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Uterine Non-Neoplastic Disorder

MedGen UID:
237043
•Concept ID:
C1336920
•
Disease or Syndrome
Synonym: Uterine Non-Neoplastic Disease

Definition

A non-neoplastic disorder that affects the uterine corpus or the cervix. Representative examples include endometritis, uterine adenomyosis, and cervicitis. [from NCI]

Professional guidelines

PubMed

Study of accuracy of colposcopy in VIA and HPV detection-based cervical cancer screening program.
Ghosh I, Mittal S, Banerjee D, Singh P, Dasgupta S, Chatterjee S, Biswas J, Panda C, Basu P
Aust N Z J Obstet Gynaecol 2014 Dec;54(6):570-5. doi: 10.1111/ajo.12282. PMID: 25476810
Prevalence and genotype distribution of human papillomavirus in non-neoplastic cervical tissue lesion: cervical erosion.
Bayram A, Erkılıç S, Balat Ö, Ekşi F, Uğur MG, Öztürk E, Kaya G
J Med Virol 2011 Nov;83(11):1997-2003. doi: 10.1002/jmv.22218. PMID: 21915876
Expression profiles of ProEx C and Ki67 in squamous cell carcinoma in situ of the skin and their relationship with human papillomavirus genotypes.
Sánchez-Hernández M, Conesa-Zamora P, García-Solano J, Corbalán-Vélez R, Martínez-Barba E, Pérez-Guillermo M
J Cutan Pathol 2010 Jul;37(7):730-6. Epub 2010 Feb 24 doi: 10.1111/j.1600-0560.2010.01530.x. PMID: 20184667

Recent clinical studies

Etiology

PTEN promoter methylation and expression in endometrial cancer tissues.
Khatami F, Shahriari S, Aminimoghaddam S, Klashami ZN, Farahani MS, Teimoori-Toolabi L, Amoli MM, Asadi M, Rashidi BH
Epigenomics 2023 Apr;15(8):507-516. Epub 2023 Jun 21 doi: 10.2217/epi-2023-0099. PMID: 37345350
Gestational trophoblastic disease- rare, sometimes dramatic, and what we know so far.
Strickland AL, Gwin K
Semin Diagn Pathol 2022 May;39(3):228-237. Epub 2022 Mar 22 doi: 10.1053/j.semdp.2022.03.002. PMID: 35400536
Pathology of gestational trophoblastic disease (GTD).
Kaur B
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:3-28. Epub 2021 Mar 31 doi: 10.1016/j.bpobgyn.2021.02.005. PMID: 34219021
Pathology of gestational trophoblastic diseases.
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885
"Mesenchymal tumor" or "decidual-like reaction"?
Karbe E
Toxicol Pathol 1999 May-Jun;27(3):354-62. doi: 10.1177/019262339902700312. PMID: 10356713

Diagnosis

Navigating through perplex morphologic changes after exogenous hormone usage.
Chang RJ, Rivera-Colon G, Chen H, Niu S, Carrick K, Lucas E, Gwin K, Zheng W
Semin Diagn Pathol 2022 May;39(3):148-158. Epub 2021 Oct 28 doi: 10.1053/j.semdp.2021.10.001. PMID: 34782217
Pathology of gestational trophoblastic disease (GTD).
Kaur B
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:3-28. Epub 2021 Mar 31 doi: 10.1016/j.bpobgyn.2021.02.005. PMID: 34219021
Iatrogenic lesions and artefacts in gynaecological pathology.
Clarke B, McCluggage WG
J Clin Pathol 2009 Feb;62(2):104-12. Epub 2008 Oct 6 doi: 10.1136/jcp.2008.061424. PMID: 18838400
Pathology of gestational trophoblastic diseases.
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885
"Mesenchymal tumor" or "decidual-like reaction"?
Karbe E
Toxicol Pathol 1999 May-Jun;27(3):354-62. doi: 10.1177/019262339902700312. PMID: 10356713

