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Giant Cell Angiofibroma

MedGen UID:
235073
•Concept ID:
C1367539
•
Neoplastic Process

Definition

A morphologic variant of angiofibroma characterized by the presence of multinucleated giant cells, collagenous or myxoid stroma, focal sclerotic areas, and angiectoid spaces. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant Cell Angiofibroma

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Contemporary management of juvenile angiofibroma.
Bertazzoni G, Schreiber A, Ferrari M, Nicolai P
Curr Opin Otolaryngol Head Neck Surg 2019 Feb;27(1):47-53. doi: 10.1097/MOO.0000000000000505. PMID: 30507688
Imaging Evaluation and Treatment of Vascular Lesions at the Skull Base.
Jindal G, Miller T, Raghavan P, Gandhi D
Radiol Clin North Am 2017 Jan;55(1):151-166. Epub 2016 Oct 25 doi: 10.1016/j.rcl.2016.08.003. PMID: 27890183

Recent clinical studies

Etiology

Giant cell-rich solitary fibrous tumour of the urinary bladder: case report of an unusual histological variant and literature review.
Su Z, Wei J, Yuan X
Diagn Pathol 2024 Jan 23;19(1):20. doi: 10.1186/s13000-024-01442-z. PMID: 38263153Free PMC Article
A review of solitary fibrous tumours of the orbit and ocular adnexa.
René C, Scollo P, O'Donovan D
Eye (Lond) 2023 Apr;37(5):858-865. Epub 2022 Jul 13 doi: 10.1038/s41433-022-02160-w. PMID: 35831617Free PMC Article
The clinicopathological significance of NAB2-STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors.
Huang SC, Li CF, Kao YC, Chuang IC, Tai HC, Tsai JW, Yu SC, Huang HY, Lan J, Yen SL, Lin PC, Chen TC
Cancer Med 2016 Feb;5(2):159-68. Epub 2015 Dec 21 doi: 10.1002/cam4.572. PMID: 26686340Free PMC Article
Giant cell angiofibroma of parapharyngeal space: a report of a new location for a rare tumour.
González-Pérez LM, Sánchez-Gallego F, Haro-Luna JJ, Infante-Cossío P
Int J Oral Maxillofac Surg 2010 Oct;39(10):1024-7. Epub 2010 May 26 doi: 10.1016/j.ijom.2010.04.044. PMID: 20537864
Recent developments in soft tissue tumors.
Fletcher CD
Verh Dtsch Ges Pathol 1998;82:33-46. PMID: 10095415

Diagnosis

Unusual intraconal localization of orbital giant cell angiofibroma.
Ekin MA, Ugurlu SK, Cakalagaoglu F
Indian J Ophthalmol 2018 Jan;66(1):160-163. doi: 10.4103/ijo.IJO_755_16. PMID: 29283151Free PMC Article
The Current Status of Solitary Fibrous Tumor: Diagnostic Features, Variants, and Genetics.
Thway K, Ng W, Noujaim J, Jones RL, Fisher C
Int J Surg Pathol 2016 Jun;24(4):281-92. Epub 2016 Jan 25 doi: 10.1177/1066896915627485. PMID: 26811389
Giant cell angiofibroma or localized periorbital lymphedema?
Lynch MC, Chung CG, Specht CS, Wilkinson M, Clarke LE
J Cutan Pathol 2013 Dec;40(12):1059-62. Epub 2013 Oct 3 doi: 10.1111/cup.12225. PMID: 24117715
Giant cell angiofibroma of the oral cavity: A case report and review of the literature.
de Andrade CR, Lopes MA, de Almeida OP, León JE, Mistro F, Kignel S
Med Oral Patol Oral Cir Bucal 2008 Sep 1;13(9):E540-3. PMID: 18758395
Orbital giant cell angiofibroma.
Ereño C, López JI, Pérez J, Grande J, Bilbao FJ
APMIS 2006 Sep;114(9):663-5. doi: 10.1111/j.1600-0463.2006.apm_382.x. PMID: 16948822

