation of esophageal submucosal tumor by prone position under artificial pneumothorax by CO2 insufflation.
Shichinohe T, Kato K, Ebihara Y, Kurashima Y, Tsuchikawa T, Matsumoto J, Nakamura T, Tanaka E, Hirano S
Surg Laparosc Endosc Percutan Tech 2014 Apr;24(2):e55-8. doi: 10.1097/SLE.0b013e31828f71e3. PMID: 24686363
Esophageal schwannoma.
Iwata H, Kataoka M, Yamakawa Y, Kuwabara Y, Kureyama Y, Masaoka A
Ann Thorac Surg 1993 Aug;56(2):376-7. doi: 10.1016/0003-4975(93)91184-o. PMID: 8347029

Recent systematic reviews

Clinicopathological features of esophageal schwannomas in mainland China: systematic review of the literature.
Gao ZY, Liu XB, Pandey S, Gao B, Liu P, Zhang QH, Gao YJ, Li SB
Int J Clin Oncol 2021 Feb;26(2):284-295. Epub 2020 Nov 20 doi: 10.1007/s10147-020-01809-4. PMID: 33216242

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