Therapy

Causal role of immune cells on cervical cancer onset revealed by two-sample Mendelian randomization study.
Zhao Z, Yan P, Zhang X, Yu X, Lv F, Gong M, Yang XA
Sci Rep 2024 Jun 28;14(1):14890. doi: 10.1038/s41598-024-65957-7. PMID: 38937531Free PMC Article
RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy.
Martinho O, Pinto F, Granja S, Miranda-Gonçalves V, Moreira MA, Ribeiro LF, di Loreto C, Rosner MR, Longatto-Filho A, Reis RM
PLoS One 2013;8(3):e59104. Epub 2013 Mar 19 doi: 10.1371/journal.pone.0059104. PMID: 23527098Free PMC Article
Dynamic spectral imaging colposcopy: higher sensitivity for detection of premalignant cervical lesions.
Louwers J, Zaal A, Kocken M, Ter Harmsel W, Graziosi G, Spruijt J, Berkhof J, Balas C, Papagiannakis E, Snijders P, Meijer C, van Kemenade F, Verheijen R
BJOG 2011 Feb;118(3):309-18. Epub 2010 Dec 23 doi: 10.1111/j.1471-0528.2010.02806.x. PMID: 21176085
Uterine fibroids risk and history of selected medical conditions linked with female hormones.
Parazzini F, Chiaffarino F, Polverino G, Chiantera V, Surace M, La Vecchia C
Eur J Epidemiol 2004;19(3):249-53. doi: 10.1023/b:ejep.0000020448.43323.2a. PMID: 15117118
Steroid receptors in normal, hyperplastic and malignant human endometria.
Vihko R, Jänne O, Kauppila A
Ann Clin Res 1980 Oct;12(5):208-15. PMID: 7015983

Prognosis

Gestational trophoblastic disease- rare, sometimes dramatic, and what we know so far.
Strickland AL, Gwin K
Semin Diagn Pathol 2022 May;39(3):228-237. Epub 2022 Mar 22 doi: 10.1053/j.semdp.2022.03.002. PMID: 35400536
Pathology of gestational trophoblastic disease (GTD).
Kaur B
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:3-28. Epub 2021 Mar 31 doi: 10.1016/j.bpobgyn.2021.02.005. PMID: 34219021
Exaggerated placental site mimicking placental site trophoblastic tumor: case report and literature review.
Yeasmin S, Nakayama K, Katagiri A, Ishikawa M, Iida K, Nakayama N, Miyazaki K
Eur J Gynaecol Oncol 2010;31(5):586-9. PMID: 21061810
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D
Eur J Gynaecol Oncol 2006;27(1):73-7. PMID: 16550975
Pathology of gestational trophoblastic diseases.
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885

Clinical prediction guides

PTEN promoter methylation and expression in endometrial cancer tissues.
Khatami F, Shahriari S, Aminimoghaddam S, Klashami ZN, Farahani MS, Teimoori-Toolabi L, Amoli MM, Asadi M, Rashidi BH
Epigenomics 2023 Apr;15(8):507-516. Epub 2023 Jun 21 doi: 10.2217/epi-2023-0099. PMID: 37345350
Intravascular Lymphocytic Accumulation in the Uterine Cervix: A Frequent Finding.
Karpathiou G, Dal P, Chauleur C, Peoc'h M
Int J Gynecol Pathol 2018 May;37(3):229-232. doi: 10.1097/PGP.0000000000000407. PMID: 28582343
Pathology of gestational trophoblastic diseases.
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885
"Mesenchymal tumor" or "decidual-like reaction"?
Karbe E
Toxicol Pathol 1999 May-Jun;27(3):354-62. doi: 10.1177/019262339902700312. PMID: 10356713
Neoplastic and non-neoplastic intermediate trophoblasts: an immunohistochemical and ultrastructural study.
Motoyama T, Ohta T, Ajioka Y, Watanabe H
Pathol Int 1994 Jan;44(1):57-65. doi: 10.1111/j.1440-1827.1994.tb02586.x. PMID: 7517758

Recent systematic reviews

Single-site port robotic-assisted hysterectomy: an update.
Iavazzo C, Minis EE, Gkegkes ID
J Robot Surg 2018 Jun;12(2):201-213. Epub 2018 Feb 16 doi: 10.1007/s11701-018-0789-2. PMID: 29453728

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