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Salivary Gland Sebaceous Lymphadenoma

MedGen UID:: 235576
•Concept ID:: C1335909
•: Neoplastic Process

Synonyms:

Sebaceous Lymphadenoma of Salivary Gland; Sebaceous Lymphadenoma of the Salivary Gland

Definition

A rare, benign epithelial neoplasm composed of irregular proliferating nests and islands of epithelium, including solid and gland-like sebaceous elements, surrounded by lymphoid stroma. Most occur in the parotid gland. Symptoms include a progressively enlarging, painless mass. Sebaceous lymphadenocarcinoma is the malignant counterpart. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSalivary Gland Sebaceous Lymphadenoma

Neoplasm
- Neoplasm by Special Category
  - Benign neoplasm
    - Benign Head and Neck Neoplasm
      - Benign neoplasm of salivary gland
        Salivary Gland Lymphadenoma
        Salivary Gland Sebaceous Lymphadenoma
        Parotid Gland Sebaceous Lymphadenoma

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.

Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666 Free PMC Article

Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.

Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944 Free PMC Article

Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.

Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

See all (608)

Recent clinical studies

Etiology

Updated Salivary Gland Immunohistochemistry: A Review.

Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980 Free PMC Article

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898 Free PMC Article

Combination chemotherapy of carboplatin and paclitaxel for advanced/metastatic salivary gland carcinoma patients: differences in responses by different pathological diagnoses.

Nakano K, Sato Y, Sasaki T, Shimbashi W, Fukushima H, Yonekawa H, Mitani H, Kawabata K, Takahashi S
Acta Otolaryngol 2016 Sep;136(9):948-51. Epub 2016 Apr 20 doi: 10.3109/00016489.2016.1170876. PMID: 27094013

Salivary gland carcinomas.

Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859

See all (4769)

Diagnosis

Updated Salivary Gland Immunohistochemistry: A Review.

Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.

Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980 Free PMC Article

Evaluation: Imaging Studies.

Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072

Salivary glands.

Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

See all (6606)

Therapy

Management of Salivary Gland Malignancy: ASCO Guideline.

Geiger JL, Ismaila N, Beadle B, Caudell JJ, Chau N, Deschler D, Glastonbury C, Kaufman M, Lamarre E, Lau HY, Licitra L, Moore MG, Rodriguez C, Roshal A, Seethala R, Swiecicki P, Ha P
J Clin Oncol 2021 Jun 10;39(17):1909-1941. Epub 2021 Apr 26 doi: 10.1200/JCO.21.00449. PMID: 33900808

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Salivary Gland Malignancies.

Rodriguez CP, Parvathaneni U, Méndez E, Martins RG
Hematol Oncol Clin North Am 2015 Dec;29(6):1145-57. Epub 2015 Oct 17 doi: 10.1016/j.hoc.2015.08.002. PMID: 26568553

Salivary Gland Cancers: Biology and Systemic Therapy.

Goyal G, Mehdi SA, Ganti AK
Oncology (Williston Park) 2015 Oct;29(10):773-80. PMID: 26470903

Radiotherapy-induced salivary dysfunction.

Ship JA, Hu K
Semin Oncol 2004 Dec;31(6 Suppl 18):29-36. doi: 10.1053/j.seminoncol.2004.12.009. PMID: 15726520

See all (1657)

Prognosis

Sialadenoma Papilliferum.

Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222

State-of-the-Art Imaging of Salivary Gland Tumors.

Abdel Razek AAK, Mukherji SK
Neuroimaging Clin N Am 2018 May;28(2):303-317. doi: 10.1016/j.nic.2018.01.009. PMID: 29622121

Combination chemotherapy of carboplatin and paclitaxel for advanced/metastatic salivary gland carcinoma patients: differences in responses by different pathological diagnoses.

Evaluation: Imaging Studies.

Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072

Salivary gland carcinomas.

Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859

See all (4039)

Clinical prediction guides

Fusion-positive salivary gland carcinomas.

Skálová A, Hyrcza MD, Vaneček T, Baněčková M, Leivo I
Genes Chromosomes Cancer 2022 May;61(5):228-243. Epub 2022 Jan 6 doi: 10.1002/gcc.23020. PMID: 34913211

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

State-of-the-Art Imaging of Salivary Gland Tumors.

Abdel Razek AAK, Mukherji SK
Neuroimaging Clin N Am 2018 May;28(2):303-317. doi: 10.1016/j.nic.2018.01.009. PMID: 29622121

Combination chemotherapy of carboplatin and paclitaxel for advanced/metastatic salivary gland carcinoma patients: differences in responses by different pathological diagnoses.

Evaluation: Imaging Studies.

Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072

See all (3046)

Recent systematic reviews

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.

Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999

Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.

Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810

A systematic review of secretory carcinoma of the salivary gland: where are we?

Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686

Canalicular adenoma: A systematic review.

Peraza AJ, Wright J, Gómez R
J Craniomaxillofac Surg 2017 Oct;45(10):1754-1758. Epub 2017 Aug 3 doi: 10.1016/j.jcms.2017.07.020. PMID: 28890252

Salivary gland transfer to prevent radiation-induced xerostomia: a systematic review and meta-analysis.

Sood AJ, Fox NF, O'Connell BP, Lovelace TL, Nguyen SA, Sharma AK, Hornig JD, Day TA
Oral Oncol 2014 Feb;50(2):77-83. Epub 2013 Nov 1 doi: 10.1016/j.oraloncology.2013.10.010. PMID: 24189058

See all (150)

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Salivary Gland Sebaceous Lymphadenoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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