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Branchioma

MedGen UID:
266100
•Concept ID:
C1266098
•
Neoplastic Process
Synonyms: Biphenotypic Branchioma; Ectopic hamartomatous thymoma; Neck Branchioma
SNOMED CT: Ectopic hamartomatous thymoma (128718003)

Definition

A rare, benign, well-circumscribed or encapsulated tumor that arises from the neck and occurs in adults. It is characterized by the presence of spindle cells, epithelial islands, and adipose tissue. [from NCI]

Professional guidelines

PubMed

Congenital preauricular communicating fistulas; diagnosis, complications and treatment.
HALL JG, ZIMMER J
Acta Otolaryngol 1958 May-Jun;49(3):213-20. doi: 10.3109/00016485809134749. PMID: 13559031

Recent clinical studies

Etiology

Primary Branchiogenic Carcinoma.
Zuzana H, Lukáš V, Marta P, Pavla U, Pavel S
Klin Onkol 2018 Summer;31(4):296-300. doi: 10.14735/amko2018296. PMID: 30541314
Congenital cystic neck masses: embryology and imaging appearances, with clinicopathological correlation.
Gaddikeri S, Vattoth S, Gaddikeri RS, Stuart R, Harrison K, Young D, Bhargava P
Curr Probl Diagn Radiol 2014 Mar-Apr;43(2):55-67. doi: 10.1067/j.cpradiol.2013.12.001. PMID: 24629659
Cysts, pits, and tumors.
Li WY, Reinisch JF
Plast Reconstr Surg 2009 Jul;124(1 Suppl):106e-116e. doi: 10.1097/PRS.0b013e3181aa2df1. PMID: 19568144
Lumps and bumps in neonates and infants.
Farvolden D, Sweeney SM, Wiss K
Dermatol Ther 2005 Mar-Apr;18(2):104-16. doi: 10.1111/j.1529-8019.2005.05016.x. PMID: 15953140
Branchiogenic carcinoma.
Black B, Maran AG
Clin Otolaryngol Allied Sci 1978 Feb;3(1):27-36. doi: 10.1111/j.1365-2273.1978.tb00662.x. PMID: 648005

Diagnosis

Parotid swelling.
Righini CA, Baguant A, Atallah I
Eur Ann Otorhinolaryngol Head Neck Dis 2017 Sep;134(4):281-282. Epub 2017 Apr 5 doi: 10.1016/j.anorl.2017.03.004. PMID: 28395960
Pediatric neck masses.
Curtis WJ, Edwards SP
Atlas Oral Maxillofac Surg Clin North Am 2015 Mar;23(1):15-20. Epub 2014 Nov 26 doi: 10.1016/j.cxom.2014.10.002. PMID: 25707561
Congenital neck masses.
Rosa PA, Hirsch DL, Dierks EJ
Oral Maxillofac Surg Clin North Am 2008 Aug;20(3):339-52. doi: 10.1016/j.coms.2008.03.003. PMID: 18603195
Congenital cervical cysts, sinuses and fistulae.
Acierno SP, Waldhausen JH
Otolaryngol Clin North Am 2007 Feb;40(1):161-76, vii-viii. doi: 10.1016/j.otc.2006.10.009. PMID: 17346566
Primary branchiogenic carcinoma.
Khafif RA, Prichep R, Minkowitz S
Head Neck 1989 Mar-Apr;11(2):153-63. doi: 10.1002/hed.2880110209. PMID: 2656582

Therapy

Cystic metastatic nasopharyngeal carcinoma presenting as branchial cleft cyst: report of two cases and review of the literature.
Zhang GZ, Liu ZL, Gong JS, Cheng ZQ, Ke C
J Oral Maxillofac Surg 2014 Nov;72(11):2366-74. Epub 2014 May 27 doi: 10.1016/j.joms.2014.05.020. PMID: 25172673
Treatments of various otolaryngological cystic diseases by OK-4321: its indications and limitations.
Ohta N, Fukase S, Suzuki Y, Ishida A, Aoyagi M
Laryngoscope 2010 Nov;120(11):2193-6. doi: 10.1002/lary.21141. PMID: 20938959
Diagnostically challenging lesions in head and neck pathology.
Thompson LD
Eur Arch Otorhinolaryngol 1997;254(8):357-66. doi: 10.1007/BF01642550. PMID: 9332890
Functional superficial parotidectomy.
Zhao K, Qi DY, Wang LM
J Oral Maxillofac Surg 1994 Oct;52(10):1038-41. PMID: 8089788
Carotid arteriospasm.
Osguthorpe JD, Adkins WY
Laryngoscope 1985 Aug;95(8):942-4. doi: 10.1288/00005537-198508000-00012. PMID: 4021689

