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Retrograde amnesia

MedGen UID:
264
•Concept ID:
C0002624
•
Mental or Behavioral Dysfunction
Synonyms: Amnesia, Retrograde; Amnesias, Retrograde; Retrograde Amnesia; Retrograde Amnesias
SNOMED CT: RA - Retrograde amnesia (51921000); Retrograde amnesia (51921000)
 
HPO: HP:0033690
Monarch Initiative: MONDO:0003040

Definition

Inability to retrieve information from the long-term memory that was acquired before the onset of amnesia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetrograde amnesia

Professional guidelines

PubMed

Effects of magnetic seizure therapy on anterograde and retrograde amnesia in treatment-resistant depression.
Kayser S, Bewernick BH, Wagner S, Schlaepfer TE
Depress Anxiety 2020 Feb;37(2):125-133. Epub 2019 Nov 4 doi: 10.1002/da.22958. PMID: 31682325
Differential diagnosis between 'unexplained' fall and syncopal fall: a difficult or impossible task.
Alboni P, Coppola P, Stucci N, Tsakiridu V
J Cardiovasc Med (Hagerstown) 2015 Feb;16(2):82-9. doi: 10.2459/JCM.0000000000000076. PMID: 24838038
A dissociation between anterograde and retrograde amnesia after treatment with electroconvulsive therapy: a naturalistic investigation.
O'Connor M, Lebowitz BK, Ly J, Panizzon MS, Elkin-Frankston S, Dey S, Bloomingdale K, Thall M, Pearlman C
J ECT 2008 Jun;24(2):146-51. doi: 10.1097/YCT.0b013e318158792f. PMID: 18580560

Recent clinical studies

Etiology

Digital dementia in the internet generation: excessive screen time during brain development will increase the risk of Alzheimer's disease and related dementias in adulthood.
Manwell LA, Tadros M, Ciccarelli TM, Eikelboom R
J Integr Neurosci 2022 Jan 28;21(1):28. doi: 10.31083/j.jin2101028. PMID: 35164464
Transient Global Amnesia.
Sealy D, Tiller RJ, Johnson K
Am Fam Physician 2022 Jan 1;105(1):50-54. PMID: 35029951
Adverse Effects of Electroconvulsive Therapy.
Andrade C, Arumugham SS, Thirthalli J
Psychiatr Clin North Am 2016 Sep;39(3):513-30. Epub 2016 Jun 25 doi: 10.1016/j.psc.2016.04.004. PMID: 27514303
Transient amnesic syndromes.
Bartsch T, Butler C
Nat Rev Neurol 2013 Feb;9(2):86-97. Epub 2013 Jan 8 doi: 10.1038/nrneurol.2012.264. PMID: 23296343
Sports-related concussions.
Poirier MP, Wadsworth MR
Pediatr Emerg Care 2000 Aug;16(4):278-83; quiz 284-6. doi: 10.1097/00006565-200008000-00018. PMID: 10966352

Diagnosis

Acute-onset amnesia: transient global amnesia and other causes.
Miller TD, Butler CR
Pract Neurol 2022 Jun;22(3):201-208. Epub 2022 May 3 doi: 10.1136/practneurol-2020-002826. PMID: 35504698
Sleep Terrors: An Updated Review.
Leung AKC, Leung AAM, Wong AHC, Hon KL
Curr Pediatr Rev 2020;16(3):176-182. doi: 10.2174/1573396315666191014152136. PMID: 31612833Free PMC Article
Adverse Effects of Electroconvulsive Therapy.
Andrade C, Arumugham SS, Thirthalli J
Psychiatr Clin North Am 2016 Sep;39(3):513-30. Epub 2016 Jun 25 doi: 10.1016/j.psc.2016.04.004. PMID: 27514303
Transient global amnesia.
Marazzi C, Scoditti U, Ticinesi A, Nouvenne A, Pigna F, Guida L, Morelli I, Borghi L, Meschi T
Acta Biomed 2014 Dec 17;85(3):229-35. PMID: 25567459
Transient global amnesia.
Szabo K
Front Neurol Neurosci 2014;34:143-9. Epub 2014 Apr 16 doi: 10.1159/000356431. PMID: 24777137

Therapy

Sleep Terrors: An Updated Review.
Leung AKC, Leung AAM, Wong AHC, Hon KL
Curr Pediatr Rev 2020;16(3):176-182. doi: 10.2174/1573396315666191014152136. PMID: 31612833Free PMC Article
Adverse Effects of Electroconvulsive Therapy.
Andrade C, Arumugham SS, Thirthalli J
Psychiatr Clin North Am 2016 Sep;39(3):513-30. Epub 2016 Jun 25 doi: 10.1016/j.psc.2016.04.004. PMID: 27514303
Amnesia and the hippocampus.
Cipolotti L, Bird CM
Curr Opin Neurol 2006 Dec;19(6):593-8. doi: 10.1097/01.wco.0000247608.42320.f9. PMID: 17102699
Poriomania.
Mayeux R, Alexander MP, Benson DF, Brandt J, Rosen J
Neurology 1979 Dec;29(12):1616-9. doi: 10.1212/wnl.29.12.1616. PMID: 574226
Amnesia.
Benson DF
South Med J 1978 Oct;71(10):1221-7, 1231. doi: 10.1097/00007611-197810000-00011. PMID: 360401