Therapy

Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature.
He Y, Zhang C, Liu G, Tian Z, Wang L, Kalfarentzos E
World J Surg Oncol 2014 Apr 24;12:117. doi: 10.1186/1477-7819-12-117. PMID: 24758544Free PMC Article
Endovascular preoperative embolization of orbital hemangiopericytoma with n-butyl cyanoacrylate glue.
Wallace KM, Alaraj A, Aakalu VK, Aletich V, Setabutr P
Ophthalmic Plast Reconstr Surg 2014 Jul-Aug;30(4):e97-100. doi: 10.1097/IOP.0b013e3182a22bd8. PMID: 24317100Free PMC Article
Four cases of solitary fibrous tumour of the eye and orbit: one with sarcomatous transformation after radiotherapy and one in a 5-year-old child's eyelid.
Blandamura S, Alaggio R, Bettini G, Guzzardo V, Valentini E, Bedogni A
J Clin Pathol 2014 Mar;67(3):263-7. Epub 2013 Oct 9 doi: 10.1136/jclinpath-2013-201820. PMID: 24108432
Extraorbital giant cell angiofibroma.
Husek K, Veselý K
Cesk Patol 2002 Jul;38(3):117-20. PMID: 12325476

Prognosis

Giant cell-rich solitary fibrous tumour of the urinary bladder: case report of an unusual histological variant and literature review.
Su Z, Wei J, Yuan X
Diagn Pathol 2024 Jan 23;19(1):20. doi: 10.1186/s13000-024-01442-z. PMID: 38263153Free PMC Article
A review of solitary fibrous tumours of the orbit and ocular adnexa.
René C, Scollo P, O'Donovan D
Eye (Lond) 2023 Apr;37(5):858-865. Epub 2022 Jul 13 doi: 10.1038/s41433-022-02160-w. PMID: 35831617Free PMC Article
The Current Status of Solitary Fibrous Tumor: Diagnostic Features, Variants, and Genetics.
Thway K, Ng W, Noujaim J, Jones RL, Fisher C
Int J Surg Pathol 2016 Jun;24(4):281-92. Epub 2016 Jan 25 doi: 10.1177/1066896915627485. PMID: 26811389
Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature.
He Y, Zhang C, Liu G, Tian Z, Wang L, Kalfarentzos E
World J Surg Oncol 2014 Apr 24;12:117. doi: 10.1186/1477-7819-12-117. PMID: 24758544Free PMC Article
Giant cell angiofibroma of parapharyngeal space: a report of a new location for a rare tumour.
González-Pérez LM, Sánchez-Gallego F, Haro-Luna JJ, Infante-Cossío P
Int J Oral Maxillofac Surg 2010 Oct;39(10):1024-7. Epub 2010 May 26 doi: 10.1016/j.ijom.2010.04.044. PMID: 20537864

Clinical prediction guides

Unusual intraconal localization of orbital giant cell angiofibroma.
Ekin MA, Ugurlu SK, Cakalagaoglu F
Indian J Ophthalmol 2018 Jan;66(1):160-163. doi: 10.4103/ijo.IJO_755_16. PMID: 29283151Free PMC Article
Orbital solitary fibrous tumor: encompassing terminology for hemangiopericytoma, giant cell angiofibroma, and fibrous histiocytoma of the orbit: reappraisal of 41 cases.
Furusato E, Valenzuela IA, Fanburg-Smith JC, Auerbach A, Furusato B, Cameron JD, Rushing EJ
Hum Pathol 2011 Jan;42(1):120-8. Epub 2010 Nov 5 doi: 10.1016/j.humpath.2010.05.021. PMID: 21056898
A study of four cases of extra-orbital giant cell angiofibroma with documentation of some unusual features.
Thomas R, Banerjee SS, Eyden BP, Shanks JH, Bisset DL, Hunt R, Byers RJ, Oogarah P, Harris M
Histopathology 2001 Oct;39(4):390-6. doi: 10.1046/j.1365-2559.2001.01227.x. PMID: 11683940
Orbital and extraorbital giant cell angiofibroma: a giant cell-rich variant of solitary fibrous tumor? Clinicopathologic and immunohistochemical analysis of a series in favor of a unifying concept.
Guillou L, Gebhard S, Coindre JM
Am J Surg Pathol 2000 Jul;24(7):971-9. doi: 10.1097/00000478-200007000-00008. PMID: 10895819
Giant cell angiofibroma of the orbit and eyelid.
Hayashi N, Borodic G, Karesh JW, Tolentino MJ, Remulla HD, Van Wesep RA, Grossniklaus HE, Jakobiec FA, Green WR
Ophthalmology 1999 Jun;106(6):1223-9. doi: 10.1016/S0161-6420(99)90270-1. PMID: 10366097

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