Prognosis

Branchiootic syndrome--a clinical case report and review of the literature.
Amer I, Falzon A, Choudhury N, Ghufoor K
J Pediatr Surg 2012 Aug;47(8):1604-6. doi: 10.1016/j.jpedsurg.2012.05.016. PMID: 22901925
Branchiogenic carcinoma--conceptual or true clinico-pathological entity?
Jereczek-Fossa BA, Casadio C, Jassem J, Luzzatto F, Viale G, Bruschini R, Chiesa F, Orecchia R
Cancer Treat Rev 2005 Apr;31(2):106-14. doi: 10.1016/j.ctrv.2004.12.007. PMID: 15847980
Common lumps and bumps of the head and neck in infants and children.
Filston HC
Pediatr Ann 1989 Mar;18(3):180-2, 184, 186. doi: 10.3928/0090-4481-19890301-07. PMID: 2664678
Branchiogenic carcinoma (malignant branchioma).
Rónay P, Bodó M, Zemplén B
J Surg Oncol 1984 Feb;25(2):141-4. doi: 10.1002/jso.2930250218. PMID: 6694403
Branchiogenic carcinoma.
Black B, Maran AG
Clin Otolaryngol Allied Sci 1978 Feb;3(1):27-36. doi: 10.1111/j.1365-2273.1978.tb00662.x. PMID: 648005

Clinical prediction guides

Branchial cleft anomalies: hybrid "Branchial Inclusion" theory.
Pupić-Bakrač J, Skitarelić N, Pupić-Bakrač A, Baraka I, Srzentić M, Novaković J, Terkeš V
Eur Arch Otorhinolaryngol 2021 Jul;278(7):2593-2601. Epub 2021 Jan 11 doi: 10.1007/s00405-020-06551-1. PMID: 33427915
Incidence and clinical predictors of cystic squamous cell carcinoma metastases in lateral cervical cysts.
Stefanicka P, Gnojcakova N, Kurinec F, Profant M
J Laryngol Otol 2019 May;133(5):430-435. Epub 2019 Apr 22 doi: 10.1017/S0022215119000823. PMID: 31006395
Bronchogenic cancer: It still exists.
Strassen U, Hofauer B, Matsuba Y, Becker K, Mansour N, Knopf A
Laryngoscope 2016 Mar;126(3):638-42. Epub 2015 Sep 15 doi: 10.1002/lary.25660. PMID: 26371793
Lumps and bumps in neonates and infants.
Farvolden D, Sweeney SM, Wiss K
Dermatol Ther 2005 Mar-Apr;18(2):104-16. doi: 10.1111/j.1529-8019.2005.05016.x. PMID: 15953140
Branchiogenic carcinoma (malignant branchioma).
Rónay P, Bodó M, Zemplén B
J Surg Oncol 1984 Feb;25(2):141-4. doi: 10.1002/jso.2930250218. PMID: 6694403

Recent systematic reviews

Postauricular Incision Versus Conventional Transcervical Incision in Second Branchial Cleft Cyst Excision: A Systematic Review and Meta-Analysis.
Ho CF, Yang TH, Hsin LJ, Yang SW, Tsai YT, Tsai MS, Yang CT, Lee YC
J Craniofac Surg 2022 Nov-Dec 01;33(8):2365-2371. Epub 2022 Jul 26 doi: 10.1097/SCS.0000000000008741. PMID: 35882056Free PMC Article
A Systematic Literature Review to Compare Clinical Outcomes of Different Surgical Techniques for Second Branchial Cyst Removal.
Meijers S, Meijers R, van der Veen E, van den Aardweg M, Bruijnzeel H
Ann Otol Rhinol Laryngol 2022 Apr;131(4):435-444. Epub 2021 Jun 17 doi: 10.1177/00034894211024049. PMID: 34137276Free PMC Article
Sclerotherapy for Benign Cystic Lesions of the Head and Neck: Systematic Review of 474 Cases.
Talmor G, Nguyen B, Mir G, Badash I, Kaye R, Caloway C
Otolaryngol Head Neck Surg 2021 Dec;165(6):775-783. Epub 2021 Mar 23 doi: 10.1177/01945998211000448. PMID: 33755513
Surgery versus endoscopic cauterization in patients with third or fourth branchial pouch sinuses: A systematic review.
Derks LS, Veenstra HJ, Oomen KP, Speleman L, Stegeman I
Laryngoscope 2016 Jan;126(1):212-7. Epub 2015 Sep 15 doi: 10.1002/lary.25321. PMID: 26372400
Retroauricular hairline approach for excision of second branchial cleft cysts: a preliminary experience.
LeBert B, Weiss S, Johnson J, Walvekar R
Laryngoscope 2010;120 Suppl 4:S160. doi: 10.1002/lary.21624. PMID: 21225758

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