Prognosis

Acute-onset amnesia: transient global amnesia and other causes.
Miller TD, Butler CR
Pract Neurol 2022 Jun;22(3):201-208. Epub 2022 May 3 doi: 10.1136/practneurol-2020-002826. PMID: 35504698
Digital dementia in the internet generation: excessive screen time during brain development will increase the risk of Alzheimer's disease and related dementias in adulthood.
Manwell LA, Tadros M, Ciccarelli TM, Eikelboom R
J Integr Neurosci 2022 Jan 28;21(1):28. doi: 10.31083/j.jin2101028. PMID: 35164464
Sleep Terrors: An Updated Review.
Leung AKC, Leung AAM, Wong AHC, Hon KL
Curr Pediatr Rev 2020;16(3):176-182. doi: 10.2174/1573396315666191014152136. PMID: 31612833Free PMC Article
Transient global amnesia.
Marazzi C, Scoditti U, Ticinesi A, Nouvenne A, Pigna F, Guida L, Morelli I, Borghi L, Meschi T
Acta Biomed 2014 Dec 17;85(3):229-35. PMID: 25567459
Amnesic disorders.
Markowitsch HJ, Staniloiu A
Lancet 2012 Oct 20;380(9851):1429-40. Epub 2012 Apr 13 doi: 10.1016/S0140-6736(11)61304-4. PMID: 22503117

Clinical prediction guides

Digital dementia in the internet generation: excessive screen time during brain development will increase the risk of Alzheimer's disease and related dementias in adulthood.
Manwell LA, Tadros M, Ciccarelli TM, Eikelboom R
J Integr Neurosci 2022 Jan 28;21(1):28. doi: 10.31083/j.jin2101028. PMID: 35164464
Sleep Terrors: An Updated Review.
Leung AKC, Leung AAM, Wong AHC, Hon KL
Curr Pediatr Rev 2020;16(3):176-182. doi: 10.2174/1573396315666191014152136. PMID: 31612833Free PMC Article
Has multiple trace theory been refuted?
Sutherland RJ, Lee JQ, McDonald RJ, Lehmann H
Hippocampus 2020 Aug;30(8):842-850. Epub 2019 Oct 4 doi: 10.1002/hipo.23162. PMID: 31584226
Anomalies of Autobiographical Memory.
Kopelman MD
J Int Neuropsychol Soc 2019 Nov;25(10):1061-1075. Epub 2019 Sep 2 doi: 10.1017/S135561771900081X. PMID: 31474234
Retrograde amnesia.
Squire LR, Clark RE, Knowlton BJ
Hippocampus 2001;11(1):50-5. doi: 10.1002/1098-1063(2001)11:1<50::AID-HIPO1019>3.0.CO;2-G. PMID: 11261772

Recent systematic reviews

Cognitive deficits and course of recovery in transient global amnesia: a systematic review.
Liampas I, Kyriakoulopoulou P, Akrioti A, Stamati P, Germeni A, Batzikosta P, Tsiamaki E, Veltsista D, Kefalopoulou Z, Siokas V, Chroni E, Dardiotis E
J Neurol 2024 Oct;271(10):6401-6425. Epub 2024 Aug 1 doi: 10.1007/s00415-024-12563-2. PMID: 39090229
Posttraumatic Amnesia: A Systematic Review and Meta-Analysis. Proposal for a New Severity Classification.
Vile AR, Jang K, Gourlay D, Marshman LAG
World Neurosurg 2022 Jun;162:e369-e393. Epub 2022 Mar 11 doi: 10.1016/j.wneu.2022.03.018. PMID: 35288355
Using a Likelihood Heuristic to Summarize Conflicting Literature on Predictors of Clinical Outcome Following Sport-Related Concussion.
Büttner F, Terry DP, Iverson GL
Clin J Sport Med 2021 Nov 1;31(6):e476-e483. doi: 10.1097/JSM.0000000000000825. PMID: 32941376
What is the level of evidence for the amnestic effects of sedatives in pediatric patients? A systematic review and meta-analyses.
Viana KA, Daher A, Maia LC, Costa PS, Martins CC, Paiva SM, Costa LR
PLoS One 2017;12(7):e0180248. Epub 2017 Jul 7 doi: 10.1371/journal.pone.0180248. PMID: 28686702Free PMC Article
Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis.
Semkovska M, McLoughlin DM
Biol Psychiatry 2010 Sep 15;68(6):568-77. Epub 2010 Jul 31 doi: 10.1016/j.biopsych.2010.06.009. PMID: 20673880

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